PhD position Madl lab, Medical University of Graz, Austria

PhD position Madl lab, Medical University of Graz, Austria
Projects starting March 1, 2019
Application deadline: September 23, 2018

We are looking for a motivated student in chemistry or biochemistry, to work
on the mechanisms of regulation of nuclear import and phase separation in the
current call of the PhD program “Molecular Medicine” in the Madl lab at the
Medical University of Graz, Austria.

The candidate will mainly use state-of-the-art solution-state NMR and SAXS
techniques as well as a wide range of biophysical methods. The successful
candidate will thus acquire a broad biophysical expertise.

The Madl lab is interested in understanding the general mechanisms of how
disordered proteins mediate signal transfer via an intricate network of
protein interactions and post-translational modifications. We work at the
interface of structural biology, biophysics, cell biology and medicine to
study the molecular mechanisms of key regulatory processes involved in
signaling. Nuclear magnetic resonance (NMR) and biophysical methods are the
primary tools employed in our laboratory that allow us to study the structural
and dynamical properties of signaling proteins and their interactions under
native-like solution conditions. Our efforts focus primarily on the highly
conserved Wnt signaling pathway and intersected pathways, forkhead
transcription factors, and the biogenesis of RNA-binding proteins. Distortions
in these pathways lead to a plethora of diseases, including cancers and
neurodegenerative disorders, and are linked to ageing.

The Medical University of Graz offers PhD positions in the international PhD
program “Molecular Medicine” (MolMed).
The PhD studies provide an in-depth, multidisciplinary training in biomedical
research in a stimulating international environment. The thesis projects focus
on aspects of inflammatory, metabolic and cardiovascular diseases, cancer and
stem cells, as well as novel therapeutic targets and the development of
medical biomarkers and therapies, and integrate basic research and clinically-
oriented sciences utilizing a wide spectrum of state-of-the-art techniques.
Selected PhD students get employed for up to 3 years (initial contract for one
year with the option of prolongation upon successful performance) with a
contract that includes social benefits.
Applicants must hold (or be close to obtaining) an undergraduate degree
equivalent to a Master in any discipline of natural or life sciences or
medicine. The selection procedure, all training activities and communications
will be in English. Thus, excellent written and spoken English skills are
Applications are exclusively accepted through the online platform Please do not send any documents by regular mail or
e-mail unless you are explicitly asked to do so by our staff. There is no
application fee.

Further information about the programs, open projects and the online
application procedure are available at:

Tobias Madl, Ph.D.
Assoc. Prof. for Integrated Structural Biology & Metabolism Research

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging
Molecular Biology and Biochemistry
Medical University of Graz
Neue Stiftingtalstraße 6/VI
8010 Graz

Tel.: +43 316 385 71972