Postdoc position in NMR studies of GPCRs

Mechanism of G-protein-coupled-receptor activation

A postdoctoral position is available in the group of Dr Daniel Nietlispach in the Department of Biochemistry at the University of Cambridge, to investigate G-protein-coupled receptors (GPCRs), a large family of cell surface located membrane-embedded molecular sensors that regulate a wide range of physiological processes in health and disease.

Using primarily solution NMR spectroscopy the project focuses on mechanistic aspects of receptor activation, including investigations into the dynamic nature of GPCRs, the influence of the membrane bilayer environment and its lipid composition on receptor function and how this modulates interactions with cytoplasmic binding partners (Solt et al., Nat Commun, 2017; Chien et al, J Am Chem Soc, 2017).

Suitable candidates will hold a PhD in Biochemistry, Molecular Biology, Biophysics or a related topic and will be highly motivated to drive an exciting fundamental research project. They will be able to demonstrate a track record of publishing high quality research. Ability to work both independently, and as part of a team, is required, together with excellent problem-solving, organizational and communication skills. Expertise in protein expression, structural biology of membrane proteins and the handling of lipid membrane mimetic systems is crucial. Experience with solution NMR spectroscopy of biomolecules and baculovirus-insect cell expression would be highly beneficial.

For further information on the position and how to apply for the post please visit the website:

Informal enquiries can be made by contacting Daniel Nietlispach -

Dr Daniel Nietlispach
University of Cambridge
Department of Biochemistry
80 Tennis Court Road
Old Addenbrookes Site
Cambridge, CB2 1GA, UK
Tel: ++44 (1223) 766023, Fax: ++44 (1223) 766002