Positions
Deborah Fass
1st deborah.fass@weizmann.ac.il Phone: +972-8-934-3214 Homepage of Deborah Fass, Opens in new windowWe have rotation projects on a variety of subjects including:
1) the structure of the giant "mucin" proteins in mucus
2) redox regulation of O-glycosylation in humoral immunology
<Rina Rosenzweig
1st rina.rosenzweig@weizmann.ac.il Phone: +972-8-934-2516 Homepage of Rina Rosenzweig, Opens in new windowElucidating the role of molecular chaperones in cancer
[Read more] about Rina RosenzweigThe Hsp70 chaperone is of prime importance to cancer biology; supporting proliferative growth and stress survival, blocking apoptosis, and fighting protein aggregation caused by aneuploidy or mutation. One central cancer-related substrate of the Hsp70 system is the p53 tumor suppressor protein, in both wild-type and mutant forms, which interacts with the Hsp70 system for (re)folding, stabilization, and degradation. The molecular basis of these interactions and pathway triaging, however, are unknown. This project therefore aims to characterize the roles these molecular chaperones play in cancer pathology.