Postdoc position in Structure-Based Cancer Drug Discovery - Astbury Centre, Leeds University

There is an immediate opening in my lab at the Astbury Centre (University of Leeds, UK) for a versatile structural biologist to work on cancer drug discovery in a collaboration with the Northern Institute for Cancer Research at Newcastle University.

The position, which is funded for 2 years by Cancer Research UK (CRUK), is for development of small molecule inhibitors of the Ras activating protein, SOS. You will preferably be an experienced X-ray crystallographer, with complementary skills and expertise in other structural and biophysical methods, including NMR, SPR or ITC. The project will also involve implementation of cell-based assays in conjunction with the lab of Dr Darren Tomlinson (Leeds). Medicinal chemistry expertise and resource will be provided by our Newcastle collaborators (Prof Mike Waring).

The successful applicant will have access to the Astbury Centre’s excellent structural biology facilities including a state-of-the-art crystallisation suite and cryoprobe-equipped 950 MHz NMR.

For more details and to apply please follow this link:

…or for informal enquiries please contact me directly.






Prof Alexander L Breeze

Professor of Biomolecular NMR

Director of NMR, Astbury BioStructure Laboratory

Astbury Centre for Structural Molecular Biology

School of Molecular and Cellular Biology

University of Leeds




T: +44 113 343 0087