3-year fully-funded PhD studentship opportunity at the University of York

Structural analysis of SasC, a repetitive staphylococcal biofilm-forming protein implicated in antibiotic resistance

Bacterial biofilms on cardiovascular devices and other surfaces cause significant morbidity and mortality and are implicated in antibiotic resistance. Cell wall-attached proteins from Staphylococcus aureus facilitate bacterial biofilm formation. The aim is to study the staphylococcal protein SasC. In addition to molecular biology, recombinant protein expression and purification, a range of biophysical and structural techniques including NMR spectroscopy, X-ray crystallography and single molecule fluorescence is available to study the different regions of the SasC molecule. The project is for three years from October 2015 and will be supervised by Prof Jennifer Potts and Dr Christoph Baumann in the Department of Biology. The University of York provides an excellent, stimulating environment for structural biology, biophysics and molecular microbiology.

Applications are welcomed from candidates with at least an upper second class honours degree in biochemistry, biophysics or a related discipline and who satisfy the eligibility criteria (see below).

Informal enquiries to: jennifer.potts@york.ac.uk or christoph.baumann@york.ac.uk

Eligibility:
Applicants must meet the British Heart Foundation (BHF) residency requirements. They should normally have a relevant connection to the EEA (European Economic Area). Relevant connection would be established if:
•    an individual is a UK/EEA national, or
•    has an appropriate degree from a university in the EEA, or
•    has worked in a university, hospital or research institution in the EEA (providing it is not for the sole purpose of full-time education) for at least the past 3 years, or did so before taking up an appointment outside the EEA.

Funding Notes:
This is a 3-year studentship fully-funded by the British Heart Foundation and covers:
    (i) a tax-free stipend at the standard BHF rate (estimated to be £19,919 for 2015-2016)
    (ii) some research costs
    (iii) tuition fees at the UK/EU rate.

Application Deadline: 31.05.2015

More information about the Department of Biology, University of York:
http://www.york.ac.uk/biology/