Monocytes are mononuclear phagocyte precursors that circulate in the blood and comprise two major subsets. Classical monocytes (CM) are highly dynamic and short-lived. Under homeostasis, these cells give rise to selected tissue resident macrophage populations in barrier tissues, as well non-classical monocytes (NCM), that patrol vessel walls and surveille them for integrity. Following injury and pathogen challenges, CM are recruited to the site of inflammation and complement functions of tissue resident mononuclear phagocytes. Interestingly, emerging evidence suggests that CM themselves are heterogeneous. Differential functions and fates of reported GMP- and MDP- derived classical monocytes remain however incompletely understood.
Publications:
Geissman, Jung and Littman Immunity 2002
Landsman et al. JI 2007
Varol et al. JExMed 2007
Varol et al. Immunity 2009
Landsman et al. Blood 2009
Yona et. Immunity 2012
Mildner & Jung. Adv. Immunol 2013
(review)
Avraham, Yona et al. JExMed 2013
Molawi, Wolf et al JExMed 2014
Mildner, Marinkovic and Jung. Microbiol. Spectrum 2016 (review)
Shmuel-Galia*, Aychek* et al. EMBO 2016, collab. with Yehiel Shai
Wolf et al. JExMed 2017
Mildner et al. Immunity 2017
Gross-Vered*, Shmuel-Galia* et al J Immunology 2019 collab. with Yehiel Shai
Gross-Vered et al. eLife 2020
Trzebanski & Jung. Imm. Letters 2020
Trzebanski et al., Immunity, 2024
Kim et al. submitted (on bioRxiv)
Past and present Jung lab members involved in these studies:
Limor Landsman, Simon Yona, Ki-Wook Kim, Yochai Wolf, Alexander Mildner, Mor Gross, Sebastien Trzebanski, Anmol Kulkarni, Nitzan Goldmann, Ayala Raanan.
Past and Current Funding:
DFG (FOR 1336-2), BSF, ISF, MINERVA foundation, AdvERC