Program

SLC2014 Program

Sunday, October 26
Time	Session/Lecture info
19:00-21:00	Welcome Reception at Radisson Blu Royal Park Hotel
19:00-21:00

Monday, October 27
Time	Session/Lecture info
09:00-09:15	Opening Adress and Welcome Aula Medica
09:00-09:15	Daniel Zajfman, President, Weizmann Institute of Science Opening Remarks
09:15-12:30	Cell Migration and Actin Dynamics Chair: Alexander Bershadsky and Brigitte Jockusch Aula Medica
09:15-09:45	Michael Sixt The role of actin branching in leukocyte chemotaxis
09:45-10:15	Klemens Rottner- Technical University Braunschweig Molecular dissection and tuning of actin-dependent protrusion
10:15-10:30	Coffee Break
10:30-11:00	Alexander Verkhovsky- Swiss Federal Institute of Technology Shape-motion feedback in rapidly migrating cells
11:00-11:30	Alexis Gautreau- CNRS The Arp2/3 inhibitory protein Arpin controls directional persistence of cell migration by inducing idling phases
11:30-11:45	Metello Innocenti- Netherlands Cancer Institute Cooperation between the actin nucleators mDia1 and Arp2/3 complex controls membrane ruffling
11:45-12:00	Dror Shlomo Chorev- Weizmann Institute of Science Vinculin and Metavinculin Interact with Different Multiprotein Complexes, Associated with Integrin Adhesions
12:00-12:30	Ben-Zion Shilo- Weizmann Institute of Science Content release of large secretory vesicles by the actomyosin network
12:30-13:45	Lunch
12:30-13:45
14:00-18:00	Tumor cell migration and invasion Chair: Christophe Ampe and Leah Gheber Aula Medica
14:00-14:30	Peter Friedl- Radboud University Nijmegen Plasticity of cell migration determined by tissue organization
14:30-15:00	Robert Insall- Beatson Inst Self-generated chemotactic gradients drive melanoma cell dispersal
15:00-15:30	Erik Sahai- Cancer Research Uk, London Research Institute Modelling cancer cell invasion in complex environments
15:30-16:00	Coffee Break
16:00-16:30	Giorgio Scita- Fondazione IFOM Endocytic control of tumor cell migration
16:30-17:00	Bob van de Water- Leiden University Systems microscopy strategies to identify candidate breast cancer metastasis drug targets.
17:00-17:30	Danijela Matic Vignjevic- Institut Curie Joined forces of cancer cells and fibroblasts in invasion
17:30-17:45	Matthias Krause- King's College London Lamellipodin cooperates with the Scar/WAVE complex and Ena/VASP proteins to regulate cancer cell invasion.
17:45-18:00	Peter Gunning- UNSW Distinct actin filament populations regulate different signalling pathways
18:00-20:00	Poster Session I (even numbers) Aula Medica
18:00-20:00

Tuesday, October 28
Time	Session/Lecture info
09:00-12:30	Cytoskeleton dynamics and mechanics in vitro Chair: Arnon Henn and Ohad Medalia Aula Medica
09:00-09:30	Enrique De La Cruz- Yale University Actin filament severing by cofilin.
09:30-10:00	Daniel Fletcher- UC Berkeley Mechanical Regulation of Actin Networks
10:00-10:30	Gijsje Koenderink- AMOLF Active cytoskeletal organization by motor and polymerization forces
10:30-10:45	Coffee Break
10:45-11:15	Michael Ostap- University of Pennsylvania Control of Myosin-I Motility and Force Sensing
11:15-11:45	Thomas Surrey- London Research Institute (CRUK) Sensing and affecting conformational transitions at microtubule plus ends
11:45-12:15	Ahmet Yildiz- University of California Berkeley The Mechanism of Cytoplasmic Dynein Motility
12:15-12:30	Dietmar Manstein- Hannover Medical School Tropomyosin-regulated Actomyosin-based Contractility in Nonmuscle Cells
12:30-14:00	Lunch
12:30-14:00
14:00-18:00	Nucleus and Intermediate filaments Chair: David Drubin and Ben-Zion Shilo Aula Medica
14:00-14:30	Yosef Gruenbaum- Hebrew University Lamin and atx-2 in C. elegans regulate the dietary restriction phenotypes of small animal size and low fat content via the mTOR pathway
14:30-15:00	Ohad Medalia- Zurich University Structural analysis of lamins and the nuclear lamina
15:00-15:30	Jan Ellenberg- EMBL Exploiting dynamics and position of single molecule events allows imaging-based proteomic and structural analyses inside cells
15:30-16:00	Coffee Break
16:00-16:30	Talila Volk- Weizmann Institute of Science An elastic shield coupled to rigid interface provides structural integrity to myonuclei
16:30-16:45	Or-Yam Revach- Department of Molecular Cell Biology, Weizmann Institute of Science Mechanical interplay between invadopodia and the nucleus in cancer cells
16:45-17:00	Winnok De Vos- University of Antwerp Loss of nuclear compartmentalization in laminopathy patient cells
17:00-17:15	Cecile Leduc- Institut Pasteur Dynamics of polarized vimentin network in migrating astrocytes and gliomas
17:15-17:30	Annica Gad- Karolinska institutet Nanoscale organization of focal adhesions, vimentin filaments and cell stiffness
17:30-18:00	Birgit Lane- Institute of Medical Biology A role for keratin intermediate filaments in epithelial cell migration and wound healing
18:00-20:00	Poster Session II (odd numbers) Aula Medica
18:00-20:00

Wednesday, October 29
Time	Session/Lecture info
09:00-12:00	Mitosis and cytokinesis Chair: Dietmar Manstein and Jan Ellenberg Aula Medica
09:00-09:30	Daniel Gerlich- IMBA, Institute of Molecular Biotechnology Austria Mitotic chromosomes acquire mechanical independence through assembly of a non-adhesive surface
09:30-10:00	Buzz Baum- UCL Cortical stiffening and polar relaxation
10:00-10:30	Mohan Balasubramanian- University of Warwick Understanding cytokinesis through synthetic rewiring and in vitro reconstitution
10:30-10:45	Coffee Break
10:45-11:00	Leah Gheber- BGU Unique mitotic function of the kinesin-5 Kip1
11:00-11:15	Daniel RIVELINE- Universite de Strasbourg A simple active gel in vivo : The cytokinetic ring
11:15-11:30	Natalie Elia- BGU Inhibition of ESCRT II-CHMP6 interactions impedes cytokinetic abscission and leads to cell death
11:30-11:45	Dietmar Oelz- New York University Force generation and contraction of random actomyosin ring.
11:45-12:00	Elisabeth Fischer-Friedrich- MPI PKS Characterizing viscoelastic properties of the cortex in mitotic cells
12:00-13:45	Lunch
12:00-13:45
14:00-18:00	Cytoskeleton, Membranes, and Intracellular Trafficking Chair: Roger Karlsson and Alex Mogilner Nanna Svartz lecture hall at the Karolinska University Hospital
14:00-14:30	David Drubin- UC Berkeley Harnessing actin assembly for endocytosis
14:30-15:00	Erika Holzbaur- University of Pennsylvania Axonal transport of autophagosomes: organelle dynamics regulate function
15:00-15:30	Michael Kozlov- Tel Aviv University Modeling ER morphologies
15:30-16:00	Coffee Break
16:00-16:30	Harvey McMahon- MRC-LMB A fast clathrin-independent endocytic mechanism
16:30-17:00	Melike Lakadamyali- ICFO-Institute of Photonic Sciences Super-resolution imaging of cargo transport
17:00-17:30	Christoph Schmidt- Georg-August-Universit?t Active random transport in cells: High-resolution mapping of non-equilibrium cytoskeletal fluctuations using carbon nanotubes
17:30-17:45	Andrea Palamidessi- IFOM A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination
17:45-18:00	Boris Shneyer- Technion Unconventional Myosin 19 is a novel mitochondrial membrane-anchored molecular motor and a regulator of the mitochondrial network

Thursday, October 30
Time	Session/Lecture info
09:00-12:30	Adhesion and mechanosensitivity Chair: Peter Gunning and Pekka Lappalainen Aula Medica
09:00-09:30	Benjamin Geiger- Weizmann Institute of Science Multi-dimensional molecular analysis of cell-matrix adhesions
09:30-10:00	Alex Mogilner- New York University Force scaling with length in actin stress fibers
10:00-10:30	David Odde- Univ. of Minnesota Motor-clutch model for substrate stiffness sensing and cell migration
10:30-10:45	Coffee Break
10:45-11:15	Staffan Stromblad- Karolinska Institutet Plasticity in the Networks that Comprise and Control Cell Migration
11:15-11:30	I-hsin Su- School of Biological Sciences Ezh2 Controls Integrin-Dependent Adhesion and Migration through Direct Methylation of Talin
11:30-11:45	Eli Zamir- Max Planck Institute of Molecular Physiology Resolving the Building Blocks and Self-Assembly Principles of Cell-Matrix Adhesion Sites
11:45-12:00	Ronen Zaidel-Bar- National University of Singapore Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions
12:00-12:15	Vania Braga- Imperial College London Defining functional interactions during biogenesis of epithelial junctions
12:15-12:30	Eugenia Piddini- The Gurdon Institute University of Cambridge Mechanically-induced cell competition among epithelial cells
12:30-14:00	Lunch
12:30-14:00
14:00-18:00	Self-Organization and Morphogenesis Chair: Klemens Rottner and Talila Volk Aula Medica
14:00-14:30	Frank Julicher- Max Planck Institute PKS, Dresden Phase separation in the cell cytoplasm
14:30-15:00	Alexander Bershadsky, Weizmann Institute of Science, Israel, and Mechanobiology Institute, NUS, Singapore Cellular chirality arising from the self-organization of the actin cytoskeleton
15:00-15:30	Stephan Grill- BIOTEC, TU Dresden Active torque generation by the actomyosin cell cortex for chiral symmetry breaking
15:30-16:00	Coffee Break
16:00-16:30	Pekka Lappalainen- University of Helsinki Generation of stress fibers depends on mechanosensitive actin filament assembly and disassembly
16:30-17:00	Roland Wedlich-Soldner- University of M?nster Isotropic acto-myosin dynamics promote organization of the apical cell cortex in epithelial cells
17:00-17:15	Dan Mulvihill- University of Kent Formins determine the functional properties of actin filaments.
17:15-17:30	Chen Luxenburg- Tel Aviv University Developmental roles for WDR1 in epidermal planar cell polarity
17:30-17:45	Anne Straube- University of Warwick A novel isoform of MAP4 organises the antiparallel microtubule array required for muscle cell differentiation
17:45-18:00	Rafael Edgardo Carazo Salas - The Gurdon Institute and Genetics Department, University of Cambridge Unraveling the genes, pathways & systems-level interactions that control cell morphogenesis and the cytoskeleton
19:00-21:30	Conference Dinner at Operakallaren Chair: Dinner Speaker: Prof. Georg Klein, Karolinska Institutet
19:00-21:30

Friday, October 31
Time	Session/Lecture info
09:00-12:30	Signaling networks Chair: Benny Geiger and Staffan Stromblad Aula Medica
09:00-09:30	Wolfgang Huber- EMBL Dissecting gene-gene and gene-drug interactions on cell cycle phenotypes, and pharmacogenetics in lymphoproliferative cancer
09:30-10:00	Olivier Pertz, Institute for Biochemistry and Genetics, University of Basel, Basel, Switzerland Multiscale analysis of spatio-temporal Rho GTPase signaling networks controlling neuronal outgrowth
10:00-10:30	Stefano PIccolo- Univ. of Padua Function and regulation of YAP/TAZ by cell mechanics and Wnt signaling
10:30-10:45	Coffee Break
10:45-11:15	Michael White- University of Manchester Dynamics and function of the NF-kappaB signalling system
11:15-11:30	Julia Sero- Institute of Cancer Research Using high content image analysis to uncover connections between YAP and cell shape
11:30-11:45	Amit Tzur- Bar-Ilan University Cytokinetic abscission is an acute G1 event
11:45-12:00	John Lock- Karolinska Institutet Spontaneous Plasticity in the Causal Networks of Cell Migration
12:15-12:30	Closing remarks
12:30-14:00	Lunch
12:30-14:00

Program

SLC2014 Program

Sunday, October 26

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