Crystallisation and Structure Determination Publications

  1. Sobolev V., Edelman M., Dym O., Unger T., Albeck S., Kirma M. & Galili G. (2013). Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.  Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 2013 Feb , 69 :84-89.
  2. Sela-Passwell N. A., Kikkeri R., Dym O., Rozenberg H., Margalit R., Arad-Yellin R., Eisenstein M., Brenner O., Shoham T., Danon T., Shanzer A. & Sagi I. (2012). Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential.  Nature Medicine. 2012 Jan , 18 (1):143-147.
  3. Xu Y., Li M., Greenblatt H., Chen W., Paz A., Dym O., Peleg Y., Chen T., Shen X., He J., Jiang H., Silman I. & Sussman J. (2012). Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.  Acta Crystallographica Section D-Biological Crystallography. 2012 Jan , 68 :13-25.
  4. Khersonsky O., Kiss G., Roethlisberger D., Dym O., Albeck S., Houk K. N., Baker D. & Tawfik D. (2012). Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.  Proceedings of the National Academy of Sciences of the United States of America. 2012 Jun , 109 (26):10358-10363.
  5. Khersonsky O., Roethlisberger D., Wollacott A. M., Murphy P., Dym O., Albeck S., Kiss G., Houk K. N., Baker D. & Tawfik D. (2011). Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution.  Journal of Molecular Biology. 2011 Apr , 407 (3):391-412.
  6. Li M., Greenblatt H. M., Dym O., Albeck S., Pais A., Gunanathan C., Milstein D., Degani H. & Sussman J. (2011). Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators.  Journal of Medicinal Chemistry. 2011 May , 54 (10):3575-3580.
  7. Karanicolas J., Com J. E., Chen I., Joachimiak L. A., Dym O., Peck S. H., Albeck S., Unger T., Hu W., Liu G., Delbecq S., Montelione G. T., Spiegel C. P., Liu D. R. & Baker D. (2011). A De Novo Protein Binding Pair By Computational Design and Directed Evolution.  Molecular Cell. 2011 Apr , 42 (2):250-260.
  8. Cohen S., Albeck S., Ben-Dov E., Cahan R., Firer M., Zaritsky A. & Dym O. (2011). Cyt1Aa Toxin: Crystal Structure Reveals Implications for Its Membrane-Perforating Function.  Journal of Molecular Biology. 2011 Nov , 413 (4):804-814.
  9. Unger T., Dym O., Albeck S., Jacobovitch Y., Bernehim R., Marom D., Pisanty O. & Breiman A. (2010). Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain.  Journal of Structural and Functional Genomics. 2010 Jun , 11 (2):113-23.
  10. Goihberg E., Peretz M., Tel-Or S., Dym O., Shimon L., Frolow F. & Burstein Y. (2010). Biochemical and Structural Properties of Chimeras Constructed by Exchange of Cofactor-Binding Domains in Alcohol Dehydrogenases from Thermophilic and Mesophilic Microorganisms.  Biochemistry. 2010 Mar , 49 (9):1943-1953.
  11. Grossman M., Tworowski D., Dym O., Lee M., Levy Y., Murphy G. & Sagi I. (2010). The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function.  Biochemistry. 2010 Jul , 49 (29):6184-6192.
  12. Yadid I., Kirshenbaum N., Sharon M., Dym O. & Tawfik D. (2010). Metamorphic proteins mediate evolutionary transitions of structure.  Proceedings of the National Academy of Sciences of the United States of America. 2010 Apr , 107 (16):7287-7292.
  13. Khersonsky O., Rothlisberger D., Dym O., Albeck S., Jackson C. J., Baker D. & Tawfik D. (2010). Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.  Journal of Molecular Biology. 2010 Mar , 396 (4):1025-1042.
  14. Levin K. B., Dym O., Albeck S., Magdassi S., Keeble A. H., Kleanthous C. & Tawfik D. (2009). Following evolutionary paths to protein-protein interactions with high affinity and selectivity.  Nature Structural & Molecular Biology. 2009 Oct , 16 (10):1049-U67.
  15. Dym O., Albeck S., Peleg Y., Schwarz A., Shakked Z., Burstein Y. & Zimhony O. (2009). Structure-Function Analysis of the Acyl Carrier Protein Synthase (AcpS) from Mycobacterium tuberculosis.  Journal of Molecular Biology. 2009 Nov , 393 (4):937-950.
  16. Rothlisberger D., Khersonsky O., Wollacott A. M., Jiang L., DeChancie J., Betker J., Gallaher J. L., Althoff E. A., Zanghellini A., Dym O., Albeck S., Houk K. N., Tawfik D. & Baker D. (2008). Kemp elimination catalysts by computational enzyme design.  Nature. 2008 May , 453 (7192):190-U4.
  17. Goihberg E., Dym O., Tel-Or S., Shimon L., Frolow F., Peretz M. & Burstein Y. (2008). Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution.  Proteins-Structure Function And Bioinformatics. 2008 Aug , 72 (2):711-719.
  18. Liberman N., Dym O., Unger T., Albeck S., Peleg Y., Jacobovitch Y., Branzburg A., Eisenstein M., Marash L. & Kimchi A. (2008). The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage.  Journal of Molecular Biology. 2008 Nov , 383 (3):539-548.
  19. Albeck S., Dym O., Unger T., Snapir Z., Bercovich Z. & Kahana C. (2008). Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function.  Protein Science. 2008 May , 17 (5):793-802.
  20. Manicka S., Peleg Y., Unger T., Albeck S., Dym O., Greenblatt H. A., Bourenkov G., Lamzin V., Krishnaswamy S. & Sussman J. (2008). Crystal structure of yagE, a putative DHDPS-like protein from Escherichia coli K12.  Proteins-Structure Function And Bioinformatics. 2008 Jun , 71 (4):2102-2108.