Ageing and age-related diseases

Ageing is accompanied by a decline of function and an exponential rise in the probability of death and in the incidence of a range of diseases. Ageing also shows increasing variation in almost every physiological parameter between individuals, even between genetically identical organisms. We ask what determines the rate of aging and its variation, and what can explain the incidence of age related diseases.

Current projects in the lab focus on the role of senescent cells in human ageing, and offer mathematical frameworks for understanding senescence, mortality and diseases incidence.



Senescent cell turnover slows with age providing an explanation for the Gompertz law

Senescent Cells and the Incidence of Age-Related Diseases

Senescent cell accumulation mechanisms inferred from parabiosis

Principles of Aging, Institute of Advanced Studies, Princeton

Damage dynamics in single E. coli and the role of chance in the timing of cell deat

A theory for aging :