Post-doctoral position in Grenoble (France)

A postdoctoral position in NMR Structural determination  & Computational Biochemistry is available at the Department of Pharmacochemistry  (DPM) and Department of Molecular Chemistry (DCM) , in Grenoble-Alpes University (web site http://dpm.ujf-grenoble.fr and http://dcm.ujf-grenoble.fr/DCM-SITE/I2BM/index.php?page=/DCM-SITE/I2BM/labo)

The project is at the interface between biology, structure determination and computational chemistry. It aims at understanding the interaction between proteins involved in the inhibition of the blood coagulation in patients with haemophilia. The research will consist of NMR experiments and restrained molecular dynamics. Molecular docking simulations will also be performed. The scientific outcome of the project will be reliable 3D structures and dynamics of the protein-protein complex, and docking of pro-coagulant drugs into the protein complex.

Protein samples will be produced in collaboration with the Experimental Recombinant Therapeutics team (TheREx) in Grenoble. The DCM lab possesses a solution-state NMR 500 MHz and has access to TGIR-NMR facilities (in Grenoble, 600, 700, 850 and 950 MHz located at IBS).

We are looking for motivated candidates who will have experience in structural study of protein by NMR and strong skills in molecular dynamics simulations of biological systems and molecular dockingProgramming and scripting is a strong plus. Ability to work independently and at the same time be able to interact with other researchers is very important. Excellent communication skills in written and spoken English are prerequisites.

This research project is funded by the French National Research Agency- labex ARCANE. Annual compensation will be $45,000/yr. Initial appointments will be for one year renewable one year.

In order to apply, please send a CV, a letter describing your research interests and skills, and either two reference letters or the contact details of two referees to muriel.jourdan@univ-grenoble-alpes.fr and aline.thomas@univ-grenoble-alpes.fr