Postdoctoral position in solution and solid-state protein NMR

Postdoctoral position is available to join a CIHR-funded project investigating synucleinopathy in Parkinson’s Disease, and specifically how alpha-synuclein mediated regulation of exosome biogenesis relates to the spread of disease pathology. The research will primarily focus on the NMR-based analysis of interactions between alpha-synuclein and the LC3 subfamily of autophagy proteins in solution and on the surface of membranes.

The successful candidate would have a Ph.D. in Chemistry, Biophysics, Biochemistry or a related field, conferred within the last 5 years. We seek a talented and ambitious postdoc who is familiar with protein expression and purification, has strong experience and publication record in experimental solution NMR of proteins and is willing to expand their expertise into state-of-the-art solid-state NMR methodologies. The work will be conducted in the Department of Molecular and Cellular Biology (MCB) and University of Guelph NMR Centre and will be co-supervised by Profs. S. Ryan (MCB) and V. Ladizhansky (Physics). The candidate would be part of a multidisciplinary research team that combines cell biology and neuroscience with biochemistry and biophysical approaches. Knowledge of FPLC and HPLC methodologies for protein purification as well as CD-spectroscopy and calorimetry methodologies for protein binding would be advantageous. The NMR Centre houses five Bruker NMR spectrometers operating at fields from 400 MHz to 800 MHz which are equipped with a wide range of solution and solid-state NMR probes, and a 600 DNP/395 GHz DNP system. Additional information is available upon request.  

Interested individuals should send a cover letter, detailed CV along with the names and email addresses of three references to the addresses below:

Dr. Scott D. Ryan, sryan03@uoguelph.ca

Dr. Vladimir Ladizhansky, vladizha@uoguelph.ca

 

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