Antigen microarray chip for profiling antibody repertoires

In collaboration with Prof. Eytan Domany of the Department of Physics of Complex Systems, we developed an antigen chip that allows the global analysis of antibody reactivities to an array of various molecules including self-molecules.

The antigen chip provides patterns of reactivities that can be analyzed by various informatic technologies as a means to detect the state of the individual immune system in health and disease: autoimmune diseases, cancer, transplantation, degenerative diseases and infections.

This information is being used for early diagnosis, disease monitoring, stratification of patients, individualized medical care, prediction of incipient disease, prediction of response to treatment, and study of the evolution from birth of the healthy antibody and autoantibody repertoires.

Peptide that inhibits apoptosis of cells

mechanism and application to therapy in ALS, lethal irradiation, Alzheimer’s disease, stroke and myocardial infarction.

In preparation for publication in collaboration with Dr. Johannes Herkel.  The peptide is being developed for clinical applications by the Israeli company Immune Pharma Limited (Eran Ovadia, CEO).

Complex systems and systems immunology in research, theory and therapy

Modeling and Simulation

Collaboration with Prof. David Harel of the Department of Applied Mathematics and Computer Science and with Dr. Sol Efroni (now of Bar-Ilan University) has led to the development of a visual language for computer simulation of living systems that is understandable to biologists - Reactive Animation. This work has given rise to GemCell - a generic platform for modeling cellular systems.

Complex Systems

Collaborations with the late Prof. Lee Segel, Prof. Henri Atlan, Prof. David Harel, Prof. Sorin Solomon, Prof. Yoram Louzoun, Prof. Eshel Ben Jacob and Dr. Sol Efroni have led to insights into computational systems biology and complex systems.