Our research is founded on the principle that cancer progression is governed not only by tumor-intrinsic genetic and metabolic alterations but also by the tumor macroenvironment, which includes host metabolism, genetic background, medication exposure, and systemic physiology. This interaction is inherently bidirectional: tumors actively reprogram the host macroenvironment, inducing systemic metabolic remodeling, cachexia, and inflammatory states, while host-derived factors in turn shape tumor evolution, progression, and therapeutic response. By explicitly integrating tumor-intrinsic and host-extrinsic determinants, we seek to define carcinogenesis as a host–tumor co-evolutionary process. This framework recognizes that effective strategies for early detection and therapy must address both malignant cells and the biological context in which they arise, enabling more precise and durable clinical interventions.
Wholly Metaboly
