Basic Services|Frogs


The African clawed frog (Xenopus laevis) is a species of African aquatic frog. Its name is derived from the three short claws on each hind foot, as the word Xenopus means "strange foot".
Xenopus has long been an important tool for in vivo studies in molecular, cell, and developmental biology of vertebrate animals. However, the wide breadth of Xenopus research stems from the additional fact that cell-free extracts made from Xenopus are a premier in vitro system for studies of fundamental aspects of cell and molecular biology. Thus, Xenopus is the only vertebrate model system that allows for high-throughput in vivo analyses of gene function and high-throughput biochemistry. Finally, Xenopus oocytes are a leading system for studies of ion transport and channel physiology.

The Xenopus unit

The unit is located at Herzberg building.
The colony includes about 50 adult female xenopus leavis for oocytes production.
Xenopus are being housed in recirculating systems in which water recirculates through mechanical, biological, and chemical filters and UV lights. 10% of the water is removed daily. The systems include 24 tanks, 27 liter each, in two racks.
Reverse Osmosis water is being supplemented automatically by dosing pumps with salts and sodium bicarbonate to reach conductivity of 1200µS and pH of 7.5. The water temperature is being kept at 18°C.

Unit Manager: Zamir Cochavi
Attending veterinarian: Dr. Noa Stettner


  • Bagriantsev SN, Chatelain FC, Clark KA, Alagem N, Reuveny E, Minor DL Jr.
    Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.
    ACS Chem Neurosci. 2014 Sep 17;5(9):812-22. PMID: 25028803
  • Kopito RB, Elbaum M.
    Nucleocytoplasmic transport: a thermodynamic mechanism.
    HFSP J. 2009;3(2):130-41. PMID: 19794817
  • Sadja R, Reuveny E.
    Activation gating kinetics of GIRK channels are mediated by cytoplasmic residues adjacent to transmembrane domains.
    Channels (Austin). 2009 May-Jun;3(3):205-14. PMID: 19574735
  • Lachish-Zalait A, Lau CK, Fichtman B, Zimmerman E, Harel A, Gaylord MR, Forbes DJ, Elbaum M.
    Transportin mediates nuclear entry of DNA in vertebrate systems.
    Traffic. 2009 Oct;10(10):1414-28. PMID: 19761539