Program

SDBI2022 Program

Saturday, November 26
Time	Session/Lecture info
19:00-19:30	Gathering Sela
19:00-19:30
19:30-20:00	Honoring the memory of Professor Aharon Katzir Moderator, Gideon Schreiber
19:30-20:00	introduction by Profs. Joshua Jortner, Doron Lancet and Yael Katzir
20:00-21:00	Screening of the movie "Science is a Beacon to all" the story of the late Aharon Katzir, directed by Yael Katzir
20:00-21:00

Sunday, November 27
Time	Session/Lecture info
08:00-08:30	Registration & Coffee Lopatie
08:00-08:30
08:30-08:45	The legacy of Aharon Katzir
08:30-08:45
08:45-10:15	The basis for specificity and promiscuity of protein-protein interactions Rony Dahan, Weizmann Institute of Science, Israel
08:45-09:15	Sachdev Sidhu, University of Toronto, Canada Systems Biologics: Large-Scale Engineering of Modulators of Protein Networks
09:15-09:45	Mikael Oliveberg, Stockholm University, Sweden Optimisation of diffusive protein-protein interactions across divergent organisms
09:45-10:15	Ben Lehner, Centre for Genomic Regulation, Spain Massively parallel mapping of the energetic and allosteric landscapes of proteins
10:15-10:45	Coffee Break
10:15-10:45
10:45-12:45	Specificity in the immune system Rony Dahan, Weizmann Institute of Science, Israel
10:45-11:15	Brian Baker, University of Notre Dame, USA Structural and physical underpinnings of specificity in cellular immunity
11:15-11:45	Ron Diskin, Weizmann Institute of Science, Israel How do viruses find their host cell?
11:45-12:15	Tzachi Hagai, Tel Aviv University, Israel The Evolutionary Paradox of Host-Virus Interactions
12:15-12:45	Philip Bradley, Fred Hutchinson Cancer Research Center, USA Hacking deep structure prediction networks to model interaction specificity in the immune system
12:45-14:00	Lunch
12:45-14:00
14:00-16:25	Specificity of drug activities Gideon Schreiber, Weizmann Institute of Science, Israel
14:00-14:30	Brian Shoichet, University of California, USA Following the rabbit into chemical space
14:30-14:50	Nir Ben-Tal, Tel Aviv University, Israel Proteins with multiple G protein-coupled receptor domains
14:50-15:20	Julia Shifman, The Hebrew University of Jerusalem, Israel Converting natural effectors into next-generation therapeutics
15:20-15:50	Nir London, Weizmann Institute of Science, Israel Discovery of specific covalent binders
15:50-16:10	Masha Niv, The Hebrew University of Jerusalem, Israel Promiscuity and Selectivity in Bitter Taste GPCRs
16:10-16:25	Yair Harel, Weizmann Institute of Science, Israel, Israel From Disorder to Order: Phase-Separation of an RNA-Binding Protein
16:25-18:30	Poster Session & Beer Lopatie
16:25-18:30

Monday, November 28
Time	Session/Lecture info
08:30-09:00	Morning Coffee Lopatie
08:30-09:00
09:00-11:00	Principles in designing and engineering macromolecular specificity Koby Levy, Weizmann Institute of Science, Israel
09:00-09:30	Sarel Fleishman , Weizmann Institute of Science, Israel Revealing evolutionarily plausible paths between two homologous but orthogonal PPIs
09:30-10:00	Tanja Kortemme , University of California, USA Allosteric control of functional specificity in the cellular context
10:00-10:30	Amy Keating, Massachusetts Institute of Technology, USA Strategies for intra-family interaction specificity used by nature and protein designers
10:30-11:00	Mickey Kosloff, University of Haifa, Israel Negative design elements govern interaction specificity between G proteins and RGS proteins
11:00-11:30	Coffee Break
11:00-11:30
11:30-13:15	Specificity in transcription regulation Koby Levy, Weizmann Institute of Science, Israel
11:30-12:00	Ariel Afek, Weizmann Institute of Science, Israel High-throughput investigation of protein-DNA interactions using damaged DNA
12:00-12:30	Naama Barkai, Weizmann Institute of Science, Israel The role of intrinsically disordered regions in directing transcription factor binding in-vivo
12:30-12:45	Jiri Zahradnik, Weizmann Institute of Science, Israel Plasticity of SARS-CoV2 Spike's RBD domain and ACE2 interaction and its implications
12:45-13:00	Beniamin Krupkin, Weizmann Institute of Science, Israel The molecular grammar hidden within intrinsically disordered regions of transcription factors
13:00-13:15	Angel Cisneros, Laval University, Canada Epistasis between promoter activity and coding mutations shapes gene evolvability
13:15-14:30	Lunch
13:15-14:30
14:30-16:00	The importance of specificity in homeostasis and assembly of macromolecular machines Sarel Fleishman, Weizmann Institute of Science, Israel
14:30-15:00	Ayala Shiber, Technion - Israel Institute of Technology, Israel Diverging co-translational assembly pathways are governed by interface energy distribution
15:00-15:30	Ofrah Faust, Weizmann Institute of Science, Israel Specificity within promiscuity in the cellular chaperone network
15:30-16:00	Sebastian Hiller, University of Basel, Switzerland Dynamic organization of a chaperone network in the human endoplasmatic reticulum
16:00-16:30	Coffee Break
16:00-16:30
16:30-17:45	The importance of specificity in homeostasis and assembly of macromolecular machines Sarel Fleishman, Weizmann Institute of Science, Israel
16:30-17:00	Tuomas Knowles, University of Cambridge, UK Kinetics of protein phase transitions
17:00-17:15	Rosi Fassler, The Hebrew University of Jerusalem, Israel Defining the binding pattern of the disordered Hsp33 chaperone using an integrative structural approach
17:15-17:45	Pierre Goloubinoff, University of Lausanne, Switzerland Specificity determinants of molecular chaperones towards structurally-compromised proteins: repair or degrade?

Tuesday, November 29
Time	Session/Lecture info
08:30-09:00	Morning Coffee Lopatie
08:30-09:00
09:00-10:50	Specificty via disordered regions Rina Rosenzweig, Weizmann Institute of Science, Israel
09:00-09:30	Alex Holehouse, Washington University School of Medicine, USA Sequence-and chemical specificity define the functional landscape of intrinsically disordered regions
09:30-10:00	Hagen Hofmann, Weizmann Institute of Science, Israel Diffusion of a disordered protein on its folded ligand
10:00-10:30	Koby Levy, Weizmann Institute of Science, Israel Specificity in binding of disordered proteins
10:30-10:50	David Lukatsky, Ben Gurion University of the Negev, Israel Repetitive DNA Sequence Elements Modulate Transcription Factor Recognition Specificity to DNA
10:50-11:20	Coffee Break
10:50-11:20
11:20-12:55	Phase seperation Rina Rosenzweig, Weizmann Institute of Science, Israel
11:20-11:50	Jeetain Mittal, Texas A&M University College of Engineering, USA Revealing molecular grammar underlying biomolecular assemblies using computer simulations
11:50-12:20	Michael Nosella, University of Toronto, Canada Poly-ADP-ribosylation regulates nucleosome dynamics to facilitate DNA damage repair within biomolecular condensates
12:20-12:40	Doron Lancet, Weizmann Institute of Science, Israel The origin of specific recognition in prebiotic molecular ensembles
12:40-12:55	Victoria Meltzer, Weizmann Institute of Science, Israel p73 protein, a paralogue of p53, undergoes liquid-liquid phase-separation in nuclei and micronuclei in response to DNA damage
12:55-14:00	Lunch
12:55-14:00
14:00-15:30	Cellular self-organization Jacob Klein, Weizmann Institute of Science, Israel
14:00-14:30	Gary Pielak, University of North Carolina, USA Protein stability in living cells & under crowded conditions in vitro
14:30-15:00	Philipp Selenko, Weizmann Institute of Science, Israel Random encounters versus meaningful interactions: How do proteins navigate cellular landscapes?
15:00-15:30	Emmanuel Levy , Weizmann Institute of Science, Israel Homotypic interactions between disordered regions: can they be specific?
15:30-16:00	Coffee Break
15:30-16:00
16:00-17:45	Macromolecular assemblies Jacob Klein, Weizmann Institute of Science, Israel
16:00-16:30	Deborah Fass, Weizmann Institute of Science, Israel Multi-scale Structural Organization Gives Mucus its Protective Properties
16:30-16:45	Peleg Ragonis-Bachar, Technion - Israel Institute of Technology, Israel Antimicrobial Peptides Self-assemble as alpha/beta Chameleon Amyloids Discovered by Sequence-Based bioinformatics Platform
16:45-17:45	Gideon Schreiber, Weizmann Institute of Science, Israel Small molecules bind everywhere and meeting summary
18:30-22:00	Farewell Dinner & Party Lopatie
18:30-22:00

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Registration

Abstract submission deadline:
October 17, 2022

Organizing Committee

Gideon Schreiber, Weizmann Institute of Science
Rony Dahan, Weizmann Institute of Science
Sarel Fleishman, Weizmann Institute of Science
Koby Levy, Weizmann Institute of Science
Rina Rosenzweig, Weizmann Institute of Science

Sponsor

The Aharon Katzir Center

More Information & Accessibility Issue

Lior Drori
lior.drori@weizmann.ac.il

Program

SDBI2022 Program

Saturday, November 26

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Organizing Committee

Sponsor

More Information & Accessibility Issue

meet@WIS