Two postdoc positions solid-state NMR at ETH Zurich

Two Postdoctoral Positions in the solid-state NMR group of Prof. Beat Meier at ETH Zürich

 

Our research is centred around solid-state NMR structure determination of biomolecules (fibrils, membrane proteins, protein-DNA complexes). Increasing the presently accessible MAS frequencies (150 kHz) to 200-250 kHz will improve dramatically the spectral quality and will, when successful, lead to a greatly improved resolution in the solid-state NMR spectra of large biological systems, e.g. amyloid fibrils, membrane proteins, virus capsids and proteins assemblies.

 

1.    Postdoctoral Position in NMR Methods Development for Fast MAS (>200 kHz)

The project will focus on the development of novel pulse sequences for fast MAS NMR spectroscopy. The theoretical and numerical spin-dynamics simulation work will be closely linked to experimental verification on model proteins and the candidate will collaborate with a postdoc developing the hardware. The experimental work of the candidate can be started with the equipment presently available in the lab at 110-140 kHz MAS. Spectrometers at 500, 600, 850 (2x) and, in the future 1100 MHz are available. 

Prerequisites: Ph.D. in Chemistry, Physics, Biology, Interdisciplinary Sciencesor related area, experience in solid-state NMR and NMR methodological development. Motivation to work in a multidisciplinary team.

See also: https://apply.refline.ch/845721/5441/pub/1/index.html

 

2.    Postdoctoral Position in Development and Construction of a MAS System for NMR Instrumentation (including Computational Fluid Dynamics)

 The project is a collaboration with Prof. Jenny, Institute of Fluid Dynamics, and focuses on the development of innovative hardware for MAS (magic-angle spinning) NMR spectroscopy.

The successful candidate will work on the development and construction of a 200 kHz MAS probe. For the applications, she/he will collaborate with two postdocs/PhD students in the Meier’s group, which will also be hired within the same project. The RF-design and mechanical construction of the MAS probe will be done by the postdoc in collaboration with an electronic engineer with experience in probe design. The design and optimization of the rotation device include large-scale fluid-dynamic simulations in the group of Prof. Jenny. The postdoc will perform the characterization and empirical optimization of the hardware, according to weaknesses detected in experiments on biological systems.

The successful candidate will be jointly supervised by Prof. Meier and Prof. Jenny

 

Prerequisites: Ph.D. in Physics, Interdisciplinary Sciences, Mechanical Engineering, Electrical Engineering, Biomedical Engineering, or related area, experience in application engineering of instrumentation,

and finite element or finite volume simulations. Motivation to work in a multidisciplinary team and a strong interest in hardware development. Previous experience in solid-state NMR, Computational Fluid Dynamics (CFD) simulations and fluid dynamics measurements, or hardware development is an important asset.

 

See also: https://apply.refline.ch/845721/5437/pub/1/index.html

More information about the ongoing projects in the solid-state NMR lab and the hardware available can be found at http://www.nmr.ethz.ch/, more information about the fluid dynamics group at http://www.ifd.mavt.ethz.ch/research/group-jenny 

Applications with motivation letter, CV, publication list, and contact information for 2 references should be sent directly to Prof. Beat Meier (beme@ethz.ch). Applications will be accepted until the positions are filled.