Postdoctoral position available studying tubulin and its modifications

A postdoctoral position is available in the Hough Lab in the BioFrontiers Institute and Department of Physics at University of Colorado-Boulder. Interviews will take place in person in Boulder on a rolling basis and the start date is flexible.

The Hough Lab works at the interface of physics and biochemistry, looking at the role of intrinsically disordered domains in protein function. In particular, this position is for a project to dissect the role of the C-terminal tail of tubulin on its function by NMR and other biophysical techniques ( Of particular interest are the effects of post-translational modifications on binding, bending, and polymerization, and as well as the corresponding changes in tubulin structure and dynamics as probed by NMR. We use Tetrahymena thermophila as a source for tubulin. We will capitalize on the broad range of mutant strains with differential levels of tubulin modifications. The lab is located in the new Jennie Smoly Caruthers Biotechnology Building in Boulder,

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The candidate will work with two others on a collaborative project to study the role of tubulin tail post-translational modifications.  Applicants interested in either the biophysical or structural aspects of this project are both encouraged to apply. The candidate will be expected to develop and pursue independent research questions within this overall framework.

Degree requirements:  PhD in biophysics, biochemistry, cell biology, or related field.

Minimum qualifications: Significant research accomplishments, including first- author publications in a related field.  Experience and expertise in NMR, protozoa cell biology or tubulin biochemistry, or relevant expertise that will bring a unique contribution to the project.  The candidate must be strongly self-motivated, responsible and collaborative.

Desired qualifications:  Experience in a subset of the common methods in the lab: Nuclear Magnetic Resonance Spectroscopy (NMR), molecular cloning, protein expression and purification, bacterial and eukaryotic cell culture, time-lapse microscopy, image processing, computational analysis of data.

The University of Colorado is an equal opportunity and affirmative action employer committed to assembling a diverse, broadly trained faculty and staff in compliance with applicable laws and in furtherance of its commitment to fostering an environment that welcomes and embraces diversity, the University of Colorado does not discriminate on the basis of race, color, creed, religion, national origin, sex (including pregnancy), disability, age, veteran status, sexual orientation, gender identity or expression, genetic information, political affiliation or political philosophy in its programs or activities, including employment, admissions, and educational programs. Inquiries may be directed to Boulder campus Title IX Coordinator by calling 303-492-2127.

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