Note: A list of previously ordered mouse strains is available.
Available strains are also listed in tables below.
Mouse Strains Databases
The Moross Repository for Genetically-Modified Mice contains strains of transgenic and gene-targeted mice that were produced or obtained by Weizmann Institute scientists, which are no longer in use, but might reasonably be needed by WIS scientists in the future. The repository maintains strains of mice either as small nuclei of breeding pairs or as stocks of frozen embryos. The aim of the Repository is to free Institute scientists from the need to maintain strains that are potentially useful but which they themselves no longer need. The repository houses mice relevant to any discipline of scientific research performed at the WIS.
The Repository is funded by the MD Moross Institute for Cancer Research and by the Weizmann Institute of Science.
The Moross Repository will also participate in financing import of new and potentially interesting strains of transgenic or gene-targeted mice that are relevant to cancer research (as defined in a rather broad way). For additional information see the Moross Repository Guidelines below.
Submitting mice to the Moross Repository
Scientists who wish to suggest strains of mice for inclusion in the Repository are requested to contact:
Prof. Ari Elson, Department of Molecular Genetics, Tel: 2331, 2209
or Dr. Rebecca Haffner, Department of Veterinary Resources, Tel: 2719.
Once approval for acceptance has been secured, scientists are required to fill out an order form via
Internal Services > Moross Cancer Bank Res.
Requesting Mice from the Moross Repository
IACUC approval must be obtained for all mice requested from the Moross Repository.
Once IACUC approval has been secured, scientists are required to fill out an order form via
Internal Services > Moross Cancer Bank Res.
Moross Repository Guidelines
- The Moross Repository of Genetically-Modified Mice aims to maintain living or frozen stocks of select strains of genetically-modified mice that are no longer in use but which may be of potential future use by WIS scientists. In so doing the Repository maintains availability of potentially-useful strains of mice while freeing WIS scientists from the burden of maintaining stains they no longer need.
- The Moross Repository accepts genetically-modified mice relevant to any discipline of scientific research performed at the WIS.
- A strain of mice will be considered for inclusion in the Repository providing that:
- The strain is not maintained in parallel by any researcher at the WIS.
- There are no frozen stocks of this strain at the WIS.
- There is reasonable expectation that the strain may be needed in the future by WIS scientists other than the scientist who donated the strain.
- The legal/IP limitations on the use of the strain are such that it can be used by scientists other than the WIS donor.
- Other issues (broad scientific interest, ease/difficulty to obtain the strain from other sources, ease/difficulty to maintain the strain, available resources) may also be considered
- Strains are accepted into the collection and are maintained without cost to the donating scientist.
- The Moross Repository maintains strains as small live breeding stocks and cannot provide large amounts of mice. WIS scientists may receive breeding pairs from the Repository with which to establish breeding colonies should they need more than a few mice for their studies.
- Strains of mice not in frequent demand will be frozen and maintained as stocks of frozen embryos. In order to preserve resources the Repository will typically not freeze strains of mice that are maintained as living colonies in the Jackson Labs or other providers, since it takes about as much time to import these mice as it does to thaw and re-establish them from frozen stock locally.
- Freezing of strains will be done at no cost to the donating scientist. However, costs of thawing embryos will be borne by the WIS scientist that requests it.
- Any WIS scientist may request breeding stocks from the Repository providing:
- He/she obtains IACUC approval.
- The legal/IP commitments undertaken by the WIS scientist who originally obtained the strain will be respected.
- If the line is frozen, costs of thawing will be borne by the WIS scientist who requests it
- WIS scientists are strongly encouraged to freeze down strains of mice they no longer need without the intervention of the Moross Repository. Such freezing is currently free, is carried out by the staff of the mouse facility, and involves little effort on the part of the scientific group. The Repository will therefore accept only strains of mice of potential future use to several WIS groups.
- In extreme cases, where a scientist wishes to freeze down a strain and cannot do so due to backlogs in the freezing process, the Repository may accept a small number of these mice to maintain the line until freezing becomes possible. This will be done at no cost to the scientist; however, the scientist will be responsible for genotyping these mice, if needed.
- The Moross Repository adheres to and respects all legal/IP limitations undertaken by the WIS scientist/s who originally obtained the strains. Therefore, WIS scientists requesting strains from the Repository may have to request permission to do so from the original non-WIS source and/or may be required to sign MTAs or undertake other commitments.
Common Name / Strain Name |
Source in the WIS
|
Source
|
Stock #
|
Description |
Link
|
Primary
Reference |
Availability |
---|---|---|---|---|---|---|---|
Marker Lines | |||||||
B5 EGFP / STOCK Tg(CAG-EGFP)B5Nagy/J |
Animal Breeding Center
|
Nagy, Toronto
|
003115
|
Transgene with GFP driven by chick beta-actin promoter. General GFP expression. | 003115 |
Cryopreserved Sperm |
|
B6/PGK neo / C57BL/6J-Tg(pPGKneobpA)3Ems/J |
Animal Breeding Center
|
Jax
|
002356
|
Source of G418-resistant feeder cells for gene targeting | Live | ||
DR4 / STOCK Tg(DR4)1Jae/J |
STOCK Tg(DR4)1Jae/J
|
Jax
|
003208
|
Resistance to G418, puromycin, 6-thioguanine and hygromycin. Donor for the production of multiple-drug resistant MEFs. | NAR 25; 3745 | Live | |
YFP-H (YFP 2.2) / B6.Cg-Tg(Thy1-YFP)HJrs/J |
Peles
|
Sanes, St. Louis
|
|
Same as YFP16, but stains different subset of neurons (see link) | Cryopreserved Embryos | ||
129 S6/SvEv / 129S6/SvEvTac |
Elson
|
Taconic
|
129SVE
|
Knockout mice developed from 129 agouti ES cell lines can be maintained on an agouti 129 background by mating to Taconic's 129 strain |
|
Live | |
129X1/SvJ / 129X1/SvJ |
Gross 05
|
Jax
|
000691
|
129 strain most closely matching the R1 ES cell line | Live | ||
C57BL/6J-Tyrc-2J / B6(Cg)-Tyrc-2J/J |
Animal Breeding Center 2003
|
Jax
|
000058
|
C57Bl mice with coat colour mutation, homozygotes are albino. Used as blastocyst donor for C57BL ES cell chimeras | Live (Cryopreserved Embryos) | ||
Cre and Flp strains | |||||||
B(MCM) cre |
Wallach
|
M.Reth, Freiburg
|
|
Inducible Cre expression in B lymphocytes |
|
Cryopreserved Embryos | |
Mogi-cre / Mogtm1(cre)Gkl |
Wallach
9.04 |
Waisman,
Cologne |
|
Cre-mediated excision in oligodendrocytes. (Mouse on C57BL/6 background) | MOG | Cryopreserved Embryos | |
Alb-cre / B6.Cg-Tg(Alb-cre)21Mgn/J |
Wallach
|
Jax
|
003574
|
Liver-specific cre-mediated excision | Cryopreserved Embryos | ||
Balancer cre (Nes-cre) / STOCK Tg(Nes-cre)1Wme/J |
Wallach
|
Jax
|
002858
|
Variable deletion of loxP genes generates mosaic mice which can bypass lethality | Cryopreserved Embryos | ||
Dhh-cre / FVB(Cg)-Tg(Dhh-cre)1Mejr/J |
Peles
|
Meijer, Holland
|
|
Cre under desert hedgehog promoter, schwann cell specific | Gene Dev 17; 1380 | Cryopreserved Embryos | |
Pgk-cre / Tg(Pgk1-cre)1Lni |
Lonai
|
Lonai
|
|
General cre deletor strain, maternally expressed. | Live (Cryopreserved Sperm) | ||
R/ERT / STOCK Polr2atm1(cre/ERT2)Bbd/J |
Hornstein 7.06
|
Barbacid
Madrid |
|
Uniform Cre activity upon systemic 4OH-Tamoxifen exposure in all tissues, low cleavage in brain. Cleavage efficiency is locus dependent. | Live | ||
MSX-limb-cre |
Animal Breeding Center
|
|
|
Cre-mediated excision in limb regions | Cryopreserved Embryos | ||
ED-cre |
Wallach
|
Waisman,
Cologne |
|
Inducible Cre expression in B lymphocytes | Cryopreserved Embryos | ||
tie-1-Cre / Tg(Tie1-cre)9Ref |
Wallach
|
Gustafsson,
Sweden |
|
Cre expression specifically in endothelial cells from embryonic stage E8 | Cryopreserved Embryos | ||
Ins2-cre (RIP-cre) / B6.Cg-Tg(Ins2-cre)25Mgn/J |
Wallach
|
Jax
|
003573
|
Pancreas specific cre-mediated excision | Cryopreserved Sperm | ||
Z/AP / STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J |
Animal Breeding Center
|
Lobe, Toronto
|
003919
|
Cre reporter, constitutive LacZ expression replaced by alk phos, following cre-mediated excision | Cryopreserved Embryos | ||
Z/EG / STOCK Tg(CAG-Bgeo/GFP)21Lbe/J |
Animal Breeding Center
|
Lobe, Toronto
|
00320
|
Cre reporter, constitutive LacZ expression replaced by GFP, following cre-mediated excision | Live | ||
K5 CRE_PR1 / Tg(KRT5-cre/PGR)1Der |
Wallach 12.07
|
Waisman Cologne
|
|
cre under inducible keratin promotor results in expression in epidermis and hair follicles | Cryopreserved Sperm | ||
B6.CD19-Cre / C.Cg-Cd19tm1(cre)Cgn Ighb/J |
Wallach
|
Waisman, Cologne
|
|
Cre under CD19 promoter deletes B-lymphocytes from the earliest stages | Cryopreserved Sperm | ||
MHC-Cre (Alpha-MyHC-Cre) / B6.FVB-Tg(Myh6-cre)2182Mds/J |
Gross 7.07
|
De Windt Utrecht
|
|
Cre recombination in cardiac muscle | Live | ||
Conditional Dicer / STOCK Dicer1tm1Bdh/J |
Groner
2.06 |
Tabin, Harvard
|
|
cre-inducible conditional allele of Dicer for studying miRNA function. Used to remove Dicer function in any tissue in which cre recombinase can be expressed. | Cryopreserved Embryos | ||
A-myosin heavy chain (MerCreMer) / B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J |
Wallach
|
Molkentin, Cincinatti
|
|
Tamoxifen inducible cre-mediated excision in adult and embryonic heart | Cryopreserved Embryos | ||
PV-cre / B6;129P2-Pvalbtm1(cre)Arbr/J |
Groner 2007
|
Arber Basel
|
|
Cre is expressed from the PV locus. Cre expressed in to PV+ proprioceptive DRG neurons | Cryopreserved Embryos/Sperm | ||
Pf4-cre / C57BL/6-Tg(Pf4-cre)Q3Rsko/J |
Groner 2008
|
Skoda Basel
|
|
Cre expressed from the Pf4 (platelet factor 4) locus. Expressed exclusively in the megakaryocytic lineage | Cryopreserved Embryos/Sperm | ||
Ckmm-cre / B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J |
Gross 2011
|
Jax
|
006475
|
Cre under muscle creatine kinase promoter, expressed in skeletal and cardiac muscle | Live | ||
LeptinR-cre / B6.129-Leprtm2(cre)Rck/J |
Elson 2011
|
Jax
|
008320
|
Cre activity in hypothalmus, limbic and cortical brain regions and retrosplenial cortex. | Live | ||
MMTV-cre / Stock (Tg (MMTV-cre) 4Mam/J) |
|
Jax
|
003553
|
Cre under MMTV LT promoter. Recombination in mammary gland, salivary gland, seminal vesicle, skin, erythrocytes, B cells and T cells. | Live | ||
Vil-cre / B6.SJL-Tg(Vil-cre)997Gum/J |
Groner 2008
|
Jax
|
004586
|
Cre under mouse villin 1 promoter, Recombination in villi and crypt cells of the small and large intestines. | 004586 | Cryopreserved Embryos | |
FlpeR - B6 / B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/RainJ |
Cancer Bank
|
Jax
|
009086
|
Widespread expression of FLPe, for deletion of frt-flanked sequences. NB the Y chromosome may not have been fixed to the genetic background during the backcross. | 009086 | Live | |
FLP1eR - 129 / 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J |
Groner 10.05
|
Jax
|
003946
|
General Flp deleter strain. FLP1 recombinase expressed constitutively under Gt(ROSA)26Sor promoter. FLPe has enhanced thermostability with recombination activity being four-fold of wild type FLP at 37°C | 003946 | Live | |
Transgenes and Knockouts | |||||||
Rag 1 k/o(C57BL/6J) / B6.129S7-Rag1tm1Mom/J |
Wallach
|
Jax
|
002216
|
-/- mice produce no mature T cells or B cells. "non-leaky" severe combined immune deficiency | Cryopreserved Embryos | ||
P19 ARF k/o / B6*P 19 ARF+/- |
Oren
|
St.Jude (Sherr)
|
|
Mice lacking tumor suppressor p19ARF but with functional p16INK4a develop tumors early in life | Cryopreserved Embryos | ||
ATM |
Groner, Elson
|
Leder, Harvard
|
|
Mice lack the ataxia-telangiectasia (AT) gene product | Cryopreserved Embryos/Sperm | ||
FGFR3 knockin(gain of function) |
Givol
|
WIS
|
|
A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3 | Cryopreserved Embryos/Sperm | ||
Src k/o / B6.129S7-Srctm1Sor/J |
Geiger
3.04 |
Jax
|
002277
|
Homozygotes display osteopetrosis and are 1/3 the size of wildtype siblings. Incisors fail to erupt. Partial absence of bone marrow. | Live | ||
Bax k/o / B6.129X1-Baxtm1Sjk/J |
Geiger
|
Jax
|
002994
|
Bax-deficient mice with lymphoid hyperplasia and male germ cell death | Cryopreserved Embryos | ||
SOD 51YG, (SOD69YG, 70YG) transgene |
Groner
|
Generated
here |
|
Overexpress human DOD1. Have abnormal neuromuscular junction in tongue. | Cryopreserved Embryos | ||
IL1alpha-beta tm (ICR) / IL1alpha-beta KO (ICR) |
Groner
2012 |
Apt BGU
|
|
Healthy and fertile (background transferred to ICR at WIS quarantine) |
|
Cryopreserved Sperm | |
Tgf beta k/o / B6.129S2-Tgfb1tm1Doe/J |
Groner 10.03
|
Jax
|
002220
|
-/- die at two to three weeks, due to a massive inflammatory cell response and tissue necrosis. Model for immune and inflammatory diseases | Cryopreserved Sperm | ||
TRAMP transgene,/ C57BL/6-Tg(TRAMP)8247Ng/J |
Eshhar 2002
|
Greenberg
Seattle |
01XC6
|
Mice carrying the (TRAMP) transgene develop progressive forms of prostate cancer with distant site metastasis. | Cryopreserved Sperm | ||
Nkx3.1 k/o(homeobox) |
Wallach 8.03
|
MMHCC NCI Frederick
|
01XB3
|
Homozygous males display prostatic epithelialhyperplasia and dysplasia Heterozygous mice display a similar, less severe phenotype. | 01XB3 | Cryopreserved Embryos | |
Mos k/o / 129S6/SvEv-Mos tm1Ev/J |
Zaffriri
1.2005 |
Jax
|
002722
|
Homozygous males are fertile; homozygous females have small litters. Eggs undergo spontaneous parthenogenetic activation. Ovarian cysts develop as young as one month. | Cryopreserved Sperm | ||
'floxed' PTEN / B6.129S4-Ptentm1Hwu/J |
Wallach
|
Pandolfi
Sloan-Kettering |
|
Allows conditional inactivation of tumor suppressor PTEN. |
|
Cryopreserved Sperm | |
CMV:tTA |
Neeman 11.07
|
Keshet HUJ
|
|
Tet inducible transgene under CMV promotor |
|
Cryopreserved Sperm | |
Talin flx / Tln1tm4Crit |
Alon 2008
|
Critchley Leicester UK
|
|
Conditional mutant of talin flaked by loxP sites | Tln1 Crit MGI | Cytopreserved Embryos | |
Jak2 tm / Jak2tm1Kuw |
Elson 2011
|
Wagner Nebraska
|
|
Mutants die around midgestation and exhibit impaired definitive erythropoiesis | Jak2 MG! | Cytopreserved sperm | |
(gc)/Rag2 common gamma/Rag2 double k/o / B10;B6-Rag2tm1Fwa II2rgtm1Wjl |
Groner 1.06
Moross Bank 5.10 |
Taconic
|
004111
|
The double knock-out lacks T cells, B cells, and NK cells. Useful for transplanting allogeneic or xenogeneic stem cells. | 004111 | Live | |
MMTV-Erbb2 tg (MMTV Neu) / FVB-Tg(MMTV-Erbb2)NK1Mul/J |
Elson 2010
|
Jax
|
005038
|
Express activated Erbb2 (c-neu) oncogene under MMTV promoter. 50% of transgenic mice develop tumors within 6-12 months of age. | 005038 | Cytopreserved Embryos/Sperm | |
MMTV-Myc Transgene / FVB-Tg(MMTV-Myc)141-3Led |
Elson 2.05
|
MMHCC NCI Frederick
|
01XG2
|
Develop adenocarcinomas of mammary tissue and in some cases lymphomas develop at low frequency. | 01XG2 | Cytopreserved Sperm | |
MMTV-PyVT / FVB/N-Tg(MMTV-PyVT)634Mul/J |
Oren 2013
|
Jax
|
002374
|
Polyoma Virus middle T antigen under MMTV promoter/enhancer. Females develop mammary tumors at 5-40 weeks, which metastasize to the lung. Males also develop mammary tumors. | 002374 | Live | |
RPTP zeta k/o |
Elson 2004
|
Harroch, IPasteur
|
|
RPTPbeta-deficient mice are viable, are fertile, and showed no gross anatomical alterations in the nervous system or other organs. | Live | ||
P55 DNS lox |
Wallach
|
Kollias, Greece
|
|
Mutation of the p55 TNF receptor, which prevents the shedding of the receptor | Cryopreserved Embryos | ||
Tg.Ac / FVB/N-Tg(MMTV-PyVT)634Mul/J |
Groner 2012
|
Taconic
|
|
Transgenic mouse carries activated v-Ha-ras oncogene under promoter of the mouse embryonic alpha-like, zeta-globin gene.Used in screening tumor promoters and assessing antitumor and antiproliferative agents. | Taconic | Cryopreserved Embryos/Sperm NOT FOR DISTRIBUTION |
Common Name |
Scientist
|
Source
|
Stock #
|
Description | Link |
Primary
Reference |
Other |
---|---|---|---|---|---|---|---|
Marker Lines | |||||||
B5 EGFP |
Animal Breeding Centre
|
Nagy,
Toronto |
003115
|
Transgene with GFP driven by chick beta-actin promoter. General GFP expression | 003115 | ||
actin eGFP transgene |
Elson 2.05
|
Matus
Basel |
|
Carry actin-GFP fusion transgene under the actin promoter. Results in mice with GFP labeled actin. | Requires an MTA from FMI, Basel | ||
ACTbEGFP |
Schwartz 4.05
|
Jax
Basel |
003291
|
Express EGFP cDNA under chicken beta-actin promoter and cytomegalovirus enhancer. All tissues green, except erythrocytes and hair. Homozygotes die 14days p.n. | 003291 | ||
UBI-GFP |
R. Alon 11.06
|
Jax
|
004353
|
GFP under human ubiqutin C promoter, express GFP in all tissues examined. Certain hematapoetic cell types display distinct expression levels of GFP, allowing identification by FACS analysis. | 004353 | ||
B6/PGK neo |
Animal Breeding Centre
|
Jax
|
002356
|
Source of G418-resistant feeder cells for gene targeting | 002356 |
|
|
Rosa 26 |
Animal Breeding Centre
|
Jax
|
002073
|
lacZ is expressed in all tissues of the embryo and in most tissues of the adult mouse. | 002073 | ||
YFP16 |
Peles
|
Sanes,
St.Louis |
|
Express YFP in motor and sensory neurons. Expression strong from a mid-gestational stage into adulthood | 003709 | ||
YFP-H (YFP 2.2) |
Peles
|
Sanes,
St.Louis |
|
Same as YFP16, but stains different subset of neurons (see link) | 003782 | ||
Col2 GFP |
Yayon 4.03
|
Horton, Portland
|
|
Transgenic mice carrying the GFP gene under the control of the collagen 2 promoter. GFP expression in chondrogenic areas | |||
SCE/LacZ |
Peles 6.03
|
Meijer,Holland
|
|
LacZ under control of schwann cell enhancer |
Unpublished
|
Restricted access, contact Ori Peles | |
SCE/GFP+/- |
Peles 6.03
|
Meijer,Holland
|
|
GFP under control of schwann cell enhancer |
Unpublished
|
Restricted access, contact Ori Peles | |
C57BL/6J-Tyrc-2J |
Animal Breeding Center 14.9.03
|
Jax
|
000058
|
C57Bl mice with coat colour mutation, homozygotes are albino. Used as blastocyst donor for C57BL ES cell chimeras | 000058 | ||
C.B 20 |
Animal Breeding Center 14.9.03
|
(Jerusalem)Cologne
|
|
BALB/c xC57Bl backcross. Used as blastocyst donor for C57BL ES cell chimeras.(C.B20 is 3 generations further backcross then C.B17) | C.B17 |
|
|
129X1/SvJ |
Gross 10.05
|
Jax
|
00691
|
129 strain most closely matching the R1 ES cell line | 000691 | ||
129 S6/SvEv |
Elson
|
Taconic
|
129SVE
|
Knockout mice developed from 129 agouti ES cell lines can be maintained on an agouti 129 background by mating to Taconic's 129 strain | 129SVE |
|
|
129/pas |
Lonai
|
Geunet,Pasteur, Paris
|
|
129 substrain recommended for breeding knockout lines | |||
B6129SF2/J |
Ravel
|
Jax
|
101045
|
Parental strains C57BL/6J, 129S1/SvImJSuggested controls for strains designated B6;129S | 101045 |
|
|
TIE2-GFP |
Zelzer 4.05
|
Jax
|
003658
|
Express GFP under endothelial-specific receptor tyrosine kinase (Tek, formerly, Tie2) promoter. | 003658 | ||
Topgal (fos-lac-Z)34Efu/J |
Zelzer 6.05
|
Jax
|
004623
|
Transgenic mice display Beta-gal activity during embryonic development in developing hair follicles. Useful in studies of the Wnt signaling pathway. | 004623 | ||
DBA/2J |
Eshhar 6.07
|
Jax
|
000671
|
Inbred strain. Vision and hearing defects, intolerant to alcohol and morphine | 000671 | ||
Hox7b-GFP tg |
Garti 7.09
|
Kispert Germany
|
|
Transgenic mouse that expresses EGFP under the Hoxb7 promoter | |||
Cre and Flp strains | |||||||
E IIa-cre |
Reiner
|
Jax
|
003314
|
Cre transgene under adenovirus EIIa promoter. General deletor strain. | 003314 | ||
Pgk-cre |
Lonai
|
Lonai
|
|
General cre deletor strain, maternally expressed | |||
R/ERT |
Hornstein 7.06
|
Barbacid
Madrid |
|
Uniform Cre activity upon systemic 4OH-Tamoxifen exposure in all tissues, low cleavage in brain. Cleavage efficiency is locus dependent. | |||
Mx-cre (Msx-1 cre) |
Wallach
|
H.Cedar,
Jerusalem |
Jax 003556
|
Cre under control of interferon-responsive promoter. Available on C57BL background. | 003556 | ||
Bf-1-cre |
Reiner
|
McConnell,
Stanford |
|
Cre targeted to Bf-1 (Foxg1) locus. cre-mediated excision in telencephalon and discrete head structures. | |||
Wnt-cre |
Zelzer 2005
|
Tabin, Harvard
|
|
Cre-activity within the embryonic central nervous system from E8.5. | |||
CAGS-Cre/ERT |
Hornstein 7.06
|
|
|
Tamoxifen-inducible form of Cre mediates recombination within the embryonic central nervous system. | |||
Pax3 Cre |
Hornstein 7.06
|
Epstein
Philadelphia |
|
Cre activity in Pax3-expressing cells including neural crest and somites. | MTA required | ||
MSX-limb-cre |
Animal Breeding Center
|
|
|
Cre-mediated excision in limb regions | Cryopreserved | ||
LysM-cre |
Wallach
|
Forster, Germany
|
|
Cre-mediated excision in myeloid cells | 004781 | Restricted to collaborators | |
Lck-cre |
Animal Breeding Center
|
Taconic
|
004204-M
|
Cre under Lck (lymphocyte protein tyrosine kinase) promotor, deletes T cell lineage at the double negative stage | 004204-M mixed background |
deletions in non-lymphoid tissue possible | |
B(MCM) |
Wallach
|
M.Reth, Freiburg
|
|
Inducible Cre expression in B lymphocytes |
|
Restricted to collaborators; Cryopreserved | |
Dhh-cre |
Peles
|
Meijer, Holland
|
|
Cre under desert hedgehog promoter, schwann cell specific | Cryopreserved. Requires permission from D.Meijer | ||
MBP-cre |
Wallach
|
Kollias, Greece
|
|
Cre-mediated excision in oligodendrocytes | kollias |
unpublished
|
Restricted to collaborators |
Mogi-cre |
Wallach
9.04 |
Waisman,
Cologne |
|
Cre-mediated excision in oligodendrocytes. (Mouse on C57BL/6 background) | MOG | Restricted to collaborators; Cryopreserved | |
CNP-Cre |
Peles
1.05 |
Nave
Göttingen |
|
Cre is expressed under the control of CNP promoters. CNP is expressed in oligodendrocytes and to a lesser extent in Schwann cells. | Permission from Peles and Nave required | ||
VChAT Cre |
Hornstein 7.06
|
Misawa, Tokyo
|
|
Cre expression in a subset of cholinergic neurons in the somatomotor nuclei and medial habenular nucleus. | MTA required | ||
Alb-cre |
Wallach
|
Jax
|
003574
|
Liver-specific cre-mediated excision | 003574 | Cryopreserved | |
Ins2-cre (RIP-cre) |
Wallach
|
Jax
|
003573
|
Pancreas specific cre-mediated excision | 003573 | ||
RIP-cre/ERT |
Hornstein 7.06
|
Dor, Harvard
|
|
Tamoxifen-inducible form of Cre mediates recombination in pancreatic beta-cells | MTA required | ||
Pdx1 Cre/ERT |
Hornstein 7.06
|
Melton, Harvard
|
|
Tamoxifen-inducible form of Cre mediates recombination in Pdx1-expressing cells | MTA required | ||
Balancer cre (Nes-cre) |
Wallach
|
Jax
|
002858
|
Variable deletion of loxP genes generates mosaic mice which can bypass lethality | 002858 | Cryopreserved | |
B6.CD4-Cre |
Wallach
|
Waisman, Cologne
|
|
Cre under CD4 promoter deletes most thymocytes at the double positive stage | |||
ED-cre |
Wallach
|
Waisman, Cologne
|
|
Inducible Cre expression in B lymphocytes | Cryopreserved, Requires Permission | ||
B6.Cg-Tg(Lck-cre) |
Wallach
|
Jax
|
003802
|
Expresses Cre recombinase in thymocytes | 003802 | ||
tie-1-Cre |
Wallach
|
Gustafsson Sweden
|
|
Cre expression specifically in endothelial cells from embryonic stage E8 | Cryopreserved, Restricted to Collaborators | ||
Vil-cre |
Jung 5.05
|
MMHCC NCI Frederick
|
01XE7
|
Cre expression in the intestine, colon and proximal tubule of the kidney | 01XE7 | ||
CaM KII cre |
Wallach 11.05
|
Probert Athens
|
|
Cre recombination in adult forebrain | Permission from Probert required | ||
Col 1-cre |
Zelzer 6.05
|
Karsenty, Baylor
|
|
Cre expression in osteoblasts | Permission from Karsenty required | ||
GDF5-cre |
Zelzer 9.06
|
Kinsley, Stanford
|
|
Cre avtivity in developing joints | |||
Z/AP |
Animal Breeding Center
|
Lobe, Toronto
|
003919
|
Cre reporter, constitutive LacZ expression replaced by alk phos, following cre-mediated excision | 003919 | ||
Z/EG |
Animal Breeding Center
|
Lobe, Toronto
|
00320
|
Cre reporter, constitutive LacZ expression replaced by GFP, following cre-mediated excision. | 003920 | ||
Rosa26R |
Zelzer 2005
|
Harvard
|
Jax 006148
|
EYFP expression is observed when bred to mice with a cre gene under a promoter of interest. Useful in monitoring Cre lineage expression. | 006148 |
|
|
RA/EG |
Jung
|
Foerster, Munich
|
|
Carry a conditional GFP gene in the RAGE locus. RA/EG, can therefore serve a reporter mice for Cre activity. | Restricted access, contact Bernd Arnold | ||
BPA -/- (R26:LacZ-PBA/DT-A) transgene |
Peles 1.05
|
Riethmacher
Hamburg |
|
Floxed diphtheria toxin fragment A gene in the ROSA26 locus. Allows depletion of specific cell types in vivo following Cre-mediated gene recombination. | Permission from Peles and Riethmacher required | ||
Isl1-cre |
Reiner 4.05
|
Pfaff Salk Inst.
|
|
Cre expression in motor neurons and in a subtype of dorsal interneurons in the spinal cord | |||
Isl1-Cre |
Zahor 11.07
|
Evans UCSD
|
|
expresses Cre in specific myocardial lineages | MTA required | ||
Isl1-MCM |
Zahor 11.07
|
Evans UCSD
|
|
Islet 1 tamoxifen inducible Cre | MTA required | ||
Cdh5-cre |
Zelzer 2008
|
Jax
|
006137
|
Cre under VE-Cadherin (Cdh5) mouse promoter. Expressed in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells | 006137 | ||
Col2a1-cre/ESR1 |
Zelzer 2008
|
Jax
|
006774
|
Strong tamoxifen-inducible cre expression directed to cells of the chondrogenic lineage (cartilage), with minimal (<0.1%) cre activity in the absence of tamoxifen | 006774 | ||
Prm-cre |
Wallach 2008
|
Jax
|
003328
|
Cre under protamine 1 promoter mediates recombination in the male germ line, but not in other tissues. Used to produce homologously recombined alleles in mice that have been secondarily rearranged by site-specific recombinase. | 003328 | ||
Neurog-3 cre |
Horenstein 2008
|
Jax
|
006333
|
Cre under neurogenin 3 promoter Recombination in the small intestine and fetal pancreatic epithelial cells. Also in islets of the adult pancreas, and other endocrine cells. | 006333 | ||
Osx1-GFP:Cre |
Zelzer 2008
|
Jax
|
006361
|
Carries both tTA under the regulation of the osterix (Sp7) promoter and a tetracycline responsive GFP/Cre fusion protein. Useful in studies of bone development, osteoblast lineage, and Hedgehog/Wnt signaling. | 006361 | ||
Pomc1 cre |
Chen 2008
|
Jax
|
05965
|
Cre under Pomc1 cre promotor. Activity in brain area neurons involved in the control of food intake (arcuate nucleus (hypothalamus) and solitary tract nucleus (hindbrain)). | 005965 | ||
ePet-Cre |
Chen 2008
|
Deneris Cleveland
|
|
Carry the Cre recombinase gene under the control of ePet promoter, Cre expression mainly in serotonergic neurons. | Requires permission from Evan Deneris | ||
Advillin cre |
Fainzilber 2008
|
Wang, Duke U
|
|
cre gene under the promotor of Advillin | |||
Th-IRES-Cre.Rosa YFP |
T. Kimchi 2009
|
Mizrahi HUJ
|
|
knock-in expressing Cre from the 3'UTR of the tyrosine hydroxylasegene by means of an IRES sequence | Requires permission from Tali Kimchi | ||
Nkx2-1-cre |
Hornstein 7.09
|
Jax
|
008661
|
cre expression in subgroups of brain interneuron progenitors, developing lung, thyroid, and pituitary | 8661 | ||
LepRb-IRES-Cre |
Elson 1.10
|
Jax
|
008320
|
Cre activity in hypothalmus and in those neurons that express neuropeptide Y or the leptin receptor | 8320 | ||
Nefh-cre |
Futerman 4.10
|
MMRRC
|
015960
|
Expression of cre in neurons of the brain and spinal cord during late development (~ E18.5). | 015960 | ||
Matn1-Cre |
Zelzer 4.09
|
|
|
Expression of Cre recombinase in all the growth plate chondrocyte with the exception of articular chondrocytes.á | |||
Shh-gfp cre |
Zelzer 4.09
|
Tabin Harvard
|
|
Cre-gfp knocked into shh locus | |||
Sox4 tm |
Jung 11.09
|
Lefebvre Cleveland
|
|
Conditional "floxed" allele of Sox4. Sox4-null mice die at embryonic day 14 from heart malformation. | |||
Transgenes and knockouts | |||||||
129 inf gamma k/o |
Harmelin
|
Jax
|
002287
|
-/- show reduced macrophage function in response to pathogens. Hyper-proliferation of splenocytes in response to mitogens | 002287 | ||
Rag 1 k/o(C57BL/6J) |
Wallach
|
Jax
|
002216
|
-/- mice produce no mature T cells or B cells. "non-leaky" severe combined immune deficiency | 002216 | ||
Rag 1 k/o(BALB/c) |
Jung
Schwartz, 4.04 |
Jax
|
003145
|
-/- mice produce no mature T cells or B cells. "non-leaky" severe combined immune deficiency (as above) | 003145 | ||
CD8 k/o |
Moses 7.06
|
Jax
|
002665
|
Homozygotes are deficient in functional cytotoxic T-cells; however, helper T-cell development and function is comparable to normal. | 002665 | ||
Nrcam k/o |
Peles 7.06
|
Grumet
Rutgers |
|
In homozygotes cerebella do not exhibit obvious histological defects, although a mild size reduction of several lobes is observed. | Nrcam | Contact Elior Peles | |
Nfasc k/o |
Peles 7.06
|
Brophy
Edinburgh |
|
In homozygotes neither paranodal adhesion junctions nor nodal complexes are formed. | Contact Elior Peles | ||
4.1B k/o (Epb4.1l3) |
Peles 7.06
|
Kissel
Philadelphia |
|
No abnormal phenotype detected in homozygotes. | Epb4.1l3 | Contact Elior Peles | |
Igh-6 k/o (muMT) |
Jung
|
Jax
|
002249
|
Homozygous mutants lack mature B-cells. | 002249 | ||
ATM |
Groner, Elson
|
Leder, Harvard
|
|
Mice lack the ataxia-telangiectasia (AT) gene product. | Requires permission from P. Leder; Cryopreserved | ||
Cntn1 k/o |
Peles 7.06
|
Ranscht, La Jolla
|
|
Homozygotes have severe ataxic phenotype consistent with defects in the cerebellum, survive until postnatal day 18. | Cntn1 | Contact Elior Peles | |
DO11.10 transgene |
Jung
|
Jax
|
003303
|
Rearranged T cell receptor transgene, ovalbumin responsive, deletes CD4+ CD8+ TCRlo thymocytes. | 003303 | ||
TcraTcrb transgene |
Jung
|
Jax
|
003831
|
Transgenic T cell receptor recognizes ovalbuminm with H2Kb, used to study peptides in positive selection and response of CD8+ T cells to antigen. | 003831 | ||
Bax -/- k/o |
Groner
|
Jax
|
002994
|
Bax-deficient mice with lymphoid hyperplasia and male germ cell death | 002994 | Cryopreserved | |
B6 Bid k/o |
Gross
|
Korsmeyer, Harvard
|
|
Bid (bcl2 family)-deficient mice are resistant to Fas-induced hepatocellular apoptosis | |||
chop-(Ddit3) k/o |
Kimchi
4.06 |
Jax
|
005530
|
homozygotes viable, fertile. MEFs and renal proximal tubular epithelial cells have decreased apoptosis in response to endoplasmic reticulum stress. Useful in studies of apoptosis due to ER stress. | 005530 |
|
|
P53 k/o (B6 background) |
Oren
|
Jax
|
002101
|
-/- mice develop tumors (lymphomas and osteosarcoma) at 3-6 months. +/- mice develop tumors at about 10 months. | 002101 | ||
P53 k/o (129 background) |
Oren
|
Jax
|
002080
|
as above | 002080 | ||
P53 515A knock in |
Oren
1.06 |
Lozano, Texas
|
|
Have a G-to-A substitution at nucleotide 515 of p53 corresponding to the p53R175H hot spot mutation in human cancers. Tumors from p53+/515A mice metastasize with high frequency. | Permission from Dr. Lozano required | ||
P63 k/o |
Oren
|
McKeon, Harvard
|
|
p63 -/- have limb truncations, craniofacial defects and no squamous epithelia including mammary, lacrymal and salivary glands. | |||
P73 k/o |
Animal Breeding Center
|
McKeon, Harvard
|
|
p73-deficient mice have neurological, pheromonal and inflammatory defects but notspontaneous tumours | |||
P19 ARF k/o |
Oren
|
St.Jude(Sherr)
|
|
Mice lacking tumor suppressor p19ARF but with functional p16INK4a develop tumors early in life | Permission required from Sherr | ||
DOCK2 k/o |
R.Alon
|
Fukui, Japan
|
|
DOCK2 -/- have migration defects of T and B lymphocytes. DOCK2 mediates cytoskeletal reorganization through Rac activation. | |||
P75 k/o |
Fainzilber
|
DechantMax Planck
|
|
-/- show hind limb ataxia, partial perinatal lethality, and defects in vascular system | |||
Runx 3 k/o |
Groner
|
Generated here
|
|
-/- have severe limb ataxia due to disruption of monosynaptic connectivity between intra spinal afferents and motoneuron | |||
Runx 2 k/o(Cbfa1) |
Groner
|
Olson,Harvard
|
|
-/- die of respiratory failure perinatally, skeleton has absence of osteoblasts and bone. -/+ have skeletal abnormalities | |||
Runx 1(lacZ) k/o(Cbfa2/ AML1) |
Groner
|
Speck,Dartmouth
|
|
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. | |||
SOD1transgene |
Schwartz/ Groner
|
Jax
|
002726
|
Mutant SOD transgene, hemizygotes become paralyzed in limbs due to loss of motor neurons from the spinal cord | 002726 | ||
SOD 51YG, (SOD69YG,70YG) transgene |
Groner
|
Generated here
|
|
Overexpress human DOD1. Have abnormal neuromuscular junction in tongue. | Cryopreserved | ||
SOD1*G93A)1Gur transgene |
Groner 2009
|
Jax
|
|
Express G93A mutant form of human SOD1.Hemizygotes exhibit a phenotype similar to amyotrophic lateral sclerosis (ALS) in humans; becoming paralyzed in limbs | 004435 | ||
Plg k/o(plasminogen) |
Miskin
|
Jax
|
002830
|
-/- viable and fertile, progressive pathology includes wasting, rectal prolapse, impaired wound healing, thrombosis etc. Die around 6 months. | 002830 | ||
alfa-MUPA transgene(urokinase-type plasminogen activator) |
Miskin
|
Generated here
|
|
Mice spontaneously eat less and live longer compared with the wild type control, thus mimicking calorically restricted mice | Cryopreserved | ||
LIS1 k/o |
Reiner
|
Generated here
|
|
Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization | |||
Fgfr2-D2 k/o |
Lonai
|
Generated here
|
|
Homozygote mid-gestation lethal. No limb development. | Cryopreserved | ||
Fgfr2-InsG33 k/o(specific k/o of 2c splice variant) |
Lonai
|
Generated here
|
|
Dwarf, skull base craniosynostosis,retarded osteogenesis mainly affecting the osteocyte lineage. | Cryopreserved | ||
Fgfr2-Cys32Tyr knockin (gain of function Fgfr2c) |
Lonai
|
Generated here
|
|
+/- viable, skull vault craniosynotosis, model for Crouzon syndrome. -/- perinatal lethal, skull, bone and lung defects | Cryopreserved | ||
FGFR3 knockin (gain of function) |
Givol
|
Generated here
|
|
A mouse model for achondroplasia produced by targeting fibroblast growth factorreceptor 3. FGFR3 loss of function also available. | Cryopreserved | ||
Cas k/o(Caspase 8) |
Wallach
|
Generated here
|
|
-/- lethal in utero, impaired heart muscle development and congested accumulation of erythrocytes. | Available on collaborative basis | ||
Cas 18.29 k/o |
Wallach
|
Generated here
|
|
Conditional caspase 8 knockout |
|
Available on collaborative basis | |
P55 DNS lox |
Wallach
|
Kollias,Greece
|
|
Mutation of the p55 TNF receptor, which prevents the shedding of the receptor |
|
Cryopreserved | |
Hex B k/o |
Futerman
|
Sandhoff,NIH
|
|
Mouse model of Sandhoff disease (neurodegenerative disorder), defective GM2 ganglioside degradation. | |||
Gba k/o(glucocerebrosidase) |
Futerman
|
Jax
|
002594
|
Animal model of Gaucher's . -/- die neonatally due to a defect in the skin vapor barrier, abnormal respiration that progresses to cyanosis and death | 002594 | ||
CHIF k/o |
Garty
|
Generated here
|
|
k/o of corticosteroid hormone-induced factor (CHIF) | Cryopreserved | ||
PTPe (protein tyrosine phosphatase e) k/o |
Elson
|
Generated here
|
|
Hypomyelination of sciatic nerve axons and increased activity of voltage-gated K+ channels in mice lacking PTPe | |||
PTPa (protein tyrosine phosphatase a) k/o |
Elson
|
Jan Sap,New York
|
|
-/- fibroblasts had impaired tyrosine kinaseactivity of both c-Src and Fyn, and an increase in c-Src Tyr527 phosphorylation. | |||
RPTP alpha k/o |
Elson 2.05
|
Hertog Utrecht
|
|
mice lack protein tyrosine phosphatase alpha (this is another strain of alpha KO mice distinct from those obtained from Jan Sap, NYU) | Requires permission from Dr. Den Hertog | ||
Dynic |
Reiner 1.05
|
Gene Trap Collection Germany
|
|
For details contact Prof. O.Reiner | http://tikus.gsf.de/ | Permission required | |
Ferritin heavy chain under fos promotor transgene |
Neeman
|
Generated here
|
|
Unpublished
|
|||
MCC (DAP kinase) k/o |
Kimchi 9.1999
|
Kimchi, Mitsubishi,Japan
|
|
Mice are viable and fertile. Hippocampalneurons are resistant to ceramide induced apoptosis | |||
K-ras LAI k/o |
Kimchi 29.9.03
|
MMHCC NCI Frederick
|
01BM2
|
Targeted latent 'hit-and-run' K-ras allele, mean age of death/ 300 days due to extensive tumor burden. Most frequent organ site is the lung. | 01BM2 | ||
HER 2 Neon Green tg |
Eshhar 9.06
|
Genentech
|
|
Over express human HER2 under the MMTV Promotor, leading to high incidence of mammary tumours. | Restricted to collaborators | ||
LFA1 k/o (Cd11a k/o) |
R. Alon 11.06
|
Jax
|
005257
|
Homozygotes do not display any gross abnormalities, exhibit peripheral leukocytosis due to an increased number of neutrophils. | 005257 | ||
DO11.10 tg |
R. Alon 11.06
|
Jax
|
003303
|
React to IP injected ovalbumin (OVA) peptide antigen, resulting in a deletion of immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. | 003303 | ||
Vegfr1 -lox FLT-1 lox Vegfr2 -lox FLT-1 lox |
Zelzer 9.06
|
Genentech
|
|
|
MTA from Genentech required | ||
IFN-gamma k/o |
Eshhar 12.06
|
Jax
|
002287
|
Homozygotes are viable and fertile. Display reduced macrophage function in response to pathogens. | 002287 | ||
MMTV-PyVMT transgene |
Wallach 2008
|
Frisch
West Virginia |
|
Carry the middle T oncogene under control of MMTV promoter/enhancer. Widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Majority developed secondary metastatic tumors in the lung. | MTA required | ||
Balb-cNeuT transgene (erbB-2) |
Eshhar 1.05
|
Melani, Milan
|
|
Carry activated rat c-erbB-2 oncogene under the MMTV LTR promoter. Develop early, multifocal tumors in breast, salivary, harderian and epididymal tissues | Requires permission from Prof. Melani | ||
Tgf beta k/o |
Groner 10.03
|
Jax
|
002220
|
-/- die at two to three weeks, due to a massive inflammatory cell response and tissue necrosis. Model for immune and inflammatory diseases | 002220 | ||
C3(1)/Tag transgene(SV 40 T underprostate promotor) |
Wallach 8.03
|
MMHCC NCI Frederick
|
01XB7
|
Model for prostate and mammary cancer. Female hemizygotes develop mammary adenocarcinoma. Male hemizygotes develop prostate adenocarcinoma. | 01XB7 | ||
TRAMP transgene |
Eshhar 2002
|
Greenberg
Seattle |
01XC6
|
Mice carrying the (TRAMP) transgene develop progressive forms of prostate cancer with distant site metastasis. | Greenberg Lab | Permission required | |
Rassf5 |
Alon 10.04
|
Kinashi,
Osaka |
|
-/- mice grow normally but lymphocytes defective in homing capability, resulting in hypoplastic secondary lymphoid organs and impairment of B cell maturation. Skin and splenic dendritic cells are severely affected in migration. | Permission required, see Alon | ||
129/Sv vim-/- |
Fainzilber 11.02
|
Pasteur Institute
|
|
Vimentin -/-. No obviouys phenotype. LacZ expression in disrupted gene demonstrates pattern of vimentin expression. | |||
BCL2-22WEHI |
Wallach 2003
|
Waisman, Cologne
|
|
Bcl2 expression in B lymphocytes | 002319 | Permission required, Dr J. Adams, WEHI | |
E![]() |
Moross Bank (Kimchi)
|
Jax
|
002728
|
Myc expression in the B cell lineage. Hemizygotes show increased pre-B cells in the bone marrow. Spontaneous pre-B and B cell lymphomas. | 002728 | Cryopreserved | |
Jh knockout |
Moses
|
Taconic
|
001147-M
|
Mice have no mature B-lymphocytes Normal,T-lymphocyte development. No IgM or IgG in serum. | 001147 | ||
p55 and p75 doubleknockout |
Wallach 19.1.02
|
Jax
|
003243
|
p55 and p75 deficient are viable and fertile. Double homozygous mutant mice fail to bind TNF. | 003243 | ||
TcrH-Y(B6D2(B6)-Tg TcrH-Y transgene |
Jung 2003
|
Institute for Genetics, Cologne
|
Taconic 004051
|
Mice have transgene encoding a TCR specific for male antigen (HY) in the context of model H2b. Used for studies on thymic negative selection. | 004051 | ||
Src k/o |
Geiger
3.04 |
Jax
|
002277
|
Homozygotes display osteopetrosis and are 1/3 the size of wildtype siblings. Incisors fail to erupt. Partial absence of bone marrow. | 002277 | ||
IL-12 k/o |
Groner
7.04 |
Jax
|
002693
|
Homozygotes have a severely restricted ability to mount a TH1 response,defective in IFN gamma production and type 1 cytokine responses. | 002693 | ||
IL-15 k/o |
Jung 5.05
|
Taconic
|
|
IL-15 KO mice lack NK cells and have a reduction in memory CD8 T cells, NKT cells and IELs. | |||
neuropilin-1 k/o conditional |
Zelzer 2.05
|
Kolodkin
Baltimore |
|
a conditional npn-1 (neuropilin-1 ) null mouse using Cre-loxP strategy | Permission from Kolodkin required | ||
neuropilin-2 k/o |
Zelzer 2.05
|
Kolodkin
Baltimore |
|
Homozygotes are viable. Npn-2 is required for the organization several cranial and spinal nerves. Several major fiber tracts in the brains severely disorganized or missing. | Permission from Kolodkin required | ||
Smoh k/o smoothened homologue |
Hermalin
4.04 |
Jax
|
004288
|
Homozygotes don’t develop past 9.5 dpc, have cyclopia and open gut, no embryonic turning, and normal rightward looping of the heart. Hedgehog pathway and L/R asymmetry disrupted. | 004288 | ||
Double transgene Mo/Hu APPswe PS1dE9 |
Schwartz
4.04 |
Jax
|
004462
|
Double transgenics express mutant human presenilin 1 and mouse/human amyloid precursor protein (APPSwe). Mice develop beta-amyloid deposits in the brains by 7 months of age. | 004462 | ||
CYLD k/o |
Wallach
3.04 |
Waisman,
Cologne |
|
Mice deficient in cylindromatosis tumor suppressor gene |
unpublished
|
Restricted to collaborators | |
Col11A2 k/o (FVB/N) |
Rousso
|
Smith
Iowa |
|
In homozygotes the mutation alters the collagen fibers network of the tectorial membrane which results in deafness. | Permission from Prof. Smith required | ||
Tectb k/o (129/C57B16J) |
Rousso 1.05
|
Richardson
Sussex |
|
-/- mice lack the tectorial membrane protein beta-tectorin. Removal of this protein was found to cause hearing impairments. | Permission from Prof. Richardson required | ||
Patched k/o (Ptch1) |
Zelzer 8.05
|
Jax
|
003081
|
Homozygotes embryonic lethal with open and overgrown neural tubes. Heterozygotes are larger than + with some hindlimb defects and brain tumors. Express lacZ in a pattern of endogenous gene expression. | 003081 | ||
B2m k/o |
Jung 5.05
|
Taconic
|
B2MN12-M
|
The B2m -/- mice are deficient in CD4-8+ T cells due to inactivation of the Beta 2-microglobulin gene. Useful for research in transplantation, gene therapy and immunological diseases. | B2m_N12.htm | ||
Msh2 k/o |
Shapiro 7.05
|
Edelmann
Albert Einstein |
|
Mutation ofMSH2 mismatch-repair (MMR) gene. Homozygotes develop spontaneous tumors by 6 months. Have a high level of MS instability in all cancerous tissues, but not in non-cancerous tissues | |||
Caspase-3 k/o CPP32 |
Gross
|
Flavell
Yale |
|
-/- mice, born at a lower than mendelian frequency, smaller than their littermates and died at 1-3 weeks of age. Abnormal brain development resulting in a variety of hyperplasias . | |||
CX3CL1(Fkn) k/o |
Jung 8.05
|
Lira, Mount Sinai, NY
|
|
The mouse harbors targeted mutation of the membrane-tethered chemokine CX3CL1/Fractalkine | Permission from Lira required | ||
hDC-SIGN transgene |
Jung 8.05
|
Littman, New York
|
|
Carries a transgen encoding the human DC-SIGN gene under the murine CD11c promoter |
unpublished
|
Permission from Littman required | |
Epas1 k/o |
Zelzer 3.07
|
Jax
|
003266
|
Homozygotes develop normally until E 11.5, but by E 16.5 there are no viable mutant embryos. Pronounced bradycardia, but overall development appears normal. Contain lacZ making them a marker for endothelial cells. | 003266 | ||
Klc k/o |
Fainzilber 7.07
|
Jax
|
004098
|
Homozygotes display perinatal mortality (60%). Surviving mice are noticeably smaller than wildtype mice and breed poorly, possibly due inadequate nurturing capabilities | 004098 | ||
MMTVPyVT tg |
Wallach 2.07
|
Jax
|
002374
|
Female mice carrying the (MMTV-PyVT) transgene developed mammary tumors by 5 weeks of age. Adenocarcinomas were found in virgin and breeder females as well as males. Model for metastatic disease | 002374 | ||
Apoe k/o |
Jung 9.07
|
Jax
|
002052
|
Apoe - mice have increased cholesterol levels. Also altered responses to stress, impaired spatial learning and memory, altered LTP, and damage. | 002052 | ||
Baff ko |
Jung 1.07
|
Biogen Idec, Inc., Cambridge
|
|
BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. | MTA required | ||
Alpha4 |
Fainzilber
|
Kohler Berlin
|
|
|
Restricted | ||
GATA knock-in |
Groner 10.07
|
Orkin Boston
|
|
GATA1 knock-in in leads to hyperproliferation of a unique, previously unrecognized yolk sac and fetal liver progenitor | Restricted | ||
STAT3-beta k/o |
Fainzilber 11.07
|
Poli Turin
|
|
STAT3-beta null mice | Restricted | ||
Klc1J ko |
Wallach 1.08
|
Jax
|
004098
|
Mice surviving to adulthood breed poorly.Motor defects are evident, as are alterations in intracellular localization of kinesin-I and COP-I components. | 004098 | ||
Ppt1tm1Hof k/o |
Reiner 2008
|
Jax
|
004313
|
Brain size of the mutant mice is reduced, neuronal loss and apoptosis in the hippocampus, cerebral cortex and cerebellum. Useful in studies of neuronal ceroid lipofuscinoses, including infantile Batten disease. | 004313 | ||
Tbx21 k/o |
Jung
|
Jax
|
004648
|
Homzygotes susceptible to Leishmania infections, females display hyper-responsiveness (AHR) with resulting airway remodeling similar to asthma. May be useful in studies human asthma and chronic intestinal inflammation. | 004648 | ||
DCTW-1 G595 knock-in |
Reiner 2008
|
Cai
NIH |
|
Knock –in of the G592 mutation causes dysfunction of Dynactin. -/- are embryonic lethal. Heterozygotes developed motor neuron disease phenotypes at 10 months. | MTA required | ||
K14-lnl/lnl k/o |
Futerman 2008
|
Karlsson
Sweden |
|
K14-lnl/lnl conditional knockout model: Exhibit rapid motor dysfunction associated with severe neurodegeneration and apoptotic cell death within the brain. Develop paralysis and die by 2 weeks. | Contact Prof. Futerman | ||
Nestin flox/flox conditional k/o |
Futerman 2008
|
Karlsson
Sweden |
|
GlcCerase deficiency is restricted to neural and glial cell progenitors and progeny. They develop similar pathological changes as the K14-lnl/lnl mice, but with delayed onset and slower progression - die by the age of 3 weeks. | Contact Prof. Futerman | ||
Tbx1deltaE5 k/o |
Horenstein 2008
|
EMMA
|
02224
|
Null allele of the Tbx1 gene. Some heterozygotes have aortic arch defects | emma 2224 | MTA required | |
Df(16)1_Bld k/o |
Horenstein 2008
|
EMMA
|
02122
|
Targeted deletion of a Chr. 16 segment between genes Es2 and Ufd1l. 5-10% of mutants die at birth because of heart defects (mainly interrupted aortic arch type B) | emma 2122 | MTA required | |
Tbx1lacZ k/o |
Horenstein 2008
|
EMMA
|
|
Null allele of Tbx1 gene with LacZ gene reporter insertion into exon 5. some heterozygotes have aortic arch defects. | MTA required | ||
TectA C1509G k/o |
Rousso 2008
|
Oghalai Houston
|
|
In heterozygotes the inner ear tectorial membrane attaches to one row of OHCs (Outer Hair Cells). Homozygotes have a tectorial membrane which does not attach to any rows. |
Unpublished
|
||
Prx1-Sox9/LacZ k/i |
Zelzer 2008
|
Akiyama Koyoto
|
|
Sox9 is misexpressed in the limb bud mesenchyme, using knockin of Sox9 to the Prx1 promoter. | |||
Csf2rb k/o |
Jung 2008
|
Jax
|
005940
|
In homozygous mice, bone marrow and splenocytes do not proliferate in response to GM-CSF. Model for PAP (pulmonary alveolar proteinosis) and other diseases. | 005940 | ||
Ccm2 gene trap |
Fainzilber 2008
|
Marchuk
Duke U |
|
Heterozygous animals develop cerebral vascular malformations, Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations. | Permission required from Douglas Marchuk | ||
Stat3-loxP |
Fainzilber 2008
|
Akira
Osaka |
|
The gene STAT-3 is flanked by two loxP sites. | Permission required from Prof. Shizuo Akira | ||
Ephb4 k/o |
Zelzer 12.08
|
Jax
|
006044
|
-/- embryonic lethal E9.5-10, growth retardation and lack of blood flow. Expression of lacZ in vascular endothelial cells. Useful for vasculogenesis and angiogenesis studies. | 006044 | ||
Thy1-ChR2-YFP tg |
Chen 1.09
|
Jax
|
007612
|
Transgene expressing light activated ion channel, and YFP fusion gene (ChR2-YFP) under thymus promoter. Useful for studies of neural activity by light stimulation. | 007612 | ||
K14-ER:Ras tg |
Oren 1.09
|
Jax
|
006403
|
Tamoxifen inducible expression of the ER:Ras fusion protein in epidermis promotes phenotypic characteristics observed in epidermal cancer. | 006403 | ||
Spp1 k/o |
Groner 1.09
|
Jax
|
004936
|
Defective wound repair and macrophage infiltration. Useful in studies of tissue remodeling, wound repair, fibrosis and granulomatous diseases. | 004936 | ||
INFg k/o |
Schwartz 12.08
|
Jax
|
002287
|
Homozygotes have no overt abnormalities, but display reduced macrophage function in response to pathogens. | 002287 | ||
INFgR k/o |
Schwartz 12.08
|
Jax
|
003288
|
Homozygotes have no overt abnormalities, but are defective in natural resistance; increased susceptibility to infection. | 003288 | ||
Rag Perforin k/o |
Hornstein 2008
|
Jax
|
004848
|
Double homozygotes lack mature T or B lymphocytes, no NK cell cytotoxic activity, and lack serum immunoglobulin. Develop thymic lymphomas. Useful in studies involving engraftment of human hematolymphoid cells. | 004848 | Permission from Schultz required | |
Rag Perforin Akita k/o |
Hornstein 2008
|
Jax
|
008659
|
Homozygous for Rag1 and perforin 1 (Prf1) and heterozygous for the spontaneous insulin 2 Akita allele. Mice immunodeficient and hyperglycemic. Useful in studies of human islet and beta stem and progenitor cell function. | 008659 |
As above and
Transplantation 76; 1036 |
Permission from Schultz required |
miR-155 k/o |
Hornstein 11.08
|
Rajewsky Harvard
|
|
Homozygotes have impaired immune function. | MTA required | ||
mir-17-92 flx/flx |
Hornstein 2008
|
Jacks MIT
|
|
Mutants for miR-17-92 die shortly after birth with lung hypoplasia and a ventricular septal defect . Also inhibited B cell development. | |||
mir-106a-363 K.O mir-106b-25 K.O |
Hornstein 2008
|
Jacks MIT
|
|
Homozygotes have no obvious phenotype. Compound mutants with mir-17-92 die at midgestation. | |||
FAK conditional k/o |
Hornstein 11.08
|
Beggs UCSF
|
|
Floxed focal adhesion kinase gene for conditional knockout. | MTA required | ||
TRPC-2 k/o |
T. Kimchi 2008
|
Dulac Harvard
|
|
Homozygotes lack the ability to detect pheromone signals via the VNO (vomeronasal organ) | Permission from Prof. Dulac required | ||
Ldlrtm1Her k/i |
Rubinstein 2009
|
Jax
|
|
Mice homozygous for the Ldlrtm1Her mutation have an elevated serum cholesterol level. Useful in Diabetes and Obesity Research | 002207 | ||
IRF-3 k/o |
Wallach 2009
|
RIKEN
|
|
Targeted mutation of the interferon regulatory factor 3. Significantly reduced production of interferon alpha/beta against virus infection. | 00858 | ||
EPAS 1 conditional tm |
Zelzer 6.09
|
Jax
|
008407
|
Floxed Epas1 allele (endothelial PAS domain protein 1 or Hif-2alpha hypoxia-inducible factor). | 8407 | ||
CAG-MIRN17-92,-EGFP |
Hornstein 9.09
|
Jax
|
008517
|
inducible expression of the human miR-17-92 cluster, associated with lymphomas and other cancers, autoimmune defects, and altered expression of tumor suppressor and pro-apoptotic genes | 8517 | ||
Myd88 floxed tm |
Jung 9.10
|
Jax
|
008888
|
Floxed allele of Myd88, useful in studies of Toll-like receptor signaling | 8888 | ||
Prnp-TARDB tg |
Hornstein 8.10
|
Jax
|
010700
|
Express a mutant human TAR DNA binding protein (TARDBP or TDP-43) associated with familial Amyotrophic Lateral Sclerosis (ALS) | 010700 | ||
Immorto-HE |
Elson 4.09
|
Charles River
|
237
238 |
Express thermolabile allele of SV40 Tantigen under MHC promotor | Immortomouse | ||
Lgals8 tm |
Zick 9.09
|
MMRRC
|
11734
|
Mutation of Lgals8 (lectin, galactose binding, soluble 8. Homozygotes have increased locomotor activity in the open field | 11734 |
|
|
á BMP4 tm |
Zelzer 2009
|
Trabin Harvard
|
|
|
Contact Eli Zelzer | ||
Mir17-92 tm |
Hornstein 6.09
|
Jacks MIT
|
008458
Jax |
Floexed miR-17~92 (overexpressed in human cancers). Homozygotes for the floxed miR17~92 allele viable, fertile, with no gross physical or behavioral abnormalities | 8458 | ||
Mir106b-25 tm |
Hornstein 6.09
|
Jacks MIT
|
008460
Jax |
Floexed miR-17~92 (overexpressed in human cancers). Homozygotes for the floxed miR17~92 allele viable, fertile, with no gross physical or behavioral abnormalities | 8460 | ||
TDP-K160R tm TDP-STOP tm |
Hornstein 6.09
|
Fisher UCL, London
|
|
Targeted point mutations in the TAR DNA binding protein |
|
||
Ihh -/- tm |
Zelzer 11.09
|
Mundlos
Max-Planck |
|
Homozygotes die before or immediately after birth due to respiratory failure. Exhibit limb dwarfism. | |||
Ephrin B2 lacz tm |
Zelzer 6.09
|
Jax
|
006039
|
Homozygotes growth retarded, enlarged heart at E10, lethality at E11. Useful in studying vasculogenesis and angiogenesis, neovascularization, including tumor angiogenesis. | 6039 | ||
TGFb RII tm |
Zelzer 7.09
|
Schweitzer Portland
|
|
Conditional knockout of TGF beta RII | |||
Adar1 f7-9 tm |
Harmelin 6.09
|
Orkin Harvard
|
|
Floxed allele of adar1. Nomozygotes viable and fertile | |||
C/EBPbeta (fl/fl) |
Rubinstein 3.09
|
Sterneck NCI, Frederick
|
|
C/EBP beta – mice have multiple phenotypes including skin. Increased apoptosis in keratinocytes after carcinogen treatment completely resistant to carcinogen-induced skin tumorigenesis | |||
RanBP-10 tm |
Fainzilber 9.09
|
Schulze Berlin
|
|
Mutant mice have platelet disfunction | |||
Alpha 5 tm |
Fainzilber 2010
|
Bader Berlin
|
|
importin-5 deficient-mice show normal brain development | |||
Spontaneous mutations etc. | |||||||
Quaking (qk) |
Volk
|
Jax
|
000506
|
Homozygous for the spontaneous quaking mutation (qk). Severely deficient in myelin in CNS and PNS | 000506 | ||
NOD scid B2m; |
Harmelin
|
Jax
|
003449
(002570) |
Model for xenograft transplantation studies and source for insulitis-free, MHC class I-negative islets for transplantation studies. | 002570 | ||
B6 scid |
Schwartz 12.04
|
Jax
|
001913
|
Mice homozygous for severe combined immune deficiency spontaneous mutation (scid) have absence of functional T cells and B cells. scid mice accept allogeneic and xenogeneic grafts -ideal for cell transfer experiments. | 001913 | ||
CD45 (ptprc)(congenic strain) |
Jung
|
Jax
|
002014
|
Used in transplant studies, carries the differential B cell antigen CD45 | 002014 |
|
|
Aly (alymphoplasia)Spontaneous mutation |
Wallach
|
Clea,Japan, Inc.
|
|
Systemic absence of lymph nodes (LN) and Peyer's patches (PP) and disorganized splenic and thymic structures with immunodeficiency | |||
BALB/c/CrSlc |
Groner 3.03
|
Japan SLC
|
|
Lymphopenic experimental autoimmune gastritis model. Following neonatal thymectomy 90% of these mice develop gastritis. | |||
C3.SW-H2b |
Jung 14.9.03
|
Jax
|
000438
|
Male mice predisposed to glucose intolerance and hyperinsulinemia with some mice exhibiting hyperglycemia. | 000438 | ||
10ScNJ (Tlr4 deletion) |
Jung 19.1.04
|
Jax
|
003752
|
Mice have a deletion of the Tlr4 gene that results in a defective response to LPS stimulation. | 003752 | ||
Toxic milk (Jackson) |
Reisner
9.04 |
Jax
|
001576
|
Tx-J/TxJ adults develop cirrhosis, infant mice copper deficient due to Cu deficient milk of mother. Useful for neurological disorders with Cu accumulation e.g. Alzheimers | 001576 | ||
splotch-delayed (Pax3Sp-d) |
Zelzer
9.04 |
Jax
|
000565
|
-/- embryos survive to birth, Homozygous splotch-delayed mutant embryos display caudal rachischisis only. Useful in dermatology ,neural crest and neural tube defects. | 000565 | ||
shiverer (Mbpshi) |
Ravel
6.04 |
Jax
|
001428
|
Homozygotes show a generalized tremor during locomotion which increases in severity with age, incoordination of hindlimbs. Severe myelin deficiency throughout the CNS. | 001428 | ||
HRS/J |
Wallach
8.05 |
Jax
|
000673
|
Homozygtes have a higher incidence and earlier onset of leukemia. Hair is lost from the follicle at 10 days. and mice eventually become continuously hairless. | 000673 | ||
Reeler (Orleans allele) |
Reiner
2005 |
Goffinet
Brussels |
|
Homozygotes exhibit an ataxic gait, and tremors from 2 weeks of age. These mutants are incapable of maintaining their hindquarters upright and often fall over during locomotor activity. | Permission from Goffinet required | ||
LOA |
Fainzilber
6.05 |
Fisher, London
|
|
ENU mutagenesis screen; harbours a point mutation in the dynein heavy chain. Homozygotes are not viable, heterozygotes exhibit impairment in retrograde transport in neurons. | Permission from Prof. Fisher required | ||
Swe |
Reiner 3.07
|
Jax
|
003012
|
Homozygotes for slow wave epilepsy spontaneous mutation (Nhe1) display locomomotor ataxia from at 11-14 days of age. Younger mice have seizure phenotypes similar to common human absence epilepsies. | 003012 | ||
Ticam1Lps2 |
Wallach 11.07
|
Jax
|
005037
|
ENU mutagenesis. Macrophages fail to respond to LPS and dsRNA with production TNF. Mice become ill and some die. Useful in studies of immunodeficiency and response to bacterial endotoxins and viruses. | 005037 | ||
B6.MRL-Faslpr/J |
Fainzilber 1.08
|
Jax
|
000482
|
Model for systemic lupus erythematosus-like autoimmune syndromes | 000482 | ||
Fe a/a-Mitfmi |
Hornstein 1.09
|
Jax
|
001573
|
Model for systemic lupus erythematosus-like autoimmune syndromes | 001573 |