Sunday, 6th | Monday, 7th | Tuesday, 8th | Wednesday, 9th

Sunday, 6th
18:45 Dinner

Opening address by the organizers

Protein interactions in disease, and drug development
Chair: Sachdev Sidhu (USA)
20:10 Jonathan Gershoni, Tel Aviv University, Israel;
Computational prediction of conformational discontinuous B-cell epitopes: a rational approach to vaccine design
20:35 Len Pagliaro, BioImage A/S:
Small Molecule Inhibitors of Protein-Protein Interactions: New Perspectives from Cell Based Pathway Screening
21:00 Gabriel Waksman, ISMB, UK:
The chaperone-usher pathway of pilus biogenesis: structural basis of the assembly process and of host recognition
21:30 Get together
Monday, 7th
Thermodynamics & kinetics: landscapes and reaction coordinates of protein interaction
Chair: Jacob Piehler (Germany)
8:30 Gideon Schreiber, Weizmann Institute of Science, Israel;
What makes a protein-protein interaction work?
9:00 Christian Herrmann, Ruhr-Universitaet-Bochum, Germany;
Calorimetry derived energy landscapes on top of protein/protein interfaces reveal specificity of interaction on the molecular level.
9:30 Sandra Smith-Gill, National Cancer Institute at Frederick, US;
Multi-step association kinetics and thermodynamics of antibody-protein binding
10:00 Allen Minton, NIH, US;
A simple didactic model for the effect of cosolutes on protein association equilibria and kinetics
10:30 Coffee break
Theory of protein-protein interaction
Chair: Colin Kleanthous (UK)
10:50 Haim Wolfson, Tel-Aviv University, Israel;
Multimolecular Assembly - Challenges and Promises
11:20 Joel Janin, CNRS, Gif-sur-Yvette, Paris, France;
Atomic packing, interface hydration and the specificity of protein-protein recognition
11:50 Aalt D.J. van Dijk, Utrecht University, Holland:
Data-driven docking for the study of biomolecular complexes
12:05 Dina Schneidman-Duhovny, Tel-Aviv University, Israel;
FlexDock - Marriage requires Flexibility
12:20 Hani Neuvirth, Weizmann Institute of Science, Israel:
ProMate - Protein Binding Sites Prediction Server and its Application to Docking
12:35 Carlos J. Camacho, University of Pittsburgh, US:
Folded to bind: Encoding recognition on the protein surface
13:05-16:30 Optional jeep tour with light lunch
13:30-15:00 Biacore Round Table
Including free lunch, by pre-registration to
Design of protein-protein interaction
Chair: Gideon Schreiber (Israel)
16:30 Andreas Plueckthun, Universitaet Zuerich:
Designed Repeat Proteins as Models, Targeting Agents and Enzyme Inhibitors
17:00 Sachdev Sidhu, Genentech, Inc, San-Francisco, US;
Insights into Molecular Recognition from Synthetic Antibodies with Minimalist Binding Sites
17:30 Dan Tawfik, Weizmann Institute of Science, Israel:
Directed evolution of protein inhibitors of DNA-nucleases
17:50 Lakshmi Kotra, University of Toronto, Canada:
Understanding Protein-Protein Interactions for Small Molecule Design - Where to Cut the Corners Rationally
18:10 Julia Shifman, Hebrew University Jerusalem, Israel:
Computational design of protein-protein interfaces
18:30 Roy A. Mariuzza, University of Maryland, US;
Structural determinants of affinity in the evolution of protein-protein interfaces
19:00 Dinner and free evening
Tuesday, 8th
Protein interaction in signal transduction; molecular switches
Chair: Roger Goody (Germany)
8:30 Wendell A. Lim, UCSF, US:
The Modular Logic of Cell Signaling Systems
9:00 Joachim Nickel, University of Wuerzburg, Germany:
Mechanisms in BMP/-Receptor Recognition
9:30 Jens Traenkle, Ruhr-Universitaet Bochum, Germany:
New type of specific inhibitors of the Ras/Raf interaction which employ the conformational constraints of the switch I region
9:50 Meytal Landau, Tel Aviv University, Israel:
A Putative Mechanism for Down-Regulation of the Catalytic Activity of the EGF Receptor via Direct Contact between its Kinase and C-Terminal Domains
10:10 Coffee break
Chair: Kay Gottschalk (Germany)
10:30 Colin Kleanthous, University of York, UK;
Fishing for protein partners in the bacterial cell envelope: The role of native disorder in colicin translocation
11:00 Marcellus Ubbink, Leiden University, Holland;
Protein:Protein Interactions Studied by NMR
11:30 Jochen Schwenk, University of Freiburg, Germany;
Solution NMR-study of KChIP4a and its interaction with Kv4.3 N-terminus
11:45 Michal Sharon, University of Cambridge, UK;
New insight into the degradation machinery

Eleanor Fish, Toronto General Research Institute Canada:
Differences in interferon- subtype-receptor interactions determine subsequent biopotency

12:20 Ian Wilson, Scripps Institute, US;
Structural Basis of Immune Recognition
13:00-16:30 Optional outing to the Underwater Observatory
Protein interaction networks
Chair: Marcellus Ubbink (Canada)
16:30 Uri Alon, Weizmann Institute of Science, Israel:
Network motifs: simple building blocks of complex biological networks
17:00 Victor Neduva, EMBL Heidelberg, Germany:
Systematic discovery of new recognition peptides mediating protein interaction networks
17:20 Ariel Notcovich and Kobi Lavie, Proteoptics, Haifa, Israel;
ProteOn-XPR36: A New System for Multi-Spot Kinetic Studies of Biomolecular Interactions
17:50 Ofran Yanay, Columbia University, NY, USA;
The Role of PPI Hot Spots in Protein Networks
18:10 Ora Schueler-Furman, Hebrew University Jerusalem, Israel;
Prospects for structure-based functional characterization of protein-protein interactions
18:30 Stephen Michnick, Montreal, Canada:
Perspectives on genetic and chemical perturbation application for genomic-scale protein interaction network inferences and dynamics
18:50 Dinner
20:00 Poster Session
Wednesday, 9th
Studying PPI by single molecule techniques
Chair: Andreas Plueckthun (Switzerland)
8:30 Peter Hinterdorfer, University of Linz, Germany;
Single Molecule Recognition Force Microscopy on Proteins and Membranes
9:00 Kay Gottschalk, LMU Munich, Germany:
Crosstalk of Integrin and Chemokine Receptors

Reinat Nevo, Weizmann Institute of Science, Israel;
Direct Measurement of Protein Energy Landscape Roughness

9:40 Akihiro Kusumi, University of Kyoto, Japan;
Raft-based signal transduction in living cells as revealed by single-molecule tracking
10:10 Coffee break
Membrane protein interactions
Chair: Aki Kusumi (Japan)
10:30 Jacob Piehler, Goethe-University Frankfurt, Germany;
Dynamics of a ternary cytokine-receptor complex on model membranes
11:00 Itzhak Fishov, Ben Gurion University, Beer-Sheva, Israel;
Membrane-Catalyzed Nucleotide Exchange on DnaA: Effect of Surface Molecular Crowding
11:20 Tsipi Shoham, Stanford University Medical Center, US;
Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments
11:40 Ilan Samish, Weizmann Institute of Science, Israel:
Weak Forces Governing Functional Dynamic Interactions in Membrane Proteins
12:00 Sandra Loch, University of Frankfurt, Germany:
Monitoring interactions between viral factors and the antigen processing machinery in living cells
12:20 Roger Goody, Max-Planck-Institute for Molecular Physiology Dortmund, Germany:
Protein-protein and protein-lipid interactions involved in the regulation of intracellular vesicular transport by Rab-GTPases
13:00 Lunch break
13:00-16:30 Leisure to swim/snorkel, enjoy the sun!
Protein interactions in vivo
Chair: Stephen Michnick (Canada)
16:30 Igor Stagljar, Toronto, Canada:
Large-scale analysis of yeast and human integral membrane protein interactions using the membrane yeast two-hybrid approach

Assaf Friedler, Hebrew University, Jerusalem, Israel:
A promiscuous, highly electrostatic, protein-binding site in p53 core domain

17:20 Irma Lemmens, Ghent University, Belgium:
Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells
17:40 Shimon Gross, Washington University, US:
Non-Invasive Imaging of Protein-Protein Interactions and Protein Processing in Intact Cells and Living Animals
18:00 Bareket Dassa, Weizmann Institute of Science, Israel;
Studying the interactions between split-intein domains in protein-ligation reactions
18:20 Ron Tynes, Covalys Biosciences AG, Switzerland;
Directed Covalent Modification Of Proteins: The SNAP-tag
18:50 Closing remarks
19:30 Farewell dinner