Research Activities

A shared theme in our research is the application of genome analyses and computational tools to biological gene and gene-like repertoires. Four main topics are:

Selected Publications

  1. Markovitch O, Lancet D (2012) Excess mutual catalysis is required for effective evolvability. Artificial Life 18 (3), 243-266.
  2. Armstrong D, Markovitch O, Zidovetzki R, Lancet D (2011) Replication of simulated prebiotic amphiphile vesicles controlled by experimental lipid physiochemical properties. Physical Biology 8, 066001.
  3. Keydar I, Ben-Asher E, Feldmesser E, Nativ N, Oshimoto A, Restrepo D, Matsunami H, Chien MS, Pinto JM, Gilad Y, Olender T, Lancet D. General olfactory sensitivity database (GOSdb): Candidate genes and their genomic variations. Hum. Mutat. 2012 Aug 30. doi: 10.1002/humu.22212.
  4. Olender T, Waszak SM, Viavant M, Khen M, Ben-Asher E, Reyes A, Nativ N, Wysocki CJ, Ge D, Lancet D. Personal receptor repertoires: olfaction as a model. BMC Genomics. 2012 Aug 21;13(1):414.
  5. Stelzer, G, Dalah, I, Iny Stein, T, Satanower, Y, Rosen, N, Nativ, N, Oz-Levi, D, Olender, T, Belinky, F, Bahir, I, Krug, H, Perco, P, Mayer, B, Kolker, E, Safran, M and Lancet, D. In-silico Human Genomics with GeneCards. Human Genomics, 2011 Oct;5(6):709-17.
  6. Safran M, Dalah I, Alexander J, Rosen N, Iny Stein T, Shmoish M, Nativ N, Bahir I, Doniger T, Krug H, Sirota-Madi A, Olender T, Golan Y, Stelzer G, Harel A and Lancet D. GeneCards Version 3: the human gene integrator. Database 2010; doi: 10.1093/database/baq020.
  7. Stelzer G, Inger A, Olender T, Iny-Stein T, Dalah I, Harel A, Safran M, Lancet D,(2009) GeneDecks: Paralog Hunting and Gene-Set Distillation with GeneCards Annotation. OMICS-A Journal of Integrative Biology 13, 477-487.
  8. Waszak SM, Hasin Y, Zichner T, Olender T, Keydar I, Khen M, Stütz AM, Schlattl A, Lancet D, Korbel JO Systematic inference of copy-number genotypes from personal genome sequencing data reveals extensive olfactory receptor gene content diversity. PLoS Comput Biol. 2010 Nov 11;6(11):e1000988.
  9. Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D.
    Genetic elucidation of human hyperosmia to isovaleric acid. PLoS Biol. 2007 Oct 30;5(11):e284.
  10. Danit Oz-Levi, Bruria Ben-Zeev, Elizabeth K. Ruzzo, Yuki Hitomi, Amir Gelman, Kimberly Pelak, Yair Anikster, Haike Reznik-Wolf, Ifat Bar-Joseph, Tsviya Olender, Anna Alkelai, Meira Weiss, Edna Ben-Asher, Dongliang Ge, Kevin V. Shianna, Zvulun Elazar, David B. Goldstein,  Elon Pras, and Doron Lancet. Mutation in the Autophagy-related TECPR2 reveals a role for Autophagy in Gene Causes Hereditary Spastic Paraparesis. AJHG. In press.