We investigate fundamental principles of mutagenesis and gene expression by high-throughput methods

Design principles and function of learning networks

A quantitative, structural, and evolutionary understanding of cells and their proteome

Developing experimental and computational approaches for multiplexed imaging of clinical specimens to uncover tumor-immune interactions

We develop algorithms and utilize single cell genomics for studying the organization and function of immune cells in a tissue

We develop algorithms for enzyme and antibody design and verify them using high-throughput experiments.

Systematic analysis of combinatorial signals during cellular fate determination processes

From Single cells to Microbial Collectives

intra-tumor heterogeneity in glioma and in head and neck cancer

Environmental microbes and their response to human-made pollution

We are interested in deciphering questions spanning from molecular to behavioral levels

Combining data analysis and experimental methods for understanding tissue function from single cells

How diverse posttranscriptional modifications regulate the fate of mRNA

Design principle of Biological circuits. Ageing and Age-related disease

Human evolution and disease

We use computers, chemistry and biology to design covalent ligands for interesting proteins, to understand biology and discovery drugs

We study the structure, function and evolution of systems that regulate gene expression, with emphasis on translation

Interactions between bacteria and the viruses that infect them

Proprioception and the the musculoskeletal system in development and disease

We study the molecular foundations and applied potential of mammalian pluripotent stem cells in early organ development, germ cell formation and whole synthetic embryo generation ex utero

Biological circuits: design, function and evolution • Regulatory genome: transcription, replication and the chromatin as a communication platform • Developmental patterning: morphogen gradients, scaling, robustness

Serotonergic control of learning, Development of learning abilities

We study interactions between peripheral circadian clocks and exercise physiology, hypoxia signaling and metabolic pathways

Isotopic fingerprint of microbial metabolism

Membrane protein folding and misfolding in health and disease