How do modifications on RNA exert their effect? We will systematically address the question of how, mechanistically, RNA modifications exert their effect. Do they recruit specific 'readers' to the modification? Do they alter the secondary structure of the RNA? Do they modulate the genetic code? We will utilize genomic, biochemical and computational strategies to address these questions, to reveal the cellular machinery underlying the decoding of RNA modifications.
Cracking the epitranscriptome
