Postdoctoral positions on LLPS in the formation and function of membrane-less organelles

Postdoctoral positions in Tanja Mittag’s laboratory at

St Jude Children’s Research Hospital

Department of Structural Biology

Memphis, TN, USA

We have several Postdoctoral positions available to study

Liquid-liquid phase separation (LLPS) in the formation and function of membrane-less organelles

We are particularly interested in

  • sequence features of disordered protein regions (IDRs) undergoing LLPS
  • structure of IDRs in the dense liquid phase
  • sequence-conformation relationships of IDRs
  • enzymatic function in the dense liquid phase
  • diseases associated with LLPS

We use high-field NMR spectroscopy, scattering methods, AUC, fluorescence methods, light microscopy, biochemical assays and cell biology. (But not all of these in a single project!)

We are collaborating with several other groups in the field. Please contact me for more information at

tanja.mittag@stjude.org

A. Molliex, J. Temirov, J. Lee, M. Coughlin, A.P. Kanagaraj, H.J. Kim, T. Mittag*, J.P. Taylor*. (2015) Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization. Cell. 163 (1): 123-33. PMID: 26406374

M. Marzahn, S. Marada, J. Lee, A. Nourse, S. Kenrick, H. Zhao, G. Ben-Nissan, R.M. Kolaitis, J.L. Peters, S. Pounds, W.J. Errington, G.G. Prive, J.P. Taylor, M. Sharon, P. Schuck, S.K. Ogden*, T. Mittag*. (2016) Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles. EMBO J. 35 (12): 1254-75.