Early Life Stress https://www.weizmann.ac.il/brain-sciences/labs/chen/ en Shoshani Haye K Friedlander G Golani O Almeida Correa S Shemesh Y Chen A Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long lasting behavioral abnormalities Neurobiology of Stress doi 10 1016 j https://www.weizmann.ac.il/brain-sciences/labs/chen/shoshani-haye-k-friedlander-g-golani-o-almeida-correa-s-shemesh-y-chen-prenatal-stress-induces <span class="field field--name-title field--type-string field--label-hidden">Shoshani Haye K Friedlander G Golani O Almeida Correa S Shemesh Y Chen A Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long lasting behavioral abnormalities Neurobiology of Stress doi 10 1016 j </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>adiaz</span></span> <span class="field field--name-created field--type-created field--label-hidden">Sun, 08/17/2025 - 13:47</span> <div class="authors-and-title"><p>Shoshani-Haye K, Friedlander G, Golani O, Almeida-Correa S, Shemesh Y, <strong>Chen A</strong>.<br /> Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities. <em>Neurobiology of Stress. doi: 10.1016/j.ynstr.2025.100749.</em></p> </div> <div class="tags-rows-container"> <div class="tags-rows">Stress Circuitry and Regulation</div> <div class="tags-rows">Stress Linked Psychopathologies</div> <div class="tags-rows">Gene X stress Interaction: Epigenetic Mechanisms</div> <div class="tags-rows">Early Life Stress</div> </div> <a href="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2025-08/Keren%202025.pdf" target="blank" ><div class="pdf-download"></div></a> <div> <div>Year</div> <div>2025</div> </div> Sun, 17 Aug 2025 10:47:42 +0000 adiaz 237 at https://www.weizmann.ac.il/brain-sciences/labs/chen Lopez JP Chen A Neuropsychiatric research in 2023 mechanisms of stress and therapies The Lancet Neurology doi 10 1016 S1474 4422 23 00469 6 https://www.weizmann.ac.il/brain-sciences/labs/chen/lopez-jp-chen-neuropsychiatric-research-2023-mechanisms-stress-and-therapies-lancet-neurology-doi <span class="field field--name-title field--type-string field--label-hidden">Lopez JP Chen A Neuropsychiatric research in 2023 mechanisms of stress and therapies The Lancet Neurology doi 10 1016 S1474 4422 23 00469 6</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>adiaz</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 05/02/2024 - 13:39</span> <div class="authors-and-title"><p>Lopez JP, <strong>Chen A</strong>.<br /> Neuropsychiatric research in 2023: mechanisms of stress and therapies. <em>The Lancet Neurology. doi: 10.1016/S1474-4422(23)00469-6.</em></p> </div> <div class="tags-rows-container"> <div class="tags-rows">Gene X stress Interaction: Epigenetic Mechanisms</div> <div class="tags-rows">Complex Behavior</div> <div class="tags-rows">Metabolism and stress</div> <div class="tags-rows">Early Life Stress</div> <div class="tags-rows">Stress Linked Psychopathologies</div> <div class="tags-rows">Stress Circuitry and Regulation</div> </div> <a href="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2024-05/mechanisms%20of%20stress%20Pablo%201.1.24.pdf" target="blank" ><div class="pdf-download"></div></a> <div> <div>Year</div> <div>2024</div> </div> Thu, 02 May 2024 10:39:45 +0000 adiaz 205 at https://www.weizmann.ac.il/brain-sciences/labs/chen דיוקנה של הטראומה במוח צעיר: המנגנון העצבי שמשתבש כתוצאה מחשיפה לאירוע קשה בגיל רך https://www.weizmann.ac.il/brain-sciences/labs/chen/dywqnh-sl-htrwmh-bmwh-zyr-hmngnwn-hzby-smstbs-ktwzh-mhsyph-lyrw-qsh-bgyl-rk <span class="field field--name-title field--type-string field--label-hidden">דיוקנה של הטראומה במוח צעיר: המנגנון העצבי שמשתבש כתוצאה מחשיפה לאירוע קשה בגיל רך</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>adiaz</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 12/28/2023 - 11:15</span> <div class="clearfix text-formatted"><p class="text-align-right">מדעני מכון ויצמן למדע חושפים בפירוט חסר תקדים כיצד טראומה בעכברים בני יומם מעצבת את מוחם ופוגעת בתפקודים החברתיים שלהם בבגרות – ומדגישים את חשיבות ההתערבות המוקדמת ליכולת השיקום</p> </div> <div class="tags-rows-container"> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/4" hreflang="en">Early Life Stress</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/1" hreflang="en">Gene X stress Interaction: Epigenetic Mechanisms</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/5" hreflang="en">Stress Linked Psychopathologies</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/2" hreflang="en">Complex Behavior</a></div> </div> <div> <img loading="lazy" src="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2023-12/%D7%AA%D7%9E%D7%95%D7%A0%D7%94%20%D7%98%D7%A8%D7%90%D7%95%D7%9E%D7%94%20%D7%91%D7%92%D7%99%D7%9C%20%D7%A6%D7%A2%D7%99%D7%A8_0.jpg" width="1920" height="647" alt="" /> </div> <div><time datetime="2023-12-03T12:00:00Z" class="datetime">Sun, 12/03/2023 - 12:00</time> </div> <div>Hebrew</div> <div><a href="https://heb.wis-wander.weizmann.ac.il/life-sciences/n-12078">https://heb.wis-wander.weizmann.ac.il/life-sciences/n-12078</a></div> Thu, 28 Dec 2023 09:15:57 +0000 adiaz 202 at https://www.weizmann.ac.il/brain-sciences/labs/chen Kos A Lopez JP Bordes J de Donno C Dine J Brivio E Karamihalev S Luecken MD Almeida Correa S Gasperoni S Dick A Miranda L B ttner M Stoffel R Flachskamm C Theis FJ Schmidt MV Chen A Early life adversity shapes social subordination and cell type specific t https://www.weizmann.ac.il/brain-sciences/labs/chen/kos-lopez-jp-bordes-j-de-donno-c-dine-j-brivio-e-karamihalev-s-luecken-md-almeida-correa-s <span class="field field--name-title field--type-string field--label-hidden">Kos A Lopez JP Bordes J de Donno C Dine J Brivio E Karamihalev S Luecken MD Almeida Correa S Gasperoni S Dick A Miranda L B ttner M Stoffel R Flachskamm C Theis FJ Schmidt MV Chen A Early life adversity shapes social subordination and cell type specific t</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>adiaz</span></span> <span class="field field--name-created field--type-created field--label-hidden">Thu, 12/28/2023 - 08:02</span> <div class="authors-and-title"><p>Kos A, Lopez JP, Bordes J, de Donno C, Dine J, Brivio E, Karamihalev S, Luecken MD, Almeida-Correa S, Gasperoni S, Dick A, Miranda L, Büttner M, Stoffel R, Flachskamm C, Theis FJ, Schmidt MV, <strong>Chen A</strong>.<br /> Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus. <em>Science Advances. doi: 10.1126/sciadv.adj3793.</em></p> </div> <div class="tags-rows-container"> <div class="tags-rows">Early Life Stress</div> <div class="tags-rows">Gene X stress Interaction: Epigenetic Mechanisms</div> <div class="tags-rows">Stress Linked Psychopathologies</div> <div class="tags-rows">Complex Behavior</div> </div> <a href="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2023-12/Aron%20pablo%2011.2023.pdf" target="blank" ><div class="pdf-download"></div></a> <div> <div>Year</div> <div>2023</div> </div> Thu, 28 Dec 2023 06:02:44 +0000 adiaz 199 at https://www.weizmann.ac.il/brain-sciences/labs/chen Lebow M Kuperman Y Chen A Chapter 19 Prenatal induced psychopathologies All roads lead to microglia Stress immunology and inflammation doi 10 1016 B978 0 12 817558 3 00016 0 https://www.weizmann.ac.il/brain-sciences/labs/chen/lebow-m-kuperman-y-chen-chapter-19-prenatal-induced-psychopathologies-all-roads-lead-microglia <span class="field field--name-title field--type-string field--label-hidden">Lebow M Kuperman Y Chen A Chapter 19 Prenatal induced psychopathologies All roads lead to microglia Stress immunology and inflammation doi 10 1016 B978 0 12 817558 3 00016 0</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>adiaz</span></span> <span class="field field--name-created field--type-created field--label-hidden">Sun, 10/22/2023 - 10:07</span> <div class="authors-and-title"><p>Lebow M, Kuperman Y, <strong>Chen A.</strong> Chapter 19 - Prenatal-induced psychopathologies: All roads lead to microglia. <em>Stress: immunology and inflammation. doi: 10.1016/B978-0-12-817558-3.00016-0.</em></p> </div> <div class="tags-rows-container"> <div class="tags-rows">Gene X stress Interaction: Epigenetic Mechanisms</div> <div class="tags-rows">Metabolism and stress</div> <div class="tags-rows">Early Life Stress</div> <div class="tags-rows">Stress Linked Psychopathologies</div> </div> <a href="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2023-10/Maya%20L%20and%20Yael%202023.pdf" target="blank" ><div class="pdf-download"></div></a> <div> <div>Year</div> <div>2023</div> </div> Sun, 22 Oct 2023 07:07:08 +0000 adiaz 196 at https://www.weizmann.ac.il/brain-sciences/labs/chen Shemesh Y Chen A A paradigm shift in translational psychiatry through rodent neuroethology Mol Psychiatry doi 10 1038 s41380 022 01913 z https://www.weizmann.ac.il/brain-sciences/labs/chen/shemesh-y-chen-paradigm-shift-translational-psychiatry-through-rodent-neuroethology-mol-psychiatry <span class="field field--name-title field--type-string field--label-hidden">Shemesh Y Chen A A paradigm shift in translational psychiatry through rodent neuroethology Mol Psychiatry doi 10 1038 s41380 022 01913 z</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>adiaz</span></span> <span class="field field--name-created field--type-created field--label-hidden">Wed, 09/27/2023 - 08:49</span> <div class="authors-and-title"><p>Shemesh Y, <strong>Chen A.</strong><br /> A paradigm shift in translational psychiatry through rodent neuroethology. <em>Mol Psychiatry</em>. doi: 10.1038/s41380-022-01913-z.</p> </div> <div class="tags-rows-container"> <div class="tags-rows">Complex Behavior</div> <div class="tags-rows">Early Life Stress</div> <div class="tags-rows">Gene X stress Interaction: Epigenetic Mechanisms</div> <div class="tags-rows">Metabolism and stress</div> <div class="tags-rows">Stress Circuitry and Regulation</div> <div class="tags-rows">Stress Linked Psychopathologies</div> </div> <a href="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2023-09/Yair%20S%202023.pdf" target="blank" ><div class="pdf-download"></div></a> <div> <div>Year</div> <div>2023</div> </div> Wed, 27 Sep 2023 05:49:49 +0000 adiaz 185 at https://www.weizmann.ac.il/brain-sciences/labs/chen Stressed Out from Birth: Mice Exposed to Prenatal Stress Are Predisposed to Eating Disorders Later in Life https://www.weizmann.ac.il/brain-sciences/labs/chen/stressed-out-birth-mice-exposed-prenatal-stress-are-predisposed-eating-disorders-later-life <span class="field field--name-title field--type-string field--label-hidden">Stressed Out from Birth: Mice Exposed to Prenatal Stress Are Predisposed to Eating Disorders Later in Life</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>renad</span></span> <span class="field field--name-created field--type-created field--label-hidden">Tue, 08/16/2022 - 14:09</span> <div class="clearfix text-formatted"><p>Scientists at the Weizmann Institute prevented the onset of eating disorders through dietary intervention</p> </div> <div class="tags-rows-container"> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/4" hreflang="en">Early Life Stress</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/1" hreflang="en">Gene X stress Interaction: Epigenetic Mechanisms</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/3" hreflang="en">Metabolism and stress</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/6" hreflang="en">Stress Circuitry and Regulation</a></div> </div> <div> <img loading="lazy" src="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2022-08/mariana%20maternal%20stress%20ED.PNG" width="400" height="493" alt="" /> </div> <div><time datetime="2016-06-01T12:00:00Z" class="datetime">Wed, 06/01/2016 - 12:00</time> </div> <div>English</div> <div><a href="https://wis-wander.weizmann.ac.il/life-sciences/stressed-out-birth-mice-exposed-prenatal-stress-are-predisposed-eating-disorders-later">https://wis-wander.weizmann.ac.il/life-sciences/stressed-out-birth-mice-exposed…</a></div> Tue, 16 Aug 2022 11:09:45 +0000 renad 166 at https://www.weizmann.ac.il/brain-sciences/labs/chen Stress and the Brain: It’s all about balance https://www.weizmann.ac.il/brain-sciences/labs/chen/stress-and-brain-its-all-about-balance <span class="field field--name-title field--type-string field--label-hidden">Stress and the Brain: It’s all about balance</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>renad</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 08/15/2022 - 16:01</span> <div class="tags-rows-container"> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/5" hreflang="en">Stress Linked Psychopathologies</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/4" hreflang="en">Early Life Stress</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/1" hreflang="en">Gene X stress Interaction: Epigenetic Mechanisms</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/6" hreflang="en">Stress Circuitry and Regulation</a></div> </div> <div> <img loading="lazy" src="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2022-08/Screen%20Shot%202022-08-15%20at%2016.04.03.png" width="1866" height="1042" alt="" /> </div> <div><time datetime="2016-12-25T12:00:00Z" class="datetime">Sun, 12/25/2016 - 12:00</time> </div> <div>English</div> <div><a href="https://www.sciencedaily.com/releases/2017/02/170213152646.htm">https://www.sciencedaily.com/releases/2017/02/170213152646.htm</a></div> Mon, 15 Aug 2022 13:01:49 +0000 renad 155 at https://www.weizmann.ac.il/brain-sciences/labs/chen Mice born to stressed mothers are more likely to binge eat https://www.weizmann.ac.il/brain-sciences/labs/chen/mice-born-stressed-mothers-are-more-likely-binge-eat <span class="field field--name-title field--type-string field--label-hidden">Mice born to stressed mothers are more likely to binge eat</span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>renad</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 08/15/2022 - 15:17</span> <div class="clearfix text-formatted"><p>"The price we pay later in life -- whether it's psychiatric disorders, metabolic syndromes, or heart-related illnesses -- is heavily impacted by the way your brain was programmed early in life," said researcher Alon Chen.</p> </div> <div class="tags-rows-container"> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/4" hreflang="en">Early Life Stress</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/1" hreflang="en">Gene X stress Interaction: Epigenetic Mechanisms</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/6" hreflang="en">Stress Circuitry and Regulation</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/3" hreflang="en">Metabolism and stress</a></div> </div> <div> <img loading="lazy" src="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2022-08/mariana%20maternal%20stress%20ED_4.PNG" width="400" height="493" alt="" /> </div> <div><time datetime="2017-05-30T12:00:00Z" class="datetime">Tue, 05/30/2017 - 12:00</time> </div> <div>English</div> <div><a href="https://www.upi.com/Mice-born-to-stressed-mothers-are-more-likely-to-binge-eat/8541496172986/">https://www.upi.com/Mice-born-to-stressed-mothers-are-more-likely-to-binge-eat/…</a></div> Mon, 15 Aug 2022 12:17:22 +0000 renad 152 at https://www.weizmann.ac.il/brain-sciences/labs/chen Prenatal stress predisposes female mice to binge eating Prenatal stress predisposes female mice to binge eating https://www.weizmann.ac.il/brain-sciences/labs/chen/prenatal-stress-predisposes-female-mice-binge-eating-prenatal-stress-predisposes-female-mice-binge <span class="field field--name-title field--type-string field--label-hidden">Prenatal stress predisposes female mice to binge eating Prenatal stress predisposes female mice to binge eating </span> <span class="field field--name-uid field--type-entity-reference field--label-hidden"><span>renad</span></span> <span class="field field--name-created field--type-created field--label-hidden">Mon, 08/15/2022 - 14:58</span> <div class="tags-rows-container"> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/4" hreflang="en">Early Life Stress</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/1" hreflang="en">Gene X stress Interaction: Epigenetic Mechanisms</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/6" hreflang="en">Stress Circuitry and Regulation</a></div> <div class="tags-rows"><a href="/brain-sciences/labs/chen/taxonomy/term/3" hreflang="en">Metabolism and stress</a></div> </div> <div> <img loading="lazy" src="/brain-sciences/labs/chen/sites/brain-sciences.labs.chen/files/2022-08/mariana%20maternal%20stress%20ED_3.PNG" width="400" height="493" alt="" /> </div> <div><time datetime="2017-05-30T12:00:00Z" class="datetime">Tue, 05/30/2017 - 12:00</time> </div> <div>English</div> Mon, 15 Aug 2022 11:58:37 +0000 renad 151 at https://www.weizmann.ac.il/brain-sciences/labs/chen