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Invited Speakers
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Invited Speakers

Computational and Systems Biology           
Boris Kholodenko
Dept. of Pathology, Anatomy & Cell Biology Thomas Jefferson University, Philadelphia PA, USA
Title: Spatio-Temporal coding of signal specificity

David Gilbert
Bioinformatics Research Center, University of Glasgow, Scotland, UK
Title: Biochemical models-what can we do with them?

Eytan Domany
Dept. of Physics of Complex Systems, the Weizmann Institute of Science, Rehovot, Israel
Title: Chromosomal instabilities and cancer     

Ravi Iyengar
Dept. of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, NY, NY, USA
Title: Spatial regulation of signaling network topology  

Biochemical Analysis and Complex Signaling Pathways 
Michael Yaffe
Depts. of Biology & Biological Engineering Massachusetts Institute of Technology, Boston, MA, USA
Title: A systems biology approach to apoptotic control and DNA damage signaling

Kun-Liang Guan
Dept. of Pharmacology & Moores Cancer Reserach University of California, San Diego, CA, USA
Title: TSC-mTOR pathway in cell growth

Piero Crespo
Dept. of Molecular Biology, University of Cantabria, Santander, Spain
Title: Dimers and scaffolds as spatial regulators of ERK signals

Rony Seger
Dept. Biological Regulation, the Weizmann Institute of Science, Rehovot, Israel
Title: Nuclear shuttling of ERKs and MEKs: Novel mechanism on the way to oncogenic transformation

Richard Marais
UK Centre of Cell & Molecular Biology, Institute of Cancer Research, London, U.K.
Title: RAS and RAF signalling in melanoma         


Clinical Applications of Signaling Networks           
Gordon Mills
Department of Systems Biology, University of Texas and M.D. Anderson Cancer Center,
Huston, TX, USA
Title: A systems approach to drug development and implementation

Stephen Friend
Merck Research Laboratories, West Point, PA, USA
Title: The emerging translational oncology toolkit

Marco Pierotti
Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei
Tumori, Milan, Italy
Title: Targeted therapy: Lesson from GIST and chordoma tumors

Josep Tabernero
Dept. Medical Oncology, Vall d’Hebron University Hospital, Barcelona, Spain
Title: Molecular biology factors determinant of antitumor activity with targeted
therapies in colorectal cancer


Short Lectures

Varda Rotter
Dept. of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
Title: Identification of specific gene signatures along the process of cell
transformation in vitro: relevance to p53

Masha Niv
Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew
University, Rehovot, Israel

Computational tools for peptidomimetic inhibitors of protein-protein

David Engelberg
Dept. of Biological Chemistry, The Institute of Life Sciences, The Hebrew
University of Jerusalem, Jerusalem, Israel

Production of constitutively active p38s and ERKs, and revealing their
mechanism of action

Noam Shomron
Tel Aviv University, Ramat Aviv, Israel
MicroRNAs as oncofetal gene regulators