We are interested to learn basic principles dictating specificity of proteinprotein interactions and how this relates to cell signaling

The interplay between viruses, cells, and the host's immune response.

Disulfide bonding in the folding, assembly, and regulation of proteins and protein complexes

We use computers, chemistry and biology to design covalent ligands for interesting proteins, to understand biology and discovery drugs

cryo-electron tomography

We investigate fundamental principles of mutagenesis and gene expression by high-throughput methods

Interactions between bacteria and the viruses that infect them

We develop algorithms for enzyme and antibody design and verify them using high-throughput experiments.

We use advanced electron microscopy to understand the cellular processes of mineral morphogenesis