PhD position at University of Warwick, UK

A PhD position is available in the Department of Chemistry at the University of Warwick entitled:

Structure and Design of Cyclic Peptides for Drug Development

under the supervision of Drs. Ann Dixon and Rebecca Notman.

This three-year studentship is funded by the Leverhulme Trust, and further information about the project and application procedure can be found at:  

http://www.jobs.ac.uk/job/BBM193/phd-studentshipstructure-and-design-of-cyclic-peptides-for-drug-development/

The application deadline is July 10th 2017.
Interested candidates may contact Dr. Dixon (ann.dixon@warwick.ac.uk)

Project Description: This PhD studentship involves the development of new, predictive tools to understand how introduction of chemical modifications into a polypeptide chain changes the global structure/properties of the peptide, with a goal of applying this understanding to rapid and efficient synthesis of cyclic peptides – one of the most exciting and promising branches of drug and therapeutic development today.  Working in collaboration with the laboratory of Prof. Mike Shipman, the project will provide an exciting  research problem for a student with a background in analytical, biological or physical chemistry, as well as an excellent opportunity for them to develop skills in advanced analytical and biological chemistry, spectroscopy methods (especially NMR), and computational chemistry methods. The project is split into two areas of research:  (i) use of analytical tools including solution-state nuclear magnetic resonance (NMR) to deduce the three-dimensional structures of modified polypeptides, and (ii) molecular dynamics (MD) simulations of designed peptides.  The experimental and computational data are highly complementary and will yield a molecular-level understanding of structure and reactivity which will form the foundation for design of new synthetic strategies and peptides with therapeutic potential.