Program
MMS 2018 Program
Print Full programTime | Session/Lecture info |
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18:00-22:00 | Sunday 14th October
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18:00-19:00 |
Registration & coffee
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19:00-19:05 |
Tony Futerman
Welcome
|
19:05-20:00 |
Tim Cox , Cambridge, UK
From Thudicum to Molecular Medicine
Chair:Tony Futerman |
20:00-22:00 |
Cocktail reception
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Time | Session/Lecture info |
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09:00-12:35 | Session 1: Monogenetic diseases of SL metabolism
Chair: Tony Futerman |
09:00-09:15 |
Tony Futerman
Overview
|
09:15-09:40 |
Thorsten Horneman, Zurich
Defects in sphingolipid de-novo synthesis as cause for neurological disorders
|
09:40-10:05 |
Hans Aerts, Leiden
Lecture
|
10:05-10:20 |
Giulia Massaro , London
Gene therapy in neuronal forms of Gaucher disease
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10:20-11:30 |
Coffee and poster session
|
11:30-11:55 |
Maria Fuller , Adelaide
Primary and secondary sphingolipid disturbances in lysosomal disease
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11:55-12:10 |
Ayelet Vardi , Rehovot
Role of interferon signalling in Gaucher disease
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12:10-12:35 |
Doris Höglinger , Heidelberg
The role of NPC1 in lysosomal lipid transport
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12:35-15:00 | Lunch and tour of the Weizmann Institute of Science
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12:35-15:00 | |
15:00-18:00 | Session 2: SLs in cancer
Chair: Rich Kolesnick |
15:00-15:15 |
Rich Kolesnick
Overview
|
15:15-16:-2 |
Mark Kester , Charlottesville
Ceramide nanoLiposomes: A Clinical Update
|
16:-2-16:05 |
Besim Ogretmen , Charleston
Ceramide-dependent mitophagy induces chemotherapy-induced tumor suppression
|
16:05-16:20 |
Trevor Tippetts, University of Utah
Targeting Dihydroceramide Desaturase-1 to Remove a Double Bond from Ceramides and Treat Insulin Resistance and Steatohepatitis
|
16:20-17:00 |
Coffee
|
17:-1-17:15 |
Carlo Greco, Lisbon
Single dose radiotherapy in the management of primary and metastatic cancer: exploiting a novel radiobiological mechanism
|
17:15-18:-3 |
Myles Cabot , Greenville
Alterations in Sphingolipid Metabolism Attribute to Resistance to Cornerstone Therapy in Acute Myeloid Leukemia
|
18:-1-18:00 |
Wing-Kee Lee, Witten/Herdecke University
Role of Ceramide Synthase 6 in Expression and Function of ABCB1 in Multidrug Resistant Renal Cancer Cells
|
18:-3-18:-1 |
Melissa Maczis , Richmond
Role of ERalpha36 and sphingosine-1-phosphate in de novo and acquired tamoxifen resistant breast cancer
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18:00-21:00 | Dinner & Lecture on archeology by Dr. John Woodhead
|
20:00-21:00 |
John Woodhead
Sennachrib and Lachish. The destinies of a man and a city
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Time | Session/Lecture info |
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09:00-12:50 | Session 3: SLs in neurological diseases
Chair: Jeff Medin |
09:00-09:15 |
Jeff Medin
Overview
|
09:15-09:40 |
Miriam Greenburg , Detroit
Perturbation of sphingolipid synthesis by mood stabilizing drugs
|
09:40-09:55 |
Guanghu Wang, University of Kentucky
S1P increases microglial inflammatory polarization induced by amyoid beta
|
09:55-10:20 |
Yoshio Hirabayashi , Tokyo
Metabolic regulation of ceramide in lipid raft and insulin resistance
|
10:20-11:30 |
Coffee and poster session
|
11:30-11:55 |
Hugh Willison , Glasgow
Guillain-Barré syndrome
|
11:55-12:10 |
Mylene Huebecker, University of Oxford
Alterations in levels of glycosphingolipids and lysosomal hydrolase activities in normal aging and in Parkinson?s disease
|
12:10-12:35 |
Christian Mueller , Erlangen
Sphingolipids in drug addiction
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12:35-12:50 |
Stefka Spassieva , Lexington
Deoxysphingolipids in chemotherapy-induced peripheral neuropathy
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12:50-14:00 | Lunch
|
12:50-14:00 | |
14:00-18:00 | Session 4: SLs in cardiovascular and metabolic disease
Chair: Toshiro Okazaki |
14:00-14:15 |
Toshiro Okazaki
Overview
|
14:15-14:40 |
Reijo Laaksonen , Tampere
Ceramides as markers of CVD
|
14:40-15:05 |
Scott Summers , Salt Lake City
Tissue-specific Roles of Ceramides in Metabolic Disorders
|
15:05-15:20 |
Michael Goodman , Cincinnati
SL in coagulation and head trauma
|
15:20-15:35 |
Mariana Nikolova-Karakashian, University of Kentucky
Ceramide-dependent regulation of hepatic glucocorticoid sensitivity
|
15:35-17:00 |
Coffee and poster session
|
17:00-17:25 |
Ashley Cowart , Charlottesville
Sphingolipids as mediators of the pathological outcomes of obesity
|
17:25-17:40 |
Alexander Koch, Goethe University Hospital Frankfurt
Blood ceramides as novel marker for lupus nephritis
|
17:40-18:00 |
Open discussion on the role of SLs in CVD and their use as diagnostic markers
|
18:00-20:00 | Dinner
|
18:00-20:00 |
Time | Session/Lecture info |
---|---|
07:00-17:00 | Trip to Jerusalem and the Dead Sea
|
07:00-17:00 | |
17:00-17:30 | Arrival at Ein Gedi Guesthouse
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17:00-17:30 | |
17:30-17:45 | Refreshments and coffee
|
17:30-17:45 | |
17:45-19:45 | Session 5: Lung diseases and SLs
Chair: Erich Gulbins |
17:45-18:00 |
Erich Gulbins
Overview
|
18:00-18:25 |
Katrin Anne Becker , Essen
Sphingosine and Sphingolipids in Pulmonary Bacterial Infections
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18:25-18:40 |
Megan Young , Hershey
SK1 inhibitors in cell death and their therapeutic potential
|
18:40-19:05 |
Wolfgang Kuebler , Toronto
Sphingolipids: Key regulators of barrier function and edema formation in the lung
|
19:05-19:20 |
Briana James , Richmond
The role of the ORMDL3 - CERAMIDE AXIS in asthma
|
19:20-19:45 |
Charles Caldwell , Cincinnati
Prophylactic and therapeutic sphingosine reduces bacterial burden in critically ill mice
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19:45-21:30 | Dinner
|
19:45-21:30 |
Time | Session/Lecture info |
---|---|
04:00-07:00 | Optional tour of Masada to see the sunrise
|
04:00-07:00 | |
09:00-12:30 | Session 6: Infection, Inflammation and Immunity
Chair: Sarah Spiegel |
09:00-09:15 |
Sarah Spiegel
Overview
|
09:15-09:40 |
Nigel Pyne , Glasgow
Targeting sphingosine kinases and dihydroceramide desaturase in autoimmune/inflammatory and infectious disease
|
09:40-10:05 |
Einat Vitner , Ness Ziona
The role of host Glycosphingolipids in viral infection of the CNS
|
10:05-10:20 |
Timon Eckes, Goethe University Hospital Frankfurt
Sphingosine 1-phosphate receptor 5 (S1P5) in renal diseases
|
10:20-11:00 |
Coffee
|
11:00-11:25 |
Karl Lang , Essen
Role of sphingolipids during virus infection
|
11:25-11:40 |
Nadine Beckmann, University of Cincinnati
Amitriptyline reduced inflammation and mortality in a murine model of sepsis
|
11:40-12:05 |
Christina Volkel-Johnson , Charleston
CerS6 and colitis
|
12:05-12:20 |
Fikadu G. Tafesse , Portland
The Roles of Sphingolipids in Viral and Bacterial Infections
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12:30-15:00 | Lunch, free time & tour of Ein Gedi botanical gardens
|
12:30-15:00 | |
15:00-15:55 | Session 7: Drug development and clinical application of SLs
Chair: Josef Pfeilschifter |
15:00-15:15 |
Josef Pfeilschifter
Overview
|
15:15-15:40 |
Jim Shayman , Ann Arbor
Next generation glucosylceramide synthase inhibitors
|
15:40-15:55 |
Jennifer Baker , Cincinnati
Role of Antimicrobial Lipid Coating on Endotracheal tubes in Preventing Endotracheal Biofilm
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15:55-17:10 | Session 8: Open session and late breaking talks
Chair: Yael Pewzner-Jung |
15:55-16:20 |
Shifra Ben-Dor , Rehovot
The contribution of bioinformatics to the molecular medicine of SLs
|
16:20-16:45 |
Maurizio Del Poeta , Stonybrook
Lecture
|
16:45-17:10 |
Tim Peterson , Washington University
Physiochemical properties of antidepressants underlie their mechanism of action
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17:30-22:00 | Gala dinner
|
17:30-22:00 |
Time | Session/Lecture info |
---|---|
06:00-10:00 | Departures to Tel Aviv international airport
|
06:00-10:00 |
Registration will open on May 8th, 2018
Organizing committee
- Tony Futerman, Chair, Rehovot
- Michael Edwards, Cincinnati
- Erich Gulbins, Essen
- Rich Kolesnick, New York
- Jeff Medin, Wisconsin
- Toshiro Okazaki, Ishikawa
- Yael Pewzner-Jung, Rehovot
- Sarah Spiegel, Richmond
- Yosef Pfeilschifter, Frankfurt
Coordinator & Accessibility Issues
Irit Veksler
irit.veksler@weizmann.ac.il
Sponsors
- The Chorafas Institute for Scientific Exchange
- Nikken Sohonsha Corp.
- Nella and Leon Benoziyo Center for Neurological Diseases
- The Faculty of Biochemistry