Crystallisation and Structure Determination Publications

  1. Daniel E., Maksimainen M. M., Smith N., Ratas V., Biterova E., Murthy S. N., Tanvir Rahman M., Kiema T. R., Sridhar S., Cordara G., Dalwani S., Venkatesan R., Prilusky J., Dym O., Lehtio L., Kristian Koski M., Ashton A. W., Sussman J. L. & Wierenga R. K. (2021). IceBear: An intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition.  Acta Crystallographica Section D: Structural Biology. 2021 Feb , 77 (2):151-163.
  2. Ben-David M., Soskine M., Dubovetskyi A., Cherukuri K., Dym O., Sussman J. L., Liao Q., Szeler K., Kamerlin S. C. L. & Tawfik D. S. (2020). Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.  Molecular Biology and Evolution. 2020 Apr , 37 (4):1133-1147.
  3. Suzumoto Y., Dym O., Roviello G. N., Worek F., Sussman J. L. & Manco G. (2020). Structural and functional characterization of new ssopox variant points to the dimer interface as a driver for the increase in promiscuous paraoxonase activity.  International Journal of Molecular Sciences. 2020 Mar , 21 (5).
  4. Saikia C., Dym O., Altman-Gueta H., Gordon D., Reuveny E. & Karbat I. (2020). A molecular lid mechanism of K+ channel blocker action revealed by a cone peptide.  BioRxiv. 2020 Jun , .
  5. Yagound B., Dogantzis K. A., Zayed A., Lim J., Broekhuyse P., Remnant E. J., Beekman M., Allsopp M. H., Aamidor S. E., Dim O., Buchmann G. & Oldroyd B. P. (2020). A Single Gene Causes Thelytokous Parthenogenesis, the Defining Feature of the Cape Honeybee Apis mellifera capensis.  Current Biology. 2020 Jun , 30 (12):2248-2259.
  6. Karbat I., Altman-Gueta H., Fine S., Szanto T., Hamer-Rogotner S., Dym O., Frolow F., Gordon D., Panyi G., Gurevitz M. & Reuveny E. (2019). Pore-modulating toxins exploit inherent slow inactivation to block K+ channels.  Proceedings of the National Academy of Sciences of the United States of America. 2019 Sept , 116 (37):18700-18709.
  7. Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Ben Nissan G., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (2019). Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.  PLoS Computational Biology. 2019 Aug , 15 (8).
  8. Novichkova D. A., Lushchekina S., Dym O., Masson P., Silman I. & Sussman J. L. (2019). The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability.  Chemico-Biological Interactions. 2019 Aug , 309 .
  9. Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y. (2019). RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.  Oncogene. 2019 Mar , 38 (13):2432-2434.
  10. Kantaev R., Riven I., Goldenzweig A., Barak Y., Dym O., Peleg Y., Albeck S., Fleishman S. J. & Haran G. (2018). Manipulating the Folding Landscape of a Multi-Domain Protein.  Journal of Physical Chemistry B. 2018 Dec , 122 (49):11030-11038.
  11. Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J. (2018). Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.  Molecular Cell. 2018 Oct , 72 (1):178-186.e5.
  12. Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J. (2018). Highly active enzymes by automated combinatorial backbone assembly and sequence design.  Nature Communications. 2018 Jul , 9 .
  13. Netzer R., Listov D., Lipsh R., Dym O., Albeck S., Knop O., Kleanthous C. & Fleishman S. J. (2018). Ultrahigh specificity in a network of computationally designed protein-interaction pairs.  Nature Communications. 2018 Dec , 9 (1).
  14. Karniel A., Mrusek D., Steinchen W., Dym O., Bange G. & Bibi E. (2018). Co-translational folding intermediate dictates membrane targeting of the signal recognition particle-receptor.  Journal of Molecular Biology. 2018 May , 430 (11):1607-1620.
  15. Baran D., Pszolla M. G., Lapidoth G. D., Norn C., Dym O., Unger T., Albeck S., Tyka M. D. & Fleishman S. J. (2017). Principles for computational design of binding antibodies.  Proceedings of the National Academy of Sciences of the United States of America. 2017 Oct , 114 (41):10900-10905.
  16. Cohen-Khait R., Dym O., Hamer-Rogotner S. & Schreiber G. (2017). Promiscuous Protein Binding as a Function of Protein Stability.  Structure (London, England : 1993). 2017 Dec , 25 (12):1867-1874.e3.
  17. Ben-Nissan G., Belov M. E., Morgenstern D., Levin Y., Dym O., Arkind G., Lipson G., Makarov A. A. & Sharon M. (2017). Triple-Stage Mass Spectrometry Unravels the Heterogeneity of an Endogenous Protein Complex.  Analytical Chemistry. 2017 Apr , 89 (8):4708-4715.
  18. Smock R. G., Yadid I., Dym O., Clarke J. & Tawfik D. (2016). De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.  Cell. 2016 Jan , 164 (3):476-486.
  19. Bednarczyk D., Dym O., Prabahar V., Peleg Y., Pike D. H. & Noy D. (2016). Fine Tuning of Chlorophyll Spectra by Protein-Induced Ring Deformation.  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2016 Jun , 55 (24):6901-6905.
  20. Goldenzweig A., Goldsmith M., Hill S. E., Gertman O., Laurino P., Ashani Y., Dym O., Unger T., Albeck S., Prilusky J., Lieberman R. L., Aharoni A., Silman I., Sussman J., Tawfik D. & Fleishman S. J. (2016). Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.  Molecular Cell. 2016 Jul , 63 (2):337-346.