ERC-funded post-doc positions in the Neuroplasticity and Neural Activity MRI-Lab in Lisbon, Portugal

Several ERC-funded post-doc positions are available early next year in the Neuroplasticity & Neural Activity MRI-Lab at the Champalimaud Neuroscience Programme (CNP) in Lisbon, Portugal. Generally, the project aims are to:

(1) Develop new approaches for mapping direct neural activity in vivo via nonBOLD fMRI at ultrahigh field;

(2) Apply these and other fMRI methods for studying specific, optogenetically-targeted neural circuits and their correlation with longitudinal behavioral changes (e.g., upon plasticity / disease);

(3) Investigate BOLD neurophysiology, using simultaneous optogenetics, calcium recordings and fMRI.

Further details about the Lab / Institute are appended below.

A successful Applicant will have a PhD (or will be very close to submitting her/his thesis) in Neuroscience/Neurobiology, Physics, Biomedical Engineering, or Chemistry.

Additionally, s/he will have extensive experience with at least one of the following:

- Experimental preclinical MRI or fMRI or MRS
- Ultrahigh field MRI
- MR Physics and pulse sequence programming 
- Optogenetics in the context of neural circuits / behavior.
- Calcium recordings / imaging in the context of neural circuits

An excellent, well-documented track-record is imperative.

To apply, please send the following items to

1. Cover Letter stating your interests
2. A full CV, including list of publications
3. Names and email addresses of at least 3 references.

Successful applicants will receive full funding and a private/national health insurance.

Call deadline: December 15th 2016.

The Shemesh Lab in Champalimaud Neuroscience Programme (CNP) investigates neural activity, neuroplasticity, and how they elicit behavioral changes in vivo. These questions are interrogated in the context of normal processes (development, learning…), as well as in neuropsychiatric and neurodegeneration animal models of disease. Our approach involves a plethora of advanced methods, mainly revolving around state-of-the-art preclinical MRI/MRS, augmented by simultaneous ancillary techniques (optogenetics, calcium recordings, advanced behavioral testing). One of the main goals in the Lab is to develop nonBOLD fMRI methods, which will report on neural activity much more directly compared to conventional fMRI. 

This ERC-funded Lab benefits from a cutting-edge, ultrahigh field 16.4T scanner, as well as a 9.4T scanner equipped with two 4-element array cryoprobes (for mice and rats, respectively), another 1T scanner for basic scanning and testing in more clinical settings, and lasers for optogenetics / calcium recordings; the Labalso has a fully equipped surgery room, ample space for performing extensive behavioural studies and access to one of Europe’s largest vivaria, including its numerous transgenic lines, neurodegeneration/psychiatric animal models of disease, and ancillary platforms for histology, microscopy, transgenics and viruses, among others.

CNP is situated within the Champalimaud Centre for the Unknown, a private, non-profit foundation residing on Lisbon’s waterfront, right where the River Tejo meets the Atlantic Ocean. CCU provides a stunning and productive working environment, harboring a Neuroscience department for basic research, and a clinical centre for treating cancer patients with pioneering methods. This unique blend of basic research and clinical practice under the same roof, which actively encourages collaborations and exchange of ideas, results in a highly interdisciplinary and stimulating atmosphere. Post-Doctoral salaries are very competitive vis-à-vis Lisbon costs of living, and post-docs further benefit from health insurance.