Monocytes

Monocytes are mononuclear phagocytes that circulate in the blood and comprise two major subsets. One monocyte population seems dedicated to patrol the inner vessel wall and surveille it for integrity. A second subset, defined as CD14+ cells and Ly6C+ cells in man and mouse respectively, is highly dynamic and short-lived. These cells can be recruited to sites of inflammation and injury where they give rise to monocyte-derived DC and macrophages. Differential functions of these cells and classical tissue-resident DC and macrophages remain largely to be defined.

Publications:

Geissman, Jung and Littman Immunity 2002

Landsman et al. JI 2007

Varol et al. JExMed 2007

Landsman et al. Blood 2009

Yona et. Immunity 2012

Mildner & Jung. Adv. Immunol 2013
 (review)
Avraham, Yona et al. JExMed 2013

Molawi, Wolf et al JExMed 2014
Mildner, Marinkovic and Jung. Microbiol. Spectrum 2016 (review)
Shmuel-Galia*, Aychek* et al. EMBO 2016, collab. with Yehiel Shai
Wolf et al. JExMed 2017
Mildner et al. Immunity 2017
Gross-Vered*, Shmuel-Galia* et al J Immunology 2019 collab. with Yehiel Shai
Gross-Vered et al. eLife 2020
Trzebanski & Jung. Imm. Letters 2020

Past and present Jung lab members involved in these studies:

Limor Landsman, Simon Yona, Ki-Wook Kim, Yochai Wolf, Alexander Mildner, Mor Gross, Sebastien Trzebanski, Anmol Kulkarni.

Past and Current Funding:

DFG (FOR 1336-2); BSF, ISF, MINERVA foundation, AdvERC