| Sunday, 6th |
| 18:45 |
Dinner |
| 20:00 |
Opening address by the organizers
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Protein interactions in disease, and drug development
Chair: Sachdev Sidhu (USA) |
| 20:10 |
Jonathan Gershoni, Tel Aviv University, Israel;
Computational prediction of conformational discontinuous B-cell epitopes: a rational approach to vaccine design |
| 20:35 |
Len Pagliaro, BioImage A/S:
Small Molecule Inhibitors of Protein-Protein Interactions: New Perspectives from Cell Based Pathway Screening |
| 21:00 |
Gabriel Waksman, ISMB, UK:
The chaperone-usher pathway of pilus biogenesis: structural basis of the assembly process and of host recognition |
| 21:30 |
Get together |
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| Monday, 7th |
Thermodynamics & kinetics: landscapes and reaction coordinates of protein interaction
Chair: Jacob Piehler (Germany) |
| 8:30 |
Gideon Schreiber, Weizmann Institute of Science, Israel;
What makes a protein-protein interaction work? |
| 9:00 |
Christian Herrmann, Ruhr-Universitaet-Bochum, Germany;
Calorimetry derived energy landscapes on top of protein/protein interfaces reveal specificity of interaction on the molecular level. |
| 9:30 |
Sandra Smith-Gill, National Cancer Institute at Frederick, US;
Multi-step association kinetics and thermodynamics of antibody-protein binding |
| 10:00 |
Allen Minton, NIH, US;
A simple didactic model for the effect of cosolutes on protein association equilibria and kinetics |
| 10:30 |
Coffee break |
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Theory of protein-protein interaction
Chair: Colin Kleanthous (UK) |
| 10:50 |
Haim Wolfson, Tel-Aviv University, Israel;
Multimolecular Assembly - Challenges and Promises |
| 11:20 |
Joel Janin, CNRS, Gif-sur-Yvette, Paris, France;
Atomic packing, interface hydration and the specificity of protein-protein recognition |
| 11:50 |
Aalt D.J. van Dijk, Utrecht University, Holland:
Data-driven docking for the study of biomolecular complexes |
| 12:05 |
Dina Schneidman-Duhovny, Tel-Aviv University, Israel;
FlexDock - Marriage requires Flexibility |
| 12:20 |
Hani Neuvirth, Weizmann Institute of Science, Israel:
ProMate - Protein Binding Sites Prediction Server and its Application to Docking |
| 12:35 |
Carlos J. Camacho, University of Pittsburgh, US:
Folded to bind: Encoding recognition on the protein surface |
| 13:05-16:30 |
Optional jeep tour with light lunch |
| 13:30-15:00 |
Biacore Round Table
Including free lunch, by pre-registration to danyel@danyel.co.il
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Design of protein-protein interaction
Chair: Gideon Schreiber (Israel) |
| 16:30 |
Andreas Plueckthun, Universitaet Zuerich:
Designed Repeat Proteins as Models, Targeting Agents and Enzyme Inhibitors |
| 17:00 |
Sachdev Sidhu, Genentech, Inc, San-Francisco, US;
Insights into Molecular Recognition from Synthetic Antibodies with Minimalist Binding Sites |
| 17:30 |
Dan Tawfik, Weizmann Institute of Science, Israel:
Directed evolution of protein inhibitors of DNA-nucleases |
| 17:50 |
Lakshmi Kotra, University of Toronto, Canada:
Understanding Protein-Protein Interactions for Small Molecule Design - Where to Cut the Corners Rationally |
| 18:10 |
Julia Shifman, Hebrew University Jerusalem, Israel:
Computational design of protein-protein interfaces |
| 18:30 |
Roy A. Mariuzza, University of Maryland, US;
Structural determinants of affinity in the evolution of protein-protein interfaces |
| 19:00 |
Dinner and free evening |
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| Tuesday, 8th |
Protein interaction in signal transduction; molecular switches
Chair: Roger Goody (Germany) |
| 8:30 |
Wendell A. Lim, UCSF, US:
The Modular Logic of Cell Signaling Systems |
| 9:00 |
Joachim Nickel, University of Wuerzburg, Germany:
Mechanisms in BMP/-Receptor Recognition |
| 9:30 |
Jens Traenkle, Ruhr-Universitaet Bochum, Germany:
New type of specific inhibitors of the Ras/Raf interaction which employ the conformational constraints of the switch I region |
| 9:50 |
Meytal Landau, Tel Aviv University, Israel:
A Putative Mechanism for Down-Regulation of the Catalytic Activity of the EGF Receptor via Direct Contact between its Kinase and C-Terminal Domains |
| 10:10 |
Coffee break |
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Structure-function
Chair: Kay Gottschalk (Germany) |
| 10:30 |
Colin Kleanthous, University of York, UK;
Fishing for protein partners in the bacterial cell envelope: The role of native disorder in colicin translocation |
| 11:00 |
Marcellus Ubbink, Leiden University, Holland;
Protein:Protein Interactions Studied by NMR |
| 11:30 |
Jochen Schwenk, University of Freiburg, Germany;
Solution NMR-study of KChIP4a and its interaction with Kv4.3 N-terminus |
| 11:45 |
Michal Sharon, University of Cambridge, UK;
New insight into the degradation machinery |
| 12:00 |
Eleanor Fish, Toronto General Research Institute Canada:
Differences in interferon-‘± subtype-receptor interactions determine subsequent biopotency
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| 12:20 |
Ian Wilson, Scripps Institute, US;
Structural Basis of Immune Recognition |
| 13:00-16:30 |
Optional outing to the Underwater Observatory |
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Protein interaction networks
Chair: Marcellus Ubbink (Canada) |
| 16:30 |
Uri Alon, Weizmann Institute of Science, Israel:
Network motifs: simple building blocks of complex biological networks |
| 17:00 |
Victor Neduva, EMBL Heidelberg, Germany:
Systematic discovery of new recognition peptides mediating protein interaction networks |
| 17:20 |
Ariel Notcovich and Kobi Lavie, Proteoptics, Haifa, Israel;
ProteOn-XPR36: A New System for Multi-Spot Kinetic Studies of Biomolecular Interactions |
| 17:50 |
Ofran Yanay, Columbia University, NY, USA;
The Role of PPI Hot Spots in Protein Networks |
| 18:10 |
Ora Schueler-Furman, Hebrew University Jerusalem, Israel;
Prospects for structure-based functional characterization of protein-protein interactions |
| 18:30 |
Stephen Michnick, Montreal, Canada:
Perspectives on genetic and chemical perturbation application for genomic-scale protein interaction network inferences and dynamics |
| 18:50 |
Dinner |
| 20:00 |
Poster Session |
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| Wednesday, 9th |
Studying PPI by single molecule techniques
Chair: Andreas Plueckthun (Switzerland) |
| 8:30 |
Peter Hinterdorfer, University of Linz, Germany;
Single Molecule Recognition Force Microscopy on Proteins and Membranes |
| 9:00 |
Kay Gottschalk, LMU Munich, Germany:
Crosstalk of Integrin and Chemokine Receptors |
| 9:20 |
Reinat Nevo, Weizmann Institute of Science, Israel;
Direct Measurement of Protein Energy Landscape Roughness
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| 9:40 |
Akihiro Kusumi, University of Kyoto, Japan;
Raft-based signal transduction in living cells as revealed by single-molecule tracking |
| 10:10 |
Coffee break |
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Membrane protein interactions
Chair: Aki Kusumi (Japan) |
| 10:30 |
Jacob Piehler, Goethe-University Frankfurt, Germany;
Dynamics of a ternary cytokine-receptor complex on model membranes |
| 11:00 |
Itzhak Fishov, Ben Gurion University, Beer-Sheva, Israel;
Membrane-Catalyzed Nucleotide Exchange on DnaA: Effect of Surface Molecular Crowding |
| 11:20 |
Tsipi Shoham, Stanford University Medical Center, US;
Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments |
| 11:40 |
Ilan Samish, Weizmann Institute of Science, Israel:
Weak Forces Governing Functional Dynamic Interactions in Membrane Proteins |
| 12:00 |
Sandra Loch, University of Frankfurt, Germany:
Monitoring interactions between viral factors and the antigen processing machinery in living cells |
| 12:20 |
Roger Goody, Max-Planck-Institute for Molecular Physiology Dortmund, Germany:
Protein-protein and protein-lipid interactions involved in the regulation of intracellular vesicular transport by Rab-GTPases |
| 13:00 |
Lunch break |
| 13:00-16:30 |
Leisure to swim/snorkel, enjoy the sun! |
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Protein interactions in vivo
Chair: Stephen Michnick (Canada) |
| 16:30 |
Igor Stagljar, Toronto, Canada:
Large-scale analysis of yeast and human integral membrane protein interactions using the membrane yeast two-hybrid approach |
| 17:00 |
Assaf Friedler, Hebrew University, Jerusalem, Israel:
A promiscuous, highly electrostatic, protein-binding site in p53 core domain
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| 17:20 |
Irma Lemmens, Ghent University, Belgium:
Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells |
| 17:40 |
Shimon Gross, Washington University, US:
Non-Invasive Imaging of Protein-Protein Interactions and Protein Processing in Intact Cells and Living Animals |
| 18:00 |
Bareket Dassa, Weizmann Institute of Science, Israel;
Studying the interactions between split-intein domains in protein-ligation reactions |
| 18:20 |
Ron Tynes, Covalys Biosciences AG, Switzerland;
Directed Covalent Modification Of Proteins: The SNAP-tag |
| 18:50 |
Closing remarks |
| 19:30 |
Farewell dinner |
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