Antibody response in cancer

The appearance of neo-antigens on malignant cells leads to the production of tumor-reactive antibodies both in cancer patients and animal models. These anti-tumor antibodies can mediate diverse immune responses which are ultimately either tumor-promoting or tumor-eliminating.  Using advanced flow-cytometry, imaging, and mass-spectrophotometry approaches to analyze the antibody response in cancer patients and animal models, we aim to mechanistically define the factors that control the opposing effects of antibodies on tumor growth. By providing mechanistic insight into key questions in the field we aim to identify new therapeutic targets for enhancing the immune response against tumors.

Antibody response in cancer