(2019) Oncogene. 38, 13, p. 2432-2434 Abstract
RASA2 has previously been shown to be a functional RasGAP in melanoma cells . Mutation or loss of RASA2 promotes RAS activation in melanoma . Our genetic analysis of RASA2 mutations identified that RASA2 and NRAS mutations are mutually exclusive (p = 0.002, Fisher’s exact test), and that NF1 mutations [2, 3] significantly co-occur with RASA2 mutations (p = 0.000011, Fisher’s exact test) in BRAF and NRAS wild-type melanomas, suggesting that loss of RASA2 and NF1 have complementary pro-tumorigenic functions (Fig. 1A).