Postdoctoral position in protein NMR and computational metadynamics

An MRC-funded 3-year postdoctoral research position is available at the University of Leeds, UK, to study dynamic mechanisms of activation of receptor tyrosine kinases by cancer-associated mutations. The project will combine experimental protein biochemistry, protein NMR and biophysics techniques with state-of-the-art computational metadynamics simulations. Successful candidates will be able to demonstrate experience in some or all of these areas, and an enthusiasm and aptitude to learn rapidly in others.

You will be based in the laboratory of Prof Alex Breeze in the Astbury Centre for Structural Molecular Biology at the University of Leeds, and will also spend time in the group of Prof Michele Vendruscolo (Department of Chemistry, University of Cambridge). Exceptional facilities are available to support the project, including a new, 950 MHz cryoprobe-equipped NMR spectrometer and state-of-the-art computational infrastructure. Applicants should have, or be about to obtain, a PhD in biomolecular NMR, structural biology, biophysics or a related area and have a strong publication record.

For informal enquiries please contact Prof Alex Breeze (