Jacob (Yaqub) Hanna

Pluripotent Stem cells and Epigenetics

  • How do mature differentiated cells revert back to an embryonic pluripotent state?
  • How do different flavors of embryonic pluripotency influence differentiation potential of stem cells
  • What are the key epigenetic pathways regulating timely execution of lineage commitment programs during early development?
  • Why do totipotent or primordial germ cells retain only some of properties of embryonic stem cells?