Gideon Berke Professor Gideon Berke
The Isaac and Elsa Bourla Professor of Cancer Research

 Complete List of Publications

  1. Schejter, A. and Berke, G. (1968). The reactions of cytochrome C1 with ligands. Biochem. Biophys. Acta 162: 459-461.
  2. Berke, G., Ax, W., Ginsburg, H. and Feldman, M. (1969). Graft reaction in tissue culture. II. Quantification of the lytic action on mouse fibroblasts by rat lymphocytes sensitized in mouse embryo monolayers. Immunology 16: 643-657.
  3. Berke, G., Ginsburg, H. and Feldman, M. (1969). Graft reaction in tissue culture. III. Effect of phytohemagglutinin. Immunology 16: 659-667.
  4. Berke, G., Yagil, G., Ginsburg, H. and Feldman, M. (1969). Kinetic analysis of a graft reaction induced in cell culture. Immunology 17: 723-740.
  5. Ginsburg, H., Ax, W. and Berke, G (1969). Graft reaction in tissue culture by normal rat lymphocytes. Transpl. Proc. 1: 551-555.
  6. Ginsburg, H., Ax, W. and Berke, G. (1970). Functional implications of cellular immunity. An analysis of graft reaction in cell cultures. In: Proceedings Symposium Pharmacological Treatment in Organ and Tissue Transplantation, (Bertelli, A. and Monaco, A.P., eds.), Williams and Wilkins, Baltimore, pp. 85-107.
  7. Berke, G.,Ginsburg, H. and Feldman, M. (1971). Mouse cell destruction by in vitro-sensitized rat lymphoid cells. In: Cell-Mediated Immunity: In vitro correlates, (Revillard, J.P., ed), Karger, Basel, pp. 103-126.
  8. Clark, W.R., Berke, G., Feldman, M. and Sarid, S. (1971). Macromolecular synthesis during the sensitization of rat lymphocytes on mouse fibroblasts in vitro. Immunochemistry, 8: 487-498.
  9. Berke, G., Clark, W.R. and Feldman, M. (1971). In vitro induction of a heterograft reaction. Immunological parameters of the sensitization of rat lymphocytes against mouse cells in vitro. Transplantation, 12: 237-248.
  10. Berke, G., Sarid, S. and Feldman, M. (1971). Studies on the nature of messenger RNA in phytohemagglutinin-stimulated rat lymphocytes. Biochem. Biophys. Acta, 254: 440-446.
  11. Goren, G., Berke, G. and Urca, I. (1972). Localization of 51Cr-labeled sensitized lymphocytes at the allograft region: A possible diagnostic test in organ transplantation. Surgery, 71: 513-521.
  12. Berke, G. and Levey, R. (1972). Cellular immunoadsorbents in transplantation immunity. Specific in vitro deletion and recovery of mouse lymphoid cells sensitized against allogeneic tumors. J. Exp. Med., 135: 972-984.
  13. Berke, G., Sullivan, K.A. and Amos, D.B. (1972). Rejection of ascites tumor allografts. I. Isolation, characterization and in vitro reactivity of peritoneal lymphoid effector cells from BALB/c mice immune to EL4 leukosis. J. Exp. Med., 135: 1334-1350.
  14. Berke, G., Sullivan, K.A. and Amos, D.B. (1972). Rejection of ascites tumor allograft. II. A pathway for cell-mediated tumor destruction in vitro by peritoneal exudate lymphoid cells. J. Exp. Med., 136: 1594-1604.
  15. Berke, G., Sullivan, K.A. and Amos, D.B. (1972). Tumor immunity in vitro: Destruction of a mouse ascites tumor through a cycling pathway. Science, 177: 433-434.
  16. Sullivan, K.A., Berke, G. and Amos, D.B. (1972). 51Cr leakage from and uptake of trypan blue by target cells undergoing cell-mediated destruction. Transplantation, 13: 627-628.
  17. Berke, G. and Amos, D.B. (1973). Mechanism of lymphocyte-mediated cytolysis. The LMC cycle and its role in transplantation immunity. Transpl. Rev., 17: 71-107.
  18. Berke, G. and Amos, D.B. (1973). Cytotoxic lymphocytes in the absence of detectable antibody. Nature New Biol., 242: 237-239.
  19. Stulting, R.D. and Berke, G. (1973). Nature of lymphocyte-tumor interaction. A general method for cellular immunoabsorption. J. Exp. Med., 137: 932-942.
  20. Kemp, A.S. and Berke, G. (1973). Inhibition of lymphocyte-mediated cytolysis by the local anaesthetics benzyl and salicyl alcohol. Eur. J. Immunol., 3: 674-677.
  21. Huber, S., Berke, G. and Amos, D.B. (1973). Serum factors in lymphocyte proliferation. I. The requirement for serum in mixed lymphocyte reactions. Cell. Immunol., 9: 405-411.
  22. Sullivan, K.A., Berke, G. and Amos, D.B. (1973). An antigenic determinant of cytotoxic lymphocytes. Transplantation, 16: 388-391.
  23. Stulting, R.D. and Berke, G. (1973). The use of 51Cr release as a measure of lymphocyte-mediated cytolysis in vitro. Cell. Immunol., 9: 474-476.
  24. Stulting, R.D., Berke, G. and Heimstra, K. (1973). Evaluation of the effects of cytochalasin B on lymphocyte-mediated cytolysis. Transplantation, 16: 684-686.
  25. Todd, R.F., III, Stulting, R.D. and Berke, G. (1973). Mechanism of blocking by hyperimmune serum of lymphocyte-mediated cytolysis of allogeneic tumor cells. Cancer Res., 33: 3203-3208.
  26. Kemp, A., Berke, G., Crowell, J. and Amos, D.B. (1973). Induction of cell-mediated immunity against leukemia EL4 in C57BL mice. J. Natl. Cancer Inst., 51: 1877-1882.
  27. Berke, G. (1973). Correlation between homograft reactions and in vitro destruction of target cells. In: Proceedings 7th Leukocyte Culture Conference (Daguillard, F., Ed.), Academic Press, New York, pp. 591-599.
  28. Berke, G. and Sullivan, K.A. (1973). Temperature control of lymphocyte mediated cytotoxicity in vitro. Transpl. Proc., 5: 421-423.
  29. Kemp, A. and Berke, G. (1973). Effects of heparin and benzyl alcohol on lymphocyte-mediated cytotoxicity in vitro. Cell. Immunol., 7: 512-515.
  30. Berke, G. and Stulting, R.D. (1974). Cellular immunoabsorbents. A new approach in transplantation and tumor immunology. In Immunological Parameters of Host-Tumor Relationships, (Weiss, D.W., ed.), Academic Press, New York, pp. 992-1000.
  31. Todd, R.F. III, Stulting, R.D. and Berke, G (1974). Mechanism of inhibition of lymphocyte-mediated cytolysis by blocking antiserum. In: Proc. 8th Leukocyte Culture Conference (Lindhal-Kiessling, K., ed), Academic Press, New York, pp. 379-387.
  32. Kemp, A., Berke, G., Dawson, J. and Amos, D.B. (1974). The influence of serum components on lymphocyte-mediated cytolysis. Transplantation, 17: 447-452.
  33. Todd, R.F. and Berke, G. (1974). Functional characterization of membrane components of cytotoxic peritoneal exudate T lymphocytes. I. Search for T cell receptor activity in lymphocyte membrane fractions. Immunochemistry, 11: 313-320.
  34. Greely, E., Berke, G. and Scott, D.W. (1974). Receptors for antigen on lymphoid cells. I. Immunoadsorption of plaque-forming cells to PLL-fixed antigen monolayers. J. Immunol., 113: 1883-1890.
  35. Berke, G. and Gabison, D (1975). Energy requirements of the binding and lytic steps of T lymphocyte-mediate cytolysis of leukemic cells in vitro. Eur. J. Immunol., 5: 671-675.
  36. Berke, G., Gabison, D. and Feldman, M. (1975). The frequency of effector cells in populations containing cytotoxic T lymphocytes. Eur. J. Immunol., 5: 813-818.
  37. Zagury, D., Bernard, J., Thierness, N., Feldman, M. and Berke, G. (1975). Isolation and characterization of individual functionally reactive cytotoxic T lymphocytes. Conjugation, killing and recycling at the single cell level. Eur. J. Immunol., 5: 818-822.
  38. Kalina, M. and Berke, G. (1976). Contact regions of cytotoxic T lymphocyte-target cell conjugates. Cell. Immunol., 25: 41-51.
  39. Berke, G. and Fishelson, Z. (1976). Possible role of nucleus-membrane interaction in capping of surface membrane receptors. Proc. Natl. Acad. Sci., 73: 4580-4583.
  40. Berke, G. (1976). Lymphocyte-target cell conjugation: Membrane receptors for alloantigens. In: Immune reactivity of lymphocytes (Feldman, M. and Globerson, A. eds) Plenum Press, New York, pp. 483-488.
  41. Berke, G. and Fishelson, Z. (1977). T lymphocyte-mediated cytolysis. Contribution of intracellular components to target cell susceptibility. Transpl. Proc., 9: 671-674.
  42. Schick, B. and Berke, G. (1977). Tumor-associated lymphoid cells. Analysis of host cells that bind to syngeneic and allogeneic tumor cells shortly after tumor administration. Transpl. Proc., 9: 1157-1160.
  43. Berke, G. (1977). Binding of immunoglobulin-bearing lymphoid cells to allogeneic and syngeneic target cells. Idem, pp. 524-526.
  44. Berke, G. (1977). Recent advances and questions in lymphocytotoxicity. In: Regulatory mechanisms in lymphocyte activation ( Lucas, D.O., ed)., Academic Press, New York, pp. 809-816.
  45. Schick, B. and Berke, G. (1977). Activity of tumor-associated lymphoid cells at short intervals after administration of irradiated syngeneic and allogeneic tumor cells. J. Immunol., 118: 986-991.
  46. Schick, B. and Berke, G. (1978). Is the presence of serologically-defined target cell antigens sufficient for binding of cytotoxic T lymphocytes? Transplantation, 26: 14-18.
  47. Berke, G., Tzur, R. and Inbar, M. (1978). Changes in fluorescence polarization of a membrane probe during lymphocyte-target cell interaction. J. Immunol., 120: 1378-1384.
  48. Fishelson, Z. and Berke, G. (1978). T lymphocyte-mediated cytolysis: Dissociation of the binding and lytic mechanisms of the effector cell. J. Immunol., 120: 1121-1126.
  49. Berke, G. (1979). Comparative analysis of single cell and population events in T lymphocyte-mediated cytolysis. In: Tumor-associated antigens and their specific immune response (Spreafico, F., ed), Academic Press, New York, pp. 85-97.
  50. Schick, B. and Berke, G. (1979). Competitive inhibition of cytotoxic T lymphocyte-target cell conjugation: A direct evaluation of membrane antigens involved in cell-mediated immunity. Transplantation, 27: 365-368.
  51. Hurt, S.N., Berke, G. and Clark, W.R. (1979). A rapid method for generating cytotoxic effector cells in vivo. J. Immunol. Meth., 28: 321-329.
  52. Berke, G., Fishelson, Z. and Schick, B. (1979). Hyperthermia and formaldehyde can dissociate the binding and killing activities of cytolytic T lymphocytes. Transpl. Proc., 11: 804-806.
  53. Schick, B. and Berke, G. (1979). Cellular activities necessary for specific binding of cytotoxic T lymphocytes and target cells. Transpl. Proc., 11: 800-803.
  54. Fishelson, Z. and Berke, G. (1979). Polar events in T lymphocyte-mediated lysis: Unidirectional killing during bidirectional interaction of cytotoxic T lymphocytes. In: 12th Leukocyte Culture Conference (Quastel, M.R., ed), Academic Press, New York, pp. 601-605.
  55. Berke, G. and Schick, B. (1980). Tumor immunity in the peritoneal cavity. Cont. Top. Immunobiol., 10: 297-315.
  56. Berke, G. (1980). Interaction of cytotoxic T lymphocytes and target cells. Prog. Allergy, 27: 69-133.
  57. Kaufmann, Y. and Berke, G. (1980). Enucleated cytotoxic T lymphocytes bind specifically to target cells in vitro. Transplantation, 29: 374-378.
  58. Grossman, Z. and Berke, G. (1980). Tumor escape from immune elimination. J. Theor. Biol., 83: 267-296.
  59. Kaufmann, Y. and Berke, G. (1981). Cell surface glycoproteins of cytotoxic T lymphocytes induced in vivo and in vitro. J. Immunol., 126: 1443-1446.
  60. Berke, G., Hu, V. McVey, E. and Clark, W.R. (1981). T lymphocyte-mediated cytolysis. I. A common mechanism for target recognition in specific and lectin-dependent cytolysis. J. Immunol., 127: 776-781.
  61. Berke, G., McVey, E., Hu, V. and Clark, W.R. (1981). T lymphocyte-mediated cytolysis. II. Role of target cell histocompatibility antigens in recognition and lysis. J. Immunol., 127: 782-787.
  62. Fishelson, Z. and Berke, G. (1981). Tumor cell destruction by cytotoxic T lymphocytes: The basis of reduced anti-tumor cell activity in syngeneic hosts. J. Immunol., 126: 2048-2052.
  63. Kaufmann, Y., Berke, G. and Eshhar, Z. (1981). Cytotoxic T lymphocyte hybridomas that mediate specific tumor cell lysis in vitro. Proc. Natl. Acad. Sci. USA, 78: 2502-2506.
  64. Kaufmann, Y., Berke, G. and Eshhar, Z. (1981). Functional cytotoxic T lymphocyte hybridomas. Transpl. Proc., 13: 1170-1174.
  65. Rosen, D., Fishelson, Z. and Berke, G. (1981). The role of CTL projections in target cell lysis. Transpl. Proc., 13: 1073-1078.
  66. Berke, G. and Clark, W.R. (1982). T lymphocyte-mediated cytolysis. A comprehensive theory. I. The mechanism of CTL-mediated cytolysis. In: Mechanisms of Cell Mediated Cytotoxicity. (Clark, W.R. and Golstein, P., eds.), New York, Plenum Publ. Corp., pp. 57-69.
  67. Clark, W.R. and Berke, G. (1982). T lymphocyte mediated cytolysis, a comprehensive theory. II. Lytic vs. nonlytic interactions of T lymphocytes. Idem, pp. 69-79.
  68. Berke, G., Hu, V., McVey, E. and Clark, W.R. (1982). A common role for target cell histocompatability antigens in both nonspecific and specific T lymphocyte-mediated cytolysis. J. Cell. Biochem., 18: 337-349.
  69. Berke, G. (1982) T lymphocyte-mediated cytolysis. IV How do mitogenic and non-mitogenic lectins mediate lymphocyte-target interactions? In: Lectins: Biology and Biochemistry, vol. 3. (Bog Hansen, ed.) pp. 55-62.
  70. Kaufmann, Y., Berke, G. and Eshhar, Z. (1982). Cytolytic T cell hybridomas. In: Lymphokines, vol. 5. Monoclonal T cells and their products (M. Feldmann and M.H. Schreier eds.), Academic Press, pp. 277-289.
  71. Geiger, B., Rosen, D. and Berke, G. (1982). Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells. J. Cell Biol., 95: 137-143.
  72. Berke, G., Rosen, D. and Moscovitch, M. (1983). T lymphocyte-mediated cytolysis. III. Delineation of mechanisms whereby mitogenic and non-mitogenic lectins mediate lymphocyte-target interaction. Immunology, 49: 585-592.
  73. Schick, B., Jakobovits, A., Sharon, N. and Berke, G. (1983) Specific lysis of antigenically irrelevant cells by cytotoxic T lymphocytes upon insertion of appropriate antigens into the target cell plasma membranes. Transplantation, 36: 84-90.
  74. Kaufmann, Y. and Berke, G. (1983). Monoclonal cytotoxic T lymphocyte hybridomas capable of specific killing activity, antigenic responsiveness and inducible interleukin secretion. J. Immunol., 131: 50-56.
  75. Berke, G. (1983) Cytotoxic T lymphocytes. How do they function? Immunol. Rev., 72: 5-42.
  76. Fishelson, Z. and Berke, G. (1983. ) CTL devoid of lytic activity can lower ATP levels of target cells. In: Proceedings Fifteenth International Leukocyte Culture Conference (Parker, J.W. and O'Brien, R.L., eds) John Wiley and Sons, USA, pp. 601-605.
  77. Keren, Z. and Berke, G. (1984). The pathway of lectin-mediated lymphocytotoxicity by Con A-coupled Sepharose beads. Cell. Immunol., 85: 556-562.
  78. Keren, Z. and Berke, G. (1984). Selective binding of Concanavalin A to target cell major histocompatibility antigens is required to induce nonspecific conjugation and lysis by cytolytic T lymphocytes in lectin-dependent cytotoxicity. Cell. Immunol., 89: 458-477
  79. Bialick, R., Gill, R., Berke, G., Clark, W.R. (1984). Modulation of cell mediated cytotoxicity function after alteration of fatty acid composition in vitro. J. Immunol., 132: 81-87.
  80. Tirosh, R., Degani, H. and Berke, G. (1984) Prelytic reduction of high energy phosphates induced by antibody and complement in nucleated cells. 31P-NMR study. Complement, 1: 207-212.
  81. Moscovitch, M., Kaufmann, Y. and Berke, G. (1984). Memory CTL-hybridoma: A model system to analyze the anamnestic response of CTL. J. Immunol., 133: 2369-2374.
  82. Berke, G. (1985). How T lymphocytes kill infected cells. Microbiological Sciences, 2: 44-48.
  83. Tirosh, R. and Berke, G. (1985). T lymphocyte-mediated cytolysis as an excitatory process of the target. I. Evidence that the target may be the site of Ca2+ action. Cell. Immunol., 95: 113-123.
  84. Berke, G. (1985). Enumeration of lymphocyte-target cell conjugates by cytofluorometry. Eur. J. Immunol., 15: 337-340.
  85. Tirosh, R. and Berke, G. (1985). Immune cytolysis viewed as a stimulatory process of the target. In: Proc. 2nd CMC Conference (Henkart, P. and Martz, E., eds.), Plenum, New York, pp. 473-492.
  86. Kaufmann, Y., Moscovitch, M., Robb, R.J., Rosenberg, S.A, and Berke, G. (1985). Antigen/mitogen induced cytolytic activity and IL-2 secretion in memory-like CTL-hybridoma. In: Proc. 2nd CMC Conference (Henkart, P. and Martz, E. eds.), Plenum, New York, pp. 535-550.
  87. Tirosh, R., H. Degani and Berke, G. (1986). Metabolic depletion preceding cytolysis induced by antibody and complement as revealed by 31P-NMR spectroscopy. In: Myocardial and Skeletal Muscle Bioenergetics (Adv. Exptl. Med. Biol, Vol. 194) (Brautbar, N. ed.), Plenum, New York, pp. 665-675.
  88. Keren, Z., Berke, G. and Gershoni, J. (1986). Identification of cell surface glycoproteins by periodate-alkaline phosphatase hydrazide. Annal. Biochem., 115: 182-187.
  89. Moscovitch, M., Grossman, Z., Rosen, D. and Berke, G. (1986). Maturation of cytolytic T lymphocytes. Cellul. Immunol., 102: 52-67.
  90. Keren, Z. and Berke, G. (1986). Interaction of periodate-oxidized target cells and cytolytic T lymphocytes: A model system of "polyclonal MHC recognition". Eur. J. Immunol., 16: 1049-1056.
  91. Denizot, F., Wilson, A., Battye, F., Berke, G. and Shortman, K. (1986). Clonal expansion of T cells: A cytotoxic T cell response in vivo that involves precursor cell proliferation. Proc. Natl. Acad. Sci. USA., 83: 6089-6092.
  92. Zehavi-Willner, T. and Berke, G. (1986). The mitogenic activity of staphylococcal enterotoxin B (SEB): A monovalent T cell mitogen that stimulates cytolytic T lymphocytes but cannot mediate their lytic interaction. J. Immunol., 137:2682-2687.
  93. Berke, G. (1987). An appraisal of some current thoughts on cytolytic T lymphocyte killing mechanisms. In: Molecular Mechanisms of T Cell-mediated Cytotoxicity. Annal. Inst. Pasteur/Immunol., 138:304-307.
  94. Keren, Z., Berke, G. and Robinson, P.J. (1987). Effect of oxidation on the conformation of cell surface H-2 antigens detected by monoclonal antibodies. Immunol. Lett., 16:83-87.
  95. Brunet, J-F., Denizot, F., Suzan, M., Haas, W., Mencia-Huerta, J-M., Berke, G., Luciani, M-F., Golstein, P. (1987). CTLA-1 and CTLA-3 serine-esterase transcripts are detected mostly in cytotoxic T cells but not only and not always. J. Immunol., 138:4102-4105. f
  96. Berke, G. and Rosen, D. (1987). Circular lesions detected on membranes of target cells lysed by antibody and complement or natural killer (spleen) cells but not by in vivo primed cytolytic T lymphocytes. In: Membrane Mediated Cytotoxicity, UCLA Symposia, Park City, 1986. (B. Bonavida and R.J. Collier, Eds.) Alan Liss, USA, pp. 367-378.
  97. Berke, G and Rosen, D. (1987). Are lytic granules, and perforin 1 involved in lysis induced by in vivo primed, peritoneal exudate CTL? Transpl. Proc., Vol XIX:412-416.
  98. Berke, G. and Keren, Z. (1988). The homology between specific and nonspecific lectin or oxidation dependent CTL/target interactions. In: "Cytolytic Lymphocyte and Complement: Effectors of the Immune System" (E.R. Podack, ed.), Vol. I, CRC Publications, pp. 155-170.
  99. Berke, G. (1988). Lymphocyte-mediated Cytolysis: Effectors, lytic signals and the mechanism whereby early membrane derangements result in target cell death. In: "Cytotoxic T cells: Biology and Relevance to Disease". Proc. N.Y. Acad. Sci., 532:314-355.
  100. Berke, G. and Rosen, D. (1988). Highly lytic in vivo primed CTL devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro. J. Immunol., 141: 1429-1436.
  101. Berke, G. and Rosen, D. (1988). IL-2 mediated induction of lytic granules, perforin, and BLT-esterase in potent, granule-free CTL indicates an alternative function of lytic granules. In: Lymphokine Activation and Differentiation (J.C. Mani and J. Dornand, eds.), Walter de Gruyter, pp. 669-672.
  102. Berke, G. (1989). Functions and mechanisms of lysis induced by cytotoxic T lymphocytes and natural killer cells. In: Fundamental Immunology (W.E. Paul, ed.), Raven Press, 2nd edition, pp. 735-764.
  103. Ozery, T., Berke, G., Moscovich, M., Ozato, K., Kaufmann, Y. (1989). T cell activation: Independent induction of killing activity and IL-2 secretion in cytolytic hybridomas. Eur. J. Immunol., 10:1965-1968.
  104. Berke, G. (1989). The cytolytic T lymphocyte and its mode of action. Imm. Lett., 20:169-178.
  105. Schick, B. and Berke, G. (1990). The lysis of cytotoxic T lymphocytes and their blasts by cytotoxic T lymphocytes. Immunology, 71:428-433.
  106. Berke, G. (1991). T-cell mediated cytotoxicity. Current Opinion in Immunology, 3: 320-325.
  107. Berke, G. (1991). Lymphocyte-triggered Internal Target Disintegration. Immunol. Today, 12: 396-399.
    *107a.  Agid, Y., Berke, G., Courtois, Y., Golstein, P., MacLennan, I.C.M., and Prochiantz, A. (1991). Cell death: mechanisms and functions in development, aging and disease. In Philippe Laudat Conferences 1990. INSERM, ed. (Paris: Les Editions INSERM), pp. 103-170.
  108. Binah, O., Marom, S., Rubinstein, I., Robinson, R.B., Berke, G. and Hoffman, B.F. (1992). Immunological rejection of heart transplant: how lytic granules from cytotoxic T lymphocytes damage guinea pig ventricular myocytes. Pflügers Arch., 420: 172-179.
  109. Halachmi, E., Ben-Nun, A., Lehmann, D., Karussis, D., Wekerle, H., and Berke, G. (1992). Delineation of tissue damage mechanisms in experimental autoimmune encephalomyelitis (EAE): I. Cell detachment and lysis induced by encephalitogenic CD4+ T lymphocytes. J. of Autoimmunity, 5: 411-425.
  110. Halachmi, E., Pinkus, R., Miron, S., Ben-Nun, A., Wekerle, H., and Berke, G. (1992). Delineation of tissue damage mechanisms in experimental autoimmune encephalomyelitis (EAE): II. Characteristics of astrocyte detachment mediated by myelin basic protein (MBP) specific CD4+ T lymphocytes. J. of Autoimmunity, 5: 427-441.
  111. Helgason, C.D., Prendergast, J.A., Berke, G. and Bleackley, R.C. (1992). Peritoneal exudate lymphocyte and mixed lymphocyte culture hybridomas are cytolytic in the absence of cytotoxic cell proteases and perforin. Eur. J. Immunol., 22: 3187-3190.
  112. Berke, G., Rosen, D. and Ronen, D. (1993). Mechanism of lymphocyte-mediated cytolysis: functional cytolytic T cells lacking perforin and granzymes. Immunology, 78: 105-112.
  113. Binah, O., Kline, R., Berke, G. and Hoffman, B. (1993). Mechanisms whereby lytic granules from cytotoxic T lymphocytes damage guinea pig ventricular myocytes. Scand. J. Immunol., 37: 53-57.
  114. Berke, G., Rosen, D., Ronen, D. and Schick, B. (1993). Immunobiology and molecular characteristics of peritoneal exudate cytotoxic T lymphocytes (PEL), their in vivo IL-2-dependent blasts and IL-2 independent cytolytic hybridomas. In: Cytotoxic Cells: Recognition, Effector Function, Generation and Methods (Sitkovsky, M.V. and Henkart, P.A. eds.), Birkh�user Boston. 10: 113-127.
  115. Berke, G. (1993). Direct contact of cytotoxic T-lymphocyte receptors with target cell membrane determinants induces a pre-lytic rise of [Ca2+]i in the target that triggers disintegration. In: Cytotoxic Cells: Recognition, Effector Function, Generation and Methods (Sitkovsky, M.V. and Henkart, P.A. eds.), Birkh�user Boston. 18: 196-201.
  116. Berke, G. (1993). The functions and mechanisms of action of cytolytic lymphocytes. In: Fund. Immunol. 3rd edition (Paul, W.E. ed.), Raven Press 28: 965-1014.
  117. Berke, G. (1994). The binding and lysis of target cells by cytotoxic lymphocytes: Molecular and cellular aspects. Ann. Rev. Immunol., 12: 735-773.
  118. Binah, Berke, G, Rosen, D., Hoffman, B.F. (1994). Calcium channel blockers modify electrophysiological effects induced by lytic granules from cytotoxic T lymphocytes in guinea pig ventricular myocytes. J. Pharm. Exp. Ther., 268: 1581-1587.
  119. Mandelboim, O., Berke, G. Fridkin, M., Feldman, M., Eisenstein, M. and Eisenbach, L. (1994). CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma. Nature, 369: 67-71.
  120. Felzen, B., Berke, G., Rosen, D., Coleman, R., Tschopp, J., Young, J.D.-E., and Binah. O. (1994). Effects of purified perforin and granzyme A from cytotoxic T lymphocytes on guinea pig ventricular myocytes. Cardiovasc. Res., 28: 643-649.
  121. Garner, R., Helgason , C.D., Atkinson, E.A., Pinkoski, M.J., Ostergaard, H.L., Sorensen, O., Fu, A., Lapchak, P.H., Rabinovitch, A., McElhaney, J.E., Berke, G. and Bleackley, E.A. (1994). Characterization of a granule-independent lytic mechanism used by CTL hybridomas. J. Immunol., 153: 5413-5422.
  122. Felzen, B., Berke, G., Rosen, D. and Binah, O. (1994). Mechanisms whereby cytotoxic T lymphocytes damage guinea pig ventricular myocytes in vitro. Pflügers Arch., 427:422-431.
  123. Lavy ,R., Mika ,Y.H., Rosen, D., Berke, G. and Binah, O. (1995). Lytic reaction of in vivo primed peritoneal exudate CTL: Induction of high-conductance single channels in the target cell membrane. J. Immunology, 154: 5039-5048.
  124. Berke, G. (1995). The CTL's kiss of death. Cell, 81: 9-12.
  125. Berke, G. (1995). CTL mediated lysis. Immunological Reviews, 146:21-31.
  126. Berke, G. (1995). Cytotoxic T cells and mechanism of tissue injury: In Transplantation Biology: Cellular and Molecular Aspects (Tilney, L. Strom, T. and Paul, L. Eds.), Raven Press, pp. 435-455.
  127. Berke, G. (1995). Unlocking the Secrets of CTL and NK cells. Immunol. Today, 16: 343-346.
  128. Mandelboim, O., Vadai, E., Fridkin, M., Katz-Hillel, A., Feldman, M., Berke, G. and Eisenbach, L. (1995). Regression of established murine carcinoma metastases following vaccination with tumor associated antigen peptides. Nature-Medicine, 1: 1179-1183.
  129. Walsh, C.M. Hayashi, F.,Saffren, D., Ju S-t., Berke, G., Clark, W.R. (1996). Cell-mediated cytotoxicity results from, but may not be critical for,primary allograft rejection. J.Immunol., 156: 1436-1441.
  130. Felzen, B., Lavy, R., Garcia, M., Berke, G., Gardner, P. and Binah, O. (1996). Interaction of Cytotoxic T Lymphocytes and guinea pig ventricular myocytes: Pharmacological modulation by blocking K+ currents in the CTL. Circulation Res., 78: 253-261.
  131. Hack, V., Gross, A., Kinscherf, R., Bockstette, M., Fiers, W., Berke, G. and Dr�ge, W.(1996) Abnormal glutathione and sulfate levels after interleukein-6 treatment and in tumor-induced cachexia. FASEB J., 10: 1219-1226.
  132. Felzen, B., Berke, G., Gardner, P. and Binah,O.(1997). Involvement of the IP3 cascade in the damage to guinea pig ventricular myocytes induced by cytotoxic T lymphocytes. Eur. J. Physiol. Pflügers Arch., 433: 721-726.
  133. Kaplan, M.R., Trubniykov, E. and Berke, G.(1997). Fluorescence depolarization as an early measure of T lymphocyte stimulation. J. Immunol. Methods, 201: 15-24.
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