Program

Sunday, February 4
Time	Session/Lecture info
12:00-14:50	Arrival and registration
12:00-14:50
14:50-18:45	Session 1 on Mitochondrial proteome and lipidome Session Chair: Heidi McBride
14:50-15:00	Greetings
15:00-15:30	Nikolaus Pfanner, University of Freiburg Mitochondrial machineries for import and assembly of proteins
15:30-16:00	Abdussalam Azem, Tel Aviv University Mitochondrial proteostasis function and dysfunction
16:00-16:30	Johannes Herrmann, University of Kaiserslautern When mitochondrial precursors go astray - early steps in mitochondrial protein sorting
16:30-16:45	Doron Rapaport , University of Tuebingen Early stages in the biogenesis of eukaryotic beta-barrel proteins
16:45-17:15	Coffee Break
17:15-17:45	Ophry Pines, The Hebrew University of Jerusalem Fumarase, a paradigm of protein dual localization, dual function and associated metabolite signals
17:45-18:15	Jeffery Gerst, Weizmann Institute of Science Translational regulation of mitochondrial proteins by specific ribosomal protein paralogs and specialized ribosomes
18:15-18:45	Thomas Langer, University of Cologne Proteolytic control of mitochondrial membrane homeostasis
19:00-21:00	Opening Dinner
19:00-21:00

Monday, February 5
Time	Session/Lecture info
08:00-10:45	Session 2 on Mitochondrial dynamics Session Chair: Jared Rutter
08:00-08:15	Registration & coffee
08:15-08:45	Heidi McBride, McGill University Mechanisms of mitochondrial vesicle formation
08:45-09:15	Mickael Cohen , IBPC-CNRS Mechanism and regulation of homotypic fusion between outer membranes
09:15-09:30	Gyorgy Hajnoczky, Thomas Jefferson University Inter-organellar membrane protein shuttling at the ER-mitochondrial interface
09:30-09:45	Evgeny Pavlov, New York University Patch-clamp study identifies presence of low-conductance cyclosporine A sensitive channel but absence of the Permeability Transition Pore channel in C-subunit knock-out mitochondria
09:45-10:15	Orian Shirihai, University California Los Angeles Not fusing with the crowd: Lipid Droplet Mitochondria, Mitochondria with an Agenda
10:15-10:45	Coffee Break
10:45-16:00	Session 3 on Mitochondrial channels Session Chair: Maya Schuldiner
10:45-11:15	Paolo Bernardi, University of Padova Between Energy Conservation and Energy Dissipation: The Dual Life of F-ATP Synthase
11:15-11:45	Varda Shoshan Barmatz, Ben-Gurion University of the Negev VDAC as a Target: Crossing the Aisle from Cancer to Neurodegeneration and Diabetes
11:45-12:15	Michael Forte, Oregon Health and Science University Characteristics of Small Molecule Inhibitors of the Mitochondrial Permeability Transition Pore
12:15-12:45	Eli Arama, Weizmann Institute of Science Paternal mitochondrial destruction after fertilization in Drosophila: a crosstalk between the ubiquitin, endocytic and autophagic pathways
12:45-16:00	Lunch & poster session
16:00-18:45	Session 4 on Mitochondrial carriers & Mitophagy Session Chair: Navdeep Chandel
16:00-16:30	Jean-Claude Martinou, University of Geneva The mitochondrial pyruvate carrier in neurons and in cancer cells: to carry or not to carry?
16:30-16:45	Andres Goldman , Weizmann Institute of Science MTCH2 alters mitochondrial dynamic behavior
16:45-17:00	Amir Bahat , Weizmann Institute of Science MTCH2-mediated mitochondrial fusion drives exit from naive pluripotency in embryonic stem cells
17:00-17:30	Karin Busch, University of Muenster Structure - dynamics - function relationships in mitochondria seen from the nanoscopic perspective
17:30-18:00	Coffee Break
18:00-18:15	Melanie Paillard , Inserm U1060-CarMeN The stoichiometry between MICU1/2 and MCU controls the mitochondrial Ca2+ uptake phenotype and contractile function in heart
18:15-18:45	Eric Shoubridge , McGill University Interrogating the Mitochondrial Interactome using BioID

Tuesday, February 6
Time	Session/Lecture info
08:00-10:30	Session 5 on Mitochondrial metabolism Session Chair: Orian Shirihai
08:00-08:15	Registration & coffee
08:15-08:45	Jared Rutter, University of Utah Mitochondria, metabolism and cell decisions: Entwined in health and disease
08:45-09:15	Ayelet Erez, Weizmann Institute of Science The mitochondrial contribution to amino acids metabolism during carcinogenesis
09:15-09:45	Eyal Gottlieb, Technion The intimate relationship between the TCA cycle and cancer
09:45-10:00	Atan Gross, Weizmann Institute of Science Do BCL-2 family proteins also function as metabolic sensors?
10:00-10:30	Coffee Break
10:30-13:30	Session 6 on Mitochondrial biology in stem cells Session Chair: Eric Shoubridge
10:30-11:00	Paul Frenette, Albert Einstein College of Medicine An adrenergic nerve-dependent angio-metabolic switch in prostate cancer
11:00-11:30	Tsvee Lapidot, Weizmann Institute of Science Metabolic regulation of bone marrow hematopoietic stem cells: The role of ROS, mitochondria transfer and nitric oxide
11:30-12:00	Hartmut Geiger, University of Ulm Aging and rejuvenation of hematopoietic stem cells
12:00-12:15	Vanessa Morais, IMM - Instituto de Medicina Molecular Importance of Mitochondria Homeostasis for Brain Function
12:30-13:30	Light lunch
13:30-22:00	Afternoon tour & Dinner
13:30-19:30	Tour of Jerusalem
19:30-22:00	Dinner

Wednesday, February 7
Time	Session/Lecture info
08:00-10:45	Session 7 on Mitochondria communication I Session Chair: Anu Suomalainen
08:00-08:15	Registration & coffee
08:15-08:45	Massimo Zeviani, University of Cambridge Perturbed mitochondrial homeostasis in the pathogenesis of mitochondrial disorders
08:45-09:15	Ann Saada, The Hebrew University of Jerusalem Primary and secondary cytochrome c oxidase deficiency
09:15-09:45	Janine Santos, National Institute of Health The crosstalk between mitochondrial metabolism and epigenetics
09:45-10:15	Haim Cohen, Bar-Ilan University Long distance relationship between SIRT6 and the mitochondria
10:15-10:45	Coffee Break
10:45-16:00	Session 8 on Mitochondria communication II Session Chair: Abdussalam Azem
10:45-11:15	John M. Denu, University of Wisconsin Sirtuin 3- and Diet- Mediated Regulation of Mitochondrial Function During Aging
11:15-11:45	Gad Asher, Weizmann Institute of Science The circadian nature of mitochondrial biology
11:45-12:15	Navdeep Chandel, Northwestern University Mitochondria as signaling organelles
12:15-12:30	Rigoni Giovanni, University of Padova Dissecting the dual role of ATAD3A: the link between nucleoid stability and cristae ultrastructure
12:30-12:35	Christoph Schmitt, Nature Metabolism Introduction to Nature Metabolism – a new Nature Research journal
12:35-16:00	Lunch & poster session
16:00-21:00	Session 9 on Mitochondria communication III Session Chair: Thomas Langer
16:30-17:00	Maya Schuldiner, Weizmann Institute of Science No Mitochondria is an Island - uncovering mitochondrial contact site machinery
17:00-17:30	Fabiana Perocchi , LMU talk ERALL: an inventory of mammalian endoplasmic reticulum proteins to elucidate inter-organelles cross-talk
17:30-17:45	Raimundo Nuno , University Medical Center Goettingen Mechanisms of cross-regulation between mitochondria and lysosomes
17:45-18:15	Coffee Break
18:15-18:30	Katja Hansen , University of Kaiserslautern ER mediated import of mitochondrial membrane proteins
18:30-19:00	Luca Scorrano, University of Padova Shedding light on the Mitochondria-Endoplasmic Reticulum contacts machinery
19:00-21:00	Dinner & Dance party

Thursday, February 8
Time	Session/Lecture info
08:00-11:15	Session 10 on Mitochondrial UPR Session Chair: Luca Scorrano
08:00-08:15	Registration & coffee
08:15-08:45	Johan Auwerx, Ecole Polytechnique Federale de Lausanne Genetic analysis of mitochondrial function
08:45-09:00	Hagai Abeliovich , The Hebrew University of Jerusalem A novel degron-like mechanism plays a role in determining intra-mitochondrial selectivity of mitophagic protein degradation
09:00-09:30	Anu Suomalainen , University of Helsinki Integrated stress response in mitochondrial disease
09:30-09:45	Dorit Ben-Shachar , Technion Mitochondrial complex l deficits in schizophrenia: a possible link to NDUFV2 pseudogene
09:45-10:15	Coffee Break
10:15-10:30	Lilach Sheiner , University of Glasgow Studying the role of mitochondrial membrane contact sites? Do it in an organism with only one mitochondrion!
10:30-11:00	Andrew Dillin, University California at Berkeley CNS control of peripheral mitochondrial function: the mitokine
11:00-11:15	Meeting Wrap-Up: Outcomes and Future Directions (Atan & Gyorgy)

Mitochondria 2018 Program

Sunday, February 4