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September 12, 2011

  • Date:21MondayMay 2012

    Bioinformatics workshop: What can I learn from DNA binding regions (ChIP-Seq peaks) using web tools?

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    Time
    09:30 - 12:00
    Location
    Harry Levine Family Building
    LecturerDr. Dena Leshkowitz
    Bioinformatics unit Weizmann Institute of Science
    Contact
    AbstractShow full text abstract about In this workshop we will learn how extract biological knowle...»
    In this workshop we will learn how extract biological knowledge from a list of genomic regions which represent the DNA binding site of proteins.

    The regions are termed peaks and are usually a result of a ChIP-Seq experiment which combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify binding sites of DNA-associated proteins.

    In the workshop we will learn how to search for relevant public peak data and how to analyze the data in order to associate it with genes, find biological enrichments and motif enrichments.
    The tools we will use are web based and include:
    GREAT (http://great.stanford.edu/public/html/splash.php) ,
    Cistrome (http://cistrome.org/), Genomatix (commercial - http://www.genomatix.de/applications/ChIP-Seq.html)
    and MEME-ChIP (http://meme.sdsc.edu/meme/doc/meme-chip.html)

    Registration is required.
    First you need to register to the BBCU activities here:
    http://bip.weizmann.ac.il/activbin/events (click on the LogIn button)
    and then you need to register to the workshop. (click on the Register button)
    Lecture
  • Date:21MondayMay 2012

    "Contemporary neuroimmunology: The immunology of the brain and the mind"

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    Time
    11:00 - 13:00
    Location
    Wolfson Building for Biological Research
    LecturerDr. Michal Schwartz
    WIS
    Organizer
    Department of Systems Immunology
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    Lecture
  • Date:21MondayMay 2012

    Faculty of Chemistry Colloquium - Prof. Thomas Walz

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    Time
    11:00 - 12:30
    Title
    USING TWO-DIMENSIONAL CRYSTALS OF AQUAPORIN-0 TO INVESTIGATE LIPID-PROTEIN INTEGRATIONS
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProfessor Thomas Walz
    Department of Cell Biology and Howard Hughes Medical Institute, Harvard Medical School, Boston, USA
    Organizer
    Faculty of Chemistry
    Contact
    AbstractShow full text abstract about Membrane proteins play crucial roles in many cellular proces...»
    Membrane proteins play crucial roles in many cellular processes such as signaling, nutrient uptake and cell adhesion. Although the lipid bilayer influences many aspects of membrane protein function, our understanding of lipid–protein interactions is limited. Aquaporin-0 (AQP0) is a water channel in the lens membrane, but it also assembles into orthogonal arrays that form membrane junctions between lens fiber cells. In vitro reconstitution of AQP0 with the lipid dimyristoyl phosphatidylcholine (DMPC) yielded large and well ordered double-layered two-dimensional (2D) crystals that allowed electron crystallographic structure determination of AQP0 and its surrounding DMPC bilayer at 1.9 Å resolution. Since AQP0 forms high-quality 2D crystals not only with DMPC but also with various other lipids, AQP0 2D crystals are an ideal model system to investigate lipid–protein interactions. By studying AQP0 2D crystals formed with different lipids, we can begin to address very basic questions in membrane biology, such as the driving forces that define lipid–protein interactions, the effects of hydrophobic mismatch, and the molecular basis of raft formation.
    Colloquia
  • Date:21MondayMay 2012

    Hsp90 Inhibition in Cancer...Now the Fun Begins

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    Time
    11:00 - 11:00
    Location
    Max and Lillian Candiotty Building
    LecturerDr. Safi Bahcall
    President and CEO Synta Pharmaceuticals Corp., Lexington, Ma., USA
    Organizer
    Department of Immunology and Regenerative Biology
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    Lecture
  • Date:21MondayMay 2012

    Equilibrium States and Time Evolution of Systems with Long-Range Interactions

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    Time
    14:15 - 14:15
    Location
    Dannie N. Heineman Laboratory
    LecturerJoel L. Lebowitz
    Rutgers University
    Organizer
    Department of Physics of Complex Systems
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    Lecture
  • Date:21MondayMay 2012

    On ramified covers of algebraic surfaces, and combinatorics of some infinite discrete groups.

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    Time
    15:00 - 15:00
    Location
    Jacob Ziskind Building
    LecturerMaxim Leyenson
    Organizer
    Faculty of Mathematics and Computer Science
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    Lecture
  • Date:21MondayMay 2012

    מפגשים בחזית המדע

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    Time
    19:15 - 21:00
    Location
    Davidson Institute of Science Education
    Organizer
    Science for All Unit
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    Lecture
  • Date:21MondayMay 2012

    Gil Shohat and Marina Maximilian Blumin

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    Time
    20:30 - 20:30
    Title
    Dulce and Yoace
    Location
    Michael Sela Auditorium
    Contact
    Cultural Events
  • Date:22TuesdayMay 2012

    " A bacterial chemotaxis-like signal transduction system leading to biofilms".

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    Time
    10:00 - 10:00
    Location
    Wolfson Building for Biological Research
    LecturerProf. Caroline Harwood
    Department of Microbiology University of Washington
    Organizer
    Department of Biomolecular Sciences
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    Lecture
  • Date:22TuesdayMay 2012

    Differential analysis of the polarity transform

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    Time
    11:00 - 11:00
    Location
    Jacob Ziskind Building
    LecturerShiri Artstein
    Tel Aviv University
    Organizer
    Faculty of Mathematics and Computer Science
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    Lecture
  • Date:22TuesdayMay 2012

    "Py-Im Polyamides – from DNA Recognition to In Vivo Experiments"

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    Time
    11:00 - 11:00
    Title
    Organic Chemistry - Departmental Seminar
    Location
    Helen and Milton A. Kimmelman Building
    LecturerDr. Evgenij Raskatov
    California Institute of Technology
    Organizer
    Department of Molecular Chemistry and Materials Science
    Contact
    AbstractShow full text abstract about Abstract: Py-Im polyamides are modular DNA minor groove bin...»
    Abstract:
    Py-Im polyamides are modular DNA minor groove binding molecules with affinities and specificities comparable to those of DNA binding proteins.

    Molecules can be constructed to recognize the four letters of the genetic code.

    Recent efforts established that Py-Im polyamides can be employed in cell culture to affect NF-kB dependent gene expression. We further identified that molecules are potent in live animals. Depending on molecular architecture the compounds remain in the mouse circulatory system for up to multiple days, can access subcutaneous tumor xenografts and lead to gene expression changes in vivo.
    Lecture
  • Date:22TuesdayMay 2012

    TBA

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    Time
    11:15 - 11:15
    Location
    Ullmann Building of Life Sciences
    LecturerProf. Ronald Herring
    Professor of Government, White Hall, Cornell University, Ithaca, NY, USA
    Organizer
    Department of Plant and Environmental Sciences
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    Lecture
  • Date:22TuesdayMay 2012

    "Leveraging Small Numbers in Social Mobilization against Biotechnology: Why Bt Aubergine Diverged from Bt Cotton in India"

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    Time
    11:15 - 11:15
    Location
    Ullmann Building of Life Sciences
    LecturerProf. Ronald J. Herring
    Atkinson Center for a Sustainable Future, Cornell University, USA http://government.arts.cornell.edu/faculty/herring/
    Organizer
    Department of Plant and Environmental Sciences
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    Lecture
  • Date:22TuesdayMay 2012

    Chemical Physics Special Guest Seminar

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    Time
    11:15 - 12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProfessor Bretislav Friedrich
    Fritz Haber Institute of the Max Planck Society, Berlin, Germany
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about The hybridization of the rotational states of an anisotropic...»
    The hybridization of the rotational states of an anisotropic molecule by a far-off-resonant optical field imparts angular momentum to the molecule or removes it, which alters the centrifugal term in the molecule’s electronic potential and hence pushes its vibrational and rotational manifolds upward or downward. The angular momentum imparted by the field may suffice to expel the highest vibrational level from the molecular potential. Our numerical simulations applied to the Rb2 and KRb Feshbach molecules indicate for feasible laser pulses that this can be used to accurately recover the square of the vibrational wave function of the expelled state and, by inversion, also the long-range part of the molecular potential.

    A combination with a weak electrostatic field can convert second-order alignment by the optical field into a strong first-order orientation that projects up to 90% of the body-fixed dipole moment of a polar molecule on the static field direction. This is the basis of a versatile orientation technique which found applications ranging from molecule optics and spectroscopy to chemistry and surface science. Recent work on OCS molecules has shown how to keep the interaction with the combined fields adiabatic and thereby make the best of the technique.

    The electric dipole-dipole interaction between a pair of polar molecules undergoes an all-out transformation when superimposed by a far-off resonant optical field. The combined interaction potential becomes tunable by variation of wavelength, polarization and intensity of the optical field and its dependence on the intermolecular separation exhibits a crossover from an inverse-power to an oscillating behavior.
    The ability thereby offered to control molecular interactions opens up avenues toward the creation and manipulation of novel phases of ultracold polar gases among whose characteristics is a long-range entanglement of the dipoles' mutual orientation.
    Lecture
  • Date:22TuesdayMay 2012

    N-WASP, an actin regulator in myelinating glia

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    Time
    12:15 - 12:15
    Location
    Wolfson Building for Biological Research
    LecturerNurit Novak
    Organizer
    Department of Molecular Cell Biology
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    Lecture
  • Date:22TuesdayMay 2012

    From Sound to Meaning –Dynamic Transformations in Auditory Signal-Processing

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    Time
    12:30 - 12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerDr. Jonathan Fritz
    Center for Auditory and Acoustic Research University of Maryland, College Park, Maryland
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about How do we make sense of sensory inputs? One important clue m...»
    How do we make sense of sensory inputs? One important clue may be the central role of selective and predictive attention, by focusing limited resources on behaviorally relevant sensory channels and modulating information flow at multiple stages, to improve perception.Our approach is to study the effect of attention on information processing at the single neuron level in the primary auditory cortex (A1) of animals trained on multiple auditory tasks that require selective attention to task-specific salient spectral frequency or temporal cues. Our results demonstrate that when animals actively attend to a task, their auditory cortical neurons can rapidly change their spectrotemporal filter characteristics to improve the animal’s performance. Thus, cortical sensory filters are not fixed, but are highly adaptive, and show dynamic, task-specific transformations during auditory behavior. To study the broader neural circuits involved in attention, we have initiated research on several other components in the network, including secondary auditory cortical areas, nucleus basalis, and the prefrontal cortex (PFC), a brain area known to play a key role in attention and decision-making. In contrast to A1, PFC responses are largely independent of the acoustic properties of sound, and encode an abstract, categorical representation of sound meaning. Recent studies show that electrical stimulation of PFC can elicit receptive field transformations in A1 neurons very similar to the attentional effects observed during behavior. Our working model suggests a top-down instructive role for PFC, and emphasizes the importance of interactions between multiple brain areas during selective attention that lead to matched auditory cortical filters for attended acoustic stimuli, creating a dynamic, evolving neural representation of task-salient sounds and thus optimizing perception on a moment-to-moment basis.

    Lecture
  • Date:22TuesdayMay 2012

    Twitching motility towards the tight junctions

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    Time
    13:30 - 13:30
    Location
    Wolfson Building for Biological Research
    LecturerBenjamin Aroeti, Ph.D.
    Department of Cell and Developmental Biology, Silberman Life Sciences Institute Edmond J. Safra Campus, Givat-Ram The Hebrew University, Jerusalem
    Organizer
    Department of Systems Immunology
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    Lecture
  • Date:22TuesdayMay 2012

    Twitching motility toward the tight junctions

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    Time
    13:30 - 13:30
    Location
    Wolfson Building for Biological Research
    LecturerProf. Benjamin Aroeti
    Department of Cell & Developmental Biology Alexander Silberman Institute of Life Sciences Faculty of Sciences Hebrew University, Jerusalem
    Organizer
    Department of Systems Immunology
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    Lecture
  • Date:22TuesdayMay 2012

    "Structural Studies on p53 Protein Family"

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    Time
    14:00 - 15:00
    Location
    Helen and Milton A. Kimmelman Building
    LecturerProf. Hector Viadiu
    Dept. of Chemistry and Biochemistry, University of California, San Diego
    Organizer
    Department of Chemical and Structural Biology
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    Lecture
  • Date:22TuesdayMay 2012

    Suppression of mRNA structure shapes codon usage at gene start in bacteria

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    Time
    14:00 - 14:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerKajetan Bentele
    Institute for Theoretical Biology, Humboldt University of Berlin, Berlin, Germany
    Contact
    Lecture

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