We aim to understand how the immune system handles the abundance of extrinsic and intrinsic challenges to the body. This includes parasitic, bacterial and viral pathogen attacks, but also cancer and metabolic pressure, as well as physiological tissue development and remodeling.

Research activities in our department cover a broad spectrum of basic and clinically relevant questions. Topics range from fundamental aspects of hematopoiesis and inter-cellular communication to the physiological principles underlying inflammation, cancer immune-surveillance and host / microbiome interactions.

Department members investigate cellular and molecular mechanisms underlying immune disorders, such as immunodeficiencies, innate immunopathologies and autoimmunity. Using pre-clinical mouse models and patient samples, we develop novel therapeutic strategies including check-point blockade, immunotherapies and improved vaccination protocols.

State-of-the-art approaches ranging from intra-vital imaging and conditional gene manipulation to advanced genomics and proteomics are used to uncover physiological and pathological roles of the immune system.