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July 01-31, 2017
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Date:02SundayJuly 201711TuesdayJuly 2017Conference
SRitp Workshop: Post Strings
More information Time 08:00 - 08:00Location Nella and Leon Benoziyo Physics LibraryChairperson Micha BerkoozOrganizer Department of Particle Physics and AstrophysicsHomepage Contact -
Date:02SundayJuly 2017Lecture
To be announced
More information Time 13:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Tzahi Noiman
Chaim Kahana's group, Dept. of Molecular Genetics, WISOrganizer Department of Molecular GeneticsContact -
Date:03MondayJuly 201707FridayJuly 2017Conference
Galois Meets Newton: Algebraic and Geometric aspects of Singularity Theory Celebrating the 70th birthday of Prof. Askold Khovanskii
More information Time 08:00 - 08:00Location David Lopatie Conference CentreChairperson Sergei YakovenkoHomepage Contact -
Date:03MondayJuly 2017Colloquia
Chemistry colloquium - title tbd
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Judith P. Klinman
UC BerkeleyOrganizer Faculty of ChemistryContact -
Date:03MondayJuly 2017Lecture
Neural Representations of Natural Self Motion: Implications for Perception & Action
More information Time 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Kathleen Cullen
Dept of Biomedical Engineering, Johns Hopkins UniversityOrganizer Department of Brain SciencesContact Details Show full text description of Host: Nachum Ulanovsky nachum.ulanovsky@weizmann.ac.il tel:6...» Host: Nachum Ulanovsky nachum.ulanovsky@weizmann.ac.il tel:6301
For assistance with accessibility issues,
please contact naomi.moses@weizmann.ac.il
Abstract Show full text abstract about The vestibular system detects self-motion and in turn genera...» The vestibular system detects self-motion and in turn generates reflexes that are crucial for our daily activities, such as stabilizing the visual axis (gaze) and maintaining head and body posture. In addition, the vestibular system provides us with our subjective sense of movement and orientation in space. The loss vestibular function due to aging, injury, or disease produces dizziness, postural imbalance, and an increased risk of falls – all symptoms that profoundly impair quality of life.
In this talk, I will describe how the brain processes vestibular information in natural conditions. Notably, our work has established how early stages of processing encode vestibular stimuli and integrate them with extra-vestibular cues – for example proprioceptive and premotor information to ensure accurate perception and behaviour. Our experiments have revealed that while vestibular afferents respond identically to externally-generated and actively-generated self-motion, this is not the case at first central stage of sensory processing. Neurons mediating the vestibulo-spinal reflexes, as well as ascending thalamocortical pathways, are robustly activated during externally-generated motion, however their sensory response are cancelled during actively-generated movements. Our work has further revealed that this cancellation of actively-generated vestibular input occurs only in conditions where the actual sensory signal matches the brain’s internal estimate of the expected sensory consequences of active movement. Moreover, when unexpected vestibular inputs becomes persistent during voluntary motion, a cerebellar-based cancellation mechanism is rapidly updated to re-enable the vital distinction between self-generated and externally-applied stimulation to ensure the maintenance of posture and stable perception. In contrast, vestibular pathways mediating the vestibulo-ocular reflex, employ a different strategy. In this pathway, head velocity is robustly encoded whenever the goal is to stabilize gaze, but when the goal is to voluntarily redirect gaze an efferent copy of the gaze command suppresses the efficacy of this reflex pathway. Taken together, these findings have important implications for understanding the neural basis of perception and action during self-motion.
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Date:04TuesdayJuly 2017Lecture
Non-deadly function of the effector protein of necroptosis- MLKL.
More information Time 10:00 - 10:30Location Wolfson Building for Biological Research
AuditoriumLecturer Dr. Seongmin Yoon
Dept. of Biomolecular Sciences - WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about The proteins believed to serve critical roles in the signali...» The proteins believed to serve critical roles in the signaling pathways activated by receptors of the TNF family have been identified almost two decades ago. However, clarification of the exact functional roles of the proteins is still at its infancy. It is obvious that none of these proteins serves only the role initially known for it. Pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) by proinflammatory ligands such as TNF triggers necroptosis, programmed cell death in which rupture of cellular membranes yields release of components that are potentially pro-inflammatory, occurs upon phosphorylation of MLKL by RIPK3. We report that MLKL also controls transport of endocytosed proteins, thereby enhancing degradation of receptors and ligands, modulating their induced signaling, and facilitating generation of extracellular vesicles. This role is exerted on two quantitative levels: a constitutive one independent of RIPK3, and an enhancement triggered by RIPK3. RIPK3 activation induces, prior to any sign of death, association of MLKL with ESCRT proteins and the flotillins, and exclusion of phospho-MLKL from cells within vesicles in association with these proteins. We suggest that release of phosphorylated MLKL within extracellular vesicles serves as a mechanism for self-restricting the necroptotic activity of this protein.
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Date:04TuesdayJuly 2017Lecture
Clock control by polyamine levels through a mechanism that declines with age
More information Time 10:30 - 11:00Location Wolfson Building for Biological Research
AuditoriumLecturer Ziv Zwighaft
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Abstract Polyamines are essential polycations present in a...» Abstract
Polyamines are essential polycations present in all living cells. Polyamine levels are maintained from the diet and de-novo synthesis, and their decline with age is associated with various pathologies. Here we found that polyamine levels oscillate in a daily manner. Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1:CLOCK to conserved DNA elements. In turn, polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1. Importantly, we show that the decline in polyamine levels with age in mice is associated with a longer circadian period that can be reversed upon polyamine supplementation in the diet. Our findings suggest a cross talk between circadian clocks and polyamines biosynthesis that participate in circadian control, and open new possibilities for nutritional interventions against the decay in clock’s function with age.
Highlights
• Diurnal regulation of polyamine biosynthesis by circadian clock and feeding.
• Polyamine levels regulate the circadian period in cultured cells and mice.
• Polyamines modulate the interaction between the core clock proteins PER2 and CRY1.
• Lengthening of the circadian period with age can be reversed by polyamines.
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Date:04TuesdayJuly 2017Lecture
AMO Journal Club
More information Time 13:15Location Edna and K.B. Weissman Building of Physical Sciences
AuditoriumOrganizer Department of Physics of Complex Systems
Optics and Atomic Physics SeminarContact Abstract Show full text abstract about Speakers: Dekel Raanan, Eilon Poem-Kalogerakis ...» Speakers: Dekel Raanan, Eilon Poem-Kalogerakis -
Date:04TuesdayJuly 2017Lecture
Molecular Neuroscience Forum Seminar
More information Time 14:00 - 15:00Title Glia control repetitive motion and sleep in C. elegans.Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Menachem Katz
Rockefeller UniversityOrganizer Department of Biomolecular SciencesHomepage Contact -
Date:04TuesdayJuly 2017Lecture
"Applications of SEC-MALS to Protein Characterization"
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Dr.. Dan Some
WyattOrganizer Department of Chemical and Structural BiologyContact Abstract Show full text abstract about Conventional analytical size exclusion chromatography (SEC),...» Conventional analytical size exclusion chromatography (SEC), often used to determine the solution molecular weight of proteins, is subject to inherent limitations and errors. Multi-angle light scattering (MALS) is a first-principles technique for determining the molar mass and size of macromolecules and nanoparticles in solution, independently of conformation. In combination with SEC, MALS overcomes these obstacles to characterize the biophysical properties of proteins and other biomolecules, including molecular weight, size, native oligomeric state, dynamic equilibria and degradation products.
This seminar will present the failure modes of analytical SEC, fundamentals of SEC-MALS and examples of applications to a variety of proteins including IgG, insulin, glycoproteins, membrane proteins and protein complexes as well as viruses and virus-like particles. It will touch on the importance of protein quality control for reproducible science and provide a glimpse into how MALS can analyze complicated protein-protein interactions.
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Date:04TuesdayJuly 2017Cultural Events
The lion that loved strawberries- Children's theater
More information Time 17:30Location Michael and Anna Wix AuditoriumContact -
Date:05WednesdayJuly 2017Lecture
"The Reactive Oxygen Driven Tumor: An Update"
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Jack L. Arbiser, M.D., Ph.D
Thomas J. Lawley Professor of Dermatology Department of Dermatology Emory University School of Medicine Winship Cancer Institute Atlanta Veterans Administration Health CenterOrganizer Department of Molecular Cell BiologyContact -
Date:05WednesdayJuly 2017Cultural Events
The Israel Camerata Jerusalem - Corners of the World
More information Time 20:00Location Michael and Anna Wix AuditoriumContact Details Show full text description of Avner Biron conductor Marita Sølberg soprano (Norway) Mark...» Avner Biron conductor
Marita Sølberg soprano (Norway)
Mark Bebbington piano (UK)
Grieg / Peer Gynt, suites no. 1 & no. 2
John Ireland / Piano Concerto in E-flat Major
Grieg / "The Last Spring" from Two Elegiac Melodies
Mozart / aria "Per Pieta Bel Idol Mio"
Mozart / aria "Non Curo L'affetto"
Mozart / aria "Basta vincesti"
Avi Eilam-Amzallag / "My Heart is in the East" (world premiere) -
Date:06ThursdayJuly 2017Lecture
Organoid Student Club Seminar ("Generation of lung organoids from fetal and adult lung progenitors")
More information Time 11:00 - 12:00Location Wolfson Building for Biological Research
Seminar RoomOrganizer Department of Molecular Cell BiologyContact -
Date:06ThursdayJuly 2017Lecture
Variability and Statistics of Failure of Commercial Li-ion Batteries
More information Time 11:00 - 12:00Location Perlman Chemical Sciences Building
Room 404Lecturer Dr. Stephen J. Harris
Lawrence Berkeley National LaboratoryOrganizer Department of Molecular Chemistry and Materials ScienceContact Details Show full text description of Traditionally, battery electrodes have been considered to be...» Traditionally, battery electrodes have been considered to be homogeneous and 1-dimensional—e.g., porosity is assumed constant everywhere, the state of charge at any point within one electrode is assumed to depend only on its distance from the other electrode. However, failure in essentially all real materials is initiated at a heterogeneity (weak spot), which might be at the largest flaw. Thus, a solid with some scratches will generally fracture at the largest one. As a result, a homogeneous electrode model normally cannot, by its very nature, predict cell failure unless it includes adjustable parameters.
In this talk I will review some evidence for the presence and possible importance of heterogeneities in battery electrodes. I will propose that in some cases the critical electrode flaws are relatively rare and statistically distributed through a collection of nominally identical battery samples. Under these conditions there will be two important consequences that are only rarely addressed or even recognized in the academic battery literature:
(1) Failure lifetime may have a wide distribution. For example, my cell phone battery lasts only 18 months; yours lasts 2½ years. In that case, characterizing battery life by a single number may not be very useful.
(2) Degradation may not be uniformly spatially distributed across a pouch cell. This can lead to a misdiagnosis of the problem. For example, if most of the degradation in a pouch cell takes place at the edges, then there may be leaks there. Trying to improve the electrode material would then be attacking the wrong problem.
I will provide evidence for (1) and (2) and discuss why thinking about these factors might be useful for producing longer-lived commercial batteries.
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Date:06ThursdayJuly 2017Lecture
Imm Student Seminars by Yadav Sandeep Kumar & Matthias Kramer -Thursday, July 6th, 2017
More information Time 14:00 - 15:00Location Wolfson Building for Biological Research
AuditoriumOrganizer Department of Systems ImmunologyContact Details Show full text description of 14:00-14:30: Yadav Sandeep Kumar- will lecture on: “The rol...» 14:00-14:30: Yadav Sandeep Kumar- will lecture on:
“The role of the leukocyte Nuclear Lamina in migration.”
14:30-15:00: Matthias Kramer- will lecture on:
“Deciphering the role of FAT10 in Cancer-Related Inflammation.” -
Date:06ThursdayJuly 2017Lecture
Imm Student Seminars by Yadav Sandeep Kumar & Matthias Kramer -Thursday, July 6th, 2017
More information Time 14:00 - 15:00Location Wolfson Building for Biological Research
AuditoriumOrganizer Department of Systems ImmunologyContact Details Show full text description of 14:00-14:30: Yadav Sandeep Kumar- will lecture on: “The rol...» 14:00-14:30: Yadav Sandeep Kumar- will lecture on:
“The role of the leukocyte Nuclear Lamina in migration.”
14:30-15:00: Matthias Kramer- will lecture on:
“Deciphering the role of FAT10 in Cancer-Related Inflammation.” -
Date:09SundayJuly 2017Lecture
Global Political and Economic Trends Affecting Energy Trade, Consumption and Production
More information Time 13:00Title Sustainability And Energy Research Initiative (SAERI) Seminar SeriesLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Brenda Shaffer
Visiting Researcher, Georgetown University and Senior Fellow, Global Energy Center, Atlantic Council, Washington, DC.Organizer Feinberg Graduate School
Alternative Sustainable Energy Research Initiative (AERI)Contact Details Show full text description of Gathering & refreshments at 12:40...» Gathering & refreshments at 12:40 -
Date:10MondayJuly 2017Lecture
Exploring the Synthesis and Applications of Graphene
More information Time 11:00 - 12:00Location Perlman Chemical Sciences Building
Room 404Lecturer Prof. Richard B. Kaner
Department of Chemistry and Biochemistry, UCLAOrganizer Department of Molecular Chemistry and Materials ScienceContact Details Show full text description of Graphene is the ultimate two-dimensional material consisti...»
Graphene is the ultimate two-dimensional material consisting of a single layer of sp2 hybridized carbon. Here we explore different approaches to synthesize this carbon allotrope, ranging from chemical conversion to vapor phase deposition. Briefly, graphite can be converted into graphene oxide (GO) sheets, which readily disperse in water, and then can be reduced by various methods.1-2 Due to its unique ability to be solution processed and patterned, GO and chemically converted graphene hold promise for applications ranging from sensors to transparent conducting electrodes.3-4 Chemical vapor deposition onto metal substrates enables the growth of continuous, large-area graphene (Fig. 1). The challenges of growing graphene, controlling the number of layers, transferring graphene and some exciting uses such as laser scribed graphene for supercapacitors will be discussed.5-6
Fig. Large-area single layer graphene transferred onto a silicon substrate with a 300 nm oxide can be seen with the naked eye, while STM imaging enables seeing the honeycomb network of carbon that makes this material so robust.
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Date:10MondayJuly 2017Lecture
Special Chemical Physics Seminar
More information Time 14:00Title The Dirac electron: spin, size, mass, charge, and universal constantsLocation Perlman Chemical Sciences Building
Room 404Lecturer Prof. Jean Maruani
CNRS & UPMCOrganizer Department of Chemical and Biological PhysicsContact