The main goal of our group is to decipher the first principles of cellular self-organization processes such as protein folding, protein-protein assembly, and protein-DNA recognition. We are focused on advancing our understanding of biomolecules (the sequence-structure-function problem) using a battery of computational and theoretical methods that capture their chemical and physical nature as well as the billions of years of evolutional design.
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Lastest Publication

  • On the Coupling between the Dynamics of Protein and Water

    . Yulian Gavrilov, Jessica Leuchter, and Yaakov Levy. 2017 Phys Chem Chem Phys, 19: 8243 - 8257
  • Cross-linking Reveals Laminin Coiled-coil Architecture

    . Gad Armony, Etai Jacob, Toot Moran, Yishai Levin, Tevie Mehlman , Yaakov Levy, and Deborah Fass. 2016 Proc. Natl. Acad. Sci. USA, 113: 13384-13389
  • Mechanism of facilitated diffusion during DNA search in crowded environments

    . Dana Krepel, David Gomez, Stefan Klumpp, and Yaakov Levy. 2016 J Phys Chem B, 120: 11113-11122

Fields of Interest


Protein Folding and Post-translational Modifications

Protein folding has long been viewed as being rich in complexities. With the development of the energy landscape theory, our view of protein folding, however, has...

Protein-Protein Assembly

Biomolecules rarely function in isolation, hence a thorough understanding of biological processes is dependent upon an examination of complexes of biomolecules, and...

Protein-DNA recognition

Essentially, most of the biological functions of DNA require the binding of specific proteins to specific DNA sequences. For binding to occur, the protein has to...