March 29, 1994 - March 29, 2027

  • Date:23SundayJune 2019

    Cell Penetration and Membrane Fusion: Two Sides of the Same Coin

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    Time
    11:00 - 12:00
    Location
    Perlman Chemical Sciences Building
    Room 404
    Lecturer
    Prof. Pavel Jungwirth
    Institute of Chemistry, Academy of Sciences, Prague
    Organizer
    Department of Molecular Chemistry and Materials Science
    Soft Matter and Biomaterials
    Contact
    AbstractShow full text abstract about Cell penetrating peptides have a unique potential for target...»
    Cell penetrating peptides have a unique potential for targeted drug delivery. While ATP-driven endocytosis is known to play a major role in their internalization, there has been also ample evidence for the importance of passive translocation for which the direct mechanism, where the peptide is thought to directly pass through the membrane via a temporary pore, has been widely advocated. In this talk, I will question this view and demonstrate that arginine-rich cell penetrating peptides can instead enter vesicles and cells by inducing multilamellarity and fusion, analogously to the action of calcium ions.

    Allolio C., Magarkar A., Jurkiewiczf P., Baxová K., Javanainen M., Mason P.E., Sachl R., Cebecauer M., Hof M., Horinek D., Heinz V., Rachel R., Zieglerg C.M., Schrofel A., Jungwirth P.: Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore. Proceedings of the National Academy of Sciences USA 115 (2018) 11923.
    Lecture