PUBLICATIONS

Publications from Abramson lab (2011-present):

Goldfarb Y, Givony T, Kadouri N, Dobeš J, Peligero-Cruz C, Zalayat I, Damari G, Dassa B, Ben-Dor S, Gruper Y, Oftedal BE, Bratland E, Erichsen MM, Berger A, Avin A, Nevo S, Haljasorg U, Kuperman Y, Ulman A, Haffner-Krausz R, Porat Z, Atasoy U, Leshkowitz D, Husebye ES, Abramson J. Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation. J Exp Med. 2021;218(11)

Peligero-Cruz C, Givony T, Sebé-Pedrós A, Dobeš J, Kadouri N, Nevo S, Roncato F, Alon R, Goldfarb Y, Abramson J. IL18 signaling promotes homing of mature Tregs into the thymus. eLife. 2020 Jul 20;9:e58213. doi: 10.7554/eLife.58213.

M Delacher, MM Barra, Y Herzig, K Eichelbaum, MR Rafiee, DM Richards, U Träger, AC Hofer, A Kazakov, Braband KL, Gonzalez M, Wöhrl L, Schambeck K, Imbusch CD, J Abramson, J Krijgsveld, M Feuerer: Quantitative Proteomics Identifies TCF1 as a Negative Regulator of Foxp3 Expression in Conventional T Cells; iScience. 2020 ;23(5):101127.

N Kadouri, S Nevo, Y Goldfarb, J Abramson: Thymic epithelial cell heterogeneity: TEC by TEC; Nat Rev Immunol. 2020 (4):239-253.

Delacher M, Schmidl C, Herzig Y, Breloer M, Hartmann W, Brunk F, Kägebein D, Träger U, Hofer AC, Bittner S, Weichenhan D, Imbusch CD, Hotz-Wagenblatt A, Hielscher T, Breiling A, Federico G, Gröne HJ, Schmid RM, Rehli M, J Abramson, M Feuerer: Rbpj expression in regulatory T cells is critical for restraining TH2 responses; Nat Commun. 2019;10(1):1621.

S Nevo, N Kadouri, J Abramson: Tuft cells: From the mucosa to the thymus; Immunol Lett. 2019;210:1-9.

C Bornstein, S Nevo, A Giladi, N Kadouri, M Pouzolles, F Gerbe, E David, A Machado, A Chuprin, B Tóth, O Goldberg, S Itzkovitz, N Taylor, P Jay, VS Zimmermann, J Abramson*, I Amit*: Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells; Nature, 2018 Jul;559(7715):622-626 (*equal contribution)

A Avin, M Levy, Z Porat & J Abramson: Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations. Nature Commiunications, 2017, 8(1):1524.

J Abramson & G Anderson: Thymic Epithelial Cells. Annual Review of Immunology2017 35 (1); link

Y Herzig, S Nevo, C Bornstein, MR Brezis, S Ben-Hur, A Shkedy, M Eisenberg, B Levi, M Delacher, Y Goldfarb, E David L Weinberger, S Viukov, S Ben-Dor, M Giraud, JH Hanna, A Breiling, F Lyko, I Amit, M Feuerer & J Abramson: Transcriptional programs that control expression of the autoimmune regulator gene Aire; Nature Immunology,2017, 19(2); DOI: 10.1038/ni.3638

M Danan-Gotthold, C Guyon, M Giraud, EY Levanon* & J Abramson*. Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells; Genome Biology,2016 17:234

Y Goldfarb, N Kadouri, B Levi, A Sela, Y Herzig, R Cohen, A Hollenberg, J Abramson: HDAC3 is a master regulator of mTEC development; Cell Rep. 2016; 15(3):651-65

J Abramson, ES Husebye: Autoimmune Regulator and self-tolerance - molecular and clinical aspects (Review); Immunol Rev. 2016; 271(1):127-40

J Abramson, Y Goldfarb: AIRE: From promiscuous molecular partnerships to promiscuous gene expression (Review), Eur J Immunol. 2016; 46(1):22-33.

A Chuprin, A Avin, Y Goldfarb, Y Herzig, B Levi, A Jacob, A Sela, S Katz, M Grossman, C Guyon, M Rathaus, HY Cohen, I Sagi, M Giraud, MW McBurney, ES Husebye, J Abramson: The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance, Nature Immunology, 2015, Jul;16(7): 737-45

BE Oftedal, A Hellesen, MM Erichsen, E Bratland, A Vardi, J Perheentupa, EH Kemp, T Fiskerstrand, MK Viken, AP. Weetman, SJ Fleishman, S Banka, WG Newman, WAC Sewell, LS Sozaeva, T Zayats, K Haugarvoll, EM Orlova, J Haavik, S Johansson, PM Knappskog, K Løvås, ASB Wolff, J Abramson*, ES Husebye*: Dominant mutations in the autoimmune regulator AIRE are associated with common organ-specific autoimmune diseases, Immunity, 2015, Jun 16;42(6):1185-96. (*equal contribution)

Publications from postdoc (2005-2010):

M. Giraud, H Yoshida, J. Abramson, PB. Rahl, RA Young, D Mathis, and C Benoist:Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells, PNAS, 2012, 109(2):535-40

J. Abramson, M. Giraud, C. Benoist, and D. Mathis: Aire’s partners in the molecular control of immunological tolerance, Cell, 2010, 140(1); 123-135

AS. Koh, AJ. Kuo, SY. Park, P. Cheung, J. Abramson, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, C. Benoist, and D. Mathis: Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity, PNAS; 2008; 105(41):15878-83

D. Gray, J. Abramson, C. Benoist, and D. Mathis: Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire, J. Exp. Med., 2007; 204(11): 2521 – 2528

Commentaries and previews on published work:

Part Peterson: Sirt-ainly Aire; Nat Immunol. 2015 Jun 18;16(7):680-1; commentary on Chuprin A et al, Nat Immunol2015

MS Anderson, JL Casanova: More than Meets the Eye: Monogenic Autoimmunity Strikes Again; Immunity 2015 Jun 16;42(6):986-8; commentary on Oftedal B et al, Immunity2015

Bruno Kyewski and Part Peterson: Aire, Master of Many Trades; Cell, 2010, 140(1); 24-26; commentary on: J. Abramson, et al, Cell, 2010

Kirsty Minton; Tolerance: How AIRE wakes up sleepy genes; Nature Reviews Immunology, 2010, 10 (2), 87-87; commentary on: J. Abramson, et al, Cell, 2010

Towns R and Pietropaolo M; Aire's partnerships: an answer for many questions and new questions in search of answers; Pediatric Diabetes, 2010, 11(2):85-7 commentary on: J. Abramson, et al, Cell, 2010

Connie Lee: Avoiding Autoimmunity with Aire; Cell, 2010, 140(1); online: http://download.cell.com/mmcs/journals/0092-8674/PIIS009286740901616X.mm... paper clip with an audio interview on: Abramson, et al, Cell, 2010