Basic Services|Mouse Strains Databases

Note: A list of previously ordered mouse strains is available.
          Available strains are also listed in tables below. 

Mouse Strains Databases

The Moross Repository for Genetically-Modified Mice contains strains of transgenic and gene-targeted mice that were produced or obtained by Weizmann Institute scientists, which are no longer in use, but might reasonably be needed by WIS scientists in the future. The repository maintains strains of mice either as small nuclei of breeding pairs or as stocks of frozen embryos. The aim of the Repository is to free Institute scientists from the need to maintain strains that are potentially useful but which they themselves no longer need. The repository houses mice relevant to any discipline of scientific research performed at the WIS.

The Repository is funded by the MD Moross Institute for Cancer Research and by the Weizmann Institute of Science.

The Moross Repository will also participate in financing import of new and potentially interesting strains of transgenic or gene-targeted mice that are relevant to cancer research (as defined in a rather broad way). For additional information see the Moross Repository Guidelines below.

Submitting mice to the Moross Repository

Scientists who wish to suggest strains of mice for inclusion in the Repository are requested to contact:

Prof. Ari Elson, Department of Molecular Genetics, Tel: 2331, 2209
or Dr. Rebecca Haffner, Department of Veterinary Resources, Tel: 2719.

Once approval for acceptance has been secured, scientists are required to fill out an order form via
Internal Services > Moross Cancer Bank Res.

Requesting Mice from the Moross Repository

IACUC approval must be obtained for all mice requested from the Moross Repository.
Once IACUC approval has been secured, scientists are required to fill out an order form via
Internal Services > Moross Cancer Bank Res.

Moross Repository Guidelines

  1. The Moross Repository of Genetically-Modified Mice aims to maintain living or frozen stocks of select strains of genetically-modified mice that are no longer in use but which may be of potential future use by WIS scientists. In so doing the Repository maintains availability of potentially-useful strains of mice while freeing WIS scientists from the burden of maintaining stains they no longer need.
  2. The Moross Repository accepts genetically-modified mice relevant to any discipline of scientific research performed at the WIS.
  3. A strain of mice will be considered for inclusion in the Repository providing that:
    1. The strain is not maintained in parallel by any researcher at the WIS.
    2. There are no frozen stocks of this strain at the WIS.
    3. There is reasonable expectation that the strain may be needed in the future by WIS scientists other than the scientist who donated the strain.
    4. The legal/IP limitations on the use of the strain are such that it can be used by scientists other than the WIS donor.
    5. Other issues (broad scientific interest, ease/difficulty to obtain the strain from other sources, ease/difficulty to maintain the strain, available resources) may also be considered 
  4. Strains are accepted into the collection and are maintained without cost to the donating scientist.
  5. The Moross Repository maintains strains as small live breeding stocks and cannot provide large amounts of mice. WIS scientists may receive breeding pairs from the Repository with which to establish breeding colonies should they need more than a few mice for their studies.
  6. Strains of mice not in frequent demand will be frozen and maintained as stocks of frozen embryos. In order to preserve resources the Repository will typically not freeze strains of mice that are maintained as living colonies in the Jackson Labs or other providers, since it takes about as much time to import these mice as it does to thaw and re-establish them from frozen stock locally.
  7. Freezing of strains will be done at no cost to the donating scientist. However, costs of thawing embryos will be borne by the WIS scientist that requests it.
  8. Any WIS scientist may request breeding stocks from the Repository providing:
    1. He/she obtains IACUC approval.
    2. The legal/IP commitments undertaken by the WIS scientist who originally obtained the strain will be respected.
    3. If the line is frozen, costs of thawing will be borne by the WIS scientist who requests it 
  9. WIS scientists are strongly encouraged to freeze down strains of mice they no longer need without the intervention of the Moross Repository. Such freezing is currently free, is carried out by the staff of the mouse facility, and involves little effort on the part of the scientific group. The Repository will therefore accept only strains of mice of potential future use to several WIS groups.
  10. In extreme cases, where a scientist wishes to freeze down a strain and cannot do so due to backlogs in the freezing process, the Repository may accept a small number of these mice to maintain the line until freezing becomes possible. This will be done at no cost to the scientist; however, the scientist will be responsible for genotyping these mice, if needed.
  11. The Moross Repository adheres to and respects all legal/IP limitations undertaken by the WIS scientist/s who originally obtained the strains. Therefore, WIS scientists requesting strains from the Repository may have to request permission to do so from the original non-WIS source and/or may be required to sign MTAs or undertake other commitments.

Moross Repository table

Common Name /
Strain Name
Source in the WIS
Source
Stock #
Description
Link
Primary
Reference
Availability
Marker Lines
B5 EGFP /
STOCK Tg(CAG-EGFP)B5Nagy/J
Animal Breeding Center
Nagy, Toronto
003115
Transgene with GFP driven by chick beta-actin promoter. General GFP expression. 003115

Cryopreserved

Sperm

B6/PGK neo /
C57BL/6J-Tg(pPGKneobpA)3Ems/J
Animal Breeding Center
Jax
002356
Source of G418-resistant feeder cells for gene targeting   Live
DR4 /
STOCK Tg(DR4)1Jae/J
STOCK Tg(DR4)1Jae/J
Jax
003208
Resistance to G418, puromycin, 6-thioguanine and hygromycin. Donor for the production of multiple-drug resistant MEFs. NAR 25; 3745 Live
YFP-H (YFP 2.2) /
B6.Cg-Tg(Thy1-YFP)HJrs/J
Peles
Sanes, St. Louis
 
Same as YFP16, but stains different subset of neurons (see link) Cryopreserved Embryos
129 S6/SvEv /
129S6/SvEvTac
Elson
Taconic
129SVE
Knockout mice developed from 129 agouti ES cell lines can be maintained on an agouti 129 background by mating to Taconic's 129 strain
 
Live
129X1/SvJ /
129X1/SvJ
Gross 05
Jax
000691
129 strain most closely matching the R1 ES cell line Live
C57BL/6J-Tyrc-2J /
B6(Cg)-Tyrc-2J/J
Animal Breeding Center 2003
Jax
000058
C57Bl mice with coat colour mutation, homozygotes are albino. Used as blastocyst donor for C57BL ES cell chimeras Live (Cryopreserved Embryos)
Cre and Flp strains
B(MCM) cre
Wallach
M.Reth, Freiburg
 
Inducible Cre expression in B lymphocytes  
 
Cryopreserved Embryos
Mogi-cre /
Mogtm1(cre)Gkl
Wallach
9.04
Waisman,
Cologne
 
Cre-mediated excision in oligodendrocytes. (Mouse on C57BL/6 background) MOG Cryopreserved Embryos
Alb-cre /
B6.Cg-Tg(Alb-cre)21Mgn/J
Wallach
Jax
003574
Liver-specific cre-mediated excision Cryopreserved Embryos
Balancer cre
(Nes-cre) /
STOCK Tg(Nes-cre)1Wme/J
Wallach
Jax
002858
Variable deletion of loxP genes generates mosaic mice which can bypass lethality Cryopreserved Embryos
Dhh-cre /
FVB(Cg)-Tg(Dhh-cre)1Mejr/J
Peles
Meijer, Holland
 
Cre under desert hedgehog promoter, schwann cell specific Gene Dev 17; 1380 Cryopreserved Embryos
Pgk-cre /
Tg(Pgk1-cre)1Lni
Lonai
Lonai
 
General cre deletor strain, maternally expressed.   Live (Cryopreserved Sperm)
R/ERT /
STOCK Polr2atm1(cre/ERT2)Bbd/J
Hornstein 7.06
Barbacid
Madrid
 
Uniform Cre activity upon systemic 4OH-Tamoxifen exposure in all tissues, low cleavage in brain. Cleavage efficiency is locus dependent. Live
MSX-limb-cre
Animal Breeding Center
 
 
Cre-mediated excision in limb regions   Cryopreserved Embryos
ED-cre
Wallach
Waisman,
Cologne
 
Inducible Cre expression in B lymphocytes   Cryopreserved Embryos
tie-1-Cre /
Tg(Tie1-cre)9Ref
Wallach
Gustafsson,
Sweden
 
Cre expression specifically in endothelial cells from embryonic stage E8 Cryopreserved Embryos
Ins2-cre (RIP-cre) /
B6.Cg-Tg(Ins2-cre)25Mgn/J
Wallach
Jax
003573
Pancreas specific cre-mediated excision Cryopreserved Sperm
Z/AP /
STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
Animal Breeding Center
Lobe, Toronto
003919
Cre reporter, constitutive LacZ expression replaced by alk phos, following cre-mediated excision Cryopreserved Embryos
Z/EG /
STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
Animal Breeding Center
Lobe, Toronto
00320
Cre reporter, constitutive LacZ expression replaced by GFP, following cre-mediated excision Live
K5 CRE_PR1 /
Tg(KRT5-cre/PGR)1Der
Wallach 12.07
Waisman Cologne
 
cre under inducible keratin promotor results in expression in epidermis and hair follicles Cryopreserved Sperm
B6.CD19-Cre /
C.Cg-Cd19tm1(cre)Cgn Ighb/J
Wallach
Waisman, Cologne
 
Cre under CD19 promoter deletes B-lymphocytes from the earliest stages Cryopreserved Sperm
MHC-Cre (Alpha-MyHC-Cre) /
B6.FVB-Tg(Myh6-cre)2182Mds/J
Gross 7.07
De Windt Utrecht
 
Cre recombination in cardiac muscle Live
Conditional Dicer /
STOCK Dicer1tm1Bdh/J
Groner
2.06
Tabin, Harvard
 
cre-inducible conditional allele of Dicer for studying miRNA function. Used to remove Dicer function in any tissue in which cre recombinase can be expressed. Cryopreserved Embryos
A-myosin heavy chain (MerCreMer) /
B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
Wallach
Molkentin, Cincinatti
 
Tamoxifen inducible cre-mediated excision in adult and embryonic heart Cryopreserved Embryos
PV-cre /
B6;129P2-Pvalbtm1(cre)Arbr/J
Groner 2007
Arber Basel
 
Cre is expressed from the PV locus. Cre expressed in to PV+ proprioceptive DRG neurons Cryopreserved Embryos/Sperm
Pf4-cre /
C57BL/6-Tg(Pf4-cre)Q3Rsko/J
Groner 2008
Skoda Basel
 
Cre expressed from the Pf4 (platelet factor 4) locus. Expressed exclusively in the megakaryocytic lineage Cryopreserved Embryos/Sperm
Ckmm-cre /
B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
Gross 2011
Jax
006475
Cre under muscle creatine kinase promoter, expressed in skeletal and cardiac muscle Live
LeptinR-cre /
B6.129-Leprtm2(cre)Rck/J
Elson 2011
Jax
008320
Cre activity in hypothalmus, limbic and cortical brain regions and retrosplenial cortex. Live
MMTV-cre /
Stock (Tg (MMTV-cre) 4Mam/J)
 
Jax
003553
Cre under MMTV LT promoter. Recombination in mammary gland, salivary gland, seminal vesicle, skin, erythrocytes, B cells and T cells. Live
Vil-cre /
B6.SJL-Tg(Vil-cre)997Gum/J
Groner 2008
Jax
004586
Cre under mouse villin 1 promoter, Recombination in villi and crypt cells of the small and large intestines. 004586 Cryopreserved Embryos
FlpeR - B6 /
B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/RainJ
Cancer Bank
Jax
009086
Widespread expression of FLPe, for deletion of frt-flanked sequences. NB the Y chromosome may not have been fixed to the genetic background during the backcross. 009086 Live
FLP1eR - 129 /
129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J
Groner 10.05
Jax
003946
General Flp deleter strain. FLP1 recombinase expressed constitutively under Gt(ROSA)26Sor promoter. FLPe has enhanced thermostability with recombination activity being four-fold of wild type FLP at 37°C 003946 Live
Transgenes and Knockouts
Rag 1 k/o(C57BL/6J) /
B6.129S7-Rag1tm1Mom/J
Wallach
Jax
002216
-/- mice produce no mature T cells or B cells. "non-leaky" severe combined immune deficiency Cryopreserved Embryos
P19 ARF k/o /
B6*P 19 ARF+/-
Oren
St.Jude (Sherr)
 
Mice lacking tumor suppressor p19ARF but with functional p16INK4a develop tumors early in life Cryopreserved Embryos
ATM
Groner, Elson
Leder, Harvard
 
Mice lack the ataxia-telangiectasia (AT) gene product Cryopreserved Embryos/Sperm
FGFR3 knockin(gain of function)
Givol
WIS
 
A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3 Cryopreserved Embryos/Sperm
Src k/o /
B6.129S7-Srctm1Sor/J
Geiger
3.04
Jax
002277
Homozygotes display osteopetrosis and are 1/3 the size of wildtype siblings. Incisors fail to erupt. Partial absence of bone marrow. Live
Bax k/o /
B6.129X1-Baxtm1Sjk/J
Geiger
Jax
002994
Bax-deficient mice with lymphoid hyperplasia and male germ cell death Cryopreserved Embryos
SOD 51YG,
(SOD69YG, 70YG)
transgene
Groner
Generated
here
 
Overexpress human DOD1. Have abnormal neuromuscular junction in tongue.   Cryopreserved Embryos
IL1alpha-beta tm (ICR) /
IL1alpha-beta KO (ICR)
Groner
2012
Apt BGU
 
Healthy and fertile (background transferred to ICR at WIS quarantine)
 
Cryopreserved Sperm
Tgf beta k/o /
B6.129S2-Tgfb1tm1Doe/J
Groner 10.03
Jax
002220
-/- die at two to three weeks, due to a massive inflammatory cell response and tissue necrosis. Model for immune and inflammatory diseases Cryopreserved Sperm
TRAMP transgene,/
C57BL/6-Tg(TRAMP)8247Ng/J
Eshhar 2002
Greenberg
Seattle
01XC6
Mice carrying the (TRAMP) transgene develop progressive forms of prostate cancer with distant site metastasis. Cryopreserved Sperm
Nkx3.1 k/o(homeobox)
Wallach 8.03
MMHCC NCI Frederick
01XB3
Homozygous males display prostatic epithelialhyperplasia and dysplasia Heterozygous mice display a similar, less severe phenotype. 01XB3 Cryopreserved Embryos
Mos k/o /
129S6/SvEv-Mos tm1Ev/J
Zaffriri
1.2005
Jax
002722
Homozygous males are fertile; homozygous females have small litters. Eggs undergo spontaneous parthenogenetic activation. Ovarian cysts develop as young as one month. Cryopreserved Sperm
'floxed' PTEN /
B6.129S4-Ptentm1Hwu/J
Wallach
Pandolfi
Sloan-Kettering
 
Allows conditional inactivation of tumor suppressor PTEN.
 
Cryopreserved Sperm
CMV:tTA
Neeman 11.07
Keshet HUJ
 
Tet inducible transgene under CMV promotor
 
Cryopreserved Sperm
Talin flx /
Tln1tm4Crit
Alon 2008
Critchley Leicester UK
 
Conditional mutant of talin flaked by loxP sites Tln1 Crit MGI Cytopreserved Embryos
Jak2 tm /
Jak2tm1Kuw
Elson 2011
Wagner Nebraska
 
Mutants die around midgestation and exhibit impaired definitive erythropoiesis Jak2 MG! Cytopreserved sperm
(gc)/Rag2 common gamma/Rag2 double k/o /
B10;B6-Rag2tm1Fwa II2rgtm1Wjl
Groner 1.06
Moross Bank 5.10
Taconic
004111
The double knock-out lacks T cells, B cells, and NK cells. Useful for transplanting allogeneic or xenogeneic stem cells. 004111 Live
MMTV-Erbb2 tg (MMTV Neu) /
FVB-Tg(MMTV-Erbb2)NK1Mul/J
Elson 2010
Jax
005038
Express activated Erbb2 (c-neu) oncogene under MMTV promoter. 50% of transgenic mice develop tumors within 6-12 months of age. 005038 Cytopreserved Embryos/Sperm
MMTV-Myc Transgene /
FVB-Tg(MMTV-Myc)141-3Led
Elson 2.05
MMHCC NCI Frederick
01XG2
Develop adenocarcinomas of mammary tissue and in some cases lymphomas develop at low frequency. 01XG2 Cytopreserved Sperm
MMTV-PyVT /
FVB/N-Tg(MMTV-PyVT)634Mul/J
Oren 2013
Jax
002374
Polyoma Virus middle T antigen under MMTV promoter/enhancer. Females develop mammary tumors at 5-40 weeks, which metastasize to the lung. Males also develop mammary tumors. 002374 Live
RPTP zeta k/o
Elson 2004
Harroch, IPasteur
 
RPTPbeta-deficient mice are viable, are fertile, and showed no gross anatomical alterations in the nervous system or other organs.   Live
P55 DNS lox
Wallach
Kollias, Greece
 
Mutation of the p55 TNF receptor, which prevents the shedding of the receptor     Cryopreserved Embryos
Tg.Ac /
FVB/N-Tg(MMTV-PyVT)634Mul/J
Groner 2012
Taconic
 
Transgenic mouse carries activated v-Ha-ras oncogene under promoter of the mouse embryonic alpha-like, zeta-globin gene.Used in screening tumor promoters and assessing antitumor and antiproliferative agents. Taconic Cryopreserved Embryos/Sperm
NOT FOR DISTRIBUTION

 

Mouse strains table

Common Name
Scientist
Source
Stock #
Description Link
Primary
Reference
Other
Marker Lines
B5 EGFP
Animal Breeding Centre
Nagy,
Toronto
003115
Transgene with GFP driven by chick beta-actin promoter. General GFP expression 003115  
actin eGFP
transgene
Elson 2.05
Matus
Basel
 
Carry actin-GFP fusion transgene under the actin promoter. Results in mice with GFP labeled actin.   Requires an MTA from FMI, Basel
ACTbEGFP
Schwartz 4.05
Jax
Basel
003291
Express EGFP cDNA under chicken beta-actin promoter and cytomegalovirus enhancer. All tissues green, except erythrocytes and hair. Homozygotes die 14days p.n. 003291  
UBI-GFP
R. Alon 11.06
Jax
004353
GFP under human ubiqutin C promoter, express GFP in all tissues examined. Certain hematapoetic cell types display distinct expression levels of GFP, allowing identification by FACS analysis. 004353  
B6/PGK neo
Animal Breeding Centre
Jax
002356
Source of G418-resistant feeder cells for gene targeting 002356
 
 
Rosa 26
Animal Breeding Centre
Jax
002073
lacZ is expressed in all tissues of the embryo and in most tissues of the adult mouse. 002073  
YFP16
Peles
Sanes,
St.Louis
 
Express YFP in motor and sensory neurons. Expression strong from a mid-gestational stage into adulthood 003709  
YFP-H (YFP 2.2)
Peles
Sanes,
St.Louis
 
Same as YFP16, but stains different subset of neurons (see link) 003782  
Col2 GFP
Yayon 4.03
Horton, Portland
 
Transgenic mice carrying the GFP gene under the control of the collagen 2 promoter. GFP expression in chondrogenic areas    
SCE/LacZ
Peles 6.03
Meijer,Holland
 
LacZ under control of schwann cell enhancer  
Unpublished
Restricted access, contact Ori Peles
SCE/GFP+/-
Peles 6.03
Meijer,Holland
 
GFP under control of schwann cell enhancer  
Unpublished
Restricted access, contact Ori Peles
C57BL/6J-Tyrc-2J
Animal Breeding Center 14.9.03
Jax
000058
C57Bl mice with coat colour mutation, homozygotes are albino. Used as blastocyst donor for C57BL ES cell chimeras 000058  
C.B 20
Animal Breeding Center 14.9.03
(Jerusalem)Cologne
 
BALB/c xC57Bl backcross. Used as blastocyst donor for C57BL ES cell chimeras.(C.B20 is 3 generations further backcross then C.B17) C.B17
 
 
129X1/SvJ
Gross 10.05
Jax
00691
129 strain most closely matching the R1 ES cell line 000691  
129 S6/SvEv
Elson
Taconic
129SVE
Knockout mice developed from 129 agouti ES cell lines can be maintained on an agouti 129 background by mating to Taconic's 129 strain 129SVE
 
 
129/pas
Lonai
Geunet,Pasteur, Paris
 
129 substrain recommended for breeding knockout lines    
B6129SF2/J
Ravel
Jax
101045
Parental strains C57BL/6J, 129S1/SvImJSuggested controls for strains designated B6;129S 101045
 
 
TIE2-GFP
Zelzer 4.05
Jax
003658
Express GFP under endothelial-specific receptor tyrosine kinase (Tek, formerly, Tie2) promoter. 003658  
Topgal
(fos-lac-Z)34Efu/J
Zelzer 6.05
Jax
004623
Transgenic mice display Beta-gal activity during embryonic development in developing hair follicles. Useful in studies of the Wnt signaling pathway. 004623  
DBA/2J
Eshhar 6.07
Jax
000671
Inbred strain. Vision and hearing defects, intolerant to alcohol and morphine 000671  
Hox7b-GFP tg
Garti 7.09
Kispert Germany
 
Transgenic mouse that expresses EGFP under the Hoxb7 promoter    
Cre and Flp strains
E IIa-cre
Reiner
Jax
003314
Cre transgene under adenovirus EIIa promoter. General deletor strain. 003314  
Pgk-cre
Lonai
Lonai
 
General cre deletor strain, maternally expressed    
R/ERT
Hornstein 7.06
Barbacid
Madrid
 
Uniform Cre activity upon systemic 4OH-Tamoxifen exposure in all tissues, low cleavage in brain. Cleavage efficiency is locus dependent.    
Mx-cre (Msx-1 cre)
Wallach
H.Cedar,
Jerusalem
Jax 003556
Cre under control of interferon-responsive promoter. Available on C57BL background. 003556  
Bf-1-cre
Reiner
McConnell,
Stanford
 
Cre targeted to Bf-1 (Foxg1) locus. cre-mediated excision in telencephalon and discrete head structures.    
Wnt-cre
Zelzer 2005
Tabin, Harvard
 
Cre-activity within the embryonic central nervous system from E8.5.    
CAGS-Cre/ERT
Hornstein 7.06
 
 
Tamoxifen-inducible form of Cre mediates recombination within the embryonic central nervous system.    
Pax3 Cre
Hornstein 7.06
Epstein
Philadelphia
 
Cre activity in Pax3-expressing cells including neural crest and somites.   MTA required
MSX-limb-cre
Animal Breeding Center
 
 
Cre-mediated excision in limb regions   Cryopreserved
LysM-cre
Wallach
Forster, Germany
 
Cre-mediated excision in myeloid cells 004781 Restricted to collaborators
Lck-cre
Animal Breeding Center
Taconic
004204-M
Cre under Lck (lymphocyte protein tyrosine kinase) promotor, deletes T cell lineage at the double negative stage 004204-M
mixed background
deletions in non-lymphoid tissue possible
B(MCM)
Wallach
M.Reth, Freiburg
 
Inducible Cre expression in B lymphocytes  
 
Restricted to collaborators; Cryopreserved
Dhh-cre
Peles
Meijer, Holland
 
Cre under desert hedgehog promoter, schwann cell specific   Cryopreserved. Requires permission from D.Meijer
MBP-cre
Wallach
Kollias, Greece
 
Cre-mediated excision in oligodendrocytes kollias
unpublished
Restricted to collaborators
Mogi-cre
Wallach
9.04
Waisman,
Cologne
 
Cre-mediated excision in oligodendrocytes. (Mouse on C57BL/6 background) MOG Restricted to collaborators; Cryopreserved
CNP-Cre
Peles
1.05
Nave
Göttingen
 
Cre is expressed under the control of CNP promoters. CNP is expressed in oligodendrocytes and to a lesser extent in Schwann cells.   Permission from Peles and Nave required
VChAT Cre
Hornstein 7.06
Misawa, Tokyo
 
Cre expression in a subset of cholinergic neurons in the somatomotor nuclei and medial habenular nucleus.   MTA required
Alb-cre
Wallach
Jax
003574
Liver-specific cre-mediated excision 003574 Cryopreserved
Ins2-cre
(RIP-cre)
Wallach
Jax
003573
Pancreas specific cre-mediated excision 003573  
RIP-cre/ERT
Hornstein 7.06
Dor, Harvard
 
Tamoxifen-inducible form of Cre mediates recombination in pancreatic beta-cells   MTA required
Pdx1 Cre/ERT
Hornstein 7.06
Melton, Harvard
 
Tamoxifen-inducible form of Cre mediates recombination in Pdx1-expressing cells   MTA required
Balancer cre
(Nes-cre)
Wallach
Jax
002858
Variable deletion of loxP genes generates mosaic mice which can bypass lethality 002858 Cryopreserved
B6.CD4-Cre
Wallach
Waisman, Cologne
 
Cre under CD4 promoter deletes most thymocytes at the double positive stage    
ED-cre
Wallach
Waisman, Cologne
 
Inducible Cre expression in B lymphocytes   Cryopreserved, Requires Permission
B6.Cg-Tg(Lck-cre)
Wallach
Jax
003802
Expresses Cre recombinase in thymocytes 003802  
tie-1-Cre
Wallach
Gustafsson Sweden
 
Cre expression specifically in endothelial cells from embryonic stage E8   Cryopreserved, Restricted to Collaborators
Vil-cre
Jung 5.05
MMHCC NCI Frederick
01XE7
Cre expression in the intestine, colon and proximal tubule of the kidney 01XE7  
CaM KII cre
Wallach 11.05
Probert Athens
 
Cre recombination in adult forebrain   Permission from Probert required
Col 1-cre
Zelzer 6.05
Karsenty, Baylor
 
Cre expression in osteoblasts   Permission from Karsenty required
GDF5-cre
Zelzer 9.06
Kinsley, Stanford
 
Cre avtivity in developing joints    
Z/AP
Animal Breeding Center
Lobe, Toronto
003919
Cre reporter, constitutive LacZ expression replaced by alk phos, following cre-mediated excision 003919  
Z/EG
Animal Breeding Center
Lobe, Toronto
00320
Cre reporter, constitutive LacZ expression replaced by GFP, following cre-mediated excision. 003920  
Rosa26R
Zelzer 2005
Harvard
Jax 006148
EYFP expression is observed when bred to mice with a cre gene under a promoter of interest. Useful in monitoring Cre lineage expression. 006148
 
 
RA/EG
Jung
Foerster, Munich
 
Carry a conditional GFP gene in the RAGE locus. RA/EG, can therefore serve a reporter mice for Cre activity.   Restricted access, contact Bernd Arnold
BPA -/-
(R26:LacZ-PBA/DT-A)
transgene
Peles 1.05
Riethmacher
Hamburg
 
Floxed diphtheria toxin fragment A gene in the ROSA26 locus. Allows depletion of specific cell types in vivo following Cre-mediated gene recombination.   Permission from Peles and Riethmacher required
Isl1-cre
Reiner 4.05
Pfaff Salk Inst.
 
Cre expression in motor neurons and in a subtype of dorsal interneurons in the spinal cord    
Isl1-Cre
Zahor 11.07
Evans UCSD
 
expresses Cre in specific myocardial lineages   MTA required
Isl1-MCM
Zahor 11.07
Evans UCSD
 
Islet 1 tamoxifen inducible Cre   MTA required
Cdh5-cre
Zelzer 2008
Jax
006137
Cre under VE-Cadherin (Cdh5) mouse promoter. Expressed in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells 006137  
Col2a1-cre/ESR1
Zelzer 2008
Jax
006774
Strong tamoxifen-inducible cre expression directed to cells of the chondrogenic lineage (cartilage), with minimal (<0.1%) cre activity in the absence of tamoxifen 006774  
Prm-cre
Wallach 2008
Jax
003328
Cre under protamine 1 promoter mediates recombination in the male germ line, but not in other tissues. Used to produce homologously recombined alleles in mice that have been secondarily rearranged by site-specific recombinase. 003328  
Neurog-3 cre
Horenstein 2008
Jax
006333
Cre under neurogenin 3 promoter Recombination in the small intestine and fetal pancreatic epithelial cells. Also in islets of the adult pancreas, and other endocrine cells. 006333  
Osx1-GFP:Cre
Zelzer 2008
Jax
006361
Carries both tTA under the regulation of the osterix (Sp7) promoter and a tetracycline responsive GFP/Cre fusion protein. Useful in studies of bone development, osteoblast lineage, and Hedgehog/Wnt signaling. 006361  
Pomc1 cre
Chen 2008
Jax
05965
Cre under Pomc1 cre promotor. Activity in brain area neurons involved in the control of food intake (arcuate nucleus (hypothalamus) and solitary tract nucleus (hindbrain)). 005965  
ePet-Cre
Chen 2008
Deneris Cleveland
 
Carry the Cre recombinase gene under the control of ePet promoter, Cre expression mainly in serotonergic neurons.   Requires permission from Evan Deneris
Advillin cre
Fainzilber 2008
Wang, Duke U
 
cre gene under the promotor of Advillin    
Th-IRES-Cre.Rosa YFP
T. Kimchi 2009
Mizrahi HUJ
 
knock-in expressing Cre from the 3'UTR of the tyrosine hydroxylasegene by means of an IRES sequence   Requires permission from Tali Kimchi
Nkx2-1-cre
Hornstein 7.09
Jax
008661
cre expression in subgroups of brain interneuron progenitors, developing lung, thyroid, and pituitary 8661  
LepRb-IRES-Cre
Elson 1.10
Jax
008320
Cre activity in hypothalmus and in those neurons that express neuropeptide Y or the leptin receptor 8320  
Nefh-cre
Futerman 4.10
MMRRC
015960
Expression of cre in neurons of the brain and spinal cord during late development (~ E18.5). 015960  
Matn1-Cre
Zelzer 4.09
 
 
Expression of Cre recombinase in all the growth plate chondrocyte with the exception of articular chondrocytes.á    
Shh-gfp cre
Zelzer 4.09
Tabin Harvard
 
Cre-gfp knocked into shh locus    
Sox4 tm
Jung 11.09
Lefebvre Cleveland
 
Conditional "floxed" allele of Sox4. Sox4-null mice die at embryonic day 14 from heart malformation.    
Transgenes and knockouts
129 inf gamma k/o
Harmelin
Jax
002287
-/- show reduced macrophage function in response to pathogens. Hyper-proliferation of splenocytes in response to mitogens 002287  
Rag 1 k/o(C57BL/6J)
Wallach
Jax
002216
-/- mice produce no mature T cells or B cells. "non-leaky" severe combined immune deficiency 002216  
Rag 1 k/o(BALB/c)
Jung
Schwartz, 4.04
Jax
003145
-/- mice produce no mature T cells or B cells. "non-leaky" severe combined immune deficiency (as above) 003145  
CD8 k/o
Moses 7.06
Jax
002665
Homozygotes are deficient in functional cytotoxic T-cells; however, helper T-cell development and function is comparable to normal. 002665  
Nrcam k/o
Peles 7.06
Grumet
Rutgers
 
In homozygotes cerebella do not exhibit obvious histological defects, although a mild size reduction of several lobes is observed. Nrcam Contact Elior Peles
Nfasc k/o
Peles 7.06
Brophy
Edinburgh
 
In homozygotes neither paranodal adhesion junctions nor nodal complexes are formed.   Contact Elior Peles
4.1B k/o
(Epb4.1l3)
Peles 7.06
Kissel
Philadelphia
 
No abnormal phenotype detected in homozygotes. Epb4.1l3 Contact Elior Peles
Igh-6 k/o (muMT)
Jung
Jax
002249
Homozygous mutants lack mature B-cells. 002249  
ATM
Groner, Elson
Leder, Harvard
 
Mice lack the ataxia-telangiectasia (AT) gene product.   Requires permission from P. Leder; Cryopreserved
Cntn1 k/o
Peles 7.06
Ranscht, La Jolla
 
Homozygotes have severe ataxic phenotype consistent with defects in the cerebellum, survive until postnatal day 18. Cntn1 Contact Elior Peles
DO11.10 transgene
Jung
Jax
003303
Rearranged T cell receptor transgene, ovalbumin responsive, deletes CD4+ CD8+ TCRlo thymocytes. 003303  
TcraTcrb transgene
Jung
Jax
003831
Transgenic T cell receptor recognizes ovalbuminm with H2Kb, used to study peptides in positive selection and response of CD8+ T cells to antigen. 003831  
Bax -/- k/o
Groner
Jax
002994
Bax-deficient mice with lymphoid hyperplasia and male germ cell death 002994 Cryopreserved
B6 Bid k/o
Gross
Korsmeyer, Harvard
 
Bid (bcl2 family)-deficient mice are resistant to Fas-induced hepatocellular apoptosis    
chop-(Ddit3) k/o
Kimchi
4.06
Jax
005530
homozygotes viable, fertile. MEFs and renal proximal tubular epithelial cells have decreased apoptosis in response to endoplasmic reticulum stress. Useful in studies of apoptosis due to ER stress. 005530
 
 
P53 k/o (B6 background)
Oren
Jax
002101
-/- mice develop tumors (lymphomas and osteosarcoma) at 3-6 months. +/- mice develop tumors at about 10 months. 002101  
P53 k/o (129 background)
Oren
Jax
002080
as above 002080  
P53 515A knock in
Oren
1.06
Lozano, Texas
 
Have a G-to-A substitution at nucleotide 515 of p53 corresponding to the p53R175H hot spot mutation in human cancers. Tumors from p53+/515A mice metastasize with high frequency.   Permission from Dr. Lozano required
P63 k/o
Oren
McKeon, Harvard
 
p63 -/- have limb truncations, craniofacial defects and no squamous epithelia including mammary, lacrymal and salivary glands.    
P73 k/o
Animal Breeding Center
McKeon, Harvard
 
p73-deficient mice have neurological, pheromonal and inflammatory defects but notspontaneous tumours    
P19 ARF k/o
Oren
St.Jude(Sherr)
 
Mice lacking tumor suppressor p19ARF but with functional p16INK4a develop tumors early in life   Permission required from Sherr
DOCK2 k/o
R.Alon
Fukui, Japan
 
DOCK2 -/- have migration defects of T and B lymphocytes. DOCK2 mediates cytoskeletal reorganization through Rac activation.    
P75 k/o
Fainzilber
DechantMax Planck
 
-/- show hind limb ataxia, partial perinatal lethality, and defects in vascular system    
Runx 3 k/o
Groner
Generated here
 
-/- have severe limb ataxia due to disruption of monosynaptic connectivity between intra spinal afferents and motoneuron    
Runx 2 k/o(Cbfa1)
Groner
Olson,Harvard
 
-/- die of respiratory failure perinatally, skeleton has absence of osteoblasts and bone. -/+ have skeletal abnormalities    
Runx 1(lacZ) k/o(Cbfa2/ AML1)
Groner
Speck,Dartmouth
 
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.    
SOD1transgene
Schwartz/ Groner
Jax
002726
Mutant SOD transgene, hemizygotes become paralyzed in limbs due to loss of motor neurons from the spinal cord 002726  
SOD 51YG,
(SOD69YG,70YG)
transgene
Groner
Generated here
 
Overexpress human DOD1. Have abnormal neuromuscular junction in tongue.   Cryopreserved
SOD1*G93A)1Gur transgene
Groner 2009
Jax
 
Express G93A mutant form of human SOD1.Hemizygotes exhibit a phenotype similar to amyotrophic lateral sclerosis (ALS) in humans; becoming paralyzed in limbs 004435  
Plg k/o(plasminogen)
Miskin
Jax
002830
-/- viable and fertile, progressive pathology includes wasting, rectal prolapse, impaired wound healing, thrombosis etc. Die around 6 months. 002830  
alfa-MUPA transgene(urokinase-type plasminogen activator)
Miskin
Generated here
 
Mice spontaneously eat less and live longer compared with the wild type control, thus mimicking calorically restricted mice   Cryopreserved
LIS1 k/o
Reiner
Generated here
 
Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization    
Fgfr2-D2 k/o
Lonai
Generated here
 
Homozygote mid-gestation lethal. No limb development.   Cryopreserved
Fgfr2-InsG33 k/o(specific k/o of 2c splice variant)
Lonai
Generated here
 
Dwarf, skull base craniosynostosis,retarded osteogenesis mainly affecting the osteocyte lineage.   Cryopreserved
Fgfr2-Cys32Tyr knockin (gain of function Fgfr2c)
Lonai
Generated here
 
+/- viable, skull vault craniosynotosis, model for Crouzon syndrome. -/- perinatal lethal, skull, bone and lung defects   Cryopreserved
FGFR3 knockin (gain of function)
Givol
Generated here
 
A mouse model for achondroplasia produced by targeting fibroblast growth factorreceptor 3. FGFR3 loss of function also available.   Cryopreserved
Cas k/o(Caspase 8)
Wallach
Generated here
 
-/- lethal in utero, impaired heart muscle development and congested accumulation of erythrocytes.    Available on collaborative basis
Cas 18.29 k/o
Wallach
Generated here
 
Conditional caspase 8 knockout  
 
Available on collaborative basis
P55 DNS lox
Wallach
Kollias,Greece
 
Mutation of the p55 TNF receptor, which prevents the shedding of the receptor  
 
Cryopreserved
Hex B k/o
Futerman
Sandhoff,NIH
 
Mouse model of Sandhoff disease (neurodegenerative disorder), defective GM2 ganglioside degradation.    
Gba k/o(glucocerebrosidase)
Futerman
Jax
002594
Animal model of Gaucher's . -/- die neonatally due to a defect in the skin vapor barrier, abnormal respiration that progresses to cyanosis and death 002594  
CHIF k/o
Garty
Generated here
 
k/o of corticosteroid hormone-induced factor (CHIF)   Cryopreserved
PTPe (protein tyrosine phosphatase e) k/o
Elson
Generated here
 
Hypomyelination of sciatic nerve axons and increased activity of voltage-gated K+ channels in mice lacking PTPe    
PTPa (protein tyrosine phosphatase a) k/o
Elson
Jan Sap,New York
 
-/- fibroblasts had impaired tyrosine kinaseactivity of both c-Src and Fyn, and an increase in c-Src Tyr527 phosphorylation.    
RPTP alpha k/o
Elson 2.05
Hertog Utrecht
 
mice lack protein tyrosine phosphatase alpha (this is another strain of alpha KO mice distinct from those obtained from Jan Sap, NYU)   Requires permission from Dr. Den Hertog
Dynic
Reiner 1.05
Gene Trap Collection Germany
 
For details contact Prof. O.Reiner http://tikus.gsf.de/ Permission required
Ferritin heavy chain under fos promotor transgene
Neeman
Generated here
 
   
Unpublished
 
MCC (DAP kinase) k/o
Kimchi 9.1999
Kimchi, Mitsubishi,Japan
 
Mice are viable and fertile. Hippocampalneurons are resistant to ceramide induced apoptosis    
K-ras LAI k/o
Kimchi 29.9.03
MMHCC NCI Frederick
01BM2
Targeted latent 'hit-and-run' K-ras allele, mean age of death/ 300 days due to extensive tumor burden. Most frequent organ site is the lung. 01BM2  
HER 2 Neon Green tg
Eshhar 9.06
Genentech
 
Over express human HER2 under the MMTV Promotor, leading to high incidence of mammary tumours.   Restricted to collaborators
LFA1 k/o
(Cd11a k/o)
R. Alon 11.06
Jax
005257
Homozygotes do not display any gross abnormalities, exhibit peripheral leukocytosis due to an increased number of neutrophils. 005257  
DO11.10 tg
R. Alon 11.06
Jax
003303
React to IP injected ovalbumin (OVA) peptide antigen, resulting in a deletion of immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. 003303  
Vegfr1 -lox FLT-1 lox
Vegfr2 -lox FLT-1 lox
Zelzer 9.06
Genentech
 
   
 
MTA from Genentech required
IFN-gamma k/o
Eshhar 12.06
Jax
002287
Homozygotes are viable and fertile. Display reduced macrophage function in response to pathogens. 002287  
MMTV-PyVMT
transgene
Wallach 2008
Frisch
West Virginia
 
Carry the middle T oncogene under control of MMTV promoter/enhancer. Widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Majority developed secondary metastatic tumors in the lung.   MTA required
Balb-cNeuT transgene
(erbB-2)
Eshhar 1.05
Melani, Milan
 
Carry activated rat c-erbB-2 oncogene under the MMTV LTR promoter. Develop early, multifocal tumors in breast, salivary, harderian and epididymal tissues   Requires permission from Prof. Melani
Tgf beta k/o
Groner 10.03
Jax
002220
-/- die at two to three weeks, due to a massive inflammatory cell response and tissue necrosis. Model for immune and inflammatory diseases 002220  
C3(1)/Tag transgene(SV 40 T underprostate promotor)
Wallach 8.03
MMHCC NCI Frederick
01XB7
Model for prostate and mammary cancer. Female hemizygotes develop mammary adenocarcinoma. Male hemizygotes develop prostate adenocarcinoma. 01XB7  
TRAMP transgene
Eshhar 2002
Greenberg
Seattle
01XC6
Mice carrying the (TRAMP) transgene develop progressive forms of prostate cancer with distant site metastasis. Greenberg Lab Permission required
Rassf5
Alon 10.04
Kinashi,
Osaka
 
-/- mice grow normally but lymphocytes defective in homing capability, resulting in hypoplastic secondary lymphoid organs and impairment of B cell maturation. Skin and splenic dendritic cells are severely affected in migration.   Permission required, see Alon
129/Sv vim-/-
Fainzilber 11.02
Pasteur Institute
 
Vimentin -/-. No obviouys phenotype. LacZ expression in disrupted gene demonstrates pattern of vimentin expression.    
BCL2-22WEHI
Wallach 2003
Waisman, Cologne
 
Bcl2 expression in B lymphocytes 002319 Permission required, Dr J. Adams, WEHI
E-myc
Moross Bank (Kimchi)
Jax
002728
Myc expression in the B cell lineage. Hemizygotes show increased pre-B cells in the bone marrow. Spontaneous pre-B and B cell lymphomas. 002728 Cryopreserved
Jh knockout
Moses
Taconic
001147-M
Mice have no mature B-lymphocytes Normal,T-lymphocyte development. No IgM or IgG in serum. 001147  
p55 and p75 doubleknockout
Wallach 19.1.02
Jax
003243
p55 and p75 deficient are viable and fertile. Double homozygous mutant mice fail to bind TNF. 003243  
TcrH-Y(B6D2(B6)-Tg TcrH-Y transgene
Jung 2003
Institute for Genetics, Cologne
Taconic 004051
Mice have transgene encoding a TCR specific for male antigen (HY) in the context of model H2b. Used for studies on thymic negative selection. 004051  
Src k/o
Geiger
3.04
Jax
002277
Homozygotes display osteopetrosis and are 1/3 the size of wildtype siblings. Incisors fail to erupt. Partial absence of bone marrow. 002277  
IL-12 k/o
Groner
7.04
Jax
002693
Homozygotes have a severely restricted ability to mount a TH1 response,defective in IFN gamma production and type 1 cytokine responses. 002693  
IL-15 k/o
Jung 5.05
Taconic
 
IL-15 KO mice lack NK cells and have a reduction in memory CD8 T cells, NKT cells and IELs.    
neuropilin-1 k/o
conditional
Zelzer 2.05
Kolodkin
Baltimore
 
a conditional npn-1 (neuropilin-1 ) null mouse using Cre-loxP strategy   Permission from Kolodkin required
neuropilin-2 k/o
Zelzer 2.05
Kolodkin
Baltimore
 
Homozygotes are viable. Npn-2 is required for the organization several cranial and spinal nerves. Several major fiber tracts in the brains severely disorganized or missing.   Permission from Kolodkin required
Smoh k/o
smoothened homologue
Hermalin
4.04
Jax
004288
Homozygotes don’t develop past 9.5 dpc, have cyclopia and open gut, no embryonic turning, and normal rightward looping of the heart. Hedgehog pathway and L/R asymmetry disrupted. 004288  
Double transgene
Mo/Hu APPswe PS1dE9
Schwartz
4.04
Jax
004462
Double transgenics express mutant human presenilin 1 and mouse/human amyloid precursor protein (APPSwe). Mice develop beta-amyloid deposits in the brains by 7 months of age. 004462  
CYLD k/o
Wallach
3.04
Waisman,
Cologne
 
Mice deficient in cylindromatosis tumor suppressor gene  
unpublished
Restricted to collaborators
Col11A2 k/o
(FVB/N)
Rousso
Smith
Iowa
 
In homozygotes the mutation alters the collagen fibers network of the tectorial membrane which results in deafness.   Permission from Prof. Smith required
Tectb k/o
(129/C57B16J)
Rousso 1.05
Richardson
Sussex
 
-/- mice lack the tectorial membrane protein beta-tectorin. Removal of this protein was found to cause hearing impairments.   Permission from Prof. Richardson required
Patched k/o
(Ptch1)
Zelzer 8.05
Jax
003081
Homozygotes embryonic lethal with open and overgrown neural tubes. Heterozygotes are larger than + with some hindlimb defects and brain tumors. Express lacZ in a pattern of endogenous gene expression. 003081  
B2m k/o
Jung 5.05
Taconic
B2MN12-M
The B2m -/- mice are deficient in CD4-8+ T cells due to inactivation of the Beta 2-microglobulin gene. Useful for research in transplantation, gene therapy and immunological diseases. B2m_N12.htm  
Msh2 k/o
Shapiro 7.05
Edelmann
Albert
Einstein
 
Mutation ofMSH2 mismatch-repair (MMR) gene. Homozygotes develop spontaneous tumors by 6 months. Have a high level of MS instability in all cancerous tissues, but not in non-cancerous tissues    
Caspase-3 k/o
CPP32
Gross
Flavell
Yale
 
-/- mice, born at a lower than mendelian frequency, smaller than their littermates and died at 1-3 weeks of age. Abnormal brain development resulting in a variety of hyperplasias .    
CX3CL1(Fkn) k/o
Jung 8.05
Lira, Mount Sinai, NY
 
The mouse harbors targeted mutation of the membrane-tethered chemokine CX3CL1/Fractalkine   Permission from Lira required
hDC-SIGN transgene
Jung 8.05
Littman, New York
 
Carries a transgen encoding the human DC-SIGN gene under the murine CD11c promoter  
unpublished
Permission from Littman required
Epas1 k/o
Zelzer 3.07
Jax
003266
Homozygotes develop normally until E 11.5, but by E 16.5 there are no viable mutant embryos. Pronounced bradycardia, but overall development appears normal. Contain lacZ making them a marker for endothelial cells. 003266  
Klc k/o
Fainzilber 7.07
Jax
004098
Homozygotes display perinatal mortality (60%). Surviving mice are noticeably smaller than wildtype mice and breed poorly, possibly due inadequate nurturing capabilities 004098  
MMTVPyVT tg
Wallach 2.07
Jax
002374
Female mice carrying the (MMTV-PyVT) transgene developed mammary tumors by 5 weeks of age. Adenocarcinomas were found in virgin and breeder females as well as males. Model for metastatic disease 002374  
Apoe k/o
Jung 9.07
Jax
002052
Apoe - mice have increased cholesterol levels. Also altered responses to stress, impaired spatial learning and memory, altered LTP, and damage. 002052  
Baff ko
Jung 1.07
Biogen Idec, Inc., Cambridge
 
BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes.   MTA required
Alpha4
Fainzilber
Kohler Berlin
 
   
 
Restricted
GATA knock-in
Groner 10.07
Orkin Boston
 
GATA1 knock-in in leads to hyperproliferation of a unique, previously unrecognized yolk sac and fetal liver progenitor   Restricted
STAT3-beta k/o
Fainzilber 11.07
Poli Turin
 
STAT3-beta null mice   Restricted
Klc1J ko
Wallach 1.08
Jax
004098
Mice surviving to adulthood breed poorly.Motor defects are evident, as are alterations in intracellular localization of kinesin-I and COP-I components. 004098  
Ppt1tm1Hof k/o
Reiner 2008
Jax
004313
Brain size of the mutant mice is reduced, neuronal loss and apoptosis in the hippocampus, cerebral cortex and cerebellum. Useful in studies of neuronal ceroid lipofuscinoses, including infantile Batten disease. 004313  
Tbx21 k/o
Jung
Jax
004648
Homzygotes susceptible to Leishmania infections, females display hyper-responsiveness (AHR) with resulting airway remodeling similar to asthma. May be useful in studies human asthma and chronic intestinal inflammation. 004648  
DCTW-1 G595
knock-in
Reiner 2008
Cai
NIH
 
Knock –in of the G592 mutation causes dysfunction of Dynactin. -/- are embryonic lethal. Heterozygotes developed motor neuron disease phenotypes at 10 months.   MTA required
K14-lnl/lnl k/o
Futerman 2008
Karlsson
Sweden
 
K14-lnl/lnl conditional knockout model: Exhibit rapid motor dysfunction associated with severe neurodegeneration and apoptotic cell death within the brain. Develop paralysis and die by 2 weeks.   Contact Prof. Futerman
Nestin flox/flox
conditional k/o
Futerman 2008
Karlsson
Sweden
 
GlcCerase deficiency is restricted to neural and glial cell progenitors and progeny. They develop similar pathological changes as the K14-lnl/lnl mice, but with delayed onset and slower progression - die by the age of 3 weeks.   Contact Prof. Futerman
Tbx1deltaE5 k/o
Horenstein 2008
EMMA
02224
Null allele of the Tbx1 gene. Some heterozygotes have aortic arch defects emma 2224 MTA required
Df(16)1_Bld k/o
Horenstein 2008
EMMA
02122
Targeted deletion of a Chr. 16 segment between genes Es2 and Ufd1l. 5-10% of mutants die at birth because of heart defects (mainly interrupted aortic arch type B) emma 2122 MTA required
Tbx1lacZ k/o
Horenstein 2008
EMMA
 
Null allele of Tbx1 gene with LacZ gene reporter insertion into exon 5. some heterozygotes have aortic arch defects.   MTA required
TectA C1509G k/o
Rousso 2008
Oghalai Houston
 
In heterozygotes the inner ear tectorial membrane attaches to one row of OHCs (Outer Hair Cells). Homozygotes have a tectorial membrane which does not attach to any rows.  
Unpublished
 
Prx1-Sox9/LacZ k/i
Zelzer 2008
Akiyama Koyoto
 
Sox9 is misexpressed in the limb bud mesenchyme, using knockin of Sox9 to the Prx1 promoter.    
Csf2rb k/o
Jung 2008
Jax
005940
In homozygous mice, bone marrow and splenocytes do not proliferate in response to GM-CSF. Model for PAP (pulmonary alveolar proteinosis) and other diseases. 005940  
Ccm2 gene trap
Fainzilber 2008
Marchuk
Duke U
 
Heterozygous animals develop cerebral vascular malformations, Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations.   Permission required from Douglas Marchuk
Stat3-loxP
Fainzilber 2008
Akira
Osaka
 
The gene STAT-3 is flanked by two loxP sites.   Permission required from Prof. Shizuo Akira
Ephb4 k/o
Zelzer 12.08
Jax
006044
-/- embryonic lethal E9.5-10, growth retardation and lack of blood flow. Expression of lacZ in vascular endothelial cells. Useful for vasculogenesis and angiogenesis studies. 006044  
Thy1-ChR2-YFP tg
Chen 1.09
Jax
007612
Transgene expressing light activated ion channel, and YFP fusion gene (ChR2-YFP) under thymus promoter. Useful for studies of neural activity by light stimulation. 007612  
K14-ER:Ras tg
Oren 1.09
Jax
006403
Tamoxifen inducible expression of the ER:Ras fusion protein in epidermis promotes phenotypic characteristics observed in epidermal cancer. 006403  
Spp1 k/o
Groner 1.09
Jax
004936
Defective wound repair and macrophage infiltration. Useful in studies of tissue remodeling, wound repair, fibrosis and granulomatous diseases. 004936  
INFg k/o
Schwartz 12.08
Jax
002287
Homozygotes have no overt abnormalities, but display reduced macrophage function in response to pathogens. 002287  
INFgR k/o
Schwartz 12.08
Jax
003288
Homozygotes have no overt abnormalities, but are defective in natural resistance; increased susceptibility to infection. 003288  
Rag Perforin k/o
Hornstein 2008
Jax
004848
Double homozygotes lack mature T or B lymphocytes, no NK cell cytotoxic activity, and lack serum immunoglobulin. Develop thymic lymphomas. Useful in studies involving engraftment of human hematolymphoid cells. 004848 Permission from Schultz required
Rag Perforin Akita k/o
Hornstein 2008
Jax
008659
Homozygous for Rag1 and perforin 1 (Prf1) and heterozygous for the spontaneous insulin 2 Akita allele. Mice immunodeficient and hyperglycemic. Useful in studies of human islet and beta stem and progenitor cell function. 008659 Permission from Schultz required
miR-155 k/o
Hornstein 11.08
Rajewsky Harvard
 
Homozygotes have impaired immune function.   MTA required
mir-17-92 flx/flx
Hornstein 2008
Jacks MIT
 
Mutants for miR-17-92 die shortly after birth with lung hypoplasia and a ventricular septal defect . Also inhibited B cell development.    
mir-106a-363 K.O
mir-106b-25 K.O
Hornstein 2008
Jacks MIT
 
Homozygotes have no obvious phenotype. Compound mutants with mir-17-92 die at midgestation.    
FAK conditional k/o
Hornstein 11.08
Beggs UCSF
 
Floxed focal adhesion kinase gene for conditional knockout.   MTA required
TRPC-2 k/o
T. Kimchi 2008
Dulac Harvard
 
Homozygotes lack the ability to detect pheromone signals via the VNO (vomeronasal organ)   Permission from Prof. Dulac required
Ldlrtm1Her k/i
Rubinstein 2009
Jax
 
Mice homozygous for the Ldlrtm1Her mutation have an elevated serum cholesterol level. Useful in Diabetes and Obesity Research 002207  
IRF-3 k/o
Wallach 2009
RIKEN
 
Targeted mutation of the interferon regulatory factor 3. Significantly reduced production of interferon alpha/beta against virus infection. 00858  
EPAS 1 conditional tm
Zelzer 6.09
Jax
008407
Floxed Epas1 allele (endothelial PAS domain protein 1 or Hif-2alpha hypoxia-inducible factor). 8407  
CAG-MIRN17-92,-EGFP
Hornstein 9.09
Jax
008517
inducible expression of the human miR-17-92 cluster, associated with lymphomas and other cancers, autoimmune defects, and altered expression of tumor suppressor and pro-apoptotic genes 8517  
Myd88 floxed tm
Jung 9.10
Jax
008888
Floxed allele of Myd88, useful in studies of Toll-like receptor signaling 8888  
Prnp-TARDB tg
Hornstein 8.10
Jax
010700
Express a mutant human TAR DNA binding protein (TARDBP or TDP-43) associated with familial Amyotrophic Lateral Sclerosis (ALS) 010700  
Immorto-HE
Elson 4.09
Charles River
237
238
Express thermolabile allele of SV40 Tantigen under MHC promotor Immortomouse  
Lgals8 tm
Zick 9.09
MMRRC
11734
Mutation of Lgals8 (lectin, galactose binding, soluble 8. Homozygotes have increased locomotor activity in the open field 11734
 
 
á BMP4 tm
Zelzer 2009
Trabin Harvard
 
   
 
Contact Eli Zelzer
Mir17-92 tm
Hornstein 6.09
Jacks MIT
008458
Jax
Floexed miR-17~92 (overexpressed in human cancers). Homozygotes for the floxed miR17~92 allele viable, fertile, with no gross physical or behavioral abnormalities 8458  
Mir106b-25 tm
Hornstein 6.09
Jacks MIT
008460
Jax
Floexed miR-17~92 (overexpressed in human cancers). Homozygotes for the floxed miR17~92 allele viable, fertile, with no gross physical or behavioral abnormalities 8460  
TDP-K160R tm
TDP-STOP tm
Hornstein 6.09
Fisher UCL, London
 
Targeted point mutations in the TAR DNA binding protein  
 
 
Ihh -/- tm
Zelzer 11.09
Mundlos
Max-Planck
 
Homozygotes die before or immediately after birth due to respiratory failure. Exhibit limb dwarfism.    
Ephrin B2 lacz tm
Zelzer 6.09
Jax
006039
Homozygotes growth retarded, enlarged heart at E10, lethality at E11. Useful in studying vasculogenesis and angiogenesis, neovascularization, including tumor angiogenesis. 6039  
TGFb RII tm
Zelzer 7.09
Schweitzer Portland
 
Conditional knockout of TGF beta RII    
Adar1 f7-9 tm
Harmelin 6.09
Orkin Harvard
 
Floxed allele of adar1. Nomozygotes viable and fertile    
C/EBPbeta (fl/fl)
Rubinstein 3.09
Sterneck NCI, Frederick
 
C/EBP beta – mice have multiple phenotypes including skin. Increased apoptosis in keratinocytes after carcinogen treatment completely resistant to carcinogen-induced skin tumorigenesis    
RanBP-10 tm
Fainzilber 9.09
Schulze Berlin
 
Mutant mice have platelet disfunction    
Alpha 5 tm
Fainzilber 2010
Bader Berlin
 
importin-5 deficient-mice show normal brain development    
Spontaneous mutations etc.
Quaking (qk)
Volk
Jax
000506
Homozygous for the spontaneous quaking mutation (qk). Severely deficient in myelin in CNS and PNS 000506  
NOD scid B2m;
Harmelin
Jax
003449
(002570)
Model for xenograft transplantation studies and source for insulitis-free, MHC class I-negative islets for transplantation studies. 002570  
B6 scid
Schwartz 12.04
Jax
001913
Mice homozygous for severe combined immune deficiency spontaneous mutation (scid) have absence of functional T cells and B cells. scid mice accept allogeneic and xenogeneic grafts -ideal for cell transfer experiments. 001913  
CD45 (ptprc)(congenic strain)
Jung
Jax
002014
Used in transplant studies, carries the differential B cell antigen CD45 002014
 
 
Aly (alymphoplasia)Spontaneous mutation
Wallach
Clea,Japan, Inc.
 
Systemic absence of lymph nodes (LN) and Peyer's patches (PP) and disorganized splenic and thymic structures with immunodeficiency    
BALB/c/CrSlc
Groner 3.03
Japan SLC
 
Lymphopenic experimental autoimmune gastritis model. Following neonatal thymectomy 90% of these mice develop gastritis.    
C3.SW-H2b
Jung 14.9.03
Jax
000438
Male mice predisposed to glucose intolerance and hyperinsulinemia with some mice exhibiting hyperglycemia. 000438  
10ScNJ (Tlr4 deletion)
Jung 19.1.04
Jax
003752
Mice have a deletion of the Tlr4 gene that results in a defective response to LPS stimulation. 003752  
Toxic milk (Jackson)
Reisner
9.04
Jax
001576
Tx-J/TxJ adults develop cirrhosis, infant mice copper deficient due to Cu deficient milk of mother. Useful for neurological disorders with Cu accumulation e.g. Alzheimers 001576  
splotch-delayed
(Pax3Sp-d)
Zelzer
9.04
Jax
000565
-/- embryos survive to birth, Homozygous splotch-delayed mutant embryos display caudal rachischisis only. Useful in dermatology ,neural crest and neural tube defects. 000565  
shiverer (Mbpshi)
Ravel
6.04
Jax
001428
Homozygotes show a generalized tremor during locomotion which increases in severity with age, incoordination of hindlimbs. Severe myelin deficiency throughout the CNS. 001428  
HRS/J
Wallach
8.05
Jax
000673
Homozygtes have a higher incidence and earlier onset of leukemia. Hair is lost from the follicle at 10 days. and mice eventually become continuously hairless. 000673  
Reeler
(Orleans allele)
Reiner
2005
Goffinet
Brussels
 
Homozygotes exhibit an ataxic gait, and tremors from 2 weeks of age. These mutants are incapable of maintaining their hindquarters upright and often fall over during locomotor activity.   Permission from Goffinet required
LOA
Fainzilber
6.05
Fisher, London
 
ENU mutagenesis screen; harbours a point mutation in the dynein heavy chain. Homozygotes are not viable, heterozygotes exhibit impairment in retrograde transport in neurons.   Permission from Prof. Fisher required
Swe
Reiner 3.07
Jax
003012
Homozygotes for slow wave epilepsy spontaneous mutation (Nhe1) display locomomotor ataxia from at 11-14 days of age. Younger mice have seizure phenotypes similar to common human absence epilepsies. 003012  
Ticam1Lps2
Wallach 11.07
Jax
005037
ENU mutagenesis. Macrophages fail to respond to LPS and dsRNA with production TNF. Mice become ill and some die. Useful in studies of immunodeficiency and response to bacterial endotoxins and viruses. 005037  
B6.MRL-Faslpr/J
Fainzilber 1.08
Jax
000482
Model for systemic lupus erythematosus-like autoimmune syndromes 000482  
Fe a/a-Mitfmi
Hornstein 1.09
Jax
001573
Model for systemic lupus erythematosus-like autoimmune syndromes 001573