Systems Medicine Course 2020

Lecture Notes and exercises 

Prolog 

Why Model?

A lecture by Joshua M. Epstein which he treats some enduring misconceptions about modeling. One of these is that the goal is always prediction. The lecture distinguishes between explanation and prediction as modeling goals, and offers sixteen reasons other than prediction to build a model. It also challenges the common assumption that scientific theories arise from and 'summarize' data, when often, theories precede and guide data collection; without theory, in other words, it is not clear what data to collect. Among other things, it also argues that the modeling enterprise enforces habits of mind essential to freedom. 

How to solve ordinary differential equations? (tutorials in various common programing enviourments)

Lecture 1 - Epidemiology of COVID-19

Exercise 1 - Solution for Q3.

Lecture 2 - The insulin-glucose circuit 

Lecture 3 - Beta-cell tissue size control has fragilities that lead to type-2 diabetes: Dynamical compensation and mutant resistance in tissues

Exercise 2 - Solution (courtesy of Alon Bar)

Lecture 4 - Two-gland feedback in the stress-hormone axis generates seasonal clocks and explains clinical phenomena with a timescale of months

Lecture 5 - Addiction

Exercise 3