Post-Doctoral Fellow at NIST

Joint Project between AMGEN &NIST
There is an immediate opening for a post‐doctoral researcher at the National Institute of Standards and Technology (NIST) to develop high resolution NMR higher order structure (HOS) characterization tools for biotherapeutics.

Project description: Using class representative, IgG1 and IgG2 monoclonal antibodies, the project aims to use comparative analysis to look for correlations between 1D PROFILE NMR signal variations assigned to higher order structure and differences observed in 2D methyl fingerprints. Side-by-side comparison and combinations of the two NMR methods will be pursued to allow structural variations to be readily detected using 1D and 2D NMR fingerprinting methods and also assigned to sequence using multi-dimensional, heteronuclear NMR methods.

Collaboration: This is a joint project as part of a Cooperative Research & Development Agreement (CRADA) between Amgen and NIST. This project is led by Mats Wikström (Amgen) and John Marino (Biomolecular Structure and Function Group, NIST). The post-doc will be a US federal employee at NIST and have his/her primary duty station at NIST but will work in close collaboration with Amgen scientists on the collaborative and have access to Amgen laboratories as required.

Suitable disciplines: Candidates with recent PhD degrees in chemistry, biochemistry, or a related field are encouraged to apply. A strong background in NMR spectroscopy is preferred, and experience with protein biochemistry and biophysics would be advantageous.

Salary and benefits: At a salary of $69,000 / year, the fellowship is funded for a maximum of three years; renewal will be granted at the end of each year based on satisfactory performance. For benefits information see

Citizenship requirement: Interested applicants must have US citizenship, since the successful candidate will be a US federal govt. employee.

Application procedure: Please send a CV, cover letter and contact information for at least three references to: