March 29, 1994 - March 29, 2027

  • Date:27MondayAugust 2018

    In situ structural studies of the cell cytoskeleton by cryo-electron tomography

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    Time
    14:00 - 15:00
    Title
    Special Guest Seminar
    Location
    Max and Lillian Candiotty Building
    Auditorium
    Lecturer
    Prof. Ohad Medalia
    Department of Biochemistry University of Zurich, Switzerland
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    AbstractShow full text abstract about Recent advances in cryo-electron microscopy revolutionized t...»
    Recent advances in cryo-electron microscopy revolutionized the possibilities and capabilities of structural analysis. This presents an exciting opportunity to explore the architecture of macromolecular-complexes which could not be crystallized, but also opens a window into in situ structural determination. Here, I will discuss the excitement in resolving macromolecular structures at atomic resolution and report on advances and challenges in studying molecular assemblies in individual cells and multicellular organisms at ~1nm of resolution. A special focus will be given to the functional organization of the cell’s cytoskeleton, i.e., the actin cytoskeleton, intermediate filaments and nuclear lamins. Our study indicates that in situ structural biology, at high-resolution, shed light on structural assemblies that can only be studied in their native environment, i.e. the cell.
    Lecture