Basic Services|Mouse Strains Databases

Note: A list of previously ordered mouse strains is available.
          Available strains are also listed in tables below. 

Mouse Strains Databases

The Moross Repository for Genetically-Modified Mice contains strains of transgenic and gene-targeted mice that were produced or obtained by Weizmann Institute scientists, which are no longer in use, but might reasonably be needed by WIS scientists in the future. The repository maintains strains of mice either as small nuclei of breeding pairs or as stocks of frozen embryos. The aim of the Repository is to free Institute scientists from the need to maintain strains that are potentially useful but which they themselves no longer need. The repository houses mice relevant to any discipline of scientific research performed at the WIS.

The Repository is funded by the MD Moross Institute for Cancer Research and by the Weizmann Institute of Science.

The Moross Repository will also participate in financing import of new and potentially interesting strains of transgenic or gene-targeted mice that are relevant to cancer research (as defined in a rather broad way). For additional information see the Moross Repository Guidelines below.

Submitting mice to the Moross Repository

Scientists who wish to suggest strains of mice for inclusion in the Repository are requested to contact:

Prof. Ari Elson, Department of Molecular Genetics, Tel: 2331, 2209
or Dr. Rebecca Haffner, Department of Veterinary Resources, Tel: 2719.

Once approval for acceptance has been secured, scientists are required to fill out an order form via
Internal Services > Moross Cancer Bank Res.

Requesting Mice from the Moross Repository

IACUC approval must be obtained for all mice requested from the Moross Repository.
Once IACUC approval has been secured, scientists are required to fill out an order form via
Internal Services > Moross Cancer Bank Res.

Moross Repository Guidelines

1. The Moross Repository of Genetically-Modified Mice aims to maintain living or frozen stocks of select strains of genetically-modified mice that are no longer in use but which may be of potential future use by WIS scientists. In so doing the Repository maintains availability of potentially-useful strains of mice while freeing WIS scientists from the burden of maintaining stains they no longer need.
2. The Moross Repository accepts genetically-modified mice relevant to any discipline of scientific research performed at the WIS.
3. A strain of mice will be considered for inclusion in the Repository providing that:
   
   1. The strain is not maintained in parallel by any researcher at the WIS.
   2. There are no frozen stocks of this strain at the WIS.
   3. There is reasonable expectation that the strain may be needed in the future by WIS scientists other than the scientist who donated the strain.
   4. The legal/IP limitations on the use of the strain are such that it can be used by scientists other than the WIS donor.
   5. Other issues (broad scientific interest, ease/difficulty to obtain the strain from other sources, ease/difficulty to maintain the strain, available resources) may also be considered 
4. Strains are accepted into the collection and are maintained without cost to the donating scientist.
5. The Moross Repository maintains strains as small live breeding stocks and cannot provide large amounts of mice. WIS scientists may receive breeding pairs from the Repository with which to establish breeding colonies should they need more than a few mice for their studies.
6. Strains of mice not in frequent demand will be frozen and maintained as stocks of frozen embryos. In order to preserve resources the Repository will typically not freeze strains of mice that are maintained as living colonies in the Jackson Labs or other providers, since it takes about as much time to import these mice as it does to thaw and re-establish them from frozen stock locally.
7. Freezing of strains will be done at no cost to the donating scientist. However, costs of thawing embryos will be borne by the WIS scientist that requests it.
8. Any WIS scientist may request breeding stocks from the Repository providing:
   
   1. He/she obtains IACUC approval.
   2. The legal/IP commitments undertaken by the WIS scientist who originally obtained the strain will be respected.
   3. If the line is frozen, costs of thawing will be borne by the WIS scientist who requests it 
9. WIS scientists are strongly encouraged to freeze down strains of mice they no longer need without the intervention of the Moross Repository. Such freezing is currently free, is carried out by the staff of the mouse facility, and involves little effort on the part of the scientific group. The Repository will therefore accept only strains of mice of potential future use to several WIS groups.
10. In extreme cases, where a scientist wishes to freeze down a strain and cannot do so due to backlogs in the freezing process, the Repository may accept a small number of these mice to maintain the line until freezing becomes possible. This will be done at no cost to the scientist; however, the scientist will be responsible for genotyping these mice, if needed.
11. The Moross Repository adheres to and respects all legal/IP limitations undertaken by the WIS scientist/s who originally obtained the strains. Therefore, WIS scientists requesting strains from the Repository may have to request permission to do so from the original non-WIS source and/or may be required to sign MTAs or undertake other commitments.

 

Mouse strains table

Common Name	Scientist	Source	Stock #	Description	Link	Primary Reference	Other
Marker Lines
B5 EGFP	Animal Breeding Centre	Nagy, Toronto	003115	Transgene with GFP driven by chick beta-actin promoter. General GFP expression	003115	Mech. Dev 76;79
actin eGFP transgene	Elson 2.05	Matus Basel		Carry actin-GFP fusion transgene under the actin promoter. Results in mice with GFP labeled actin.		Nat. Neurosci. 3;887	Requires an MTA from FMI, Basel
ACTbEGFP	Schwartz 4.05	Jax Basel	003291	Express EGFP cDNA under chicken beta-actin promoter and cytomegalovirus enhancer. All tissues green, except erythrocytes and hair. Homozygotes die 14days p.n.	003291	FEBS Lett. 407;313
UBI-GFP	R. Alon 11.06	Jax	004353	GFP under human ubiqutin C promoter, express GFP in all tissues examined. Certain hematapoetic cell types display distinct expression levels of GFP, allowing identification by FACS analysis.	004353	Cell Immunol 214;110
B6/PGK neo	Animal Breeding Centre	Jax	002356	Source of G418-resistant feeder cells for gene targeting	002356
Rosa 26	Animal Breeding Centre	Jax	002073	lacZ is expressed in all tissues of the embryo and in most tissues of the adult mouse.	002073	Genes & Dev. 5;1513
YFP16	Peles	Sanes, St.Louis		Express YFP in motor and sensory neurons. Expression strong from a mid-gestational stage into adulthood	003709	Neuron 28; 41
YFP-H (YFP 2.2)	Peles	Sanes, St.Louis		Same as YFP16, but stains different subset of neurons (see link)	003782	Neuron 28; 41
Col2 GFP	Yayon 4.03	Horton, Portland		Transgenic mice carrying the GFP gene under the control of the collagen 2 promoter. GFP expression in chondrogenic areas		Seminars Med Gen, 106;251
SCE/LacZ	Peles 6.03	Meijer,Holland		LacZ under control of schwann cell enhancer		Unpublished	Restricted access, contact Ori Peles
SCE/GFP+/-	Peles 6.03	Meijer,Holland		GFP under control of schwann cell enhancer		Unpublished	Restricted access, contact Ori Peles
C57BL/6J-Tyrc-2J	Animal Breeding Center 14.9.03	Jax	000058	C57Bl mice with coat colour mutation, homozygotes are albino. Used as blastocyst donor for C57BL ES cell chimeras	000058	Biotechniques 5;1022
C.B 20	Animal Breeding Center 14.9.03	(Jerusalem)Cologne		BALB/c xC57Bl backcross. Used as blastocyst donor for C57BL ES cell chimeras.(C.B20 is 3 generations further backcross then C.B17)	C.B17
129X1/SvJ	Gross 10.05	Jax	00691	129 strain most closely matching the R1 ES cell line	000691	Nat Genetics 16;19
129 S6/SvEv	Elson	Taconic	129SVE	Knockout mice developed from 129 agouti ES cell lines can be maintained on an agouti 129 background by mating to Taconic's 129 strain	129SVE
129/pas	Lonai	Geunet,Pasteur, Paris		129 substrain recommended for breeding knockout lines		Nature Genet. 16; 19
B6129SF2/J	Ravel	Jax	101045	Parental strains C57BL/6J, 129S1/SvImJSuggested controls for strains designated B6;129S	101045
TIE2-GFP	Zelzer 4.05	Jax	003658	Express GFP under endothelial-specific receptor tyrosine kinase (Tek, formerly, Tie2) promoter.	003658	Genesis 28;75
Topgal (fos-lac-Z)34Efu/J	Zelzer 6.05	Jax	004623	Transgenic mice display Beta-gal activity during embryonic development in developing hair follicles. Useful in studies of the Wnt signaling pathway.	004623	Dev.126;4457
DBA/2J	Eshhar 6.07	Jax	000671	Inbred strain. Vision and hearing defects, intolerant to alcohol and morphine	000671	mouse phenome database
Hox7b-GFP tg	Garti 7.09	Kispert Germany		Transgenic mouse that expresses EGFP under the Hoxb7 promoter		Dev Genet 24;241
Cre and Flp strains
E IIa-cre	Reiner	Jax	003314	Cre transgene under adenovirus EIIa promoter. General deletor strain.	003314	PNAS 93;5860
Pgk-cre	Lonai	Lonai		General cre deletor strain, maternally expressed		Transgenic Res. 7,105
R/ERT	Hornstein 7.06	Barbacid Madrid		Uniform Cre activity upon systemic 4OH-Tamoxifen exposure in all tissues, low cleavage in brain. Cleavage efficiency is locus dependent.		Cancer Cell 4;111
Mx-cre (Msx-1 cre)	Wallach	H.Cedar, Jerusalem	Jax 003556	Cre under control of interferon-responsive promoter. Available on C57BL background.	003556	Science 269;1427
Bf-1-cre	Reiner	McConnell, Stanford		Cre targeted to Bf-1 (Foxg1) locus. cre-mediated excision in telencephalon and discrete head structures.		Dev. Biol. 222;296
Wnt-cre	Zelzer 2005	Tabin, Harvard		Cre-activity within the embryonic central nervous system from E8.5.		Curr Biol 8;1323
CAGS-Cre/ERT	Hornstein 7.06			Tamoxifen-inducible form of Cre mediates recombination within the embryonic central nervous system.		Curr. Biol. 8; 1323
Pax3 Cre	Hornstein 7.06	Epstein Philadelphia		Cre activity in Pax3-expressing cells including neural crest and somites.		Dev Biol 280; 396	MTA required
MSX-limb-cre	Animal Breeding Center			Cre-mediated excision in limb regions		Nature Genet. 25;83	Cryopreserved
LysM-cre	Wallach	Forster, Germany		Cre-mediated excision in myeloid cells	004781	Transgen. Res. 8;265	Restricted to collaborators
Lck-cre	Animal Breeding Center	Taconic	004204-M	Cre under Lck (lymphocyte protein tyrosine kinase) promotor, deletes T cell lineage at the double negative stage	004204-M mixed background	Immunity 15;763	deletions in non-lymphoid tissue possible
B(MCM)	Wallach	M.Reth, Freiburg		Inducible Cre expression in B lymphocytes			Restricted to collaborators; Cryopreserved
Dhh-cre	Peles	Meijer, Holland		Cre under desert hedgehog promoter, schwann cell specific		Gene Dev 17; 1380	Cryopreserved. Requires permission from D.Meijer
MBP-cre	Wallach	Kollias, Greece		Cre-mediated excision in oligodendrocytes	kollias	unpublished	Restricted to collaborators
Mogi-cre	Wallach 9.04	Waisman, Cologne		Cre-mediated excision in oligodendrocytes. (Mouse on C57BL/6 background)	MOG	J.Immunol 175;5875	Restricted to collaborators; Cryopreserved
CNP-Cre	Peles 1.05	Nave Göttingen		Cre is expressed under the control of CNP promoters. CNP is expressed in oligodendrocytes and to a lesser extent in Schwann cells.		Nat.Gen. 33:336	Permission from Peles and Nave required
VChAT Cre	Hornstein 7.06	Misawa, Tokyo		Cre expression in a subset of cholinergic neurons in the somatomotor nuclei and medial habenular nucleus.		Genesis 37; 44	MTA required
Alb-cre	Wallach	Jax	003574	Liver-specific cre-mediated excision	003574	JBC 274;305	Cryopreserved
Ins2-cre (RIP-cre)	Wallach	Jax	003573	Pancreas specific cre-mediated excision	003573	JBC 274; 375
RIP-cre/ERT	Hornstein 7.06	Dor, Harvard		Tamoxifen-inducible form of Cre mediates recombination in pancreatic beta-cells		Nature 429;6987	MTA required
Pdx1 Cre/ERT	Hornstein 7.06	Melton, Harvard		Tamoxifen-inducible form of Cre mediates recombination in Pdx1-expressing cells		Development 129;2447	MTA required
Balancer cre (Nes-cre)	Wallach	Jax	002858	Variable deletion of loxP genes generates mosaic mice which can bypass lethality	002858	Curr Biol 6; 1307	Cryopreserved
B6.CD4-Cre	Wallach	Waisman, Cologne		Cre under CD4 promoter deletes most thymocytes at the double positive stage		Immunity 15;763
ED-cre	Wallach	Waisman, Cologne		Inducible Cre expression in B lymphocytes		Nuc. Acid Res. 26: 1427	Cryopreserved, Requires Permission
B6.Cg-Tg(Lck-cre)	Wallach	Jax	003802	Expresses Cre recombinase in thymocytes	003802	PNAS, 92:12070.pdf
tie-1-Cre	Wallach	Gustafsson Sweden		Cre expression specifically in endothelial cells from embryonic stage E8		PNAS, 92:12070.pdf	Cryopreserved, Restricted to Collaborators
Vil-cre	Jung 5.05	MMHCC NCI Frederick	01XE7	Cre expression in the intestine, colon and proximal tubule of the kidney	01XE7	Genesis 39;186
CaM KII cre	Wallach 11.05	Probert Athens		Cre recombination in adult forebrain		Genesis 26;133	Permission from Probert required
Col 1-cre	Zelzer 6.05	Karsenty, Baylor		Cre expression in osteoblasts		Dev. Dyn. 224; 245	Permission from Karsenty required
GDF5-cre	Zelzer 9.06	Kinsley, Stanford		Cre avtivity in developing joints		PLoS Biol. 2;e355
Z/AP	Animal Breeding Center	Lobe, Toronto	003919	Cre reporter, constitutive LacZ expression replaced by alk phos, following cre-mediated excision	003919	Dev. Biol. 208: 281
Z/EG	Animal Breeding Center	Lobe, Toronto	00320	Cre reporter, constitutive LacZ expression replaced by GFP, following cre-mediated excision.	003920	Genesis 28;147
Rosa26R	Zelzer 2005	Harvard	Jax 006148	EYFP expression is observed when bred to mice with a cre gene under a promoter of interest. Useful in monitoring Cre lineage expression.	006148
RA/EG	Jung	Foerster, Munich		Carry a conditional GFP gene in the RAGE locus. RA/EG, can therefore serve a reporter mice for Cre activity.		Genesis 1;36	Restricted access, contact Bernd Arnold
BPA -/- (R26:LacZ-PBA/DT-A) transgene	Peles 1.05	Riethmacher Hamburg		Floxed diphtheria toxin fragment A gene in the ROSA26 locus. Allows depletion of specific cell types in vivo following Cre-mediated gene recombination.		not published, see Mol Cell Biol 24,7636 for similar	Permission from Peles and Riethmacher required
Isl1-cre	Reiner 4.05	Pfaff Salk Inst.		Cre expression in motor neurons and in a subtype of dorsal interneurons in the spinal cord		Cell 26;309
Isl1-Cre	Zahor 11.07	Evans UCSD		expresses Cre in specific myocardial lineages		Dev Biol 304;286	MTA required
Isl1-MCM	Zahor 11.07	Evans UCSD		Islet 1 tamoxifen inducible Cre		Dev Biol 304;286	MTA required
Cdh5-cre	Zelzer 2008	Jax	006137	Cre under VE-Cadherin (Cdh5) mouse promoter. Expressed in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells	006137	Dev Dyn 235; 759
Col2a1-cre/ESR1	Zelzer 2008	Jax	006774	Strong tamoxifen-inducible cre expression directed to cells of the chondrogenic lineage (cartilage), with minimal (<0.1%) cre activity in the absence of tamoxifen	006774	Dev Dyn 235; 2603
Prm-cre	Wallach 2008	Jax	003328	Cre under protamine 1 promoter mediates recombination in the male germ line, but not in other tissues. Used to produce homologously recombined alleles in mice that have been secondarily rearranged by site-specific recombinase.	003328	PNAS 94; 14602
Neurog-3 cre	Horenstein 2008	Jax	006333	Cre under neurogenin 3 promoter Recombination in the small intestine and fetal pancreatic epithelial cells. Also in islets of the adult pancreas, and other endocrine cells.	006333	Dev Biol 240; 443
Osx1-GFP:Cre	Zelzer 2008	Jax	006361	Carries both tTA under the regulation of the osterix (Sp7) promoter and a tetracycline responsive GFP/Cre fusion protein. Useful in studies of bone development, osteoblast lineage, and Hedgehog/Wnt signaling.	006361	Dev 133, 3231
Pomc1 cre	Chen 2008	Jax	05965	Cre under Pomc1 cre promotor. Activity in brain area neurons involved in the control of food intake (arcuate nucleus (hypothalamus) and solitary tract nucleus (hindbrain)).	005965	Cell 42; 983
ePet-Cre	Chen 2008	Deneris Cleveland		Carry the Cre recombinase gene under the control of ePet promoter, Cre expression mainly in serotonergic neurons.		PNAS 102; 16472	Requires permission from Evan Deneris
Advillin cre	Fainzilber 2008	Wang, Duke U		cre gene under the promotor of Advillin		J Neurosci 27;14404
Th-IRES-Cre.Rosa YFP	T. Kimchi 2009	Mizrahi HUJ		knock-in expressing Cre from the 3'UTR of the tyrosine hydroxylasegene by means of an IRES sequence		Genesis 40; 67	Requires permission from Tali Kimchi
Nkx2-1-cre	Hornstein 7.09	Jax	008661	cre expression in subgroups of brain interneuron progenitors, developing lung, thyroid, and pituitary	8661	J Comp Neur 506; 16
LepRb-IRES-Cre	Elson 1.10	Jax	008320	Cre activity in hypothalmus and in those neurons that express neuropeptide Y or the leptin receptor	8320	Science 291; 5513
Nefh-cre	Futerman 4.10	MMRRC	015960	Expression of cre in neurons of the brain and spinal cord during late development (~ E18.5).	015960	Neurosci Res 40; 125
Matn1-Cre	Zelzer 4.09			Expression of Cre recombinase in all the growth plate chondrocyte with the exception of articular chondrocytes.á		Dev Biol 304; 825
Shh-gfp cre	Zelzer 4.09	Tabin Harvard		Cre-gfp knocked into shh locus		Cell 118; 517
Sox4 tm	Jung 11.09	Lefebvre Cleveland		Conditional "floxed" allele of Sox4. Sox4-null mice die at embryonic day 14 from heart malformation.		Genesis 45;776
Transgenes and knockouts
129 inf gamma k/o	Harmelin	Jax	002287	-/- show reduced macrophage function in response to pathogens. Hyper-proliferation of splenocytes in response to mitogens	002287	Science 259;1739
Rag 1 k/o(C57BL/6J)	Wallach	Jax	002216	-/- mice produce no mature T cells or B cells. "non-leaky" severe combined immune deficiency	002216	Cell 68;869
Rag 1 k/o(BALB/c)	Jung Schwartz, 4.04	Jax	003145	-/- mice produce no mature T cells or B cells. "non-leaky" severe combined immune deficiency (as above)	003145	Cell 68; 869
CD8 k/o	Moses 7.06	Jax	002665	Homozygotes are deficient in functional cytotoxic T-cells; however, helper T-cell development and function is comparable to normal.	002665	Cell 65; 443
Nrcam k/o	Peles 7.06	Grumet Rutgers		In homozygotes cerebella do not exhibit obvious histological defects, although a mild size reduction of several lobes is observed.	Nrcam	J Cell Biol 154;1259	Contact Elior Peles
Nfasc k/o	Peles 7.06	Brophy Edinburgh		In homozygotes neither paranodal adhesion junctions nor nodal complexes are formed.		Neuron 48; 737	Contact Elior Peles
4.1B k/o (Epb4.1l3)	Peles 7.06	Kissel Philadelphia		No abnormal phenotype detected in homozygotes.	Epb4.1l3	Mol. Cell Biol 25; 10052	Contact Elior Peles
Igh-6 k/o (muMT)	Jung	Jax	002249	Homozygous mutants lack mature B-cells.	002249	Nature 350;423
ATM	Groner, Elson	Leder, Harvard		Mice lack the ataxia-telangiectasia (AT) gene product.		PNAS 93,13084-89,1996	Requires permission from P. Leder; Cryopreserved
Cntn1 k/o	Peles 7.06	Ranscht, La Jolla		Homozygotes have severe ataxic phenotype consistent with defects in the cerebellum, survive until postnatal day 18.	Cntn1	Neuron 24;739	Contact Elior Peles
DO11.10 transgene	Jung	Jax	003303	Rearranged T cell receptor transgene, ovalbumin responsive, deletes CD4+ CD8+ TCRlo thymocytes.	003303	Science 250; 1720
TcraTcrb transgene	Jung	Jax	003831	Transgenic T cell receptor recognizes ovalbuminm with H2Kb, used to study peptides in positive selection and response of CD8+ T cells to antigen.	003831	Cell 76; 17
Bax -/- k/o	Groner	Jax	002994	Bax-deficient mice with lymphoid hyperplasia and male germ cell death	002994	Science 270;96	Cryopreserved
B6 Bid k/o	Gross	Korsmeyer, Harvard		Bid (bcl2 family)-deficient mice are resistant to Fas-induced hepatocellular apoptosis		Nature 400; 886
chop-(Ddit3) k/o	Kimchi 4.06	Jax	005530	homozygotes viable, fertile. MEFs and renal proximal tubular epithelial cells have decreased apoptosis in response to endoplasmic reticulum stress. Useful in studies of apoptosis due to ER stress.	005530
P53 k/o (B6 background)	Oren	Jax	002101	-/- mice develop tumors (lymphomas and osteosarcoma) at 3-6 months. +/- mice develop tumors at about 10 months.	002101	Curr. Biol. 4; 1
P53 k/o (129 background)	Oren	Jax	002080	as above	002080	Curr. Biol. 4; 1
P53 515A knock in	Oren 1.06	Lozano, Texas		Have a G-to-A substitution at nucleotide 515 of p53 corresponding to the p53R175H hot spot mutation in human cancers. Tumors from p53+/515A mice metastasize with high frequency.		Cell 119; 861	Permission from Dr. Lozano required
P63 k/o	Oren	McKeon, Harvard		p63 -/- have limb truncations, craniofacial defects and no squamous epithelia including mammary, lacrymal and salivary glands.		Nature 398;714
P73 k/o	Animal Breeding Center	McKeon, Harvard		p73-deficient mice have neurological, pheromonal and inflammatory defects but notspontaneous tumours		Nature 404;99
P19 ARF k/o	Oren	St.Jude(Sherr)		Mice lacking tumor suppressor p19ARF but with functional p16INK4a develop tumors early in life		Cell;91:649	Permission required from Sherr
DOCK2 k/o	R.Alon	Fukui, Japan		DOCK2 -/- have migration defects of T and B lymphocytes. DOCK2 mediates cytoskeletal reorganization through Rac activation.		Nature 412; 826
P75 k/o	Fainzilber	DechantMax Planck		-/- show hind limb ataxia, partial perinatal lethality, and defects in vascular system		Nature Neurosci. 4; 997
Runx 3 k/o	Groner	Generated here		-/- have severe limb ataxia due to disruption of monosynaptic connectivity between intra spinal afferents and motoneuron		EMBOJ 21;3454
Runx 2 k/o(Cbfa1)	Groner	Olson,Harvard		-/- die of respiratory failure perinatally, skeleton has absence of osteoblasts and bone. -/+ have skeletal abnormalities		Cell 89; 765
Runx 1(lacZ) k/o(Cbfa2/ AML1)	Groner	Speck,Dartmouth		Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.		Development 126;2563
SOD1transgene	Schwartz/ Groner	Jax	002726	Mutant SOD transgene, hemizygotes become paralyzed in limbs due to loss of motor neurons from the spinal cord	002726	Science 264; 1772
SOD 51YG, (SOD69YG,70YG) transgene	Groner	Generated here		Overexpress human DOD1. Have abnormal neuromuscular junction in tongue.		Cell 54; 823	Cryopreserved
SOD1*G93A)1Gur transgene	Groner 2009	Jax		Express G93A mutant form of human SOD1.Hemizygotes exhibit a phenotype similar to amyotrophic lateral sclerosis (ALS) in humans; becoming paralyzed in limbs	004435	Science 264; 1772
Plg k/o(plasminogen)	Miskin	Jax	002830	-/- viable and fertile, progressive pathology includes wasting, rectal prolapse, impaired wound healing, thrombosis etc. Die around 6 months.	002830	Genes Dev 9; 794
alfa-MUPA transgene(urokinase-type plasminogen activator)	Miskin	Generated here		Mice spontaneously eat less and live longer compared with the wild type control, thus mimicking calorically restricted mice		Neurobiol. Aging 20; 555	Cryopreserved
LIS1 k/o	Reiner	Generated here		Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization		PNAS 98;6429
Fgfr2-D2 k/o	Lonai	Generated here		Homozygote mid-gestation lethal. No limb development.		PNAS 96; 11895	Cryopreserved
Fgfr2-InsG33 k/o(specific k/o of 2c splice variant)	Lonai	Generated here		Dwarf, skull base craniosynostosis,retarded osteogenesis mainly affecting the osteocyte lineage.		Development 129; 3873	Cryopreserved
Fgfr2-Cys32Tyr knockin (gain of function Fgfr2c)	Lonai	Generated here		+/- viable, skull vault craniosynotosis, model for Crouzon syndrome. -/- perinatal lethal, skull, bone and lung defects		PNAS101;12555	Cryopreserved
FGFR3 knockin (gain of function)	Givol	Generated here		A mouse model for achondroplasia produced by targeting fibroblast growth factorreceptor 3. FGFR3 loss of function also available.		PNAS 96;4455	Cryopreserved
Cas k/o(Caspase 8)	Wallach	Generated here		-/- lethal in utero, impaired heart muscle development and congested accumulation of erythrocytes.		Immunity 9; 267	Available on collaborative basis
Cas 18.29 k/o	Wallach	Generated here		Conditional caspase 8 knockout			Available on collaborative basis
P55 DNS lox	Wallach	Kollias,Greece		Mutation of the p55 TNF receptor, which prevents the shedding of the receptor			Cryopreserved
Hex B k/o	Futerman	Sandhoff,NIH		Mouse model of Sandhoff disease (neurodegenerative disorder), defective GM2 ganglioside degradation.		Nature Genet. 2; 111
Gba k/o(glucocerebrosidase)	Futerman	Jax	002594	Animal model of Gaucher's . -/- die neonatally due to a defect in the skin vapor barrier, abnormal respiration that progresses to cyanosis and death	002594	Nature 357; 407
CHIF k/o	Garty	Generated here		k/o of corticosteroid hormone-induced factor (CHIF)		Am.J.Phys.RenalPhys. 289; 583	Cryopreserved
PTPe (protein tyrosine phosphatase e) k/o	Elson	Generated here		Hypomyelination of sciatic nerve axons and increased activity of voltage-gated K+ channels in mice lacking PTPe		EMBO J 19;4036
PTPa (protein tyrosine phosphatase a) k/o	Elson	Jan Sap,New York		-/- fibroblasts had impaired tyrosine kinaseactivity of both c-Src and Fyn, and an increase in c-Src Tyr527 phosphorylation.		Curr. Biol 9;505
RPTP alpha k/o	Elson 2.05	Hertog Utrecht		mice lack protein tyrosine phosphatase alpha (this is another strain of alpha KO mice distinct from those obtained from Jan Sap, NYU)		J Cell Biol 168;127	Requires permission from Dr. Den Hertog
Dynic	Reiner 1.05	Gene Trap Collection Germany		For details contact Prof. O.Reiner	http://tikus.gsf.de/	Nat. Gen. 24;13	Permission required
Ferritin heavy chain under fos promotor transgene	Neeman	Generated here				Unpublished
MCC (DAP kinase) k/o	Kimchi 9.1999	Kimchi, Mitsubishi,Japan		Mice are viable and fertile. Hippocampalneurons are resistant to ceramide induced apoptosis		Nature Cell Biol. 3:1
K-ras LAI k/o	Kimchi 29.9.03	MMHCC NCI Frederick	01BM2	Targeted latent 'hit-and-run' K-ras allele, mean age of death/ 300 days due to extensive tumor burden. Most frequent organ site is the lung.	01BM2	Nature, 410;1111
HER 2 Neon Green tg	Eshhar 9.06	Genentech		Over express human HER2 under the MMTV Promotor, leading to high incidence of mammary tumours.		Clin. Cancer Res. 10; 2499	Restricted to collaborators
LFA1 k/o (Cd11a k/o)	R. Alon 11.06	Jax	005257	Homozygotes do not display any gross abnormalities, exhibit peripheral leukocytosis due to an increased number of neutrophils.	005257	J Immunol 163;5029
DO11.10 tg	R. Alon 11.06	Jax	003303	React to IP injected ovalbumin (OVA) peptide antigen, resulting in a deletion of immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes.	003303	Science 250; 1720
Vegfr1 -lox FLT-1 lox Vegfr2 -lox FLT-1 lox	Zelzer 9.06	Genentech					MTA from Genentech required
IFN-gamma k/o	Eshhar 12.06	Jax	002287	Homozygotes are viable and fertile. Display reduced macrophage function in response to pathogens.	002287	Science 259; 1739
MMTV-PyVMT transgene	Wallach 2008	Frisch West Virginia		Carry the middle T oncogene under control of MMTV promoter/enhancer. Widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Majority developed secondary metastatic tumors in the lung.		Mol Cell Biol 12; 954	MTA required
Balb-cNeuT transgene (erbB-2)	Eshhar 1.05	Melani, Milan		Carry activated rat c-erbB-2 oncogene under the MMTV LTR promoter. Develop early, multifocal tumors in breast, salivary, harderian and epididymal tissues		Cancer Lett 63;203	Requires permission from Prof. Melani
Tgf beta k/o	Groner 10.03	Jax	002220	-/- die at two to three weeks, due to a massive inflammatory cell response and tissue necrosis. Model for immune and inflammatory diseases	002220	Nature 359;693
C3(1)/Tag transgene(SV 40 T underprostate promotor)	Wallach 8.03	MMHCC NCI Frederick	01XB7	Model for prostate and mammary cancer. Female hemizygotes develop mammary adenocarcinoma. Male hemizygotes develop prostate adenocarcinoma.	01XB7	PNAS 91;11236
TRAMP transgene	Eshhar 2002	Greenberg Seattle	01XC6	Mice carrying the (TRAMP) transgene develop progressive forms of prostate cancer with distant site metastasis.	Greenberg Lab	PNAS 92;3439	Permission required
Rassf5	Alon 10.04	Kinashi, Osaka		-/- mice grow normally but lymphocytes defective in homing capability, resulting in hypoplastic secondary lymphoid organs and impairment of B cell maturation. Skin and splenic dendritic cells are severely affected in migration.		Nature Imm; 5, 1045	Permission required, see Alon
129/Sv vim-/-	Fainzilber 11.02	Pasteur Institute		Vimentin -/-. No obviouys phenotype. LacZ expression in disrupted gene demonstrates pattern of vimentin expression.		Cell 79;679
BCL2-22WEHI	Wallach 2003	Waisman, Cologne		Bcl2 expression in B lymphocytes	002319	Nuc. Acid Res. 26:1427	Permission required, Dr J. Adams, WEHI
E-myc	Moross Bank (Kimchi)	Jax	002728	Myc expression in the B cell lineage. Hemizygotes show increased pre-B cells in the bone marrow. Spontaneous pre-B and B cell lymphomas.	002728	Nature 318;533	Cryopreserved
Jh knockout	Moses	Taconic	001147-M	Mice have no mature B-lymphocytes Normal,T-lymphocyte development. No IgM or IgG in serum.	001147	Int. Immunol. 5;647
p55 and p75 doubleknockout	Wallach 19.1.02	Jax	003243	p55 and p75 deficient are viable and fertile. Double homozygous mutant mice fail to bind TNF.	003243	Immunol. 160;943
TcrH-Y(B6D2(B6)-Tg TcrH-Y transgene	Jung 2003	Institute for Genetics, Cologne	Taconic 004051	Mice have transgene encoding a TCR specific for male antigen (HY) in the context of model H2b. Used for studies on thymic negative selection.	004051	Nature 333;742
Src k/o	Geiger 3.04	Jax	002277	Homozygotes display osteopetrosis and are 1/3 the size of wildtype siblings. Incisors fail to erupt. Partial absence of bone marrow.	002277	Cell 65; 693
IL-12 k/o	Groner 7.04	Jax	002693	Homozygotes have a severely restricted ability to mount a TH1 response,defective in IFN gamma production and type 1 cytokine responses.	002693	Immunity 4; 471
IL-15 k/o	Jung 5.05	Taconic		IL-15 KO mice lack NK cells and have a reduction in memory CD8 T cells, NKT cells and IELs.		J Exp. Med 191;771
neuropilin-1 k/o conditional	Zelzer 2.05	Kolodkin Baltimore		a conditional npn-1 (neuropilin-1 ) null mouse using Cre-loxP strategy		Dev. Cell5; 45	Permission from Kolodkin required
neuropilin-2 k/o	Zelzer 2.05	Kolodkin Baltimore		Homozygotes are viable. Npn-2 is required for the organization several cranial and spinal nerves. Several major fiber tracts in the brains severely disorganized or missing.		Neuron 25;29	Permission from Kolodkin required
Smoh k/o smoothened homologue	Hermalin 4.04	Jax	004288	Homozygotes don’t develop past 9.5 dpc, have cyclopia and open gut, no embryonic turning, and normal rightward looping of the heart. Hedgehog pathway and L/R asymmetry disrupted.	004288	Cell 105;781
Double transgene Mo/Hu APPswe PS1dE9	Schwartz 4.04	Jax	004462	Double transgenics express mutant human presenilin 1 and mouse/human amyloid precursor protein (APPSwe). Mice develop beta-amyloid deposits in the brains by 7 months of age.	004462	Biomol. Eng. 17;157
CYLD k/o	Wallach 3.04	Waisman, Cologne		Mice deficient in cylindromatosis tumor suppressor gene		unpublished	Restricted to collaborators
Col11A2 k/o (FVB/N)	Rousso	Smith Iowa		In homozygotes the mutation alters the collagen fibers network of the tectorial membrane which results in deafness.		Nature Genet. 23;413	Permission from Prof. Smith required
Tectb k/o (129/C57B16J)	Rousso 1.05	Richardson Sussex		-/- mice lack the tectorial membrane protein beta-tectorin. Removal of this protein was found to cause hearing impairments.		Neuron 28;273	Permission from Prof. Richardson required
Patched k/o (Ptch1)	Zelzer 8.05	Jax	003081	Homozygotes embryonic lethal with open and overgrown neural tubes. Heterozygotes are larger than + with some hindlimb defects and brain tumors. Express lacZ in a pattern of endogenous gene expression.	003081	Science 277;1109
B2m k/o	Jung 5.05	Taconic	B2MN12-M	The B2m -/- mice are deficient in CD4-8+ T cells due to inactivation of the Beta 2-microglobulin gene. Useful for research in transplantation, gene therapy and immunological diseases.	B2m_N12.htm	Nature 344;709
Msh2 k/o	Shapiro 7.05	Edelmann Albert Einstein		Mutation ofMSH2 mismatch-repair (MMR) gene. Homozygotes develop spontaneous tumors by 6 months. Have a high level of MS instability in all cancerous tissues, but not in non-cancerous tissues		Genes Chromosomes Cancer 29;229
Caspase-3 k/o CPP32	Gross	Flavell Yale		-/- mice, born at a lower than mendelian frequency, smaller than their littermates and died at 1-3 weeks of age. Abnormal brain development resulting in a variety of hyperplasias .		Nature 384;368
CX3CL1(Fkn) k/o	Jung 8.05	Lira, Mount Sinai, NY		The mouse harbors targeted mutation of the membrane-tethered chemokine CX3CL1/Fractalkine		Mol. Cell Biol. 21;3159	Permission from Lira required
hDC-SIGN transgene	Jung 8.05	Littman, New York		Carries a transgen encoding the human DC-SIGN gene under the murine CD11c promoter		unpublished	Permission from Littman required
Epas1 k/o	Zelzer 3.07	Jax	003266	Homozygotes develop normally until E 11.5, but by E 16.5 there are no viable mutant embryos. Pronounced bradycardia, but overall development appears normal. Contain lacZ making them a marker for endothelial cells.	003266	Genes Dev;12 3320
Klc k/o	Fainzilber 7.07	Jax	004098	Homozygotes display perinatal mortality (60%). Surviving mice are noticeably smaller than wildtype mice and breed poorly, possibly due inadequate nurturing capabilities	004098	J Cell Biol 146;1277
MMTVPyVT tg	Wallach 2.07	Jax	002374	Female mice carrying the (MMTV-PyVT) transgene developed mammary tumors by 5 weeks of age. Adenocarcinomas were found in virgin and breeder females as well as males. Model for metastatic disease	002374	Mol Cell Bio 12;954
Apoe k/o	Jung 9.07	Jax	002052	Apoe - mice have increased cholesterol levels. Also altered responses to stress, impaired spatial learning and memory, altered LTP, and damage.	002052	PNAS 89;4471
Baff ko	Jung 1.07	Biogen Idec, Inc., Cambridge		BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes.		Science 293;2111	MTA required
Alpha4	Fainzilber	Kohler Berlin					Restricted
GATA knock-in	Groner 10.07	Orkin Boston		GATA1 knock-in in leads to hyperproliferation of a unique, previously unrecognized yolk sac and fetal liver progenitor		Nature Gen. 37;61	Restricted
STAT3-beta k/o	Fainzilber 11.07	Poli Turin		STAT3-beta null mice		Nat. Immunol. 5;401	Restricted
Klc1J ko	Wallach 1.08	Jax	004098	Mice surviving to adulthood breed poorly.Motor defects are evident, as are alterations in intracellular localization of kinesin-I and COP-I components.	004098	J Cell Biol 146;1277
Ppt1tm1Hof k/o	Reiner 2008	Jax	004313	Brain size of the mutant mice is reduced, neuronal loss and apoptosis in the hippocampus, cerebral cortex and cerebellum. Useful in studies of neuronal ceroid lipofuscinoses, including infantile Batten disease.	004313	PNAS 98; 13566
Tbx21 k/o	Jung	Jax	004648	Homzygotes susceptible to Leishmania infections, females display hyper-responsiveness (AHR) with resulting airway remodeling similar to asthma. May be useful in studies human asthma and chronic intestinal inflammation.	004648	Science 295; 5553
DCTW-1 G595 knock-in	Reiner 2008	Cai NIH		Knock –in of the G592 mutation causes dysfunction of Dynactin. -/- are embryonic lethal. Heterozygotes developed motor neuron disease phenotypes at 10 months.		J Neurosci 27; 3982	MTA required
K14-lnl/lnl k/o	Futerman 2008	Karlsson Sweden		K14-lnl/lnl conditional knockout model: Exhibit rapid motor dysfunction associated with severe neurodegeneration and apoptotic cell death within the brain. Develop paralysis and die by 2 weeks.		PNAS 104; 17483	Contact Prof. Futerman
Nestin flox/flox conditional k/o	Futerman 2008	Karlsson Sweden		GlcCerase deficiency is restricted to neural and glial cell progenitors and progeny. They develop similar pathological changes as the K14-lnl/lnl mice, but with delayed onset and slower progression - die by the age of 3 weeks.		PNAS 104; 17483	Contact Prof. Futerman
Tbx1deltaE5 k/o	Horenstein 2008	EMMA	02224	Null allele of the Tbx1 gene. Some heterozygotes have aortic arch defects	emma 2224	Dev 131; 3217	MTA required
Df(16)1_Bld k/o	Horenstein 2008	EMMA	02122	Targeted deletion of a Chr. 16 segment between genes Es2 and Ufd1l. 5-10% of mutants die at birth because of heart defects (mainly interrupted aortic arch type B)	emma 2122	Nature 401; 379	MTA required
Tbx1lacZ k/o	Horenstein 2008	EMMA		Null allele of Tbx1 gene with LacZ gene reporter insertion into exon 5. some heterozygotes have aortic arch defects.		Nature 410; 97	MTA required
TectA C1509G k/o	Rousso 2008	Oghalai Houston		In heterozygotes the inner ear tectorial membrane attaches to one row of OHCs (Outer Hair Cells). Homozygotes have a tectorial membrane which does not attach to any rows.		Unpublished
Prx1-Sox9/LacZ k/i	Zelzer 2008	Akiyama Koyoto		Sox9 is misexpressed in the limb bud mesenchyme, using knockin of Sox9 to the Prx1 promoter.		PNAS 102; 14665
Csf2rb k/o	Jung 2008	Jax	005940	In homozygous mice, bone marrow and splenocytes do not proliferate in response to GM-CSF. Model for PAP (pulmonary alveolar proteinosis) and other diseases.	005940	Blood 97; 922
Ccm2 gene trap	Fainzilber 2008	Marchuk Duke U		Heterozygous animals develop cerebral vascular malformations, Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations.		Mamm. Genome 17; 119	Permission required from Douglas Marchuk
Stat3-loxP	Fainzilber 2008	Akira Osaka		The gene STAT-3 is flanked by two loxP sites.		J Neurosci 28; 7231	Permission required from Prof. Shizuo Akira
Ephb4 k/o	Zelzer 12.08	Jax	006044	-/- embryonic lethal E9.5-10, growth retardation and lack of blood flow. Expression of lacZ in vascular endothelial cells. Useful for vasculogenesis and angiogenesis studies.	006044	Mol Cell 4; 403
Thy1-ChR2-YFP tg	Chen 1.09	Jax	007612	Transgene expressing light activated ion channel, and YFP fusion gene (ChR2-YFP) under thymus promoter. Useful for studies of neural activity by light stimulation.	007612	Neuron 54; 205
K14-ER:Ras tg	Oren 1.09	Jax	006403	Tamoxifen inducible expression of the ER:Ras fusion protein in epidermis promotes phenotypic characteristics observed in epidermal cancer.	006403	Cancer Res 63; 319
Spp1 k/o	Groner 1.09	Jax	004936	Defective wound repair and macrophage infiltration. Useful in studies of tissue remodeling, wound repair, fibrosis and granulomatous diseases.	004936	J Clin Invest 101; 1468
INFg k/o	Schwartz 12.08	Jax	002287	Homozygotes have no overt abnormalities, but display reduced macrophage function in response to pathogens.	002287	Science 259; 1739
INFgR k/o	Schwartz 12.08	Jax	003288	Homozygotes have no overt abnormalities, but are defective in natural resistance; increased susceptibility to infection.	003288	Science 259; 1693
Rag Perforin k/o	Hornstein 2008	Jax	004848	Double homozygotes lack mature T or B lymphocytes, no NK cell cytotoxic activity, and lack serum immunoglobulin. Develop thymic lymphomas. Useful in studies involving engraftment of human hematolymphoid cells.	004848	Transplantation 76; 1036	Permission from Schultz required
Rag Perforin Akita k/o	Hornstein 2008	Jax	008659	Homozygous for Rag1 and perforin 1 (Prf1) and heterozygous for the spontaneous insulin 2 Akita allele. Mice immunodeficient and hyperglycemic. Useful in studies of human islet and beta stem and progenitor cell function.	008659	As above and Transplantation 76; 1036	Permission from Schultz required
miR-155 k/o	Hornstein 11.08	Rajewsky Harvard		Homozygotes have impaired immune function.		Science 316; 604	MTA required
mir-17-92 flx/flx	Hornstein 2008	Jacks MIT		Mutants for miR-17-92 die shortly after birth with lung hypoplasia and a ventricular septal defect . Also inhibited B cell development.		Cell 132; 875
mir-106a-363 K.O mir-106b-25 K.O	Hornstein 2008	Jacks MIT		Homozygotes have no obvious phenotype. Compound mutants with mir-17-92 die at midgestation.		Cell 132; 875
FAK conditional k/o	Hornstein 11.08	Beggs UCSF		Floxed focal adhesion kinase gene for conditional knockout.		Mol Cell Biol 27; 5352	MTA required
TRPC-2 k/o	T. Kimchi 2008	Dulac Harvard		Homozygotes lack the ability to detect pheromone signals via the VNO (vomeronasal organ)		Science 295; 5559	Permission from Prof. Dulac required
Ldlrtm1Her k/i	Rubinstein 2009	Jax		Mice homozygous for the Ldlrtm1Her mutation have an elevated serum cholesterol level. Useful in Diabetes and Obesity Research	002207	J Clin Invest 92; 883
IRF-3 k/o	Wallach 2009	RIKEN		Targeted mutation of the interferon regulatory factor 3. Significantly reduced production of interferon alpha/beta against virus infection.	00858	Immunity 13; 539
EPAS 1 conditional tm	Zelzer 6.09	Jax	008407	Floxed Epas1 allele (endothelial PAS domain protein 1 or Hif-2alpha hypoxia-inducible factor).	8407	PNAS 104; 2301
CAG-MIRN17-92,-EGFP	Hornstein 9.09	Jax	008517	inducible expression of the human miR-17-92 cluster, associated with lymphomas and other cancers, autoimmune defects, and altered expression of tumor suppressor and pro-apoptotic genes	8517	Nat Immunol 9; 405
Myd88 floxed tm	Jung 9.10	Jax	008888	Floxed allele of Myd88, useful in studies of Toll-like receptor signaling	8888	Immunity 29; 272
Prnp-TARDB tg	Hornstein 8.10	Jax	010700	Express a mutant human TAR DNA binding protein (TARDBP or TDP-43) associated with familial Amyotrophic Lateral Sclerosis (ALS)	010700	PNAS 106,18809
Immorto-HE	Elson 4.09	Charles River	237 238	Express thermolabile allele of SV40 Tantigen under MHC promotor	Immortomouse	PNAS 88; 5096
Lgals8 tm	Zick 9.09	MMRRC	11734	Mutation of Lgals8 (lectin, galactose binding, soluble 8. Homozygotes have increased locomotor activity in the open field	11734
á BMP4 tm	Zelzer 2009	Trabin Harvard					Contact Eli Zelzer
Mir17-92 tm	Hornstein 6.09	Jacks MIT	008458 Jax	Floexed miR-17~92 (overexpressed in human cancers). Homozygotes for the floxed miR17~92 allele viable, fertile, with no gross physical or behavioral abnormalities	8458	Cell 132; 875
Mir106b-25 tm	Hornstein 6.09	Jacks MIT	008460 Jax	Floexed miR-17~92 (overexpressed in human cancers). Homozygotes for the floxed miR17~92 allele viable, fertile, with no gross physical or behavioral abnormalities	8460	Cell 132; 875
TDP-K160R tm TDP-STOP tm	Hornstein 6.09	Fisher UCL, London		Targeted point mutations in the TAR DNA binding protein
Ihh -/- tm	Zelzer 11.09	Mundlos Max-Planck		Homozygotes die before or immediately after birth due to respiratory failure. Exhibit limb dwarfism.		Genes Dev 13; 2072
Ephrin B2 lacz tm	Zelzer 6.09	Jax	006039	Homozygotes growth retarded, enlarged heart at E10, lethality at E11. Useful in studying vasculogenesis and angiogenesis, neovascularization, including tumor angiogenesis.	6039	Cell 93;741
TGFb RII tm	Zelzer 7.09	Schweitzer Portland		Conditional knockout of TGF beta RII		Genesis 32;73
Adar1 f7-9 tm	Harmelin 6.09	Orkin Harvard		Floxed allele of adar1. Nomozygotes viable and fertile		Nat Immunol 10;109
C/EBPbeta (fl/fl)	Rubinstein 3.09	Sterneck NCI, Frederick		C/EBP beta – mice have multiple phenotypes including skin. Increased apoptosis in keratinocytes after carcinogen treatment completely resistant to carcinogen-induced skin tumorigenesis		Oncogene 25; 1272
RanBP-10 tm	Fainzilber 9.09	Schulze Berlin		Mutant mice have platelet disfunction		Bloodn114; 5532
Alpha 5 tm	Fainzilber 2010	Bader Berlin		importin-5 deficient-mice show normal brain development		Nat cell Biol 9;1337
Spontaneous mutations etc.
Quaking (qk)	Volk	Jax	000506	Homozygous for the spontaneous quaking mutation (qk). Severely deficient in myelin in CNS and PNS	000506	Neurosciene 16;7941
NOD scid B2m;	Harmelin	Jax	003449 (002570)	Model for xenograft transplantation studies and source for insulitis-free, MHC class I-negative islets for transplantation studies.	002570	J. Immunol 158;3578
B6 scid	Schwartz 12.04	Jax	001913	Mice homozygous for severe combined immune deficiency spontaneous mutation (scid) have absence of functional T cells and B cells. scid mice accept allogeneic and xenogeneic grafts -ideal for cell transfer experiments.	001913	J. Immunol 154;180
CD45 (ptprc)(congenic strain)	Jung	Jax	002014	Used in transplant studies, carries the differential B cell antigen CD45	002014
Aly (alymphoplasia)Spontaneous mutation	Wallach	Clea,Japan, Inc.		Systemic absence of lymph nodes (LN) and Peyer's patches (PP) and disorganized splenic and thymic structures with immunodeficiency		Nature Genet. 22;74
BALB/c/CrSlc	Groner 3.03	Japan SLC		Lymphopenic experimental autoimmune gastritis model. Following neonatal thymectomy 90% of these mice develop gastritis.		Am.J. Physiol. 277;209
C3.SW-H2b	Jung 14.9.03	Jax	000438	Male mice predisposed to glucose intolerance and hyperinsulinemia with some mice exhibiting hyperglycemia.	000438	Endocrinology 116:2450-5
10ScNJ (Tlr4 deletion)	Jung 19.1.04	Jax	003752	Mice have a deletion of the Tlr4 gene that results in a defective response to LPS stimulation.	003752	Immunol. 122;619
Toxic milk (Jackson)	Reisner 9.04	Jax	001576	Tx-J/TxJ adults develop cirrhosis, infant mice copper deficient due to Cu deficient milk of mother. Useful for neurological disorders with Cu accumulation e.g. Alzheimers	001576	Mamm Genome 12,793
splotch-delayed (Pax3Sp-d)	Zelzer 9.04	Jax	000565	-/- embryos survive to birth, Homozygous splotch-delayed mutant embryos display caudal rachischisis only. Useful in dermatology ,neural crest and neural tube defects.	000565	PNAS 91,3685
shiverer (Mbpshi)	Ravel 6.04	Jax	001428	Homozygotes show a generalized tremor during locomotion which increases in severity with age, incoordination of hindlimbs. Severe myelin deficiency throughout the CNS.	001428	J. Hered 72;128
HRS/J	Wallach 8.05	Jax	000673	Homozygtes have a higher incidence and earlier onset of leukemia. Hair is lost from the follicle at 10 days. and mice eventually become continuously hairless.	000673	PNAS 91;7717
Reeler (Orleans allele)	Reiner 2005	Goffinet Brussels		Homozygotes exhibit an ataxic gait, and tremors from 2 weeks of age. These mutants are incapable of maintaining their hindquarters upright and often fall over during locomotor activity.		Brain Res Mol Brain Res. 50;85	Permission from Goffinet required
LOA	Fainzilber 6.05	Fisher, London		ENU mutagenesis screen; harbours a point mutation in the dynein heavy chain. Homozygotes are not viable, heterozygotes exhibit impairment in retrograde transport in neurons.		Science 300;808	Permission from Prof. Fisher required
Swe	Reiner 3.07	Jax	003012	Homozygotes for slow wave epilepsy spontaneous mutation (Nhe1) display locomomotor ataxia from at 11-14 days of age. Younger mice have seizure phenotypes similar to common human absence epilepsies.	003012	Cell 91;139
Ticam1Lps2	Wallach 11.07	Jax	005037	ENU mutagenesis. Macrophages fail to respond to LPS and dsRNA with production TNF. Mice become ill and some die. Useful in studies of immunodeficiency and response to bacterial endotoxins and viruses.	005037	Nature 424;743
B6.MRL-Faslpr/J	Fainzilber 1.08	Jax	000482	Model for systemic lupus erythematosus-like autoimmune syndromes	000482	J Exp Med 148;1198
Fe a/a-Mitfmi	Hornstein 1.09	Jax	001573	Model for systemic lupus erythematosus-like autoimmune syndromes	001573	Cell 74; 395