Program

ECM2023 Program

Tuesday, June 20
Time	Session/Lecture info
08:30-09:00	Registration & Coffee
08:30-09:00
09:00-09:15	Opening remarks
09:00-09:15	Antoine Dufour Irit Sagi
09:15-09:30	Welcome talk Chair: Prof. Israel Pecht
09:15-09:30
09:30-11:55	Session 1 - Interplay of proteases and matrix biology Chair: Taina Pihlajaniemi
09:30-10:10	Ulrich auf dem Keller, DTU - Technical University of Denmark Protease network degradomics in repair and regeneration
10:10-10:40	Wee Yong, University of Calgary The extracellular matrix in CNS lesions as an impediment to neuroregeneration
10:40-11:10	Coffee Break
11:10-11:40	Galia Blum, The Hebrew University of Jerusalem Chemical Tools to Detect and Inhibit Protease Activity for Disease Management
11:40-11:55	Dror Chorev, Weizmann Institute of Science A mass-spectrometry based platform for membrane embedded protease interactome and drug discovery
11:55-13:00	Lunch
11:55-13:00
13:00-15:15	Session 2 - From basic biochemical principles to tissue morphogenesis and homeostasis in diseases Chair: Ulrich auf dem Keller
13:00-13:30	Chen Varol , Tel-Aviv Sourasky Medical Center Macrophages are both builders and destroyers of collagenous matrix
13:30-14:00	Roman Krawetz , University of Calgary Post translational modifications of proteoglycsn 4 impact tissue homeostasis
14:00-14:30	Benjamin Geiger, Weizmann Institute of Science Mechano-biological regulation of invadopodia in cancer cells
14:30-14:45	Rita Caracuel, Genyo Unveiling new ECM immunomodulatory actions within the tumor microenvrionment: the axis ADAMTS1/Nidogen 1
14:45-15:15	Coffee Break
15:15-16:45	Session 3 - Biological mechanisms of proteases and the matrix: their implications in disease Chair: Antoine Dufour
15:15-15:45	Xavier Gomis Ruth , IBMB Barcelona Molecular analysis of a new potential glutenase for the treament of coeliac disease.
15:45-16:15	Elisabeth Nystroem, University of Calgary Interplay between Cat-S and CLCA1 in intestinal mucus
16:15-16:30	Shay-Lee Aharoni Lotati, Weizmann Institute of Science Designing Next Generation Substrate-Specific Protease Inhibitors
16:30-16:45	Anjana Shenoy Katapadi, Weizmann Institute of Science Novel MMP-7 substrates in pancreatic cancer
16:45-17:30	Poster session/ Discussion groups
16:45-17:30

Wednesday, June 21
Time	Session/Lecture info
08:30-09:00	Gathering
08:30-09:00
09:00-12:10	Session 4 - Matrix biology and immunity Chair: Nikos Afratis
09:00-09:40	Stefan Rose John, Kiel University ADAM17 and IL-6 Trans-Signaling in Autoimmunity and Cancer
09:40-10:10	Steffen Jung, Weizmann Institute of Science Tissue Macrophages and Monocytes, revisited
10:10-10:40	Jennifer Vandooren, KU Leuvan Neutrophil and macrophage metalloproteinases in inflammation
10:40-11:10	Coffee Break
11:10-11:40	Rama Khokha, University of Toronto Protease based regulation of liver progenitor cell fate
11:40-11:55	Francesco Farris, The AIRC Institute of Molecular Oncology BACE2-dependent amyloid aggregates drive mechanotransduction in cancer
11:55-12:10	Daniel Martin, Cleveland Clinic Determining the molecular mechanisms of ADAMTS1 and 5 in renal development and disease
12:10-13:00	Lunch
12:10-13:00
13:00-15:30	Session 5 - Cancer Therapeutics and Mechanisms of the matrix Chair: Chen Varol
13:00-13:30	Stephen Robbins, McGill University IL33 and regulation of the tumor microenvironment
13:30-14:00	Nikolaos Afratis, National and Kapodistrian University of Athens Bi-selective remodeling of melanoma tumor microenvironment extracellular matrix prevents metastasis and increases efficacy of immune checkpoint inhibitors
14:00-14:30	Salvatore Santamaria, University of Surrey Molecular interactions between ADAMTS proteases and proteoglycans
14:30-15:00	Donna Lorraine Senger, Mcgill University DPEP1: More than a dipeptidase
15:00-15:30	Coffee Break
15:30-18:15	Session 6 - Translating protease remodeling activity and matrix biology to the clinic Chair: Irit Sagi
15:30-16:00	Moti Klepfish , Anima Biotech Collagen type-I mRNA translation inhibitor reduces fibrosis in the lungs
16:00-16:30	Olga Vasiljeva, CytomX Therapeutics Activatable Probody Therapeutics Based Techniques for Characterization of Protease Activity in Health and Disease.
16:30-17:00	Yael Klionsky, Yeda – TTO of the Weizmann Institute Breaking Barriers: Pharma’s Interest in ECM and Protease Modulators for Therapeutic Applications
17:00-17:30	Vered Gigi , aMoon Fund Thinking beyond the bench
17:30-18:15	Discussion Panel: Moderators: Tony Dufour Rama Khokka Stefan Rose John Taina Pihlajaniemi

Thursday, June 22
Time	Session/Lecture info
09:00-09:30	Gathering
09:00-09:30
09:30-12:25	Session 7a - The molecular complexity of the matrix within cellular microenvironments Chair: Suneel Apte
09:30-10:10	Taina Pihlajaniemi , University of Oulu Complex roles of the multiplexin collagen 18 in health and disease
10:10-10:40	Valery Krizhanovsky, Weizmann Institute of Science Molecular mechanisms of senescence on the crossroads of aging and cancer
10:40-11:55	Padmanabhan Pattabiraman, Indiana University Purdue University Indianapolis Novel crosstalk between Cathepsin K and Adrenomedullin in the regulation of extracellular matrix in intraocular pressure homeostasis
10:55-11:15	Coffee Break
11:15-11:45	Suneel Apte , Cleveland Clinic The osteoarthritis degradome and its translation for management of a global health challenge
11:45-12:00	Vahap Canbay, Technical University of Denmark Functional characterization of dermokine in epidermal differentiation
12:00-13:00	Lunch
12:00-13:00
13:00-17:30	Session 7b - The molecular complexity of the matrix within cellular microenvironments Chair: Achim Kruger
13:00-13:30	Einat Segev, Weizmann Institute of Science Unveiling the Microbial ECM
13:30-14:00	Shani Stern, University of Haifa Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons derived from Parkinson's disease patients
14:00-14:30	Achim Kruger, Technical University of Munich TIMP-1 - an emerging cytokine in inflammation
14:30-15:00	Dieter Bromme, University of British Columbia Spatial and time-dependent inhibition of human osteoclastic bone resorption with cathepsin K inhibitors. A time-lapse study
15:00-15:30	Coffee Break
15:30-16:00	Ruth Scherz-Shouval, Weizmann Institute of Science The role of fibroblasts in modulation of the structural tumor microenvironment
16:00-16:30	Raphael Reuten, University of Freiburg The two-face protein netrin-4: Invasion inhibition dispensable of proteases versus protease-mediated invasion promotion
16:30-17:00	Zoi Piperigkou, University of Patras ECM remodeling in cancer: old and new bioactive players
17:00-17:10	Antonio Jesus Diaz Quintana, The Federation Of European Biochemical Societies (FEBS)
17:00-17:10
17:10-17:25	Awards
17:10-17:25
17:25-20:00	Festive Dinner
17:25-20:00

Friday, June 23
Time	Session/Lecture info
08:00-17:00	Tour of Jerusalem
08:00-17:00

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Registration

Deadline for abstracts submission:
May 1st

Deadline for FEBS YTF AWARD application:
March 26th

Organizing committee

Prof. Irit Sagi, Chair
Weizmann Institute of Science, Israel
Antoine Dufour, Co-Chair
University of Calgary, Canada
Nikos K. Karamanos, Co-Chair
University of Patras, Greece

Program

ECM2023 Program

Tuesday, June 20

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Organizing committee

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