The synaptic basis for sexual dimorphism in the nervous system

Chromosome Catastrophes in Cancer

Why do some people succumb to infection - while others don't?

The interplay between viruses and their hosts

Illuminating antigen presenters and their cross-talk with T cells to execute inflammatory and peaceful immune responses.

We study how antibodies are generated in response to invading pathogens in mouse models, infected subjects and cancer patients. We use this information to produce novel antibodies for immunotherapy.

We study bacterial ecological interactions, diversity, stability and stress in communities from pre-Cambrian oceans

Our studies proceed along three major lines: (1) Microbial population dynamics under stress, (2) Understanding drought resistance and engineering drought-resistant nutritious plants (3) The plant microbiome and its dynamics

We study how osteoclasts, the only cells in our body that can degrade bone, are formed and how they function, both in health and in disease

intra-tumor heterogeneity in glioma and in head and neck cancer

Combining data analysis and experimental methods for understanding tissue function from single cells

Human evolution and disease

Drug resistance in cancer, effects that intra-tumor bacteria on cancer biology and drug resistance, ex vivo organ culture for the prediction of drug response

We develop algorithms and utilize single cell genomics for studying the organization and function of immune cells in a tissue

Functional genomics and systematic screens to uncover new protein functions

We study the molecular foundations and applied potential of mammalian pluripotent stem cells in early organ development, germ cell formation and whole synthetic embryo generation ex utero

Our lab is a major driver in developing and applying cutting edge single-cell genomics technologies and advanced computational approaches. We apply these novel tools in animal models and human patients to uncover immune regulatory mechanisms and pathways

Understanding epithelial, stem and immune cell interactions in the gut

Organ growth, regeneration and aging: A focus on the vascular system.

Functional genomics and transcriptomics in mouse models and humans

We study interactions between peripheral circadian clocks and exercise physiology, hypoxia signaling and metabolic pathways

From Single cells to Microbial Collectives

Developing experimental and computational approaches for multiplexed imaging of clinical specimens to uncover tumor-immune interactions

Systematic analysis of combinatorial signals during cellular fate determination processes

We study morphogenesis, cell biology and function of hypothalamic neurons, which regulate appetite, stress and social behavior

Why the human hematopoietic system is aging and how it relates to the evolution of leukemia. Can we diagnose leukemia early and apply preventive therapy. Why mutations accumulate in HSCs and how do they change their function

Proprioception and the the musculoskeletal system in development and disease

Proteomic analysis of cancer heterogeneity to elucidate disease progression mechanisms and resistance to therapy

An integrative approach for the exploration of melanoma genetic and immunological interactions

We study the functional roles of epigenetics during cell-fate decisions

Biological circuits: design, function and evolution • Regulatory genome: transcription, replication and the chromatin as a communication platform • Developmental patterning: morphogen gradients, scaling, robustness

The role of cellular mechanisms, signaling and metabolic crosstalk in mediating microbial interaction (host-virus, host-bacteria, predator-prey) in the marine environment