Crystallisation and Structure Determination Publications

  1. Daniel E., Maksimainen M. M., Smith N., Ratas V., Biterova E., Murthy S. N., Tanvir Rahman M., Kiema T. R., Sridhar S., Cordara G., Dalwani S., Venkatesan R., Prilusky J., Dym O., Lehtio L., Kristian Koski M., Ashton A. W., Sussman J. L. & Wierenga R. K. (2021). IceBear: An intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition.  Acta Crystallographica Section D: Structural Biology. 2021 Feb , 77 (2):151-163.
  2. Mohan V., Gaffney J. P., Solomonov I., Levin M., Klepfish M., Akbareian S., Grünwald B., Dym O., Eisenstein M., Yu K. H., Kelsen D. P., Krüger A., Edwards D. R. & Sagi I. (2021). Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill.  Cancers. 2021 Apr , 13 (7).
  3. Peleg Y., Vincentelli R., Collins B. M., Chen K., Livingstone E. K., Weeratunga S., Leneva N., Guo Q., Remans K., Perez K., Bjerga G. E., Larsen Ø., Vaněk O., Skořepa O., Jacquemin S., Poterszman A., Kjaer S., Christodoulou E., Albeck S., Dym O., Ainbinder E., Unger T., Schuetz A., Matthes S., Bader M., de Marco A., Storici P., Semrau M. S., Stolt-Bergner P., Aigner C., Suppmann S., Goldenzweig A. & Fleishman S. J. (2021). Community-Wide Experimental Evaluation of the PROSS Stability-Design Method.  Journal of Molecular Biology. 2021 Jun , 433 (13):166964-166964.
  4. Saikia C., Dym O., Altman-Gueta H., Gordon D., Reuveny E. & Karbat I. (2021). A Molecular Lid Mechanism of K+ Channel Blocker Action Revealed by a Cone Peptide.  Journal of Molecular Biology. 2021 Mar , .
  5. Zahradník J., Marciano S., Shemesh M., Zoler E., Harari D., Chiaravalli J., Meyer B., Rudich Y., Li C., Marton I., Dym O., Elad N., Lewis M., Andersen H., Gagne M., Seder R., Douek D. & Schreiber G. (2021). SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution.  Nature Microbiology. 2021 Sept , 6 (9):1188-1198.
  6. Ben-David M., Soskine M., Dubovetskyi A., Cherukuri K., Dym O., Sussman J. L., Liao Q., Szeler K., Kamerlin S. C. L. & Tawfik D. S. (2020). Enzyme Evolution: An Epistatic Ratchet versus a Smooth Reversible Transition.  Molecular Biology and Evolution. 2020 Apr , 37 (4):1133-1147.
  7. Suzumoto Y., Dym O., Roviello G. N., Worek F., Sussman J. L. & Manco G. (2020). Structural and functional characterization of new ssopox variant points to the dimer interface as a driver for the increase in promiscuous paraoxonase activity.  International Journal of Molecular Sciences. 2020 Mar , 21 (5).
  8. Saikia C., Dym O., Altman-Gueta H., Gordon D., Reuveny E. & Karbat I. (2020). A molecular lid mechanism of K+ channel blocker action revealed by a cone peptide.  BioRxiv. 2020 Jun , .
  9. Yagound B., Dogantzis K. A., Zayed A., Lim J., Broekhuyse P., Remnant E. J., Beekman M., Allsopp M. H., Aamidor S. E., Dim O., Buchmann G. & Oldroyd B. P. (2020). A Single Gene Causes Thelytokous Parthenogenesis, the Defining Feature of the Cape Honeybee Apis mellifera capensis.  Current Biology. 2020 Jun , 30 (12):2248-2259.
  10. Arafeh R., Di Pizio A., Elkahloun A. G., Dym O., Niv M. Y. & Samuels Y. (2019). RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma.  Oncogene. 2019 Mar , 38 (13):2432-2434.
  11. Karbat I., Altman-Gueta H., Fine S., Szanto T., Hamer-Rogotner S., Dym O., Frolow F., Gordon D., Panyi G., Gurevitz M. & Reuveny E. (2019). Pore-modulating toxins exploit inherent slow inactivation to block K+ channels.  Proceedings of the National Academy of Sciences of the United States of America. 2019 Sept , 116 (37):18700-18709.
  12. Warszawski S., Katz A. B., Lipsh R., Khmelnitsky L., Ben Nissan G., Javitt G., Dym O., Unger T., Knop O., Albeck S., Diskin R., Fass D., Sharon M. & Fleishman S. J. (2019). Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.  PLoS Computational Biology. 2019 Aug , 15 (8).
  13. Novichkova D. A., Lushchekina S., Dym O., Masson P., Silman I. & Sussman J. L. (2019). The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability.  Chemico-Biological Interactions. 2019 Aug , 309 .
  14. Karniel A., Mrusek D., Steinchen W., Dym O., Bange G. & Bibi E. (2018). Co-translational folding intermediate dictates membrane targeting of the signal recognition particle-receptor.  Journal of Molecular Biology. 2018 May , 430 (11):1607-1620.
  15. Kantaev R., Riven I., Goldenzweig A., Barak Y., Dym O., Peleg Y., Albeck S., Fleishman S. J. & Haran G. (2018). Manipulating the Folding Landscape of a Multi-Domain Protein.  Journal of Physical Chemistry B. 2018 Dec , 122 (49):11030-11038.
  16. Khersonsky O., Lipsh R., Avizemer Z., Ashani Y., Goldsmith M., Leader H., Dym O., Rogotner S., Trudeau D. L., Prilusky J., Amengual-Rigo P., Guallar V., Tawfik D. S. & Fleishman S. J. (2018). Automated Design of Efficient and Functionally Diverse Enzyme Repertoires.  Molecular Cell. 2018 Oct , 72 (1):178-186.e5.
  17. Lapidoth G., Khersonsky O., Lipsh R., Dym O., Albeck S., Rogotner S. & Fleishman S. J. (2018). Highly active enzymes by automated combinatorial backbone assembly and sequence design.  Nature Communications. 2018 Jul , 9 .
  18. Netzer R., Listov D., Lipsh R., Dym O., Albeck S., Knop O., Kleanthous C. & Fleishman S. J. (2018). Ultrahigh specificity in a network of computationally designed protein-interaction pairs.  Nature Communications. 2018 Dec , 9 (1).
  19. Baran D., Pszolla M. G., Lapidoth G. D., Norn C., Dym O., Unger T., Albeck S., Tyka M. D. & Fleishman S. J. (2017). Principles for computational design of binding antibodies.  Proceedings of the National Academy of Sciences of the United States of America. 2017 Oct , 114 (41):10900-10905.
  20. Cohen-Khait R., Dym O., Hamer-Rogotner S. & Schreiber G. (2017). Promiscuous Protein Binding as a Function of Protein Stability.  Structure (London, England : 1993). 2017 Dec , 25 (12):1867-1874.e3.