Abstract Submission Deadline:
November 1st, 2022
Program
20S2021 Program
Print Full program| Time | Session/Lecture info |
|---|---|
| 16:30-17:00 | Registration and Gathering
|
| 16:30-17:00 | |
| 17:00-19:00 | Opening Session
Chair: Mark Hochstrasser (Yale School of Medicine) |
| 17:00-17:15 |
Michal Sharon/Seth Margolis
Welcome and Introduction
|
| 17:15-18:15 |
KEYNOTE LECTURE: Yossi Shaul, Weizmann Institute of Science
The mechanisms of degradation of the intrinsically disordered proteins by the 20S proteasome
|
| 18:15-19:00 |
Erin Schuman , Max Planck Institute
Proteosomes and Proteostasis in Neurons
|
| 19:00-21:00 | Gala Dinner
|
| 19:00-21:00 |
| Time | Session/Lecture info |
|---|---|
| 09:00-10:30 | SESSION 1
Chair: Richard Vierstra (Washington University) |
| 09:00-09:30 |
David Smith , West Virginia University Health Sciences
Physiological consequences of opening the proteasome?s gate in C. elegans
|
| 09:30-10:00 |
Mark Hochstrasser , Yale School of Medicine
Trafficking and degradation of the yeast 20S proteasome
|
| 10:00-10:30 |
Lan Huang , University of California
Understanding multi-layer regulation of the proteasome complex through protein-protein interactions
|
| 10:30-11:00 | Coffee Break and meet the speakers session
|
| 10:30-11:00 | |
| 11:00-12:45 | SESSION 2
Chair: Richard Vierstra (Washington University) |
| 11:00-11:30 |
Marie-Pierre Bousquet-Dubouch , Institut de Pharmacologie et de Biologie Structurale
Dissecting proteasome diversity using mass spectrometry as a swiss army knife
|
| 11:30-12:00 |
Tommer Ravid, The Hebrew University of Jerusalem
Quality control substrates of the proteasome
|
| 12:00-12:30 |
Michal Sharon , Weizmann Institute of Science
Unraveling the substrate landscape of the 20S proteasome
|
| 12:30-12:45 |
Florence Boon , De Duve Institute - UCLouvain
Short Talk: A TAP-independent peptide recognized by a cytolytic T lymphocyte
|
| 12:45-14:00 | Lunch Break and meet the speakers session
|
| 12:45-14:00 | |
| 14:00-15:30 | SESSION 3
Chair: Erin Schuman (Max Planck Institute) |
| 14:00-14:30 |
Matthew Bogyo , Stanford University
The Plasmodium falciparum proteasome as a therapeutic target for the treatment of malaria
|
| 14:30-15:00 |
Silke Meiners , Research Center Borstel / Leibniz Lung Center
DNA stress activates the immunoproteasome and adaptive T cell responses: implications for lung fibrosis
|
| 15:00-15:15 |
Justine Laulin , Institut Gustave Roussy
Short Talk: Identification and characterization of the REGg-20S Proteasome inhibitors
|
| 15:15-15:30 |
Sinem Yilmaz
Short Talk: Identification of novel Cycloastragenol derivatives as potent NRF2 activators that delay replicative senescence
|
| 15:30-16:00 | Coffee Break and meet the speakers session
|
| 15:30-16:00 | |
| 16:00-17:30 | SESSION 4
Chair: Erin Schuman (Max Planck Institute) |
| 16:00-16:30 |
Julien Marcoux , Institute of Pharmacology and Structural Biology, Toulouse
Structural MS of mammalian proteasome subtypes reveals subtle structural rearrangements upon subunit substitution or regulator binding
|
| 16:30-16:45 |
Cascio Paolo, University of Turin
Short talk:PA28gamma-20S proteasome is a proteolytic complex committed to degrade unfolded proteins
|
| 16:45-17:00 |
Stefano Giandomenico , Max Planck Institute for Brain Research
Short talk:The interplay between protein synthesis and proteasomal degradation in neuronal proteostasis
|
| 17:00-17:30 |
Kelvin Davies , USC Leonard Davis School of Gerontolgy
Degradation of oxidatively modified proteins by the eucaryotic 20s proteasome
|
| 17:30-19:00 | Poster Session and Cocktail Dinner
|
| 17:30-19:00 |
| Time | Session/Lecture info |
|---|---|
| 09:00-10:30 | SESSION 5
Chair: Olivier Coux (Institute of Pharmacology and Structural Biology, Toulouse) |
| 09:00-09:30 |
Yifat Merbl , Weizmann Institute of Science
Insights into the degradation landscape
|
| 09:30-10:00 |
Jonathan Yewdell , National Institutes of Health
Immuno proteasome function and substrates
|
| 10:00-10:30 |
Kapil Ramachandran, Harvard University
Neuroproteasomes as pivotal factors in neurodegeneration
|
| 10:30-11:00 | Coffee BREAK and meet the speakers session
|
| 10:30-11:00 | |
| 11:00-21:00 | Tour for registered participants
|
| 11:00-21:00 |
| Time | Session/Lecture info |
|---|---|
| 09:00-10:30 | SESSION 6:
Chair: Seth Margolis (Johns Hopkins Medicine) |
| 09:00-09:30 |
Cordula Enenkel , University of Toronto
Dynamic organisation of yeast proteasomes
|
| 09:30-10:00 |
Michael Groll , Technical University of Munich
Structural prerequisites of natural β-lactone products for proteasome inhibition
|
| 10:00-10:30 |
Haiyan He, Georgetown University
Visual experience drives neuronal membrane proteasome-mediated degradation of nascent
|
| 10:30-11:00 | Coffee Break and meet the speakers session
|
| 10:30-11:00 | |
| 11:00-12:45 | Session 7
Chair: Seth Margolis (Johns Hopkins Medicine) |
| 11:00-11:30 |
Anthony O’Donoghue , UC San Diego
Substrate profiling of parasite proteasomes to develop optimized reporter substrates and inhibitors
|
| 11:30-12:00 |
Richard D. Vierstra , Washington University
Extracellular plant proteasomes and their role(s) in pathogen defense
|
| 12:00-12:30 |
Eilika Weber-Ban , ETH Zurich
Proteasomal degradation and the DNA damage response in Mycobacteria
|
| 12:30-12:45 |
Fulya Türker , The Johns Hopkins University
Short talk:Identification of neuroproteasome-derived peptides that modulate neuronal signali
|
| 12:45-14:00 | Lunch
|
| 12:45-14:00 | |
| 14:00-15:30 | Session 8
Chair: Eilika Weber-Ban (ETH Zurich) |
| 14:00-14:30 |
Olivier Coux , University of Montpellier
PA28y, a proteasome regulator involved in intranuclear dynamics and cancer
|
| 14:30-15:00 |
Glenn Oyong , De La Salle University
Small molecule 20S proteasome enhancement by labdane diterpenoids regulates c-Myc stability and demonstrates cytotoxic and genotoxic activity in CD133+ multi-drug resistant colon cancer
|
| 15:00-15:15 |
Andrej Besse , Cantonal Hospital St.Gallen
Short Talk:Bortezomib resistant multiple myeloma shows a specific dependency on ecpas in vitro and in vivo
|
| 15:15-15:30 |
Nathalie Vigneron , University of Louvain
Short Talk:Oxidation impacts the nature of the peptides
|
| 15:30-16:00 | Coffee Break and meet the speakers session
|
| 15:30-16:00 | |
| 16:00-17:30 | Open Discussion: Q&A
|
| 16:00-17:30 | |
| 17:30-18:30 | SPECIAL LECTURE: Alfred Goldberg –Molecular Mechanisms that Stimulate 26S Proteasome Activity in Mammalian Cells
|
| 17:30-18:30 | |
| 18:30-20:00 | Dinner
|
| 18:30-20:00 |
| Time | Session/Lecture info |
|---|---|
| 09:00-10:30 | Session 9
Chair: Michal Sharon (Weizmann Institute of Science) |
| 09:00-09:15 |
Gili Ben- Nissan , Weizmann Institute of Science
Short talk:Characterization of free, circulating 20S proteasomes from blood
|
| 09:15-09:30 |
Michal Arie , Weizmann Institute of Science
Short Talk:- Capturing a P97 conformation favorable for Ufd1/Npl4 recruitment
|
| 09:30-10:00 |
Niki Chondrogianni , Institute of Biology, Medicinal Chemistry & Biotechnology
Proteasome activation during aging and proteinopathies
|
| 10:00-10:30 |
Jetze Tepe , Michigan State University
Targeting the undruggable through proteasome activation
|
| 10:30-11:00 | Coffee Break and meet the speakers session
|
| 10:30-11:00 | |
| 11:00-13:00 | Session 10
Chair: Michal Sharon (Weizmann Institute of Science) |
| 11:00-11:30 |
Michael Glickman , Technion, Israel Institute of Technology
Disassembly of 26S proteasomes and potential roles of liberated 20S proteasomes
|
| 11:30-12:00 |
Bertrand Friguet , Sorbonne Universities
Oxidized protein breakdown : implication of circadian rhythm, oxidative stress and aging
|
| 12:00-12:30 |
Seth Margolis , Johns Hopkins Medicine
Neuronal proteasomes in health and neurodegeneration
|
| 12:30-12:45 |
Chul-Su Yang, Hanyang University
Short talk:Inhibition of CD82 improves colitis by increasing deubiquitination activities in NLRP3 by BRCC3
|
| 12:45-13:00 |
Michal Sharon and Seth Margolis
CLOSING REMARKS:Summary and Awards
|
| 13:00-14:00 | Lunch Break
|
| 13:00-14:00 |
Registration_button_new
Organizing committee
- Wolfgang Baumeister, Germany
- Kelvin Davies, USA
- Seth Margolis, USA
- Michal Sharon, Israel
Co- Organizer
Sponsors
82nd Katzir Conference
The Chorafas Institute for Scientific Exchange
Conference Coordinator
Inbal Azoulay
inbal.azoulay@weizmann.ac.il