Ofer Lider Prof. Ofer Lider
The Weizmann League Career Development Chair
in Children's Diseases

 List of Publications (last 3 years):
  1. Levite, M., Cahalon, L., Hershkoviz, R., Netzer, L., Steinman, L., and Lider, O. (1998). Neuropeptides, via specific receptors, regulate T cell adhesion to fibronectin. J. Immunol. 160, 993-1000.
  2. Hodak, E., Yosipovich, G., Lider, O., David, M., Cahalon, L., Ingber, A., Chorev, L., and Cohen, I. R. (1998). Low-dose low-molecular weight heparin (enoxaparin) is beneficial in lichen planus: a preliminary report. J. Am. Acad. Dermatol. 38, 564-568.
  3. Preciado-Patt, L., Cahalon, L., Hershkoviz, R., Lider, O., and Fridkin, M. 1998. Serum amyloid A complexed with extracellular matrix induced the secretion of tumor necrosis factor-a by human T lymphocytes. Lett. Pep. Sci. 5, 349-355.
  4. Ariel, A., Yavin, E. J., Hershkoviz, R., Franitza, S., Avron, A., Cahalon, L., Fridkin, M., and Lider, O. (1998). IL-2 induces T cell adherence to extracellular matrix: Inhibition of adherence and migration by IL-2 peptides generated by leukocyte elastase. J. Immunol. 161, 2465-2472.
  5. Rechter, M., Lider, O., Cahalon, L., Baharav, E., Dekel, M., Seigel, D., Vlodavsky, I., Aingorn, H., Cohen, I. R., and Shoseyov, O. (1999). A cellulose binding domain-fused recombinant human T cell chemokine CTAP-III manifests heparanase activity. Biochem. Biophys. Res. Commun. 255, 657-662.
  6. Preciado-Patt, L., Hershkoviz, R., Lider, O., Freietag, S., Jung, G., and Fridkin, M. (1999). A structure-function study of extracellular matrix-related cell adhesion epitopes of serum amyloid A (SAA). Lett. Pep. Sci. 6, 99-108.
  7. Rabinovich, G. A., Ariel, A., Hershkoviz, R., Hirabashi, J., Kasai, K-I. and Lider, O. (1999). Specific inhibition of T-cell adhesion to extracellular matrix and pro-inflammatory cytokine secretion by human recombinant galectin-1. Immunol. 97, 100-106.
  8. Franitza, S., Alon, R., and Lider, O. 1999. Dynamic mechanisms of integrin-mediated migration of T lymphocytes along chemotaxis gradients of IL-2 and RANTES within 3-dimensional extracellular matrix-like gels. J. Immunol. Methods 225, 9-25.
  9. Peled, A., Petit, I., Kollet, O., Magid, M., Ponomaryov, T., Byk, T., Nagler, A., Ben-Hur, H., Many, A., Shultz, L., Lider, O., Alon, R., Zipori, D., and Lapidot, T. 1999. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283, 845-848.
  10. Shapira, O. M., Rene, H., Lider, O., Pfeffermann, R.A., Shemin, R.J., and Cohen, I. R. (1999). Prolongation of rat skin and cardiac allograft survival by low molecular weight heparin. J. Surg. Res. 85, 83-88.
  11. Yavin, E.J., Preciado-Patt, L., Rosen, O., Yaron, M., Suessmuth, R. D., Levartowsky, D., Jung, G., Lider, O., and Fridkin, M. (2000). Serum amyloid A-derived peptides, present in human rheumatic synovial fluids, induce the secretion of interferon-gamma by human CD4+ T-lymphocytes. FEBS Lett. 472, 259-262.
  12. Hershkoviz, R., Schor, H., Ariel, A., Hecht, I., Cohen, I. R., Lider, O., and Cahalon, L. (2000). Disaccharides generated from heparan sulfate or heparin modulate chemokine-induced T cell adhesion to extracellular matrix. Immunol. 99, 87-93.
  13. Ariel, A., Lider, O., Brill, A., Cahalon, L., Savion, N., Varon, D., and Hershkoviz, R. (2000). Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro-inflammatory mediators. Immunol. 100, 345-351.
  14. Levite, M., Cahalon, L., Hershkoviz, R., Peretz, A., Sobko, A., Ariel, A., Avron, A., Attali, B., and Lider O. (2000). Opening of voltage-gated potassium channels drives T cells into adhesion and migration: Physical and functional association between Kv1.3 channels and b1 integrins. J. Exp. Med. 191, 1167-1176.
  15. Franitza, S., Hershkoviz, R., Kam, N., Lichtenstein, N., Gayle G., Vaday, G., R. Alon, and Lider, O. (2000). TNFa associated with extracellular matrix fibronectin provides a stop signal for chemotactically migrating T cells. J. Immunol. 165, 2738-2747.
  16. Vaday, G. G., Hershkoviz, R., Rahat, M. A., Lahat, N., Cahalon, L., and Lider O. (2000). Fibronectin-bound TNFa stimulates monocyte 92-kDa gelatinase secretion independent of b1 integrin-mediated adhesion. J. Leuk. Biol. 68, 737-747.
  17. Ariel, A., Hershkoviz, R., Altbaum-Weiss, I., Ganor, S., and Lider, O. (2000). Cell surface-expressed moesin-like receptor regulates T cell interactions with tissue components and binds an adhesion-modulating IL-2 peptide generated by elastase. J. Immunol. 166, 3052-3060.
  18. Miller, A., Kraiem, Z., Sobel, E., Lider, O., and Lahat, N. (2000). Modulation of human leukocyte antigen and intracellular adhesion molecule-1 surface expression in malignant and nonmalignant human thyroid cells by cytokines in the context of extracellular matrix. Thyroid 10, 945-950.
  19. Fllaishon, L., Hershkoviz, R., Lantner, F, Lider, O., Alon, R., Levo, Y., Flavell, R. A., and Shachar, I. (2000). Autocrine secretion of interferon-g negatively regulates homing of immature B cells. J. Exp. Med. 192, 1381-1388.
  20. Vaday, G. G., Schor, H., Rahat, M., Lahat, N., and Lider, O. (2000). TGFb suppresses TNFa-induced matrix metalloproteinase-9 (MMP-9) expression in monocytes. J. Leuk. Biol. 69, 613-621.
  21. Vaday, G. G., and Lider, O. 2000. Extracellular matrix moieties, cytokines, and enzymes: Dynamic effects on lymphocyte behavior and inflammation. J. Leuk. Biol. 67, 149-159.
  22. Chowers, Y., Lider, O., Schor, H., Barshack, I., Tal, R., Ariel, A., Bar-Meir, S., Cohen, I. R., and Cahalon, L. (2001). Disaccharides derived from heparin or heparan sulfate regulate IL-8 and IL-1b secretion by Intestinal epithelial cells. Gastroenterology 120, 449-459.
  23. Brill, A., Hershkoviz, R., Vaday, G. and Lider, O. (2001). Augmentation of RANTES-induced ERK-mediated signalling and T cell adhesion by elastase-treated immobilized fibronectin. J. Immunol. 166, 7121-7127.
  24. Brill, A. Hershkoviz, R., Franitza, S. and Lider O. (2001). Short-Term Exposure of T Cells to TGF-b Differentially Regulates their Interactions with Fibronectin by Modulation of Pyk2 Phosphorylation. Immunol. In press.
  25. Vaday, G., Franitza, S., Schor, H., Hecht, I., Brill, A., Cahalon, L., Hershkoviz, R., and Lider, O. (2001). Inflammatory mediators provide combinatorial signals that mediate leukocyte Interactions with extracellular matrix and secretion of enzymes. J. Leuk. Biol. 69, 621-631.