Decoding the latent state of infection

Primary infection with HCMV results in the establishment of a lifelong infection, which is aided by the ability of HCMV to undergo a latent infection. Reactivation from viral latency causes serious disease in immunocompromised individuals, underscoring the need to better understand the latency state. Although there are a few well-characterized latent transcripts, the full transcriptional program during latency is still unclear. We tackle the issue of latency by taking advantage of single cell RNA-seq technology.